The effects of dietary polyunsaturated fatty acids on miR-126 promoter DNA methylation status and VEGF protein expression in the colorectal cancer cells
ConclusionsOur results provide evidence thatn-3 PUFAs are able to modulate cellular miR-126 DNA methylation and inhibit VEGF expression level in a cell-type specific manner in colorectal cancer cells. DHA always showed higher efficacy than EPA and LA in our experiment. Overall, our results suggest a potential clinical application ofn-3 PUFAs as anti-angiogenic agents in CRC therapy. (Source: Genes and Nutrition)
Source: Genes and Nutrition - December 18, 2018 Category: Nutrition Source Type: research
Genetic variation in the TAS2R38 taste receptor contributes to the oral microbiota in North and South European locations: a pilot study
ConclusionGeographical location and genetic variation in the hTAS2R38 taste receptor impact oral mucosa microbial composition. These findings provide an advance in the knowledge regarding the interactions between taste receptor genes and oral microbiota. This study suggests the role of host-microbiota interactions on the food taste perception in food choices, nutrition, and eating behavior. (Source: Genes and Nutrition)
Source: Genes and Nutrition - December 4, 2018 Category: Nutrition Source Type: research
Food intake biomarkers for apple, pear, and stone fruit
AbstractFruit is a key component of a healthy diet. However, it is still not clear whether some classes of fruit may be more beneficial than others and whether all individuals whatever their age, gender, health status, genotype, or gut microbiota composition respond in the same way to fruit consumption. Such questions require further observational and intervention studies in which the intake of a specific fruit can be precisely assessed at the population and individual levels. Within the Food Biomarker Alliance Project (FoodBAll Project) under the Joint Programming Initiative “A Healthy Diet for a Healthy Life”, an amb...
Source: Genes and Nutrition - November 29, 2018 Category: Nutrition Source Type: research
Targeting myomiRs by tocotrienol-rich fraction to promote myoblast differentiation
ConclusionTRF can potentially promote myoblast differentiation by modulating the expression of myomiRs, which regulate the expression of myogenic genes. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 29, 2018 Category: Nutrition Source Type: research
SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice
ConclusionsThese data demonstrate thatserpinA3 expression is implicated in nutritionally mediated hypothalamic inflammation. (Source: Genes and Nutrition)
Source: Genes and Nutrition - November 29, 2018 Category: Nutrition Source Type: research
Correction to: Biomarkers of legume intake in human intervention and observational studies: a systematic review
Following publication of the original article [1], the authors reported a spelling error of the third author ’s name, Mar Garcia Aloy. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 16, 2018 Category: Nutrition Source Type: research
Biomarker of food intake for assessing the consumption of dairy and egg products
AbstractDairy and egg products constitute an important part of Western diets as they represent an excellent source of high-quality proteins, vitamins, minerals and fats. Dairy and egg products are highly diverse and their associations with a range of nutritional and health outcomes are therefore heterogeneous. Such associations are also often weak or debated due to the difficulty in establishing correct assessments of dietary intake. Therefore, in order to better characterize associations between the consumption of these foods and health outcomes, it is important to identify reliable biomarkers of their intake. Biomarkers ...
Source: Genes and Nutrition - September 29, 2018 Category: Nutrition Source Type: research
Biomarkers of legume intake in human intervention and observational studies: a systematic review
In conclusion, despite many studies suggesting proposed biomarkers for soy, there is a lack of information on markers of other different subtypes of legumes. Further discovery and validation studies are needed in order to identify reliable biomarkers of legume intake. (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 10, 2018 Category: Nutrition Source Type: research
Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population
ConclusionsThe results suggest that genetic susceptibility to higher adult BMI can be tracked from childhood in this African population. This supports the notion that prevention of adult obesity should begin early in life. The genetic risk score combined with other non-genetic risk factors, such as BMI trajectory membership in our case, has the potential to be used to screen for early identification of individuals at increased risk of obesity and other related NCD risk factors in order to reduce the adverse health risk outcomes later. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 1, 2018 Category: Nutrition Source Type: research
Biomarkers of food intake for cocoa and liquorice (products): a systematic review
ConclusionsFor cocoa, specific BFIs were missing, mainly because the individual BFIs were also found in foods having a similar composition, such as tea (polyphenols) or coffee (caffeine). However, a combination of individual BFIs might lead to discriminating profiles between cocoa (products) and foods with a similar composition. Therefore, studies directly comparing the consumption of cocoa to these similar products are needed, enabling efforts to find a unique profile per product. For liquorice, we identified 18-GA as a promising BFI; however, important information on its validity is missing; thus, more research is necess...
Source: Genes and Nutrition - July 27, 2018 Category: Nutrition Source Type: research
High nutrient intake during the early postnatal period accelerates skeletal muscle fiber growth and maturity in intrauterine growth-restricted pigs
ConclusionThe present findings suggest that high nutrient intake during the suckling period could improve skeletal muscle growth and maturity, which is associated with increasing the expression of protein deposition-related genes and accelerating the development of glycolytic-type myofiber in pigs. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 27, 2018 Category: Nutrition Source Type: research
Betaine reduces β-amyloid-induced paralysis through activation of cystathionine-β-synthase in an Alzheimer model of Caenorhabditis elegans
ConclusionOur studies show that betaine is able to reduce homocysteine levels and β-amyloid-induced toxicity in aC. elegans model for Alzheimer ’s disease. This effect is independent of the remethylation pathway but requires the transsulfuration pathway mediated by cystathionine-β-synthase. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 27, 2018 Category: Nutrition Source Type: research
