Validation of biomarkers of food intake —critical assessment of candidate biomarkers
AbstractBiomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objective measurement of food intake. However, the number of comprehensively validated biomarkers of food intake is limited to just a few. Many new candidate biomarkers emerge from metabolic profiling studies and from advances in food chemistry. Furthermore, candidate food intake biomarkers may also be iden...
Source: Genes and Nutrition - May 30, 2018 Category: Nutrition Source Type: research
Dietary and genetic risk scores and incidence of type 2 diabetes
ConclusionsThe findings thus show that both genetic heredity and dietary habits previously associated with T2D add to the risk of T2D, but they seem to act in an independent fashion, with the consequence that all individuals, whether at high or low genetic risk, would benefit from favourable food choices. (Source: Genes and Nutrition)
Source: Genes and Nutrition - May 16, 2018 Category: Nutrition Source Type: research
Investigation of the influence of high glucose on molecular and genetic responses: an in vitro study using a human intestine model
ConclusionsTo our knowledge, this is the first investigation of high glucose-regulated molecular responses in an intestinal enterocyte model. Our findings identify new target genes that may be important in the intestinal glucose absorption and metabolism during high glucose consumption. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 30, 2018 Category: Nutrition Source Type: research
ONS: an ontology for a standardized description of interventions and observational studies in nutrition
ConclusionsThe ONS is the first systematic effort to provide a solid and extensible formal ontology framework for nutritional studies. Integration of new information can be easily achieved by the addition of extra modules (i.e., nutrigenomics, metabolomics, nutrikinetics, and quality appraisal). The ONS provides a unified and standardized terminology for nutritional studies as a resource for nutrition researchers who might not necessarily be familiar with ontologies and standardization concepts. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 30, 2018 Category: Nutrition Source Type: research
Investigation of the influence of high glucose on molecular and genetic responses: an in vitro study using a human intestine model
ConclusionsTo our knowledge, this is the first investigation of high glucose-regulated molecular responses in an intestinal enterocyte model. Our findings identify new target genes that may be important in the intestinal glucose absorption and metabolism during high glucose consumption. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 30, 2018 Category: Nutrition Source Type: research
ONS: an ontology for a standardized description of interventions and observational studies in nutrition
ConclusionsThe ONS is the first systematic effort to provide a solid and extensible formal ontology framework for nutritional studies. Integration of new information can be easily achieved by the addition of extra modules (i.e., nutrigenomics, metabolomics, nutrikinetics, and quality appraisal). The ONS provides a unified and standardized terminology for nutritional studies as a resource for nutrition researchers who might not necessarily be familiar with ontologies and standardization concepts. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 30, 2018 Category: Nutrition Source Type: research
Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects
ConclusionGenes involved in lipid metabolism were differentially expressed in PBMCs depending on the plasma fatty acid levels. This finding may increase our understanding of how fatty acids influence lipid metabolism at a molecular level in humans. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 10, 2018 Category: Nutrition Source Type: research
Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide
ConclusionsOur results suggest that ESC pre-incubated with HMB and exposed to H2O2 could affect expression on miRNA levels responsible for skeletal muscle development, cell proliferation and differentiation, and activation of tissue repair after injury. Enrichment analyses for targeted genes revealed that a large group of genes was associated with the regulation of signaling pathways crucial for muscle tissue development, protein metabolism, muscle injury, and regeneration, as well as with oxidative stress response. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 10, 2018 Category: Nutrition Source Type: research
Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects
ConclusionGenes involved in lipid metabolism were differentially expressed in PBMCs depending on the plasma fatty acid levels. This finding may increase our understanding of how fatty acids influence lipid metabolism at a molecular level in humans. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 10, 2018 Category: Nutrition Source Type: research
Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide
ConclusionsOur results suggest that ESC pre-incubated with HMB and exposed to H2O2 could affect expression on miRNA levels responsible for skeletal muscle development, cell proliferation and differentiation, and activation of tissue repair after injury. Enrichment analyses for targeted genes revealed that a large group of genes was associated with the regulation of signaling pathways crucial for muscle tissue development, protein metabolism, muscle injury, and regeneration, as well as with oxidative stress response. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 10, 2018 Category: Nutrition Source Type: research
Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells
ConclusionWt-p53, survivin, and microRNA-16-1 appear to be promising molecular targets of DHA. Thus, DHA might represent an attractive anti-tumor agent directed against KRAS-mutant CCSCs. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 2, 2018 Category: Nutrition Source Type: research
Analysis of circulating angiopoietin-like protein 3 and genetic variants in lipid metabolism and liver health: the DiOGenes study
ConclusionWe clarify the link between circulating levels of ANGPTL3 and specific markers of liver function. We demonstrate that changes in ANGPLT3 and CK-18 during LCD are under genetic control fromtrans-acting variants. Our results suggest an extended function of ANGPTL3 in the inflammatory state of liver steatosis and toward liver metabolic processes. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 2, 2018 Category: Nutrition Source Type: research
Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells
ConclusionWt-p53, survivin, and microRNA-16-1 appear to be promising molecular targets of DHA. Thus, DHA might represent an attractive anti-tumor agent directed against KRAS-mutant CCSCs. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 2, 2018 Category: Nutrition Source Type: research
