Evaluation of candidate reference genes for quantitative real-time PCR analysis in a male rat model of dietary iron deficiency
ConclusionThese results indicate the selection and use of RG should be empirically determined and RG selection may vary across experimental conditions and biological tissues. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 2, 2021 Category: Nutrition Source Type: research
Vegetarian diet duration ’s influence on women’s gut environment
ConclusionsThe vegetarian diet is beneficial more than harmful to women. Gut microbiota play roles in the ability of the human body to adapt to external changes. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 2, 2021 Category: Nutrition Source Type: research
Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms
ConclusionWe found evidence thatVDR genotype may modify the association between 25(OH)D and some PMSx. Insufficient 25(OH)D was associated with a higher risk of premenstrual fatigue in those with the CC genotype, but lower risk in those with the TT genotype. (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 22, 2021 Category: Nutrition Source Type: research
Expression of proposed methionine transporters along the gastrointestinal tract of pigs and their regulation by dietary methionine sources
ConclusionA high expression of several Met transporters in small intestinal segments underlines the primary role of these segments in amino acid absorption; however, some Met transporters show high transcript and protein levels also in large intestine, oral mucosa, and stomach. A diet containing DL-Met has potential to increase apical Met transport in the small intestine, whereas a diet containing DL-HMTBA has potential to increase basolateral Met transport in the small intestine and, partly, other gastrointestinal tissues. (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 6, 2021 Category: Nutrition Source Type: research
Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq
ConclusionsThe 3 differentially expressed circRNAs may play an important role in the process of AST promoting cholesterol efflux and may be used as biomarkers to prevent AS. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 28, 2021 Category: Nutrition Source Type: research
Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesis
ConclusionsTranscriptomic changes in PBMCs do occur in response to weight change. Transparent and standardised data reporting is needed to realise the potential of transcriptomics for investigating phenotypic features.Registration numberPROSPERO:CRD42019106582 (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 19, 2021 Category: Nutrition Source Type: research
Correction to: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis
(Source: Genes and Nutrition)
Source: Genes and Nutrition - July 12, 2021 Category: Nutrition Source Type: research
The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study
ConclusionIdentification of circulating miRNAs associated with insulin impairment may offer novel approaches of assessing early variations in insulin sensitivity and provide evidence about the molecular mechanisms connected to early changes in glycaemic homeostasis.Trial registrationISRCTN, ISRCTN62310987. Retrospectively registered,http://isrctn.com/ISRCTN62310987 (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 9, 2021 Category: Nutrition Source Type: research
Serum iron status and the risk of breast cancer in the European population: a two-sample Mendelian randomisation study
ConclusionIn our MR study, the liberal approach suggested that changes in the concentration of transferrin could increase the risk of ER-negative breast cancer, although the levels of other iron status markers had no effect on the risk of breast cancer or its subtypes. This should be verified in future studies. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 6, 2021 Category: Nutrition Source Type: research
TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis
ConclusionOur findings suggest the involvement of TCONS_00230836 in stearic acid-induced β-cell dysfunction, which provides novel insight into stearic acid-induced lipotoxicity to β cells. Anti-lncRNA TCONS_00230836 might be a new therapeutic strategy for alleviating stearic acid-induced β-cell dysfunction in the progression of T2DM. (Source: Genes and Nutrition)
Source: Genes and Nutrition - May 22, 2021 Category: Nutrition Source Type: research
An 8-week freeze-dried blueberry supplement impacts immune-related pathways: a randomized, double-blind placebo-controlled trial
ConclusionAn 8-week BBP intervention did not significantly improve traditional markers of cardiometabolic health in adults at risk of developing MetS. However, changes in gene expression and metabolite abundance suggest that clinically significant cardiometabolic changes could take longer than 8 weeks to present and/or could result from whole blueberry consumption or a higher dosage. BBP may also have an effect on factors such as immunity even within a shorter 8-week timeframe.Clinical trial registrationclinicaltrials.gov,NCT03266055, 2017 (Source: Genes and Nutrition)
Source: Genes and Nutrition - May 17, 2021 Category: Nutrition Source Type: research
A systematic review to identify biomarkers of intake for fermented food products
ConclusionsFermented foods comprise a heterogeneous group of foods. While many of the candidate FIBs identified were found to be non-specific, greater specificity may be observed when considering a combination of compounds identified for individual fermented foods, food groups, and from fermentation processes. Future studies that focus on how fermentation impacts the composition and nutritional quality of food substrates could help to identify novel biomarkers of fermented food intake. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 21, 2021 Category: Nutrition Source Type: research
Association of vitamin D pathway genes polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population
ConclusionOur study suggested thatGC SNPs were associated with the genetic background of PTB.CYP27A1,GC, andDHCR7 genetic variations might contribute to several clinical phenotypes of PTB in Chinese. (Source: Genes and Nutrition)
Source: Genes and Nutrition - April 21, 2021 Category: Nutrition Source Type: research
Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese
ConclusionsThis study indicated that dietary BCAAs could amplify the genetic association with T2D risk and fasting glucose. Moreover, higher BCAA intake showed positive association with T2D when genetic predisposition was also high but changed to negative when genetic predisposition was low. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 4, 2021 Category: Nutrition Source Type: research
Consumer acceptance of genetic-based personalized nutrition in Hungary
ConclusionsCompared with the magnitude of the effect of socio-demographic criteria, it can be concluded that, on the whole, psychological processes in the individual have a greater influence on the development of preferences for genetic-based personalized nutrition than any socio-demographic factor. This also confirms the trend that there are more and more value-added products or value propositions (where a significant part of the value added is to be found in product innovation), for which psychological characteristics are/should be given more emphasis among the segmentation criteria. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 1, 2021 Category: Nutrition Source Type: research
