High nutrient intake during the early postnatal period accelerates skeletal muscle fiber growth and maturity in intrauterine growth-restricted pigs
ConclusionThe present findings suggest that high nutrient intake during the suckling period could improve skeletal muscle growth and maturity, which is associated with increasing the expression of protein deposition-related genes and accelerating the development of glycolytic-type myofiber in pigs. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 27, 2018 Category: Nutrition Source Type: research
Biomarkers of food intake for cocoa and liquorice (products): a systematic review
ConclusionsFor cocoa, specific BFIs were missing, mainly because the individual BFIs were also found in foods having a similar composition, such as tea (polyphenols) or coffee (caffeine). However, a combination of individual BFIs might lead to discriminating profiles between cocoa (products) and foods with a similar composition. Therefore, studies directly comparing the consumption of cocoa to these similar products are needed, enabling efforts to find a unique profile per product. For liquorice, we identified 18-GA as a promising BFI; however, important information on its validity is missing; thus, more research is necess...
Source: Genes and Nutrition - July 27, 2018 Category: Nutrition Source Type: research
Betaine reduces β-amyloid-induced paralysis through activation of cystathionine-β-synthase in an Alzheimer model of Caenorhabditis elegans
ConclusionOur studies show that betaine is able to reduce homocysteine levels and β-amyloid-induced toxicity in aC. elegans model for Alzheimer ’s disease. This effect is independent of the remethylation pathway but requires the transsulfuration pathway mediated by cystathionine-β-synthase. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 27, 2018 Category: Nutrition Source Type: research
Genetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes
ConclusionsOur study indicates that genetically determined variation inSELENOP leads to different responses in expression of selenoproteins following consumption of selenium-rich foods. This study also emphasizes the importance of taking individual aspects such as genotypes into consideration when assessing risk in public health recommendations. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 13, 2018 Category: Nutrition Source Type: research
Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport ( SERT ) and degradation ( MAO-A ) gene expression in cultured rat serotonergic neuronal cell lines
ConclusionsThese results are consistent with the concept that vitamin D maintains extracellular fluid serotonin concentrations in the brain, thereby offering an explanation for how vitamin D could influence the trajectory and development of neuropsychiatric disorders. Given the profile of gene regulation in cultured RN46A-B14 serotonergic neurons, we conclude that 1,25D acts not only to induce serotonin synthesis, but also functions at an indirect, molecular-genomic stage to mimic SSRIs and MAO inhibitors, likely elevating serotonin in the CNS. These data suggest that optimal vitamin D status may contribute to improving be...
Source: Genes and Nutrition - July 11, 2018 Category: Nutrition Source Type: research
Metabolic transition of milk triacylglycerol synthesis in response to varying levels of palmitate in porcine mammary epithelial cells
ConclusionsResults from this study suggest that palmitate stimulated the cytosolic TAG accumulation in pMECs, probably by promoting lipogenic genes and proteins that are involved in lipid synthesis. However, addition of palmitate decreased the fatty acid de novo synthesis in pMECs. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 6, 2018 Category: Nutrition Source Type: research
Correction to: Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects
Unfortunately, after publication of this article [1], it was noticed that some corrections to Table 2 were not carried out. The corrected Table 2 can be seen below and the original article has also been updated to reflect this. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 5, 2018 Category: Nutrition Source Type: research
Exploring the cellular network of metabolic flexibility in the adipose tissue
ConclusionWe have constructed an abstracted network covering glucose and fatty acid oxidation, as well as thePDC-PDK regulatory switch. In addition, we have shown how the network can be used for data visualisation and as a resource for follow-up studies. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 5, 2018 Category: Nutrition Source Type: research
Correction to: Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects
Unfortunately, after publication of this article [1], it was noticed that some corrections to Table 2 were not carried out. The corrected Table 2 can be seen below and the original article has also been updated to reflect this. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 5, 2018 Category: Nutrition Source Type: research
Biomarkers of intake for coffee, tea, and sweetened beverages
AbstractNon-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine. They may be used as compliance markers in intervention studies or as biomarkers of intake to improve measurements of beverage consumption in cohort studies and reveal new associations with disease outcomes that may have been overlooked when using dietary questionnaires. Here, biomarkers of intake of some major non-alcoholic beve...
Source: Genes and Nutrition - July 4, 2018 Category: Nutrition Source Type: research
