Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats
ConclusionThe results obtained suggest that the anti-diabetic effects of PFJ may be due to mechanisms other than an increase in insulin secretion. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 21, 2016 Category: Nutrition Source Type: research
Improper hydration induces global gene expression changes associated with renal development in infant mice
ConclusionsAltogether, we demonstrate transcriptional events during renal development in infancy and show that the impacts of inadequate water intake in the early postnatal state heavily rely on the impairment of normal renal development. Here, we provide a meaningful perspective of renal development in infancy with a molecular and physiological explanation of why infants are more vulnerable to dehydration than adults. These results provide new insights into the molecular effects of dehydration on renal physiology and indicate that optimal nutritional interventions are necessary for pediatric renal development. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 19, 2016 Category: Nutrition Source Type: research
The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport
ConclusionsChanges in cholesterol transport may contribute to altered tissue development in the fetus and hence programme risk of disease in later life. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 11, 2016 Category: Nutrition Source Type: research
Effect of diets supplemented with different conjugated linoleic acid (CLA) isomers on protein expression in C57/BL6 mice
ConclusionsAdministration of CLA in humans has to be carefully personalized, since even considering the presence of a species-specific effect, adverse effects might occur on long-term supplementation. Here we demonstrated that, in mouse, CLA is effective in reducing fat mass, but it also induces liver steatosis. The increase of lean mass is linked to an induction of cell proliferation, which, on long-term supplementation, might also lead to adverse effects. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 3, 2016 Category: Nutrition Source Type: research
The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study
ConclusionsThese results suggest that knowledge ofMTHFR 677C → T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant.Trial registrationClinicalTrials.govNCT01530139 (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 28, 2016 Category: Nutrition Source Type: research
Erratum to: Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation
(Source: Genes and Nutrition)
Source: Genes and Nutrition - August 15, 2016 Category: Nutrition Source Type: research
Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup ’ik people
ConclusionWe provide evidence of linkage between several biologically plausible genomic regions and vitamin D metabolism in a circumpolar population. Additionally, these findings suggest that a traditional dietary pattern may modulate genetic effects on circulating vitamin D. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 1, 2016 Category: Nutrition Source Type: research
Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation
Conclusions < /h3 > < p class= " a-plus-plus " > We show for the first time that EFA-CLA can regulate genes engaged in AKT/mTOR pathway and inhibiting cell cycle progression. The observed results are most likely achieved by the combined effect of both: incorporated CLA isomers and other fatty acids in eggs organically modified through hens ’ diet. Our results suggest that CLA-enriched eggs could be easily available food products with a potential of a cancer chemopreventive agent. < /p > < /span > (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 26, 2016 Category: Nutrition Source Type: research
Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species
Conclusions
We found that VAAM ingestion had an effect on multiple tissue transcriptomes of freely moving mice. Utilization of glycogenic amino acids may have been activated in the liver. Fatty acid conversion into phospholipid, not to triacylglycerol, may have been stimulated in adipocytes contrasting that a little effect was observed in BAT. Analysis of upstream factors revealed that multiple hormonal signals were activated in the liver, WAT, and BAT. Our data provide some clues to understanding the role of VAAM in metabolic regulation. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 10, 2016 Category: Nutrition Source Type: research
Coordinated regulation of hepatic and adipose tissu/e transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species
Conclusions
We found that VAAM ingestion had an effect on multiple tissue transcriptomes of freely moving mice. Utilization of glycogenic amino acids may have been activated in the liver. Fatty acid conversion into phospholipid, not to triacylglycerol, may have been stimulated in adipocytes contrasting that a little effect was observed in BAT. Analysis of upstream factors revealed that multiple hormonal signals were activated in the liver, WAT, and BAT. Our data provide some clues to understanding the role of VAAM in metabolic regulation. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 10, 2016 Category: Nutrition Source Type: research
Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort
Conclusion
We found some evidence of an interaction between diet quality and GRSLDL-C on ischemic stroke. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 6, 2016 Category: Nutrition Source Type: research
Metallothioneins 1 and 2, but not 3, are regulated by nutritional status in rat white adipose tissue
Conclusions
This study showed that the expressions of MT1 and MT2 genes in WAT are regulated by nutritional status, and the regulation may be independent of total zinc concentration. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 22, 2016 Category: Nutrition Source Type: research
Moderately decreased maternal dietary energy intake during pregnancy reduces fetal skeletal muscle mitochondrial biogenesis in the pigs
Conclusions
The observed decrease in muscle mitochondrial biogenesis and antioxidant defense capacity suggests that moderately decreased maternal energy intake during pregnancy impairs mitochondrial function in fetal pigs. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 22, 2016 Category: Nutrition Source Type: research
Dibutyryl-cAMP affecting fat deposition of finishing pigs by decreasing the inflammatory system related to insulin sensitive or lipolysis
Conclusions
In summary, the effect of db-cAMP on suppressing fat synthesis and accumulation is better in the earlier phase than in the later phase of finishing pigs, and db-cAMP plays this function by increasing the activity of the GH-IGF-1 axis and POMC system, while decreasing the inflammatory system within the adipose tissue related to insulin sensitive or lipolysis. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 2, 2016 Category: Nutrition Source Type: research
The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects
Conclusion
The suggested concern linking lipid oxidation products to short-term unfavorable health effects may therefore not be evident at a molecular level in this explorative study.
Trial registration
ClinicalTrials.gov, NCT01034423 (Source: Genes and Nutrition)
Source: Genes and Nutrition - May 30, 2016 Category: Nutrition Source Type: research
