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Total 675 results found since Jan 2013.
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination
This study explores the relationship between HECTD4, GluN2B, and MALT1, focusing on their role in brain injury in ischemic stroke. Rats were subjected to 2 h-ischemia followed by 24-h reperfusion to establish an ischemic stroke model. We observed the downregulation of HECTD4 and the upregulation of MALT1. Additionally, an increased GluN2B phosphorylation was concomitant with weakened interactions between HECTD4 and GluN2B, followed by decreased stria tal-enriched protein phosphatase (STEP61). Knockdown of HECTD4 exacerbated hypoxia- or NMDA-induced injury in nerve cells coincident with a decrease in GluN2B and MALT1 ubiq...
Source: Molecular Neurobiology - March 1, 2023 Category: Neurology Source Type: research
Anti-inflammatory role of extracellular l-arginine through calcium sensing receptor in human renal proximal tubular epithelial (HK-2) cells
Int Immunopharmacol. 2023 Feb 22;117:109853. doi: 10.1016/j.intimp.2023.109853. Online ahead of print.ABSTRACTRenal tubular epithelial cells are capable of synthesizing interleukins (IL) in response to a variety of proinflammatory cytokines. Moreover, elevated urinary levels of IL have been shown in patients with various forms of nephritic diseases. However, the underlying intracellular signaling mechanism is unclear. Here we show the immunological signaling role of l-Arginine (l-Arg) through Ca2+-sensing receptor (CaSR) in human kidney 2 (HK-2) renal proximal tubular epithelial cells, using Ca2+ imaging and patch clamp te...
Source: International Immunopharmacology - February 24, 2023 Category: Allergy & Immunology Authors: Samuel Shin Eugenia Awuah Boadi Saloni Shah Madison Ezell Peijun Li Bidhan C Bandyopadhyay Source Type: research
S100A9 promotes glycolytic activity in HER2-positive breast cancer to induce immunosuppression in the tumour microenvironment
CONCLUSIONS: S100A9 overexpression upregulated the glycolysis activity of tumour cells through the c-Myc-related pathway, suppressing lymphocyte infiltration in the tumour stroma, affecting the efficacy of immune regulation and long-term survival of patients.PMID:36755606 | PMC:PMC9900376 | DOI:10.1016/j.heliyon.2023.e13294
Source: Cancer Control - February 9, 2023 Category: Cancer & Oncology Authors: Jia-Qi Yuan Shou-Man Wang Lei Guo Source Type: research
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination
This study explores the relationship between HECTD4, GluN2B, and MALT1, focusing on their role in brain injury in ischemic stroke. Rats were subjected to 2 h-ischemia followed by 24-h reperfusion to establish an ischemic stroke model. We observed the downregulation of HECTD4 and the upregulation of MALT1. Additionally, an increased GluN2B phosphorylation was concomitant with weakened interactions between HECTD4 and GluN2B, followed by decreased stria tal-enriched protein phosphatase (STEP61). Knockdown of HECTD4 exacerbated hypoxia- or NMDA-induced injury in nerve cells coincident with a decrease in GluN2B and MALT1 ubiq...
Source: Molecular Neurobiology - February 4, 2023 Category: Neurology Source Type: research
Impact of silencing eEF2K expression on the malignant properties of chordoma
CONCLUSION: Our findings indicate that the loss of eEF2K expression in chordoma cell lines results in the reduction of metastatic capacity.PMID:36652154 | DOI:10.1007/s11033-023-08257-z
Source: Mol Biol Cell - January 18, 2023 Category: Molecular Biology Authors: Esra Aydemir Emre Can T üysüz Ömer Faruk Bayrak Didem Tecimel Ay şen Aslı Hızlı-Deniz Fikrettin Şahin Source Type: research
Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro
ConclusionsTaken together, this study provides evidence that the protective effect of ANXA1 (Ac2-26) on SI-AKI largely depends on the negative regulation of inflammation and apoptosis via the Fpr2 receptor.
Source: Inflammation Research - December 22, 2022 Category: Research Source Type: research
Intestinal enteroendocrine cells rely on ryanodine and IP < sub > 3 < /sub > calcium store receptors for mechanotransduction
This study has found that the signal amplification involves calcium induced calcium release (CICR) mechanisms activated through intracellular stores receptors, RyR3 and IP3Rs. Activation of these receptors leads to large and sustained increase in Ca2+ that results in the release of serotonin (5-HT) that plays an important role in many local and systemic processes. This article is protected by copyright. All rights reserved.PMID:36428286 | DOI:10.1113/JP283383
Source: The Journal of Physiology - November 26, 2022 Category: Physiology Authors: Kaitlyn R Knutson Sara T Whiteman Constanza Alcaino Arnaldo Mercado-Perez Isabelle Finholm Hannah K Serlin Shreya S Bellampalli David R Linden Gianrico Farrugia Arthur Beyder Source Type: research
Cancers, Vol. 14, Pages 5838: Suppression of Calcium Entry Modulates the Expression of TR & beta;1 and Runx2 in Thyroid Cancer Cells, Two Transcription Factors That Regulate Invasion, Proliferation and Thyroid-Specific Protein Levels
In conclusion, we show that TR&beta;1 is downregulated in thyroid cancer cells and that restoration of its expression can reverse the cancer cell phenotype towards a normal thyroid cell phenotype.
Source: Cancers - November 26, 2022 Category: Cancer & Oncology Authors: Muhammad Yasir Asghar Taru Knuutinen Emilia Holm Tommy Nordstr öm Van Dien Nguyen You Zhou Kid T örnquist Tags: Article Source Type: research
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells
In this study, the involvement of calreticulin (CRT) in autophagy induced by CQ was investigated. Our results illustrated the endoplasmic reticulum (ER) stress induced by CQ and DTT led to the cell death in different manners. DTT, an ER stress positive control, induced UPR accompanied with up-regulation of CRT and apoptosis, while CQ inhibited UPR accompanied with down-regulation of CRT，resulting in autophagy. Then, overexpression of CRT was shown to cause UPR and decrease [Ca2+]i, leading to cell apoptosis and inhibition of S-phase arrest induced by CQ. While the UPR was alleviated and autophagy was further enhanced in ...
Source: Chemico-Biological Interactions - November 17, 2022 Category: Molecular Biology Authors: Xiaoguang Lv Zheyu Fan Fangqi Cao Wenbin Liu Zhiwei Huang Ping Shi Source Type: research
The mechanosensitive Piezo1 channels contribute to the arterial medial calcification
Vascular calcification (VC) is associated with a number of cardiovascular diseases, as well as chronic kidney disease. The role of smooth muscle cells (SMC) has already been widely explored in VC, as has the role of intracellular Ca2+ in regulating SMC function. Increased intracellular calcium concentration ([Ca2+]i) in vascular SMC has been proposed to stimulate VC. However, the contribution of the non-selective Piezo1 mechanosensitive cation channels to the elevation of [Ca2+]i, and consequently to the process of VC has never been examined. In this work the essential contribution of Piezo1 channels to arterial medial cal...
Source: Frontiers in Physiology - November 10, 2022 Category: Physiology Source Type: research
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy
Autophagy. 2022 Nov 7:1-21. doi: 10.1080/15548627.2022.2139921. Online ahead of print.ABSTRACTAlpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts and has developed multiple strategies to counteract the host defense. Here, we demonstrate that the tegument protein UL21 (unique long region 21) in pseudorabies virus (PRV) dampens type I interferon signaling by triggering the degradation of CGAS (cyclic GMP-AMP synthase) through the macroautophagy/autophagy-lysosome pathway. Mechanistically, the UL21 protein scaffolds the E3 ligase UBE3C (ubiquitin protein ligase E3C) to catalyze the K27-l...
Source: Autophagy - November 7, 2022 Category: Cytology Authors: Zicheng Ma Juan Bai Chenlong Jiang Huixin Zhu Depeng Liu Mengjiao Pan Xianwei Wang Jiang Pi Ping Jiang Xing Liu Source Type: research
