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Nutrition: Calcium

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Total 675 results found since Jan 2013.

Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether ‐à‐go‐go–Related Gene and Cav1.2
Conclusion: Chronic incubation with FLV and LPV produced more severe channel-blocking effects and contributed to altered channel gating and shortened action potential duration by inhibiting hERG and Cav1.2.
Source: Frontiers in Pharmacology - July 7, 2022 Category: Drugs & Pharmacology Source Type: research

Lipid-coated albumin-paclitaxel nanoparticles loaded with sorcin-siRNA reverse cancer chemoresistance via restoring intracellular calcium ion homeostasis
Chemoresistance is often a cause of the failure of chemotherapy in cancer treatment. Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpress...
Source: Journal of Nanobiotechnology - July 7, 2022 Category: Nanotechnology Authors: Chenglong Wang, Xiaolin Xu, Peipei Zhang, Shuhan Xiong, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Hongjing Dou and Guoxiong Xu Tags: Research Source Type: research

Kalirin mediates Rac1 activation downstream of calcium/calmodulin ‐dependent protein kinase II to stimulate glucose uptake during muscle contraction
In this study, we investigated the role of calcium/calmodulin-dependent protein kinase II (CaMKII) in contraction-stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS), and treadmill running was used to exercise mice. The activities of CaMKII, the small G protein Rac1, and the Rac1 effector kinase PAK1 were elevated in muscle by running exercise or EPS, while they were lowered by the CaMKII inhibitor KN-93 and/or small interfering RNA (siRNA)-mediated knockdown. EPS induced the mRNA and protein expression of the Rac1-GEF Kalirin in a CaMKII-dependent manner. EPS-...
Source: FEBS Letters - June 30, 2022 Category: Biochemistry Authors: Sasa Liu, Rui Qi, Juan Zhang, Chang Zhang, Liming Chen, Zhi Yao, Wenyan Niu Tags: Research Article Source Type: research

Galectin-3 induces vascular smooth muscle cells calcification via AMPK/TXNIP pathway
In this study, we evaluated the role of TXNIP in galectin-3-induced vascular calcification. A primary culture of mouse VSMCs was established by enzymatic digestion of aorta. Small interfering (si) RNA was used to knock down the expression of target gene. VSMCs were treated with 3-methyladenine (3-MA) or compound C respectively. Western blot was performed to detect the protein level in VSMCs, Alkaline phosphatase (ALP) and Alizarin red staining was used to observe calcium deposition. Dihydroethidium (DHE) staining was used to observe the reactive oxygen species (ROS) production. Here we showed that galectin-3 increased aort...
Source: Aging - June 30, 2022 Category: Biomedical Science Authors: Lei Tian Yong Wang Ruiyan Zhang Source Type: research

Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium
Targeting proteins to a specific membrane is crucial for proper epithelial cell function. KCa3.1, a calcium-activated, intermediate-conductance potassium channel, is targeted to the basolateral membrane (BLM) in epithelial cells. Surprisingly, the mechanism of KCa3.1 membrane targeting is poorly understood. We previously reported that targeting of KCa3.1 to the BLM of epithelial cells is Myosin-Vc-, Rab1-and Rab8-dependent. Here, we examine the role of the SNARE proteins VAMP3, SNAP-23 and syntaxin 4 (STX-4) in the targeting of KCa3.1 to the BLM of Fischer rat thyroid (FRT) epithelial cells. We carried out immunoblot, siRN...
Source: Frontiers in Physiology - June 27, 2022 Category: Physiology Source Type: research

Persistent Escherichia coli infection in renal tubular cells enhances calcium oxalate crystal-cell adhesion by inducing ezrin translocation to apical membranes via Rho/ROCK pathway
In this study, Escherichia coli, the most common bacterium found in recurrent UTI was used to establish the in vitro model for persistent infection of renal epithelial cells. The promoting effects of persistent E. coli infection on kidney stone formation were validated by COM crystal-cell adhesion assay, followed by immunofluorescence study for changes in surface expression of the known COM crystal receptors. Among the five receptors examined, only ezrin had significantly increased level on the surface of persistently infected cells without change in its total level. Such translocation of ezrin to apical membranes was conf...
Source: Cellular and Molecular Life Sciences : CMLS - June 24, 2022 Category: Cytology Authors: Rattiyaporn Kanlaya Visith Thongboonkerd Source Type: research

Kalirin mediates Rac1 activation downstream of calcium/calmodulin ‐dependent protein kinase II to stimulate glucose uptake during muscle contraction
In this study, we investigated the role of calcium/calmodulin-dependent protein kinase II (CaMKII) in contraction-stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS) and treadmill running was used to exercise mice. The activities of CaMKII, the small G protein Rac1, and the Rac1 effector kinase PAK1 were elevated in muscle by running exercise or EPS, while they were lowered by the CaMKII inhibitor KN-93 and/or siRNA-mediated knockdown. EPS induced the mRNA and protein expression of the Rac1-GEF Kalirin in a CaMKII-dependent manner. EPS-induced Rac1 activation w...
Source: FEBS Letters - June 18, 2022 Category: Biochemistry Authors: Sasa Liu, Rui Qi, Juan Zhang, Chang Zhang, Liming Chen, Zhi Yao, Wenyan Niu Tags: Research Article Source Type: research

GSE206103 Human skin specific long noncoding RNA HOXC13-AS regulates keratinocyte differentiation by inferfering with Golgi-ER retrograde transport
Contributors : Ning X Land én ; Letian ZhangSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn an RNAseq analysis, we have identified the HOXC13-AS significantly downregulated in wound biopsies and epidermal cells compared to skin counterparts.To study the genes regulated by HOXC13-AS, we transfected HOXC13-AS siRNA pool into human primary epidermal keratinocytes to knockdown HOXC13-AS and induced cell differentiation for 3 days by 1.5 mM calcium. We performed a global transcriptome analysis of keratinocytes upon the HOXC13-AS knockdown using Affymetrix arrays.
Source: GEO: Gene Expression Omnibus - June 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Extracellular adenosine triphosphate induces IDO and IFN γ expression of human periodontal ligament cells through P < sub > 2 < /sub > X < sub > 7 < /sub > receptor signaling
CONCLUSION: eATP induced immunosuppressive function of hPDLCs by promoting IDO and IFNγ production via P2 X7 receptor signaling. eATP may become a promising target for periodontal regeneration by modulating immune response and further triggering tissue healing.PMID:35510301 | DOI:10.1111/jre.12997
Source: Cell Research - May 5, 2022 Category: Cytology Authors: Maythwe Kyawsoewin Phoonsuk Limraksasin Utapin Ngaokrajang Prasit Pavasant Thanaphum Osathanon Source Type: research

Functions and Clinical Significance of CACNA2D1 in Gastric Cancer
CONCLUSIONS: The present study indicates that CACNA2D1 regulates the apoptosis signaling pathway and may have potential as a biomarker for cancer growth and as a therapeutic target for GC.PMID:35445337 | DOI:10.1245/s10434-022-11752-5
Source: Ann Oncol - April 21, 2022 Category: Cancer & Oncology Authors: Hiroyuki Inoue Atsushi Shiozaki Toshiyuki Kosuga Hiroki Shimizu Michihiro Kudou Takuma Ohashi Tomohiro Arita Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eiichi Konishi Eigo Otsuji Source Type: research