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Nutrition: Calcium
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Total 675 results found since Jan 2013.
CCAAT/Enhancer-Binding Protein Alpha Is a Novel Regulator of Vascular Smooth Muscle Cell Osteochondrogenic Transition and Vascular Calcification
CONCLUSION: Findings in this study indicate that C/EBPα is a key regulator of the osteochondrogenic transdifferentiation of VSMCs and vascular calcification, which may represent a novel therapeutic target for vascular calcification.PMID:35295585 | PMC:PMC8918665 | DOI:10.3389/fphys.2022.755371
Source: Atherosclerosis - March 17, 2022 Category: Cardiology Authors: Pengyuan Chen Wanzi Hong Ziying Chen Flora Gordillo-Martinez Siying Wang Hualin Fan Yuanhui Liu Yining Dai Bo Wang Lei Jiang Hongjiao Yu PengCheng He Source Type: research
UV ‐induced DNA Damage in Skin is Reduced by CaSR Inhibition
In this study we investigated whether the CaSR is involved more directly in protection from UV damage in studies of human keratinocytes in primary culture and in mouse skin studiedin vivo. siRNA-directed reductions in CaSR protein levels in human keratinocytes significantly reduced UV-induced direct cyclobutane pyrimidine dimers (CPD) by around 80% and oxidative DNA damage (8-OHdG) by around 65% compared to control transfected cells. Similarly, in untransfected cells, the CaSR negative modulator, NPS-2143 (500 nM), reduced UV-induced CPD and 8-OHdG by around 70%. NPS-2143 also enhanced DNA repair and reduced reactive oxyge...
Source: Photochemistry and Photobiology - March 15, 2022 Category: Science Authors: Chen Yang,
Mark Stephen Rybchyn,
Warusavithana Gunawardena Manori De Silva,
Jim Matthews,
Andrew J.A. Holland,
Arthur David Conigrave,
Rebecca Sara Mason Tags: RESEARCH ARTICLE Source Type: research
Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment
Drug Deliv. 2022 Dec;29(1):889-905. doi: 10.1080/10717544.2022.2050845.ABSTRACTAs there is currently no effective therapy for patients with prostate cancer (PCa) bone metastasis, it was stringent to explore the relevant treatment strategies. Actually, the interaction between cancer cells and bone microenvironment plays important role in prostate cancer bone metastasis, especially the Sonic hedgehog protein (SHH) signaling in the bone microenvironment. The SHH promotes osteoblast maturation and osteoblast then secretes RANKL to induce osteoclastogenesis. Herein, this study develops bone-targeting calcium phosphate lipid hyb...
Source: Drug Delivery - March 14, 2022 Category: Drugs & Pharmacology Authors: Xiangyu Zhang Qingbin Liu Tingting Zhang Pei Gao Hui Wang Lu Yao Jingwen Huang Shulong Jiang Source Type: research
CXCR4 inhibition attenuates calcium oxalate crystal deposition-induced renal fibrosis
Int Immunopharmacol. 2022 Mar 4;107:108677. doi: 10.1016/j.intimp.2022.108677. Online ahead of print.ABSTRACTNephrolithiasis is a highly prevalent urological disease and results in a correspondingly heavy socioeconomic and healthcare burden. Calcium oxalate (CaOx) stones are among the most common types of kidney stones. They are associated with renal tubular damage, interstitial fibrosis and chronic kidney disease (CKD). However, the molecular mechanisms in CaOx crystal deposition-induced renal fibrosis remain unclear. Chemokines and their receptors act a crucial role in the progression of renal fibrosis through inflammato...
Source: International Immunopharmacology - March 7, 2022 Category: Allergy & Immunology Authors: Zehua Ye Yuqi Xia Xiangjun Zhou Bojun Li Weimin Yu Yuan Ruan Haoyong Li JinZhuo Ning Lijia Chen Ting Rao Fan Cheng Source Type: research
Annexin A1 Is a Potential Prognostic Marker for, and Enhances the Metastasis of, Cholangiocarcinoma
CONCLUSION: These findings strongly imply that ANXA1 contributes to the progression of CCA. ANXA1 can serve as a potential prognostic marker for CCA. Ablation of ANXA1 action may be an alternative strategy to prevent metastasis of CCA.PMID:35225485 | DOI:10.31557/APJCP.2022.23.2.715
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2022 Category: Cancer & Oncology Authors: Kwuntida U Kotepui Sumalee Obchoei Kulthida Vaeteewoottacharn Seiji Okada Sopit Wongkham Kanlayanee Sawanyawisuth Source Type: research
