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Nutrition: Calcium
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Total 675 results found since Jan 2013.
Zn < sup > 2+ < /sup > protect cardiac H9c2 cells from endoplasmic reticulum stress by preventing mPTP opening through MCU
Cell Signal. 2022 Sep 17:110467. doi: 10.1016/j.cellsig.2022.110467. Online ahead of print.ABSTRACTZn2+ regulates endoplasmic reticulum stress (ERS) and is essential for myocardial protection through gating the mitochondrial permeability transition pore (mPTP). However, the underlining mechanism of the mPTP opening remains uncertain. Cells under sustained ERS induce unfolded protein responses (UPR) and cell apoptosis. Glucose regulatory protein 78 (GRP 78) and glucose regulatory protein 94 (GRP 94) are marker proteins of ERS and regulate the onset of apoptosis through the endoplasmic reticulum signaling pathway. We found t...
Source: Cellular Signalling - September 20, 2022 Category: Cytology Authors: Yang Zhao Pei Wang Tianyu Liu Ying Yang Jiabao Guo Jinkun Xi Yonggui He Source Type: research
KRAP is required for diffuse and punctate IP < sub > 3 < /sub > -mediated Ca < sup > 2+ < /sup > liberation and determines the number of functional IP < sub > 3 < /sub > R channels within clusters
Cell Calcium. 2022 Aug 19;107:102638. doi: 10.1016/j.ceca.2022.102638. Online ahead of print.ABSTRACTKRas-induced actin-interacting protein (KRAP) has been identified as crucial for the appropriate localization and functioning of the inositol trisphosphate receptors (IP3Rs) that mediate Ca2+ release from the endoplasmic reticulum. Here, we used siRNA knockdown of KRAP expression in HeLa and HEK293 cells to examine the roles of KRAP in the generation of IP3-mediated local Ca2+ puffs and global, cell-wide Ca2+ signals. High resolution Ca2+ imaging revealed that the mean amplitude of puffs was strongly reduced by KRAP knockdo...
Source: Cell Calcium - August 28, 2022 Category: Cytology Authors: Irene Vorontsova Jeffrey T Lock Ian Parker Source Type: research
Inhibition of Dyrk1A Attenuates LPS-Induced Neuroinflammation via the TLR4/NF- κB P65 Signaling Pathway
This study investigated the role of Dyrk1A in regulating neuroinflammation, another critical factor that contributes to AD. In the present study, we used an immortalized murine BV2 microglia cell line induced by lipopolysaccharide (LPS) to study neuroinflammation. The expression and activity of Dyrk1A kinase were both increased by inflammation. Dyrk1A inhibition using harmine or siRNA silencing significantly reduced the production of proinflammatory factors in LPS-stimulated BV2 cells. Reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and nitric oxide (NO), as well as the expression of the inflammatory prot...
Source: Inflammation - August 2, 2022 Category: Allergy & Immunology Source Type: research
The Regulatory Mechanism and Effect of Receptor-Interacting Protein Kinase 3 on Phenylephrine-Induced Cardiomyocyte Hypertrophy
In this study, we aimed to investigate the regulatory mechanism of RIPK3 on phenylephrine (PE)-induced cardiomyocyte hypertrophy. Cardiomyocyte hypertrophy was induced by exposure to PE (100 μM) for 48 hours. Primary cardiomyocytes were pretreated with RIPK3 inhibitor GSK′872 (10 μM), and RIPK3 siRNA was used to deplete the intracellular expression of RIPK3. The indexes related to myocardial hypertrophy, cell injury, necroptosis, CaMKII activation, gene expression, oxidative stress, and mitochondrial membrane potential were measured. We found that after cardiomyocytes were stimulated by PE, the expressions of hypertrop...
Source: Journal of Cardiovascular Pharmacology - August 1, 2022 Category: Cardiology Tags: Original Article Source Type: research
HSP70 protects H9C2 cells from hypoxia and reoxygenation injury through STIM1/IP3R
Cell Stress Chaperones. 2022 Jul 16. doi: 10.1007/s12192-022-01290-0. Online ahead of print.ABSTRACTHypoxia/reoxygenation (H/R) is used as an in vivo model of ischemia/reperfusion injury, and myocardial ischemia can lead to heart disease. Calcium overload is an important factor in myocardial ischemia-reperfusion injury and can lead to apoptosis of myocardial cells. Therefore, it is of great clinical importance to find ways to regulate calcium overload and reduce apoptosis of myocardial cells, and thus alleviate myocardial ischemia-reperfusion injury. There is evidence that heat shock protein 70 (HSP70) has a protective eff...
Source: Cell Stress and Chaperones - July 16, 2022 Category: Cytology Authors: TianYu Liu Zhaodong Juan Bin Xia GuanHua Ren Zhen Xi JunWen Hao ZhongDong Sun Source Type: research
