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Nutrition: Calcium
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Total 675 results found since Jan 2013.
Effect of miR-381-3p/FGF7 axis on the osteogenic differentiation of bone marrow mesenchymal stem cells through MEK/ERK signaling pathway
Tissue Cell. 2022 Apr 1;76:101791. doi: 10.1016/j.tice.2022.101791. Online ahead of print.ABSTRACTAlthough microRNAs (miRNAs) exert an important role in the osteogenesis of mesenchymal stem cells (MSCs), the effect of miR-381-3p on the osteogenic differentiation in MBD‑MSCs is still unclear. The BMMSCs from patients with MBD (MBD‑MSC) or normal participants (Normal‑MSC) were isolated and induced to differentiation with dexamethasone. BMMSCs were transfected with miR-381-3p mimic, miR-381-3p inhibitor, and FGF7 siRNA to regulate the expression of miR-381-3p or FGF7. The direct binding between miR-381-3p and FGF7 was p...
Source: Tissue and Cell - April 15, 2022 Category: Cytology Authors: Ling Qiu Jiao Cai Nan Zhang Lei Ma Fang-Yi Fan Xiao-Ming Li Source Type: research
Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress
Biochem Biophys Res Commun. 2022 Mar 31;608:156-162. doi: 10.1016/j.bbrc.2022.03.156. Online ahead of print.ABSTRACTCalpains are cysteine proteases activated in response to intracellular calcium signaling. Activated calpains regulate various cellular functions by degrading substrate molecules in a site-specific manner. Although most calpains are localized in the cytosol, we previously reported that calpain-5 exists in the mitochondria. The mitochondrial calpain-5 is activated during endoplasmic reticulum (ER) stress. However, the substrate of calpain-5, as well as the physiological significance of calpain-5 activation, has...
Source: Biochemical and Biophysical Research communications - April 10, 2022 Category: Biochemistry Authors: Yusaku Chukai Ginga Ito Masahide Konno Yuri Sakata Taku Ozaki Source Type: research
Cathelicidin Mediates an Anti-Inflammatory Role of Active Vitamin D (Calcitriol) During M. paratuberculosis Infection
This study examines the role of vitamin D deficiency in the regulation of Cathelicidin Antimicrobial Peptide (CAMP) in CD-like macrophages. The latter includes macrophages infected with Mycobacterium avium subsp. paratuberculosis (MAP) isolated from CD patient. Initially, we measured cathelicidin and calcitriol in ex vivo plasma samples from CD patients with or without MAP infection (N=40 per group). We also measured the expression and production of CAMP/LL-37, TNF-α, IL-1β, IL-10, cellular oxidative stress markers, and bacterial viability following treatment of MAP-infected macrophages with four different forms of vitam...
Source: Frontiers in cellular and infection microbiology - April 4, 2022 Category: Microbiology Source Type: research
SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells
Biochem Biophys Res Commun. 2022 Mar 25;607:44-48. doi: 10.1016/j.bbrc.2022.03.121. Online ahead of print.ABSTRACTIn pulmonary arterial smooth muscle cells (PASMCs), an increase in the cytosolic Ca2+ concentration ([Ca2+]cyt) is involved in many physiological processes such as cell contraction and proliferation. However, chronic [Ca2+]cyt increases cause pulmonary vasoconstriction and vascular remodeling, resulting in pulmonary arterial hypertension (PAH). Therefore, [Ca2+]cyt signaling plays a substantial role in the regulation of physiological and pathological functions in PASMCs. In the present study, the effects of SKF...
Source: Cell Research - April 2, 2022 Category: Cytology Authors: Riko Miyaki Aya Yamamura Akiko Kawade Moe Fujiwara Rubii Kondo Yoshiaki Suzuki Hisao Yamamura Source Type: research
Requirement of Na+/H+ exchanger NHE1 for vasopressin-induced osteogenic signaling and calcification in human aortic smooth muscle cells
Conclusion: Vasopressin stimulates NHE1 expression and ROS generation, an effect dependent on SGK1 and required for vasopres sin-induced stimulation of osteogenic signaling and calcification of VSMCs.
Source: Kidney and Blood Pressure Research - March 25, 2022 Category: Urology & Nephrology Source Type: research
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway
Arch Pharm Res. 2022 Mar 24. doi: 10.1007/s12272-022-01377-3. Online ahead of print.ABSTRACTGinsenoside-Rh1 (Rh1) is a ginseng-derived compound that has been reported to exert anticancer effects by regulating cell cycle arrest and apoptosis according to reactive oxygen species (ROS) production. However, the effects of Rh1 on mitochondrial dysfunction are involved in triple negative breast cancer (TNBC) cell apoptosis, and the related molecular mechanisms remain unknown. Rh1 treatment induced cell toxicity less than 50% at 50 μM. In addition, Rh1 induced apoptosis in TNBC cells through cleaved caspase-3 activation and G1/S...
Source: Archives of Pharmacal Research - March 24, 2022 Category: Drugs & Pharmacology Authors: Yujin Jin Diem Thi Ngoc Huynh Kyung-Sun Heo Source Type: research
MCU-dependent mitochondrial calcium uptake-induced mitophagy contributes to apelin-13-stimulated VSMCs proliferation
Vascul Pharmacol. 2022 Mar 16:106979. doi: 10.1016/j.vph.2022.106979. Online ahead of print.ABSTRACTApelin is an endogenous ligand of the G protein-coupled receptor APJ. Both apelin and APJ receptors, which are expressed in vascular smooth muscle cells (VSMCs), play important roles in the cardiovascular system. Our previous studies researches indicated that mitophagy mediated apelin-13-induced VSMCs proliferation. However, little is known about how apelin-13 regulates mitophagy to participate in VSMC proliferation. The results of the present study demonstrated that mitochondrial calcium uniporter (MCU) uptake-dependent mit...
Source: Vascular Pharmacology - March 20, 2022 Category: Drugs & Pharmacology Authors: Zhe Chen Qionglin Zhou Jun Chen Yiyuan Yang Wei Chen Hui Mao Xueqian Ouyang Kai Zhang Mingzhu Tang Jialong Yan Linzhi Wang Linxi Chen Lanfang Li Source Type: research
