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Nutrition: Calcium
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Total 675 results found since Jan 2013.
25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research
The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization
Gene. 2022 Sep 30:146928. doi: 10.1016/j.gene.2022.146928. Online ahead of print.ABSTRACTBone formation is controlled by histone modifying enzymes that regulate post-translational modifications on nucleosomal histone proteins and control accessibility of transcription factors to gene promoters required for osteogenesis. Enhancer of Zeste homolog 2 (EZH2/Ezh2), a histone H3 lysine 27 (H3K27) methyl transferase, is a suppressor of osteoblast differentiation. Ezh2 is regulated by SET and MYND domain-containing protein 2 (SMYD2/Smyd2), a lysine methyltransferase that modifies both histone and non-histone proteins. Here, we exa...
Source: Gene - October 3, 2022 Category: Genetics & Stem Cells Authors: Parisa Dashti Jeroen van de Peppel Roman Thaler Christopher R Paradise Gary S Stein Martin A Montecino Johannes P T M van Leeuwen Bram J van der Eerden Amel Dudakovic Andre J van Wijnen Source Type: research
Cancers, Vol. 14, Pages 4794: AKT Regulation of ORAI1-Mediated Calcium Influx in Breast Cancer Cells
ry R. Monteith
Although breast cancer cells often exhibit both abnormal AKT signaling and calcium signaling, the association between these two pathways is unclear. Using a combination of pharmacological tools, siRNA and CRISPR/Cas9 gene silencing techniques, we investigated the association between PTEN, AKT phosphorylation and calcium signaling in a basal breast cancer cell line. We found that siRNA-mediated PTEN silencing promotes AKT phosphorylation and calcium influx in MDA-MB-231 cells. This increase in AKT phosphorylation and calcium influx was phenocopied by the pharmacological AKT activator, SC79. The increased ...
Source: Cancers - September 30, 2022 Category: Cancer & Oncology Authors: Alice Hui Li Bong Trinh Hua Choon Leng So Amelia A. Peters M élanie Robitaille Yin Yi Tan Sarah J. Roberts-Thomson Gregory R. Monteith Tags: Article Source Type: research
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
CONCLUSIONS: In human PAH and experimental PH, Orai1 expression and activity are increased. Orai1 inhibition normalizes the PAH-hPASMCs phenotype and attenuates PH in rat models. These results suggest that Orai1 should be considered as a relevant therapeutic target for PAH.PMID:36164973 | DOI:10.1161/CIRCRESAHA.122.321041
Source: Circulation Research - September 27, 2022 Category: Cardiology Authors: Bastien Masson H élène Le Ribeuz Jessica Sabourin Loann Laubry Emily Woodhouse Richard Foster Yann Ruchon Mary Dutheil Ang èle Boët Maria-Rosa Ghigna Vincent De Montpreville Olaf Mercier David J Beech Jean-Pierre Benitah Marc A Bailey Marc Humbert Dav Source Type: research
