Intestinal enteroendocrine cells rely on ryanodine and IP < sub > 3 < /sub > calcium store receptors for mechanotransduction

This study has found that the signal amplification involves calcium induced calcium release (CICR) mechanisms activated through intracellular stores receptors, RyR3 and IP3Rs. Activation of these receptors leads to large and sustained increase in Ca2+ that results in the release of serotonin (5-HT) that plays an important role in many local and systemic processes. This article is protected by copyright. All rights reserved.PMID:36428286 | DOI:10.1113/JP283383

Source: The Journal of Physiology - November 26, 2022 Category: Physiology Authors: Kaitlyn R Knutson Sara T Whiteman Constanza Alcaino Arnaldo Mercado-Perez Isabelle Finholm Hannah K Serlin Shreya S Bellampalli David R Linden Gianrico Farrugia Arthur Beyder Source Type: research