S100A9 promotes glycolytic activity in HER2-positive breast cancer to induce immunosuppression in the tumour microenvironment

CONCLUSIONS: S100A9 overexpression upregulated the glycolysis activity of tumour cells through the c-Myc-related pathway, suppressing lymphocyte infiltration in the tumour stroma, affecting the efficacy of immune regulation and long-term survival of patients.PMID:36755606 | PMC:PMC9900376 | DOI:10.1016/j.heliyon.2023.e13294

Source: Cancer Control - February 9, 2023 Category: Cancer & Oncology Authors: Jia-Qi Yuan Shou-Man Wang Lei Guo Source Type: research