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Condition: Heart Failure

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Total 253 results found since Jan 2013.

Tanshinone IIA Prevents Leu27IGF-II-induced Cardiomyocyte Hypertrophy Mediated by Estrogen Receptor and Subsequent Akt Activation.
This study investigates the role of ER signaling in mediating the protective effects of tanshinone IIA on IGF-IIR-induced myocardial hypertrophy. Leu27IGF-II (IGF-II analog) was shown in this study to specifically activate IGF-IIR expression and ICI 182,780 (ICI), an ER antagonist used to investigate tanshinone IIA estrogenic activity. We demonstrated that tanshinone IIA significantly enhanced Akt phosphorylation through ER activation to inhibit Leu27IGF-II-induced calcineurin expression and subsequent NFATc3 nuclear translocation to suppress myocardial hypertrophy. Tanshinone IIA reduced the cell size and suppressed ANP a...
Source: The American Journal of Chinese Medicine - November 30, 2015 Category: Complementary Medicine Authors: Weng YS, Wang HF, Pai PY, Jong GP, Lai CH, Chung LC, Hsieh DJ, HsuanDay C, Kuo WW, Huang CY Tags: Am J Chin Med Source Type: research

Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4.
Abstract Cardiac myocyte oxidative stress and apoptosis are considered important mechanisms for the development of heart failure (HF). Chronic HF is characterized by increased circulating catecholamines to augment cardiac output. Long-term stimulation of myocardial β-adrenergic receptors (β-ARs) is deleterious in cardiac myocytes, however, the potential mechanisms underlying increased cell death are unclear. We hypothesize that GRK2, a critical regulator of myocardial β-AR signaling, plays an important role in mediating cellular oxidative stress and apoptotic cell death in response to β-agonist stimulation. St...
Source: Cellular Signalling - November 26, 2015 Category: Cytology Authors: Theccanat T, Philip JL, Razzaque A, Ludmer N, Li J, Xu X, Akhter SA Tags: Cell Signal Source Type: research

Olfactory receptors in pulmonary arterial hypertension: A novel pathway of vascular remodeling?
Pulmonary arterial hypertension (PAH) is due to progressive obstruction of pulmonary arteries, thus leading to right heart failure and death. Breath volatile organic compounds (VOCs) can discriminate PAH and controls. Thus, a unique breath-print of PAH is detected using an artificial nose. VOCs target olfactory receptors (ORs) in olfaction. Interestingly, ORs are detected in peripheral tissues not related to olfaction and their deregulation is associated to cancer development. PSGR, encoded by the OR51E2 gene, is one of the ORs. Because vascular cells in PAH exhibit properties of cancer cells, we propose the ground-breakin...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Courboulin, A., Sanz, G., Breuils-Bonnet, S., Quatredeniers, M., Vocelle, M., Lafond, M., Perros, F., Bonnet, S., Pajot-Augy, E., Humbert, M., Cohen-Kaminsky, S. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Nanocarriers Assisted siRNA Gene Therapy for the Management of Cardiovascular Disorders.
This article reviews the application of siRNA against CVDs with special emphasis on gene targets in combination with delivery systems such as cationic hydrogels, polyplexes, peptides, liposomes and dendrimers. PMID: 26471319 [PubMed - in process]
Source: Current Pharmaceutical Design - October 18, 2015 Category: Drugs & Pharmacology Authors: Maheshwari R, Tekade M, Sharma PA, Tekade RK Tags: Curr Pharm Des Source Type: research

Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy
Conclusions: Our results indicate that corin plays an important role in cardioprotection by activating pro-atrial natriuretic peptide pathway in DCM. Corin deficiency leads to endothelial dysfunction and vascular remodeling.
Source: Cardiovascular Diabetology - October 7, 2015 Category: Cardiology Authors: Aiming PangYahui HuPengfei ZhouGuangfeng LongXin TianLi MenYanna ShenYunde LiuYujie Cui Source Type: research

Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis Original Articles
Conclusions— This study highlights the key role of cardiomyocyte ADAM17 in post-MI recovery by regulating VEGFR2 transcription and angiogenesis, thereby limiting left ventricular dilation and dysfunction. Therefore, ADAM17 upregulation, within the physiological range, could provide protective effects in ischemic cardiomyopathy.
Source: Circulation: Heart Failure - September 15, 2015 Category: Cardiology Authors: Fan, D., Takawale, A., Shen, M., Wang, W., Wang, X., Basu, R., Oudit, G. Y., Kassiri, Z. Tags: Other heart failure, Angiogenesis, Cell signalling/signal transduction, Gene expression, Acute myocardial infarction Original Articles Source Type: research

Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites
We examined the molecular forms of secreted and intracellular BNP in atrial and ventricular myocytes; levels of corin and furin mRNA in atrial and ventricular myocytes; the effect their knockdown on proBNP processing; plasma molecular forms of BNP from rats and humans with and without heart failure; and the impact of the distance between the glycosylation and cleavage sites in wild-type and mutant human proBNP, expressed in rat myocytes transfected with lentiviral vectors. BNP was the major molecular form secreted by atrial and ventricular myocytes. Transfection of furin siRNA reduced proBNP processing in both atrial and v...
Source: AJP: Regulatory, Integrative and Comparative Physiology - September 15, 2015 Category: Physiology Authors: Nishikimi, T., Nakagawa, Y., Minamino, N., Ikeda, M., Tabei, K., Fujishima, A., Takayama, K., Akimoto, K., Yamada, C., Nakao, K., Minami, T., Kuwabara, Y., Kinoshita, H., Tsutamoto, T., Ishimitsu, T., Kangawa, K., Kuwahara, K., Nakao, K. Tags: Hormones, Reproduction and Development Source Type: research

Mitochondrial DNA has a pro-inflammatory role in AMD
This study contributes to our understanding of the potential pro-inflammatory role of mtDNA in the pathogenesis of AMD. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 7, 2015 Category: Molecular Biology Source Type: research

Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression.
CONCLUSIONS: We propose that elevated Ang II serum concentrations, as occur in CHF patients, could activate the PKD1/HDAC5/TFEB/MuRF1 pathway to induce skeletal muscle wasting. PMID: 26137861 [PubMed - as supplied by publisher]
Source: Circulation Research - July 2, 2015 Category: Cardiology Authors: Du Bois P, Pablo Tortola C, Lodka D, Kny M, Schmidt F, Song K, Schmidt S, Bassel-Duby R, Olson EN, Fielitz J Tags: Circ Res Source Type: research

Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites.
We examined the molecular forms of secreted and intracellular BNP in atrial and ventricular myocytes; levels of corin and furin mRNA in atrial and ventricular myocytes; the effect their knockdown on proBNP processing; plasma molecular forms of BNP from rats and humans with and without heart failure; and the impact of the distance between the glycosylation and cleavage sites in wild-type and mutant human proBNP expressed in rat myocytes transfected with lentiviral vectors. BNP was the major molecular form secreted by atrial and ventricular myocytes. Transfection of furin siRNA reduced proBNP processing in both atrial and ve...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 1, 2015 Category: Physiology Authors: Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure
Conclusion These data demonstrate interplay between Ser208 phosphorylation and Ser190 O-GlcNAcylation of TnT in ischaemic HF, linked to decreased activity of both PKC and O-GlcNAcase and increased O-GlcNAc transferase activity. Modulation of these post-translational modifications of TnT may be a new therapeutic strategy in HF.
Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Dubois-Deruy, E., Belliard, A., Mulder, P., Bouvet, M., Smet-Nocca, C., Janel, S., Lafont, F., Beseme, O., Amouyel, P., Richard, V., Pinet, F. Tags: Cardiac biology and remodelling Source Type: research

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity
by Firhan A. Malik, Anja Meissner, Illya Semenkov, Steven Molinski, Stan Pasyk, Saumel Ahmadi, Hai H. Bui, Christine E. Bear, Darcy Lidington, Steffen-Sebastian Bolz The cystic fibrosis transmembrane conductance regulator (CFTR) attenuates sphingosine-1-phosphate (S1P) signaling in resistance arteries and has emerged as a prominent regulator of myogenic vasoconstriction. This investigation demonstrates that S1P inhibits CFTR activity via adenosine monophosphate-activated kinase (AMPK), establishing a potential feedback link. In Baby Hamster Kidney (BHK) cells expressing wild-type human CFTR, S1P (1μmol/L) attenuates fors...
Source: PLoS One - June 16, 2015 Category: Biomedical Science Authors: Firhan A. Malik et al. Source Type: research

Calpain-10 Activity Underlies Angiotensin II-induced Aldosterone Production in an Adrenal Glomerulosa Cell Model.
Abstract Aldosterone is a steroid hormone important in the regulation of blood pressure. Aberrant production of aldosterone results in the development and progression of diseases including hypertension and congestive heart failure; therefore, a complete understanding of aldosterone production is important for developing more effective treatments. Angiotensin II (AngII) regulates steroidogenesis, in part through its ability to increase intracellular calcium levels. Calcium can activate calpains, proteases classified as typical or atypical based on the presence or absence of penta-EF-hands, that are involved in vari...
Source: Endocrinology - April 2, 2015 Category: Endocrinology Authors: Seremwe M, Schnellmann RG, Bollag WB Tags: Endocrinology Source Type: research

Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway
Publication date: Available online 9 February 2015 Source:Prostaglandins & Other Lipid Mediators Author(s): Jian Cao , Peter L. Tsenovoy , Ellen A. Thompson , John R. Falck , Robert Touchon , Komal Sodhi , Rita Rezzani , Joseph I. Shapiro , Nader G. Abraham Myocardial infarction (MI) is complicated by ventricular fibrosis and associated diastolic and systolic failure. Emerging studies implicate Wnt1 signaling in the formation of new blood vessels. Epoxyeicosatrienoic acids (EETs)-mediated up-regulation of heme oxygenase-1 (HO-1) protects against the detrimental consequences of MI in several animal models, however...
Source: Prostaglandins and Other Lipid Mediators - March 23, 2015 Category: Lipidology Source Type: research

Contribution of sodium channel neuronal isoform Nav 1.1 to late sodium current in ventricular myocytes from failing hearts.
In conclusion, we have discovered an Nav 1.1-originated INaL component in dog heart ventricular cells. This component is physiologically relevant to controlling AP shape and duration, as well as to cell Ca(2+) dynamics. PMID: 25772296 [PubMed - in process]
Source: The Journal of Physiology - March 15, 2015 Category: Physiology Authors: Mishra S, Reznikov V, Maltsev VA, Undrovinas NA, Sabbah HN, Undrovinas A Tags: J Physiol Source Type: research