Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure

Conclusion
These data demonstrate interplay between Ser208 phosphorylation and Ser190 O-GlcNAcylation of TnT in ischaemic HF, linked to decreased activity of both PKC and O-GlcNAcase and increased O-GlcNAc transferase activity. Modulation of these post-translational modifications of TnT may be a new therapeutic strategy in HF.

Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Dubois-Deruy, E., Belliard, A., Mulder, P., Bouvet, M., Smet-Nocca, C., Janel, S., Lafont, F., Beseme, O., Amouyel, P., Richard, V., Pinet, F. Tags: Cardiac biology and remodelling Source Type: research