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Condition: Heart Failure
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Total 253 results found since Jan 2013.
GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress
CONCLUSION: According to the results of this study, GRK2 participated in cardiac hypertrophy induced by ISO by mitigating NLRP3 inflammasome and oxidative stress through the signaling of Nrf2 in H9c2 cells.PMID:37012864 | DOI:10.1016/j.intimp.2023.109957
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Jing Liu Xiaoli Li Lu Ding Wei Li Xiaolin Niu Dengfeng Gao Source Type: research
Recombinant Adenovirus siRNA Knocking Down the Ndufs4 Gene Alleviates Myocardial Apoptosis Induced by Oxidative Stress Injury
In conclusion, we successfully constructed Ndufs4 siRNA recombinant adenovirus; furthermore, the downexpression of the Ndufs4 gene may alleviate H2O2-induced H9c2 cell apoptosis.PMID:36741296 | PMC:PMC9897913 | DOI:10.1155/2023/8141129
Source: Cardiology Research and Practice - February 6, 2023 Category: Cardiology Authors: Beibei Wang Jinsheng Zhang Aijun Xu Source Type: research
Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats
Tumor necrosis factor (TNF)-α converting enzyme (TACE) is a key metalloprotease mediating ectodomain shedding of a variety of inflammatory mediators, substrates, and growth factors. We previously reported that TACE-mediated production of TNF-α in the hypothalamic paraventricular nucleus (PVN) contributes to sympathetic excitation in heart failure (HF). Here, we sought to determine whether central interventions in TACE activity attenuate neuroinflammation and improve cardiac function in heart failure. Myocardial infarction-induced HF or sham-operated (SHAM) rats were treated with bilateral paraventricular nucleus microinj...
Source: Frontiers in Physiology - November 9, 2022 Category: Physiology Source Type: research
BRD4 Silencing Protects Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting TLR4/NF- < em > κ < /em > B and Activating Nrf2-HO-1 Pathways
CONCLUSION: Our results speculate that the BRD4/TLR4 axis might be a promising strategy for treating cardiovascular diseases with cardiac hypertrophy, including HF.PMID:36247184 | PMC:PMC9553838 | DOI:10.1155/2022/8372707
Source: Cardiology Research and Practice - October 17, 2022 Category: Cardiology Authors: Ming Fang Jun Luo Xi Zhu Yingbiao Wu Xinming Li Source Type: research
Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress
In this study, high AVP doses were found to induce H9c2 cardiomyoblast apoptosis, demonstrated by increased terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells, pro-apoptotic B-cell lymphoma-2 (Bcl-2)-associated X protein (Bax) up-regulation, and anti-apoptotic Bcl-2 downregulation. This AVP-induced apoptotic increase, along with lowered cell viability, was also associated with higher reactive oxygen species (ROS) levels and lowered mitochondrial membrane potentials (MMP), which were all reversed upon Mel administration. Further investigations found that apoptosis, ROS, and MMP outcomes unde...
Source: Biochemical Pharmacology - October 2, 2022 Category: Drugs & Pharmacology Authors: Shuang Chen You Li Shuai Fu Yang Li Chao Wang Ping Sun Hairu Li Jiawei Tian Guo-Qing Du Source Type: research
