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Condition: Heart Failure
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Total 253 results found since Jan 2013.
Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure
Acta Pharmacol Sin. 2021 Dec 16. doi: 10.1038/s41401-021-00830-1. Online ahead of print.ABSTRACTWe previously found that the levels of metabolite N-acetylglutamine were significantly increased in urine samples of patients with heart failure (HF) and in coronary artery ligation (CAL)-induced HF mice, whereas the expression of its specific metabolic-degrading enzyme aminoacylase-1 (ACY1) was markedly decreased. In the current study, we investigated the role of ACY1 in the pathogenesis of HF and the therapeutic effects of 20(S)-ginsenoside Rg3 in HF experimental models in vivo and in vitro. HF was induced in mice by CAL. The ...
Source: Acta Pharmacologica Sinica - December 17, 2021 Category: Drugs & Pharmacology Authors: Qiong Lai Fu-Ming Liu Wang-Lin Rao Guang-Ying Yuan Zhao-Yang Fan Lu Zhang Fei Fu Jun-Ping Kou Bo-Yang Yu Fang Li Source Type: research
Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells
ConclusionCana conveys anti-inflammatory actions in LPS-treated HCAECs through 1) reductions in HKII and ERK1/2 phosphorylation and 2) AMPK activation. These data suggest a novel anti-inflammatory mechanism of Cana through HKII.
Source: Cardiovascular Drugs and Therapy - December 1, 2021 Category: Cardiology Source Type: research
Advances in the treatment of transthyretin cardiac amyloidosis: Current and emerging therapies
AbstractTransthyretin cardiac amyloidosis (ATTR-CA) has been recognized as an underdiagnosed and undertreated cause of heart failure with often unrecognized multiorgan involvement. Guideline development and the establishment of nonbiopsy criteria for diagnosis of ATTR-CA have led to an increased rate of diagnosis and hence patients referred for therapies. ATTR is a protein misfolding disorder where the TTR tetramer disassociates into monomers which form insoluble amyloid depositions in organs, including the heart. ATTR-CA can be due to autosomal dominant transmitted gene mutation or due to misfolding of wild-type TTR. Prio...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2021 Category: Drugs & Pharmacology Authors: Alberta L. Warner Tags: REVIEW OF THERAPEUTICS Source Type: research
Advances in the Treatment of Transthyretin Cardiac Amyloidosis: Current and Emerging Therapies
AbstractTransthyretin cardiac amyloidosis (ATTR-CA) has been recognized as an underdiagnosed and undertreated cause of heart failure with often unrecognized multiorgan involvement. Guideline development and the establishment of nonbiopsy criteria for diagnosis of ATTR-CA has led to an increased rate of diagnosis and hence patients referred for therapies. ATTR is a protein misfolding disorder where the TTR tetramer disassociates into monomers which form insoluble amyloid depositions in organs, including the heart. ATTR-CA can be due to autosomal dominant transmitted gene mutation or due to misfolding of wild type TTR. Prior...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 20, 2021 Category: Drugs & Pharmacology Authors: Alberta L. Warner Tags: TI ON ADVANCES IN CARDIOVASCULAR PHARMACOTHERAPY Source Type: research
Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart
Conclusions: Our data demonstrates that exosome-associated MFGE8 on one hand enhances opsonization of dead cells and on the other activates phagocytic signaling thus augmenting removal of apoptotic cells, resolution of inflammation and therefore efficient cardiac recovery after injury.PMID:34623174 | DOI:10.1161/CIRCRESAHA.120.317900
Source: Circulation Research - October 8, 2021 Category: Cardiology Authors: Mallikarjun Patil Sherin Saheera Praveen K Dubey Asher Kahn-Krell Prem Kumar Govindappa Sarojini Singh Sultan Tousif Qinkun Zhang Hind Lal Jianyi Zhang Gangjian Qin Prasanna Krishnamurthy Source Type: research
Perturbed ER homeostasis by IGF-IIR α promotes cardiac damage under stresses
In this study, we investigate the molecular mechanism and contribution of IGF-IIRα in endoplasmic reticulum stress induction in the heart under doxorubicin-induced cardiotoxicity. Using in vitro H9c2 cells, in vivo transgenic rat cardiac tissues, siRNAs against CHOP, chemical ER chaperone PBA, and western blot experiments, we found that IGF-IIRα overexpression enhanced ER stress markers ATF4, ATF6, IRE1α, and PERK which were further aggravated by DOX treatment. This was accompanied by a significant perturbation in stress-associated MAPKs such as p38 and JNK. Interestingly, PARKIN, a stress responsive cellular protective...
Source: Molecular and Cellular Biochemistry - September 29, 2021 Category: Biochemistry Authors: Sudhir Pandey Chia-Hua Kuo William Shao-Tsu Chen Yu-Lan Yeh Wei-Wen Kuo Ray-Jade Chen Cecilia Hsuan Day Pei-Ying Pai Tsung-Jung Ho Chih-Yang Huang Source Type: research
β-elemene blocks lipid-induced inflammatory pathways via PPARβ activation in heart failure
This study aims to investigate the effects of β-elemene on a mouse model of heart failure (HF) and to elucidate the underlying mechanisms in vitro approaches. In this study, left anterior descending (LAD)-induced HF mouse model and oxygen-glucose deprivation/recovery (OGD/R)-induced H9C2 model were leveraged to assess the therapeutic effects of β-elemene. Histological examination, western blot and quantitative real-time PCR analysis (RT-qPCR) and immunofluorescence staining was utilized to elucidate mechanism of β-elemene in lipid-induced inflammation. Results showed that β-elemene improved heart function in HF mice ev...
Source: European Journal of Pharmacology - August 29, 2021 Category: Drugs & Pharmacology Authors: Mingyan Shao Mingmin Wang Lin Ma Qian Wang Pengrong Gao Xue Tian Changxiang Li Linghui Lu Chun Li Wei Wang Yong Wang Source Type: research
