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Condition: Heart Failure
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Total 253 results found since Jan 2013.
Digoxin protects against intervertebral disc degeneration via TNF/NF- κB and LRP4 signaling
ConclusionThese findings suggest that digoxin may be a potential therapeutic agent for intervertebral disc degeneration through anti-catabolism and pro-anabolism. Digoxin might also work as an alternative for other inflammation-related diseases.
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research
Paeoniflorin alleviates AngII-induced cardiac hypertrophy in H9c2 cells by regulating oxidative stress and Nrf2 signaling pathway
In conclusion, Our data confirm that paeoniflorin alleviates cardiac hypertrophy through modulating oxidative stress and Nrf2 signaling pathway in vitro.PMID:37542855 | DOI:10.1016/j.biopha.2023.115253
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 5, 2023 Category: Drugs & Pharmacology Authors: Shan Ren Yuge Wang Yanyan Zhang Peimei Yan Dan Xiao Yu Zhao Weiwei Jia Lin Ding Haiying Dong Can Wei Song Lin Yan Lin Source Type: research
SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF- β1
Cell Signal. 2023 Jun 19;109:110778. doi: 10.1016/j.cellsig.2023.110778. Online ahead of print.ABSTRACTCardiac fibroblasts (CFs) activation is a common response to most pathological conditions affecting the heart, characterized by increased cellular secretory capacity and increased expression of fibrotic markers, such as collagen I and smooth muscle actin type alpha (α-SMA). Fibrotic activation of CFs induces the increase in tissue protein content, with the consequent tissue stiffness, diastolic dysfunction, and heart failure. Therefore, the search for new mechanisms of CFs activation is important to find novel treatments...
Source: Cellular Signalling - June 21, 2023 Category: Cytology Authors: Fabiola Gonz ález-Herrera Mabel Catal án Renatto Anfossi Juan Diego Maya Zully Pedrozo Guillermo D íaz-Araya Ra úl Vivar Source Type: research
Inhibition of MEG3 ameliorates cardiomyocyte apoptosis and autophagy by regulating the expression of miRNA-129-5p in a mouse model of heart failure
In conclusion, inhibition of MEG3 ameliorates the maladaptive cardiac remodeling induced by ISO, probably by targeting the miRNA-129-5p/ATG14/Akt signaling pathway and may provide a tool for pharmaceutical intervention.PMID:37338021 | DOI:10.1080/13510002.2023.2224607
Source: Redox Report : communications in free radical research - June 20, 2023 Category: Biochemistry Authors: Shan Mi Feng Huang Mingli Jiao Zhuang Qian Mingming Han Zheng Miao Heqin Zhan Source Type: research
Epac1 participates in β < sub > 1 < /sub > -adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes
This study confirmed that Epac1 upregulation is indeed involved β1-AA-induced decreased cardiomyocyte autophagy through CE3F4 pretreatment, Epac1 siRNA transfection, western blot and immunofluorescence methods. On this basis, we constructed β1-AR and β2-AR knockout mice, and used receptor knockout mice, β1-AR selective blocker (atenolol), and the β2-AR/Gi-biased agonist ICI 118551 to show that β1-AA upregulated Epac1 expression through β1-AR and β2-AR to inhibit autophagy, and biased activation of β2-AR/Gi signaling downregulated myocardial Epac1 expression to reverse β1-AA-induced myocardial autophagy inhibition...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Yang Li Yuan Tian Shu Shi Xiaohong Hou Haihu Hao Mingxia Ma Na Ning Yuan Yuan Xiaohui Wang Huirong Liu Li Wang Source Type: research
Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha
In conclusion, we confirmed that NCTS improves myocardial energy metabolism, including fatty acid oxidation and mitochondrial biogenesis, by regulating the RXRα/PPARα pathway in mice with HF post-AMI.PMID:37201263 | DOI:10.1016/j.biopha.2023.114868
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 18, 2023 Category: Drugs & Pharmacology Authors: Lin Ma Mingyan Shao Wenkun Cheng Jinchi Jiang Xu Chen Nannan Tan Guanjing Ling Ye Yang Qian Wang Ran Yang Chun Li Yong Wang Source Type: research
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1
Phytother Res. 2023 May 1. doi: 10.1002/ptr.7831. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism is a critical factor that affects the occurrence and development of DCM. Additionally, the upregulation/activation of silent information regulation 2 homolog-1 (SIRT1) has been shown to protect against DCM. Tanshinone II A (Tan IIA), the main active component of Salviae miltiorrhizae radix et rhizome (a valuable Chinese medicine), has protective effe...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Shun Wu Dingchun Lu Babu Gajendran Qilan Hu Jian Zhang Shengquan Wang Minzhen Han Yini Xu Xiangchun Shen Source Type: research
< em > SOX17 < /em > Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension
CONCLUSIONS: Common PAH risk variants upstream of the SOX17 promoter reduce endothelial SOX17 expression, at least in part, through differential binding of HOXA5 and ROR-α. Reduced SOX17 expression results in disturbed hPAEC function and PAH. Existing drug compounds can reverse the disturbed SOX17 pulmonary endothelial transcriptomic signature.PMID:37066790 | DOI:10.1161/CIRCULATIONAHA.122.061940
Source: Circulation - April 17, 2023 Category: Cardiology Authors: Rachel Walters Eleni Vasilaki Jurjan Aman Chien-Nien Chen Yukyee Wu Olin D Liang Ali Ashek Olivier Dubois Lin Zhao Farah Sabrin In ês Cebola Jorge Ferrer Nicholas W Morrell James R Klinger Martin R Wilkins Lan Zhao Christopher J Rhodes Source Type: research
