The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation.
The objective was to identify cases with short QT and their consequences. Our hospital ECG database was screened for cases with a QTc based on the Bazett formula (QTcBZT) of less than 340 ms. The QTc was recalculated using the spline (QTcRBK) formula, which more accurately adjusts for the heart rate and identifies cases based on percentile distribution of the QT interval. The exclusion criteria were presence of bundle branch block, arrhythmias, or electronic pacemakers. An age- and sex-matched cohort was obtained from individuals with normal QT intervals with the same exclusion criteria. There were 28 cases with a s...
Source: Cardiology Research and Practice - November 24, 2020 Category: Cardiology Authors: Rabkin SW, Tang JKK Tags: Cardiol Res Pract Source Type: research

Bioinformatics Analysis Reveals Diagnostic Markers and Vital Pathways Involved in Acute Coronary Syndrome.
Conclusion: This study suggests that three genes (VEGFA, SPP1, and VCAM1) were involved in the molecular mechanisms of ACS pathogenesis and could serve as biomarkers of disease progression. PMID: 33224526 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - November 24, 2020 Category: Cardiology Authors: Li M, Ren C, Wu C, Li X, Li X, Mao W Tags: Cardiol Res Pract Source Type: research

Managing Nonagenarians with Acute Myocardial Infarction: Invasive versus Conservative Treatment.
Abstract Background: Limited data are available to support an invasive treatment strategy in nonagenarians with acute myocardial infarction (AMI). We aimed to investigate whether percutaneous coronary intervention (PCI) is beneficial in this frail population. Methods: We retrospectively analyzed 41 nonagenarians with AMI (both ST-segment-elevation and non-ST-segment-elevation MI) between 2006 and 2015 in a single center. We assessed 30-day and one-year mortality rates according to the treatment strategy. Results: Among study subjects, 24 (59%) were treated with PCI (PCI group) and 17 (41%) were treated w...
Source: Cardiology Research and Practice - November 24, 2020 Category: Cardiology Authors: Lee J, Seo KW, Park JS, Yang HM, Lim HS, Choi BJ, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Shin JH Tags: Cardiol Res Pract Source Type: research

Metabolic Modulation and Potential Biomarkers of the Prognosis Identification for Severe Aortic Stenosis after TAVR by a Metabolomics Study.
Conclusion: This is the first study to reveal systemic and cardiac metabolites changed significantly in patients with AS after TAVR. Some altered metabolites involved in the arginine and proline metabolism pathway in the peripheral vein could predict left ventricle regression, which merited further study. PMID: 33204525 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - November 20, 2020 Category: Cardiology Authors: Liao Y, Liu C, Xiong T, Zhao M, Zheng W, Feng Y, Li Y, Ou Y, Zhao Z, Peng Y, Wei J, Li Q, Meng W, Liu X, Chen M Tags: Cardiol Res Pract Source Type: research

Rejuvenated Circulating Endothelial Progenitor Cells and Nitric Oxide in Premenopausal Women with Hyperhomocysteinemia.
Abstract Hyperhomocysteinemia (HHcy) induced endothelial dysfunction is associated with disturbance in circulating endothelial progenitor cells (EPCs). Nevertheless, whether this unfavorable effect of HHcy on circulating EPCs also exists in premenopausal women is still unknown. Therefore, this leaves an area for the investigation of the difference on the number and activity of circulating EPCs in premenopausal women with hyperhomocysteinemia and its underlying mechanism. The number of circulating EPCs was measured by fluorescence-activated cell sorter analysis, as well as DiI-acLDL and lectin fluorescent staining....
Source: Cardiology Research and Practice - November 20, 2020 Category: Cardiology Authors: Peng L, Gu Q, Huang Z, Zeng L, Chu C, Yang X Tags: Cardiol Res Pract Source Type: research

Systemic Lupus Erythematosus, Its Impact on Selected Cardiovascular Risk Factors, and Correlation with Duration of Illness: A Pilot Study.
Conclusions. Patients with SLE are at greater risk of developing cardiovascular diseases as the illness progresses. The activity of the disease according to the SLEDAI-2K scale may have an impact on the LVEF values which was significantly decreased in the group with active disease, but further thorough investigation is required to fully evaluate the impact of individual components of the disease and its treatment on the CVD development and mortality. PMID: 33204527 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - November 20, 2020 Category: Cardiology Authors: Przywara-Chowaniec B, Blachut D, Harpula J, Bereś M, Nowak A, Nowalany-Kozielska E Tags: Cardiol Res Pract Source Type: research

Prognostic Value of the Residual SYNTAX Score on In-Hospital and Follow-Up Clinical Outcomes in ST Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Interventions.
Abstract Aims: We investigated the prognostic significance of residual SYNTAX score (RSS) in patients undergoing PCI due to STEMI and relationship between RSS and in-hospital and long-term ischemic cardiac events. Methods: Between June 2015 and December 2018, 538 patients who underwent primary PCI were evaluated for in-hospital events and 478 patients were evaluated for clinical events during follow-up. Primary and secondary endpoints for both in-hospital and follow-up periods were cardiac death and major adverse cardiac events (MACE). Results: 538 patients were included the study. RSS values of 131 pati...
Source: Cardiology Research and Practice - November 14, 2020 Category: Cardiology Authors: Altekin RE, Kilinc AY, Onac M, Cicekcibasi O Tags: Cardiol Res Pract Source Type: research

In-Stent Restenosis and a Drug-Coated Balloon: Insights from a Clinical Therapeutic Strategy on Coronary Artery Diseases.
Abstract Coronary heart disease is a major cause of death and disability in developed countries. Stent implantation has become an efficacious treatment for a culprit lesion vessel of the coronary artery. However, 10%-20% restenosis is still an important complication that restricts the clinical safety and efficacy of drug-eluting stents. In-stent restenosis may lead to the recurrence of major cardiovascular adverse events, including angina pectoris, acute myocardial infarction, and even sudden cardiac death. These events are currently serious problems that occur after coronary stent implantation. Clinical physician...
Source: Cardiology Research and Practice - November 11, 2020 Category: Cardiology Authors: Zhang DM, Chen S Tags: Cardiol Res Pract Source Type: research

Out-of-Hospital Cardiac Arrest due to Drowning in North America: Comparison of Patient Characteristics between Survival and Mortality Groups.
This study aims to compare patient characteristics between the survival group and mortality group of OHCA due to drowning. OHCA due to drowning cases were selected from the North America Termination of Resuscitation Association database between 2011 and 2015. The retrospective analysis of epidemiological characteristics and clinical features of all OHCA patients were performed. Of the 17,094 OHCA cases in the registry, 54 cases of OHCA due to drowning were included in this study. Among the 54 OHCAs due to drowning, 7 (13.0%) survived, while 47 (87.0%) died. Compared to the mortality group, the survival group had a higher b...
Source: Cardiology Research and Practice - November 7, 2020 Category: Cardiology Authors: Huang Z, Zhang W, Liao J, Liu Z, Xiong Y, Zhan H Tags: Cardiol Res Pract Source Type: research

Vitamin D (1,25-(OH)2D3) Improves Endothelial Progenitor Cells Function via Enhanced NO Secretion in Systemic Lupus Erythematosus.
Abstract It has been proven that vitamin D was decreased and function of circulating endothelial progenitor cells (EPCs) was injured in systemic lupus erythematosus (SLE) patients. However, the effect of vitamin D on the function of EPCs in vitro and its mechanism need further study. Therefore, we investigated whether vitamin D improved the function of EPCs in vitro. The peripheral blood mononuclear cells of the participants were isolated from SLE patients and control subjects and cultured to EPCs. After the EPCs were treated with vitamin D (1,25-(OH)2D3), we evaluated the number, migratory and proliferative activ...
Source: Cardiology Research and Practice - November 1, 2020 Category: Cardiology Authors: Huang Z, Liu L, Huang S, Li J, Feng S, Huang N, Ai Z, Long W, Jiang L Tags: Cardiol Res Pract Source Type: research

Postoperative New-Onset Atrial Fibrillation following Noncardiac Operations: Prevalence, Complication, and Long-Term MACE.
This study was intended to examine the incidence of POAF in noncardiothoracic surgeries performed under general anesthesia and its effects on the length of hospitalization stay, short-term and long-term morbidity, and mortality. Methodology. We conducted a retrospective observational descriptive study. The study population consists of patients hospitalized in surgical wards from January 2014 to December 2017. Surgery was defined as noncardiac or thoracic procedure conducted under general anesthesia. Results: A total of 24,125 general anesthesia operations were performed at 7 surgical wards. About two-fifth of the oper...
Source: Cardiology Research and Practice - November 1, 2020 Category: Cardiology Authors: Koren O, Hakim R, Israeli A, Rozner E, Turgeman Y Tags: Cardiol Res Pract Source Type: research

Value of Plasma NGAL and Creatinine on First Day of Admission in the Diagnosis of Cardiorenal Syndrome Type 1.
This study was aimed to evaluate the diagnostic efficacy of plasma NGAL in the diagnosis of CRS1. Methods: There were 139 patients with AHF or ADHF in the department of Cardiovascular Resuscitation and Interventional Cardiology at Ho Chi Minh City 115 People Hospital from September 2018 to March 2019. This was a prospective cohort study. Results: There were 48 cases (rate 34.5%) with CRS1, mean age was 66.12 ± 15.77 and men accounted for 50.4%. There were no significant differences of vital signs at admission, diagnosis, and EF-based heart failure between CRS1 and non-CRS1 groups. The urea, c...
Source: Cardiology Research and Practice - October 22, 2020 Category: Cardiology Authors: Phan Thai H, Hoang Bui B, Hoang Anh T, Huynh Van M Tags: Cardiol Res Pract Source Type: research

The Association of New-Onset Atrial Fibrillation and Risk of Cancer: A Systematic Review and Meta-Analysis.
This study aims to explore the relationship between NOAF and the risk of developing cancer through a meta-analysis with a large sample size. Methods: Electronic databases, such as PubMed and EMBASE, were searched for published relevant studies on NOAF patients diagnosed with cancer after and during follow-ups, including reported records of baseline information and the statistical result of morbidity. Two investigators independently reviewed the articles and extracted the data using uniform standards and definitions. The meta-analysis was conducted using the Cochrane Program Review Manager. Results: This meta-anal...
Source: Cardiology Research and Practice - October 21, 2020 Category: Cardiology Authors: Zhang M, Li LL, Zhao QQ, Peng XD, Wu K, Li X, Ruan YF, Bai R, Liu N, Ma CS Tags: Cardiol Res Pract Source Type: research

Impaired Mitophagy: A New Potential Mechanism of Human Chronic Atrial Fibrillation.
Abstract Mitophagy is an autophagic response and plays essential roles in survival, development, and homeostasis of cells. It has been reported that mitophagic dysfunction is involved in several cardiovascular diseases. However, the effect of mitophagy on atrial fibrillation (AF) is still unknown. Therefore, we investigated the exact role of mitophagy in human chronic AF. Western blot was used to detect the protein abundance. The mitochondrial morphology and structure were observed by transmission electron microscopy. Immunofluorescent stainings were performed to analyze colocalization of mitochondria with autopha...
Source: Cardiology Research and Practice - October 21, 2020 Category: Cardiology Authors: Zhou S, Dai W, Zhong G, Jiang Z Tags: Cardiol Res Pract Source Type: research

Effects of N-Acetylcysteine and N-Acetylcysteine Amide on Erythrocyte Deformability and Oxidative Stress in a Rat Model of Lower Extremity Ischemia-Reperfusion Injury.
Conclusion. The results of our study demonstrated the protective effects of NAC and NACA on erythrocyte deformability and oxidative damage in skeletal muscle in lower extremity ischemia-reperfusion. NAC and NACA exhibited similar protective effects on oxidative damage and erythrocyte deformability. PMID: 33062321 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - October 21, 2020 Category: Cardiology Authors: Erol G, Kartal H, Comu FM, Cetin E, Demirdas E, Sicim H, Unal CS, Gunay C, Oz BS, Bolcal C Tags: Cardiol Res Pract Source Type: research

Predictive Value of Fasting Blood Glucose for Microvascular Obstruction in Nondiabetic Patients with ST-Segment Elevation Myocardial Infarction after Primary Percutaneous Coronary Intervention.
Conclusion: FBG was independently associated with MVO in nondiabetic STEMI patients. PMID: 33062322 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - October 21, 2020 Category: Cardiology Authors: Wu H, Li R, Wang K, Mu D, Chen JZ, Wei X, Bao X, Wei ZH, Xie J, Xu B Tags: Cardiol Res Pract Source Type: research

Matrix Metalloproteinase-2 Isoforms Differ within the Aortic Wall of Ascending Aortic Aneurysms Associated with Bicuspid Aortic Valve.
Abstract The pathogenesis of ascending thoracic aortic aneurysm (aTAA) is thought to differ between patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV), and one of the causes is different hemodynamics. Influenced by hemodynamics, the tissue levels of proteins associated with aTAA might differ between aTAAs with BAV and TAV and between different localities within the aortic wall. We therefore analyzed aTAA tissue levels of MMP-2 (matrix metalloproteinase-2) isoforms (Pro-MMP-2, active MMP-2, and total MMP-2) and tissue levels of MMP-14, TIMP-2 (tissue inhibitor of metalloproteinase-2), MMP-9,...
Source: Cardiology Research and Practice - October 9, 2020 Category: Cardiology Authors: Schmitt R, Tscheuschler A, Laschinski P, Discher P, Fuchs J, Kari FA Tags: Cardiol Res Pract Source Type: research

Left Atrial Appendage Thrombus Formation Despite Continuous Non-Vitamin K Antagonist Oral Anticoagulant Therapy in Atrial Fibrillation Patients Undergoing Electrical Cardioversion or Catheter Ablation: A Comparison of Dabigatran and Rivaroxaban.
We examined the factors predisposing to LAAT in patients treated with the anticoagulants dabigatran and rivaroxaban. We retrospectively evaluated 1,256 AF patients from three centres who underwent TOE before electrical cardioversion (n = 611, 51.4%) or catheter ablation (n = 645, 48.6%) from January 2013 to December 2019 and had been on at least three weeks of continuous dabigatran (n = 603, 48%) or rivaroxaban (n = 653, 52%) therapy. Preprocedural TOE diagnosed LAAT in 51 patients (4.1%), including 30 patients (5%) treated with dabigatran and 21 patients (3.2%) treat...
Source: Cardiology Research and Practice - October 6, 2020 Category: Cardiology Authors: Gorczyca I, Chrapek M, Jelonek O, Michalska A, Kapłon-Cieślicka A, Uziębło-Życzkowska B, Budnik M, Gawałko M, Krzesiński P, Jurek A, Scisło P, Kochanowski J, Kiliszek M, Gielerak G, Filipiak KJ, Opolski G, Wożakowska-Kapłon B Tags: Cardiol Res Pract Source Type: research

Myocardial Scar on Surface ECG: Selvester Score, but Not Fragmentation, Predicts Response to CRT.
Conclusion: In HF patients with true-LBBB and LVEF ≤35% eligible for CRT, myocardial scar assessed by calculating the SSc on preimplant ECG is an independent predictor of nonresponse after multiple adjustments. Neither SSc nor fQRS is associated with overall and cardiac death, ventricular arrhythmias, or hospitalization for heart failure at a 24-month follow-up. PMID: 33014454 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - October 6, 2020 Category: Cardiology Authors: Nesti M, Perini AP, Bani R, Cartei S, Checchi L, Ricciardi G, Pieragnoli P, Michelotti F, Mascioli G, Cavarretta E, Sciarra L Tags: Cardiol Res Pract Source Type: research

The Effect of Sex Differences on Endothelial Function and Circulating Endothelial Progenitor Cells in Hypertriglyceridemia.
Abstract Background: Men have a higher risk and earlier onset of cardiovascular diseases compared with premenopausal women. Hypertriglyceridemia is an independent risk factor for the occurrence of ischemic heart disease. Endothelial dysfunction is related to the development of ischemic heart disease. Whether sex differences will affect the circulating endothelial progenitor cells (EPCs) and endothelial function in hypertriglyceridemia patients or not is not clear. Methods: Forty premenopausal women and forty age- and body mass index (BMI)-matched men without cardiovascular and metabolic disease were recruited...
Source: Cardiology Research and Practice - October 6, 2020 Category: Cardiology Authors: Ren Z, Guo J, Xiao X, Huang J, Li M, Cai R, Zeng H Tags: Cardiol Res Pract Source Type: research

Upregulation of MicroRNA-125b Leads to the Resistance to Inflammatory Injury in Endothelial Progenitor Cells.
Conclusions: miR-125b protects EPCs against TNF-α-induced inflammation and cell apoptosis by attenuating the activation of NF-κB pathway and consequently improves the cardiac function recovery and EPC-mediated neovascularization in the ischemic hearts. PMID: 33005452 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - October 3, 2020 Category: Cardiology Authors: Yang K, Liu X, Lin W, Zhang Y, Peng C Tags: Cardiol Res Pract Source Type: research

Correlation between the Serum Platelet-Derived Growth Factor, Angiopoietin-1, and Severity of Coronary Heart Disease.
Conclusion: The serum PDGF concentration in patients with acute coronary syndrome was significantly increased, especially in the local coronary artery. The serum Ang-1 in the coronary artery was significantly increased in patients with acute myocardial infarction and was related to the degree of coronary artery stenosis. Coronary sinus PDGF and Ang-1 levels can reflect the severity of lesions in patients with acute coronary syndrome. PMID: 32963822 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - September 25, 2020 Category: Cardiology Authors: Pang S, Tao Z, Min X, Zhou C, Pan D, Cao Z, Wang X Tags: Cardiol Res Pract Source Type: research

Echocardiography in Confirmed and Highly Suspected Symptomatic COVID-19 Patients and Its Impact on Treatment Change.
Conclusions: Echocardiography may be useful for the management of selected COVID-19 patients, especially those with elevated D-Dimer and Troponin levels, in up to 16% of patients. PMID: 32963823 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - September 25, 2020 Category: Cardiology Authors: Benyounes N, Van Der Vynckt C, Tibi S, Iglesias A, Salomon L, Gout O, Tibi T Tags: Cardiol Res Pract Source Type: research

Balloon Deflation Strategy during Primary Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Clinical Trial and Numerical Simulation-Based Analysis.
Conclusion: This randomized study demonstrated that the slow balloon deflation during stent implantation improved coronary flow and reduced infarct size in reperfused STEMI. The change of flow in the balloon-vessel gap and WSS resulted from different balloon deflation velocity might be partly accounted for this results. PMID: 32963824 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - September 25, 2020 Category: Cardiology Authors: Gu J, Zhuo Y, Liu TJ, Li J, Yin ZF, Xu ZJ, Fan L, He Q, Chen K, Zeng HS, Wang XF, Fan YQ, Zhang JF, Liang FY, Wang CQ Tags: Cardiol Res Pract Source Type: research

Urban vs Suburban: Is the Door-to-Balloon Time Affected by Geographic, Socioeconomic, or Racial Differences? A Tale of Two Campuses.
Conclusions: Our study demonstrated that we have been able to provide high-quality care to all of our patients presenting with STEMI at either campus, regardless of socioeconomic differences in the populations they serve. Additionally, each campus has demonstrated DTB well below the nationally recommended guidelines. PMID: 32963825 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - September 25, 2020 Category: Cardiology Authors: Zughaib M, Ters P, Singh R, Zughaib M Tags: Cardiol Res Pract Source Type: research

A Predictive Model for Super-Response to Cardiac Resynchronization Therapy: The QQ-LAE Score.
Abstract Objectives: It is important to identify super-responders who can derive most benefits from cardiac resynchronization therapy (CRT). We aimed to establish a scoring model that can be used for predicting super-response to CRT. Methods: We retrospectively reviewed 387 CRT patients. Multivariate logistic regression analysis was performed to identify predictors for super-response (defined as an absolute increase in left ventricular ejection fraction of ≥15% at 6-month follow-up) and to create a score model. Multivariate Cox proportional-hazard regression analysis was conducted to assess associations wi...
Source: Cardiology Research and Practice - September 12, 2020 Category: Cardiology Authors: Liu X, Hu Y, Hua W, Yang S, Gu M, Niu HX, Ding LG, Wang J, Zhang S Tags: Cardiol Res Pract Source Type: research

The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden.
Abstract Introduction: Growing evidence suggests that fibrotic changes can be observed in atrial fibrillation (AF) in both atria. Quantification of the scar burden during electroanatomical mapping might have important therapeutic and prognostic consequences. However, as the current invasive treatment of AF is focused on the left atrium (LA), the role of the right atrium (RA) is less well understood. We aimed to characterize the clinical determinates of the RA low-voltage burden and its relation to the LA scaring. Methods: We have included 36 patients who underwent catheter ablation for AF in a prospective obs...
Source: Cardiology Research and Practice - August 30, 2020 Category: Cardiology Authors: Herczeg S, Galvin J, Keaney JJ, Keelan E, Byrne R, Howard C, Geller L, Szeplaki G Tags: Cardiol Res Pract Source Type: research

The Association between Trimethylamine N-Oxide and Its Predecessors Choline, L-Carnitine, and Betaine with Coronary Artery Disease and Artery Stenosis.
Abstract Background: Trimethylamine N-oxide (TMAO) and its predecessor products, choline, L-carnitine, and betaine, were reported to be associated with cardiovascular events risk. However, the association of TMAO and its predecessors with extent of artery stenosis in coronary artery disease (CAD) and in different gender is still unknown. Our aim is to investigate the association of plasma TMAO and its predecessors in CAD and extent of artery lesion in different gender. Methods: 94 CAD patients and 75 healthy controls (CON) were enrolled. Fasting plasma TMAO, choline, L-carnitine, and betaine were detected usi...
Source: Cardiology Research and Practice - August 30, 2020 Category: Cardiology Authors: Guo F, Zhou J, Li Z, Yu Z, Ouyang D Tags: Cardiol Res Pract Source Type: research

Corrigendum to "Left Atrial Anatomy Relevant to Catheter Ablation".
Corrigendum to "Left Atrial Anatomy Relevant to Catheter Ablation". Cardiol Res Pract. 2020;2020:3490543 Authors: Sánchez-Quintana D, López-Mínguez JR, Macías Y, Cabrera JA, Saremi F Abstract [This corrects the article DOI: 10.1155/2014/289720.]. PMID: 32850145 [PubMed - in process] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - August 29, 2020 Category: Cardiology Authors: Sánchez-Quintana D, López-Mínguez JR, Macías Y, Cabrera JA, Saremi F Tags: Cardiol Res Pract Source Type: research

Effect of Stress on Autonomic and Cardiovascular Systems in Military Population: A Systematic Review.
itros AA, Clemente-Suárez VJ Abstract Stress is regulated by the autonomous nervous system, increasing the sympathetic modulation when a threat is perceived. A multifactorial response usually leads to significant behavioural modifications and alterations on homeostasis and physical and psychological status. Moreover, stress is an emotional response that can lead to psychosocial and psychophysiological adversity. Regarding military population, military operations and combat exposure are important stressors that influence acute and chronic stress response in soldiers, affecting their performance and health. A...
Source: Cardiology Research and Practice - August 29, 2020 Category: Cardiology Authors: Bustamante-Sánchez Á, Tornero-Aguilera JF, Fernández-Elías VE, Hormeño-Holgado AJ, Dalamitros AA, Clemente-Suárez VJ Tags: Cardiol Res Pract Source Type: research

Extracellular Matrix Remodeling Factors as Markers of Carotid Artery Atherosclerosis.
Abstract Materials and Methods: 20 patients undergoing routine carotid endarterectomy and 40 healthy volunteers were enrolled in this study. MMPs activity and OPG and FN concentrations were measured in atherosclerotic plaques and nonchanged contiguous tissue after homogenization as well as in plasma from patients and reference group. The activity of MMPs was evaluated by gelatin zymography, and the concentration of OPG and FN was assessed by ELISA. Results: OPG concentration and MMP-9 activity showed differences between plaque and nonchanged tissue; OPG was higher in adjacent tissue (P=0.0009), whereas MMP-9 ...
Source: Cardiology Research and Practice - August 29, 2020 Category: Cardiology Authors: Sapa-Wojciechowska A, Rak-Pasikowska A, Pormańczuk K, Czapla B, Bil-Lula I Tags: Cardiol Res Pract Source Type: research

Association of c.56C   >  G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis.
Association of c.56C > G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis. Cardiol Res Pract. 2020;2020:5981971 Authors: Morjane I, Charoute H, Ouatou S, Elkhattabi L, Benrahma H, Saile R, Rouba H, Barakat A Abstract Purpose: Coronary artery diseases (CAD) are clinical cardiovascular events associated with dyslipidemia in common. The interaction between environmental and genetic factors can be responsible for CAD. The present paper aimed to examine the association between c.56C &...
Source: Cardiology Research and Practice - August 26, 2020 Category: Cardiology Authors: Morjane I, Charoute H, Ouatou S, Elkhattabi L, Benrahma H, Saile R, Rouba H, Barakat A Tags: Cardiol Res Pract Source Type: research

Sex Difference in Risk Factors, GRACE Scores, and Management among Post-Acute Coronary Syndrome Patients in Sri Lanka.
Abstract Objective: To assess sex-based differences in the prevalence of risk factor, their management, and differences in the prognosis among acute coronary syndrome (ACS) in Sri Lanka. Methods: Patients diagnosed with ACS were recruited from hospitals throughout the island. The Joint European Societies guidelines were used to assess recommended targets for coronary heart disease risk factors, and the GRACE score was used to assess the post-ACS prognosis. Age-adjusted regression was performed to calculate odds ratios for men versus women in risk factor control. Results: A total of 2116 patients, of whom...
Source: Cardiology Research and Practice - August 19, 2020 Category: Cardiology Authors: Galappatthy P, Bataduwaarachchi V, Ranasinghe P, Galappatthy G, Senerath U, Wijeyaratne C, Ekanayake R Tags: Cardiol Res Pract Source Type: research

The Role of Gender in the Importance of Risk Factors for Coronary Artery Disease.
This study is a cross-sectional study. More than one thousand (N = 1012) patients referring to the Nuclear Medicine Department in Namazi Hospital, Shiraz, Iran, from March 2017 to March 2018 were studied. The patients' demographic data and their clinical history were collected. The results of the myocardial perfusion scan were recorded and compared between groups. Statistical analysis was implemented by SPSS version 18.0, and P values below 0.05 were considered statistically significant. Out of the 1012 patients participating in this study, 698 (69%) were female and 314 (31%) were male. Ischemic heart disease...
Source: Cardiology Research and Practice - August 19, 2020 Category: Cardiology Authors: Gheisari F, Emami M, Raeisi Shahraki H, Samipour S, Nematollahi P Tags: Cardiol Res Pract Source Type: research

Comparison of the CAMI-NSTEMI and GRACE Risk Model for Predicting In-Hospital Mortality in Chinese Non-ST-Segment Elevation Myocardial Infarction Patients.
Abstract Introduction: The ability of risk models to predict in-hospital mortality and the influence on downstream therapeutic strategy has not been fully investigated in Chinese Non-ST-segment elevation myocardial infarction (NSTEMI) patients. Thus, we sought to validate and compare the performance of the Global Registry of Acute Coronary Events risk model (GRM) and China Acute Myocardial Infarction risk model (CRM) and investigate impacts of the two models on the selection of downstream therapeutic strategies among these patients. Methods: We identified 2587 consecutive patients with NSTEMI. The primary end...
Source: Cardiology Research and Practice - August 13, 2020 Category: Cardiology Authors: Wang P, Cong H, Zhang Y, Liu Y Tags: Cardiol Res Pract Source Type: research

The Impact of Beta Blockers on Survival in Heart Transplant Recipients: Insights from the Zabrze HTx Registry.
Conclusions: The use of BBs in our cohort of patients after HTx was not associated with survival benefits. PMID: 32774914 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - August 13, 2020 Category: Cardiology Authors: Kubiak GM, Kwieciński R, Ciarka A, Tukiendorf A, Przybyłowski P, Hrapkowicz T, Zembala MO Tags: Cardiol Res Pract Source Type: research

miRNA-22 as a Candidate Diagnostic Biomarker for Coronary Slow Flow.
Abstract Background: Coronary slow flow (CSF) refers to the phenomenon of delayed distal flow in the absence of lesions detected on coronary angiography. Although the detection rate of CSF has been increasing in clinical practice, early diagnosis is difficult and the factors contributing to this condition remain unclear. Given the increasing demonstration of the roles of microRNAs (miRNAs) in disease and as diagnostic biomarkers, the aim of this study was to analyze the expression of serum miRNA-22 in patients with CSF detected using coronary angiography and its diagnostic efficacy. Methods and Results: A ret...
Source: Cardiology Research and Practice - August 13, 2020 Category: Cardiology Authors: Chen T, Wang ZY, Li CC Tags: Cardiol Res Pract Source Type: research

Relation of Mitral Annulus and Left Atrial Dysfunction to the Severity of Functional Mitral Regurgitation in Patients with Dilated Cardiomyopathy.
Abstract Methods: 56 patients (58 ± 17 years, 42 men) with DCM and FMR and 52 controls, prospectively enrolled, underwent 3DTTE dedicated for mitral valve (MV), LA, and left ventricle (LV) quantitative analysis. Results: Patients with FMR vs. controls presented increased MA size and sphericity during the entire systole, whereas MA fractional area change (MAFAC) and MA displacement were decreased (15 ± 5 vs. 28 ± 5%; and 5 ± 3 vs. 10 ± 2 mm, p
Source: Cardiology Research and Practice - July 24, 2020 Category: Cardiology Authors: Mihaila Baldea S, Muraru D, Miglioranza MH, Iliceto S, Vinereanu D, Badano LP Tags: Cardiol Res Pract Source Type: research

Agarwood Alcohol Extract Ameliorates Isoproterenol-Induced Myocardial Ischemia by Inhibiting Oxidation and Apoptosis.
This study was carried out to investigate the potential cardioprotective effect of the whole-tree agarwood-inducing technique-produced agarwood alcohol extract (WTAAE) on isoproterenol- (ISO-) induced myocardial ischemia (MI) in rats and explore the underlying molecular mechanisms. Compared to the MI group, WTAAE pretreatment significantly improved ST wave abnormal-elevation, mitigated myocardial histological damage; decreased creatinine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), and aspartate transaminase (AST) levels; reduced hydrogen peroxide (H2O2) and lipid peroxide (LPO) production; and inc...
Source: Cardiology Research and Practice - July 24, 2020 Category: Cardiology Authors: Wang C, Peng D, Liu Y, Yu Z, Guo P, Wei J Tags: Cardiol Res Pract Source Type: research

Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy.
Abstract Background: Few studies regarding chronic kidney disease (CKD) and anemia have been conducted in patients with Chagas cardiomyopathy (CC). We evaluated the risk prediction performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and anemia in CC patients. Methods: From 2000 to 2010, a total of 232 patients were studied in a single-center retrospective study. CKD was defined as creatinine clearance
Source: Cardiology Research and Practice - July 24, 2020 Category: Cardiology Authors: Nakazone MA, Machado MN, Otaviano AP, Rodrigues AMS, Cardinalli-Neto A, Bestetti RB Tags: Cardiol Res Pract Source Type: research

Circulating Platelet-Derived Microparticles Associated with Postdischarge Major Adverse Cardiac Events in ST-Elevation Acute Myocardial Infarction.
Conclusion: The PDMPs level was increased from the day of admission to 30 days after discharge in patients with STEMI. The persistent increase in the PDMPs level in 30 days after the STEMI event was associated with the 30-day postdischarge MACE and trended toward increased MACE during the 90-day and 1-year follow-up. PMID: 32695505 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - July 24, 2020 Category: Cardiology Authors: Hartopo AB, Mayasari DS, Puspitawati I, Mumpuni H Tags: Cardiol Res Pract Source Type: research

Good Practices in the Clinical Management of Patients with Acute Coronary Syndrome: Retrospective Analysis in a Third-Level Hospital in Mexico.
Conclusions: There is a higher percentage of coronary interventionism and improvement in pharmacological treatment, which is reflected in lower mortality. The substantial burden of T2DM could be related to a higher number of cases of STEMI. Diabetics with precedent percutaneous coronary intervention and smokers with previous heart surgery have an increased risk of subsequent infarction. PMID: 32695506 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - July 24, 2020 Category: Cardiology Authors: Flores-Salinas HE, Casillas-Muñoz F, Valle Y, Guzmán-Sánchez CM, Padilla-Gutiérrez JR Tags: Cardiol Res Pract Source Type: research

Artificial Intelligence (AI) and Cardiovascular Diseases: An Unexpected Alliance.
Abstract Cardiovascular disease (CVD), despite the significant advances in the diagnosis and treatments, still represents the leading cause of morbidity and mortality worldwide. In order to improve and optimize CVD outcomes, artificial intelligence techniques have the potential to radically change the way we practice cardiology, especially in imaging, offering us novel tools to interpret data and make clinical decisions. AI techniques such as machine learning and deep learning can also improve medical knowledge due to the increase of the volume and complexity of the data, unlocking clinically relevant information....
Source: Cardiology Research and Practice - July 19, 2020 Category: Cardiology Authors: Romiti S, Vinciguerra M, Saade W, Anso Cortajarena I, Greco E Tags: Cardiol Res Pract Source Type: research

Association of Biomarker Level with Cardiovascular Events: Results of a 4-Year Follow-Up Study.
We examined 363 people aged 30 to 65 who have been living permanently in the city of Saran, Karaganda region. The selected participants were people registered at a clinic at the city of Saran, who were screened between August and September 2014. Results: The follow-up period was 48 months (from August-September 2014 to November 2018). The results showed that CXCL16 (p
Source: Cardiology Research and Practice - July 19, 2020 Category: Cardiology Authors: Turgunova L, Baidildina B, Laryushina Y, Koichubekov B, Turmukhambetova A, Akhmaltdinova L Tags: Cardiol Res Pract Source Type: research

Screening of Abdominal Aortic Aneurysm Using Portable Transthoracic Echocardiography among Patients with Acute Coronary Syndrome.
Abstract Background: Abdominal aortic aneurysm (AAA) and acute coronary syndrome (ACS) share common risk factors. Objectives: To assess the abdominal aortic diameter (AAD) among patients with ACS using transthoracic echocardiography (TTE). Methods: Patients with ACS admitted to our intensive cardiac care unit from December 2013 to June 2014 were screened prospectively for AAA via AAD measurement in the subcostal TTE view. AAA was defined as an aneurysm with a transverse diameter of ≥30 mm. Results: Sixty seven patients were included. The male-to-female sex ratio was 7 : 1. Th...
Source: Cardiology Research and Practice - July 19, 2020 Category: Cardiology Authors: Shukha Y, Koren O, Or T, Turgeman Y, Mahamid M, Jabaren M Tags: Cardiol Res Pract Source Type: research

Left Ventricular End-Systolic Volume Is a Reliable Predictor of New-Onset Heart Failure with Preserved Left Ventricular Ejection Fraction.
Abstract Background: Left ventricular (LV) ejection fraction (EF) and LV volumes were reported to have prognostic efficacy in cardiac diseases. In particular, the end-systolic volume index (LVESVI) has been featured as the most reliable prognostic indicator. However, such efficacy in patients with LVEF ≥ 50% has not been elucidated. Methods: We screened the patients who received cardiac catheterization to evaluate coronary artery disease concomitantly with both left ventriculography and LV pressure recording using a catheter-tipped micromanometer and finally enrolled 355 patients with LVEF&th...
Source: Cardiology Research and Practice - July 17, 2020 Category: Cardiology Authors: Kato M, Kitada S, Kawada Y, Nakasuka K, Kikuchi S, Seo Y, Ohte N Tags: Cardiol Res Pract Source Type: research

Ezetimibe and Improving Cardiovascular Outcomes: Current Evidence and Perspectives.
Abstract Low-density lipoprotein lowering with statins has convincingly and consistently proven to reduce cardiovascular events in both primary and secondary prevention. However, despite high-dose statin therapy, residual cardiovascular risk remains and many patients also do not tolerate statins. Ezetimibe was initially projected as a frontline alternative to statin. It is an intestinal cholesterol absorption inhibitor with modest LDL lowering effects. But, major studies failed to demonstrate any beneficial effect of CV outcomes, and the drug was relegated to oblivion. IMPROVE-IT, a contemporary, large, and well-d...
Source: Cardiology Research and Practice - July 17, 2020 Category: Cardiology Authors: Pradhan A, Bhandari M, Sethi R Tags: Cardiol Res Pract Source Type: research

Biomarkers for Predicting Left Atrial or Left Atrial Appendage Thrombus in Anticoagulated Patients with Nonvalvular Atrial Fibrillation.
Conclusion: In anticoagulation patients with NVAF, elevated NT-proBNP and RDW are related to LA/LAA thrombus. Therefore, these might be considered as useful prognostic markers in the management and treatment of NVAF patients. PMID: 32655946 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - July 14, 2020 Category: Cardiology Authors: Zhou X, Wang Z, Dou S, Chen K, Liu E, Liu T, Li G, Che J Tags: Cardiol Res Pract Source Type: research

Initial Experience Using the Radiofrequency Needle Visualization on the Electroanatomical Mapping System for Transseptal Puncture.
Conclusions: TSP using an RF needle is an effective technique, also in congenital patients with artificial patch material and in normal patients with multiple previous TSPs. Moreover, the RF needle tip visualization on EAM allows a low (or even zero) fluoroscopy approach. PMID: 32655947 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - July 14, 2020 Category: Cardiology Authors: Guarguagli S, Cazzoli I, Kempny A, Gatzoulis MA, Ernst S Tags: Cardiol Res Pract Source Type: research

Adaptive Autophagy Offers Cardiorenal Protection in Rats with Acute Myocardial Infarction.
Conclusion: Autophagy will undergo adaptive changes and play a protective role in the heart and kidney of rats after AMI. PMID: 32655948 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - July 14, 2020 Category: Cardiology Authors: Feng Z, Jiang HX, Chen H, Liu YN, Wang Y, Yang RB, Han X, Xia CH, Zhu ZB, Shang H, Wu A, Liu WJ Tags: Cardiol Res Pract Source Type: research