Combination of Left Ventricular End-Diastolic Diameter and QRS Duration Strongly Predicts Good Response to and Prognosis of Cardiac Resynchronization Therapy.
Abstract Background: Approximately 20-40% of recipients of cardiac resynchronization therapy (CRT) do not respond to it based on the current patient selection criteria. The purpose of this study was to identify baseline parameters that can predict CRT response and to evaluate the effect of those predictive parameters on long-term prognosis. Methods: This was a retrospective, nonrandomized, noncontrolled cohort study. Patients who received CRT in our centre were divided into responders and nonresponders by the definition of CRT response (an increase in left ventricular ejection fraction (LVEF) of ≥5% and im...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Guo Z, Liu X, Cheng X, Liu C, Li P, He Y, Rao R, Li C, Chen Y, Zhang Y, Luo X, Wang J Tags: Cardiol Res Pract Source Type: research

Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance.
Conclusions: The endothelial repair capacity was impaired in i-IGT premenopausal women but was preserved in i-IFG counterparts. The underlying mechanism may be associated with the downregulated GTCPH I pathway and reduced NO productions. PMID: 32411442 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Liu J, Xing X, Wu X, Li X, Yao S, Ren Z, Zeng H, Wu S Tags: Cardiol Res Pract Source Type: research

Clinical Characteristics and Factors Associated with Heart Failure Readmission at a Tertiary Hospital in North-Eastern Tanzania.
Abstract Introduction: Heart failure (HF) is characterized by frequent episodes of decompensation, leading to a high hospitalization burden. More than 50% of index hospitalizations for HF patients return within 6 months of discharge. Once the patient is readmitted, the risk of further disease progression and the mortality rate are increased. A lot of patients are readmitted due to factors such as poor medication adherence, infections, or worsening comorbidities. The aim of our study was to identify the inpatient burden of HF readmission and to identify the factors associated with early readmission. Met...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Sadiq AM, Chamba NG, Sadiq AM, Shao ER, Temu GA Tags: Cardiol Res Pract Source Type: research

Low Expression of FFAR2 in Peripheral White Blood Cells May Be a Genetic Marker for Early Diagnosis of Acute Myocardial Infarction.
Abstract Objective: To find molecular markers for the diagnosis of acute myocardial infarction (AMI), this research further verified the relationship between the expression level of FFAR2 gene and AMI by expanding the sample size based on the previous gene chip results. Methods: Peripheral venous leukocytes were collected from 113 patients with AMI and 94 patients with noncoronary artery disease as the experimental group and the control group, respectively. Real-time fluorescence quantitative polymerase chain reaction was used to detect the expression of the FFAR2 gene. Western blot analysis was applied to de...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Ruan J, Meng H, Wang X, Chen W, Tian X, Meng F Tags: Cardiol Res Pract Source Type: research

Pathophysiological and Genetic Aspects of Vascular Calcification.
Abstract Recent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic factors that promote the osteochondrogenic differentiation of vascular smooth muscle cells (VSMC). This review will evaluate the main mechanisms involved in the pathophysiology and genetics modulation of the process of vascular calcification. Objective. A systematic review of the pathophysiology factors involved in...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Escobar Guzman LF, Escobar Guzman CA, Lopes NHM Tags: Cardiol Res Pract Source Type: research

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases.
Abstract Cardiovascular disease, which can lead to angina and shortness of breath, remains one of the most serious threats to human health. Owing to its imperceptible symptoms, it is difficult to determine the pathogenesis and treatment methods for cardiovascular disease. Nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) is a protein found in all cells of the human body. It is activated, transferred to the nucleus, and bound to DNA by antioxidant response elements (AREs). As a regulator of the antioxidant system, it upregulates the expression of HO-1 to reduce oxidative stress. Nrf2/HO-...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Zhang X, Yu Y, Lei H, Cai Y, Shen J, Zhu P, He Q, Zhao M Tags: Cardiol Res Pract Source Type: research

The Hemodynamic Effect of Enhanced External Counterpulsation Treatment on Atherosclerotic Plaque in the Carotid Artery: A Framework of Patient-Specific Computational Fluid Dynamics Analysis.
Abstract Long-term enhanced external counterpulsation (EECP) therapy has been recommended for antiatherogenesis in recent clinical observations and trials. However, the precise mechanism underlying the benefits has not been fully clarified. To quantify the effect of EECP intervention on arterial hemodynamic environment, a framework of numerical assessment was introduced using a parallel computing algorithm. A 3D endothelial surface of the carotid artery with mild atherosclerotic plaque was constructed from images of magnetic resonance angiography (MRA). Physiologic boundary conditions were derived from images of t...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Du J, Wu G, Wu B, Liu C, Mai Z, Liu Y, Wang Y, Zhang P, Wu G, Liu J Tags: Cardiol Res Pract Source Type: research

Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice.
Abstract Background: We hypothesized that daily administration of a potent antioxidant (α-lipoic acid: ALA) would protect the heart against both acute myocardial infarction (AMI) and left ventricular remodeling (LVR) post-AMI. Methods and Results: Two separate studies were conducted. In the AMI study, C57Bl/6 mice were fed ALA daily for 7 d prior to a 45-minute occlusion of the left coronary artery (LCA). Mean infarct size in control mice (fed water) was 60 ± 2%. Mean infarct size in ALA-treated mice was 42 ± 3% in the 15 mg/kg·d group and 3...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Yang Z, Tian Y, Berr SS, French BA Tags: Cardiol Res Pract Source Type: research

Serum VEGF: Diagnostic Value of Acute Coronary Syndrome from Stable Angina Pectoris and Prognostic Value of Coronary Artery Disease.
Abstract Background: Although the level of serum vascular endothelial growth factor (VEGF) is elevated in coronary artery disease (CAD) patients, its potential role in acute coronary syndrome (ACS) or stable angina pectoris (SAP) patients remains unclear. Objectives: To evaluate diagnostic accuracy of serum VEGF in determining ACS patients from SAP and analyze the association of serum VEGF with coronary artery lesions in SAP or the GRACE score in ACS, which is involved in the poor prognosis of low serum VEGF. Methods: 248 CAD patients and 48 healthy subjects were enrolled in this study. Serum VEGF levels...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Huang A, Qi X, Cui Y, Wu Y, Zhou S, Zhang M Tags: Cardiol Res Pract Source Type: research

Plasma Choline as a Diagnostic Biomarker in Slow Coronary Flow.
This study aimed to explore the utility of plasma choline as a diagnostic biomarker for SCF. Methods: Patients with coronary artery stenosis
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Zhu YT, Zhu LP, Wang ZY, Qiu XT, Wu WZ, Liu WW, Feng YY, Xiao WK, Luo X, Li ZY, Li CC Tags: Cardiol Res Pract Source Type: research

The Impact of Statins before High-Risk CABG on Postoperative Multiple Organ Function.
Abstract Background: The purpose of this cohort study was to investigate the independent relationship between preoperative statin therapy (PST) and postoperative severe multiorgan failure, measured by the Sequential Organ Failure Assessment (SOFA) maximum greater than 11, in high-risk patients undergoing isolated coronary artery bypass grafting (CABG). Methods: The present study is a perspective, single-center, cohort analysis enrolling high-risk patients undergoing CABG from Jan 1, 2018, to Dec 31, 2018, in Beijing Anzhen hospital. Results: Among a total of 880 high-risk patients undergoing isolated CAB...
Source: Cardiology Research and Practice - May 17, 2020 Category: Cardiology Authors: Wang J, Yuan W, Zhang K, Liu N, Liu D, Zhou Y Tags: Cardiol Res Pract Source Type: research

Urine-Derived Induced Pluripotent Stem Cells in Cardiovascular Disease.
Abstract Recent studies have demonstrated that stem cells are equipped with the potential to differentiate into various types of cells, including cardiomyocytes. Meanwhile, stem cells are highly promising in curing cardiovascular diseases. However, owing to the ethical challenges posed in stem cell acquisition and the complexity and invasive nature of the method, large-scale expansions and clinical applications in the laboratory have been limited. The current generation of cardiomyocytes is available from diverse sources; urine is one of the promising sources among them. Although advanced research was established ...
Source: Cardiology Research and Practice - May 8, 2020 Category: Cardiology Authors: Huang P, Li Y, Nasser MI, Guo H, Huang H, Zhao M, Zhu P Tags: Cardiol Res Pract Source Type: research

Macrophage Activities in Myocardial Infarction and Heart Failure.
Abstract Heart diseases remain the major cause of death worldwide. Advances in pharmacological and biomedical management have resulted in an increasing proportion of patients surviving acute heart failure (HF). However, many survivors of HF in the early stages end up increasing the disease to chronic HF (CHF). HF is an established frequent complication of myocardial infarction (MI), and numerous influences including persistent myocardial ischemia, shocked myocardium, ventricular remodeling, infarct size, and mechanical impairments, as well as hibernating myocardium trigger the development of left ventricular systo...
Source: Cardiology Research and Practice - May 8, 2020 Category: Cardiology Authors: Duncan SE, Gao S, Sarhene M, Coffie JW, Linhua D, Bao X, Jing Z, Li S, Guo R, Su J, Fan G Tags: Cardiol Res Pract Source Type: research

Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women.
Conclusions. This investigation provides the first evidence for sex-based differences in EPC activity and endothelial function in overweight middle-aged individuals; these differences are associated with alterations in NO production and may partly occur through downregulation of the GTPCH I pathway. The present results provide new insights into the mechanism underlying the preserved endothelial function in overweight premenopausal women and may uncover a potential therapeutic target for endothelial repair in overweight population. PMID: 32377428 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - May 8, 2020 Category: Cardiology Authors: Wu S, He H, Liu GX, Li XP, Yao S, Su HX, Li X, Ren Z, Zeng H, Liao J Tags: Cardiol Res Pract Source Type: research

Profile of Endothelin-1, Nitric Oxide, and Prostacyclin Levels in Pulmonary Arterial Hypertension Related to Uncorrected Atrial Septal Defect: Results from a Single Center Study in Indonesia.
Abstract Methods: The study design was cross-sectional. The subjects were adult uncorrected secundum ASD with PAH. Pulmonary artery pressure was measured with right heart catheterization. Pulmonary venous blood was obtained during catheterization for measuring endothelin-1, prostacyclin, and nitric oxide. Correlation tests were performed to determine any association between biomarkers and mean pulmonary artery pressure (mPAP). The levels of biomarkers were compared based on the severity of PAH. Statistical significance was determined at p
Source: Cardiology Research and Practice - May 8, 2020 Category: Cardiology Authors: Dinarti LK, Hartopo AB, Anggrahini DW, Sadewa AH, Setianto BY, Wahab AS Tags: Cardiol Res Pract Source Type: research

Change in Atrial Fibrillation Burden over Time in Patients with Nonpermanent Atrial Fibrillation.
n D Abstract Introduction: The natural course of atrial fibrillation (AF) is not well defined. We aimed to investigate the change in AF burden over time and its associated risk factors among AF patients. Methods: Fifty-four participants with recently documented paroxysmal or persistent AF were enrolled. Main exclusion criteria were permanent AF or previous catheter ablation for AF. AF burden was calculated as time in AF divided by total recording time using yearly continuous 7-day Holter-ECG recordings. A relative change ≥10% or an absolute change>0.5% in AF burden between two yearly Holter-ECG recordin...
Source: Cardiology Research and Practice - May 8, 2020 Category: Cardiology Authors: Krisai P, Aeschbacher S, Bossard M, Herber E, Blum S, Meyre P, Burkard T, Kühne M, Osswald S, Kaufmann BA, Conen D Tags: Cardiol Res Pract Source Type: research

Functional Genetic Variant in ATG5 Gene Promoter in Acute Myocardial Infarction.
In this study, the promoter of the ATG5 gene was genetically and functionally investigated in large groups of AMI patients (n = 378) and ethnic-matched healthy controls (n = 386). The results showed that a total of 15 genetic variants including 6 single-nucleotide polymorphisms (SNPs) in the ATG5 gene promoter were found in this study population. A novel deletion variant (g.106326168_70delTCT) and an SNP [g.106325757C > G (rs190825454)] were found in one 66-year-old male patient with non-ST-segment elevated AMI, but in none of controls. In cultured HEK-293 and H9c2 cells, the de...
Source: Cardiology Research and Practice - May 8, 2020 Category: Cardiology Authors: Zhang Y, He X, Li J, Yang W, Cui Y, Pang S, Wang H, Yan B Tags: Cardiol Res Pract Source Type: research

Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement.
This study aims to investigate the clinical relationship between Neu5Ac and AF and left atrial enlargement. Methods: Forty-five patients with AF (AF group) and forty-five patients with non-AF (control group) matched for age, sex, and hospitalization date were recruited for our study. Plasma concentrations of Neu5Ac from peripheral venous blood were analyzed using enzyme-linked immunosorbent assay (ELISA). The baseline characteristics, plasma level of Neu5Ac, and echocardiographic characteristics were evaluated. Results: The plasma level of Neu5Ac was significantly higher in the AF group than in the control group ...
Source: Cardiology Research and Practice - May 1, 2020 Category: Cardiology Authors: Hu W, Xie J, Zhu T, Meng G, Wang M, Zhou Z, Guo F, Chen H, Wang Z, Wang S, Liu H, Jiang H Tags: Cardiol Res Pract Source Type: research

Translation and Validation of the Arrhythmia-Specific Questionnaire in Tachycardia and Arrhythmia (ASTA) to the Brazilian Context: An Instrument Focusing on Arrhythmia Symptoms.
Conclusion: The psychometric properties of the Brazilian version of ASTA-symptom scale evaluated in this study were satisfactory, and the scale was proved to be a valid and reliable tool to assess the symptom burden in patients with different forms of tachyarrhythmia. The ASTA-Br-symptom scale questionnaire can be an important addition to PROMs for patients with arrhythmias and could help healthcare professionals in decision-making. PMID: 32351731 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - May 1, 2020 Category: Cardiology Authors: Cannavan PMS, Cannavan FPS, Walfridsson U, Lopes MHBM Tags: Cardiol Res Pract Source Type: research

Effect of Combined Antihypertensive and Lipid-Lowering Therapies on Cognitive Function: A New Treatment Strategy?
Abstract Risk factors for cardiovascular disease such as hypertension and hyperlipidemia are associated with cognitive decline. However, there is still no clear evidence that the use of antihypertensive or lipid-lowering therapy can prevent or delay cognitive decline or development of dementia. To provide a reference for clinical treatment, we analyzed the potential mechanisms of cognitive dysfunction induced by hypertension and hyperlipidemia, the clinical research and controversy of antihypertensive and lipid-lowering therapies on cognitive function, and the clinical value of combined antihypertensive and lipid-...
Source: Cardiology Research and Practice - May 1, 2020 Category: Cardiology Authors: Kuang ZM Tags: Cardiol Res Pract Source Type: research

Cryoablation Combined with Left Atrial Appendage Closure: A Safe and Effective Procedure for Paroxysmal Atrial Fibrillation Patients.
Conclusion: Combining CBA with LAAC in a single procedure is a feasible strategy for PAF patients, with comparable short-term safety and efficacy to CBA alone. PMID: 32351733 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - May 1, 2020 Category: Cardiology Authors: Ren Z, Zhang J, Zhu M, Zhao D, Li S, Yang H, Zheng Y, Meng W, Zhang J, Xu Y Tags: Cardiol Res Pract Source Type: research

Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging.
Abstract The present study explored the clinical value of plasma microRNA-21 as a novel biomarker for early prediction of stable and unstable angina patients and its relationship with aging. A total of 255 participants, 123 patients with chronic stable angina, 82 patients with unstable angina, and 50 healthy subjects, were included in our study. Stable coronary and unstable coronary patients were confirmed following AHA/ACC clinical protocols. Total RNA was extracted from plasma by using miRNA-based TRIzol reagent. Plasma miR-21 expression levels were determined by real-time polymerase chain reaction. To evaluate ...
Source: Cardiology Research and Practice - May 1, 2020 Category: Cardiology Authors: Ali Sheikh MS Tags: Cardiol Res Pract Source Type: research

Mixture of MMP-2, MLC, and NOS Inhibitors Affects NO Metabolism and Protects Heart from Cardiac I/R Injury.
Conclusions: Synergistic effect of the multidrug therapy with the subthreshold doses allows addressing a few pathways of I/R injury simultaneously to achieve protection of cardiac function during I/R. PMID: 32322413 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - April 25, 2020 Category: Cardiology Authors: Krzywonos-Zawadzka A, Franczak A, Sawicki G, Bil-Lula I Tags: Cardiol Res Pract Source Type: research

Omentin-1 Ameliorated Free Fatty Acid-Induced Impairment in Proliferation, Migration, and Inflammatory States of HUVECs.
Conclusion: Omentin-1 could partly ameliorate FFA-induced endothelial cell injury. PMID: 32300482 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - April 18, 2020 Category: Cardiology Authors: Chen Y, Liu F, Han F, Lv L, Tang CE, Luo F Tags: Cardiol Res Pract Source Type: research

Conversion from Nonshockable to Shockable Rhythms and Out-of-Hospital Cardiac Arrest Outcomes by Initial Heart Rhythm and Rhythm Conversion Time.
Conclusions: The conversion from a nonshockable rhythm to a shockable rhythm was associated with better outcomes only when occurred early in initial nonshockable rhythm OHCA, and it has greater prognostic significance when the initial rhythm was asystole. PMID: 32300483 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - April 18, 2020 Category: Cardiology Authors: Zhang W, Luo S, Yang D, Zhang Y, Liao J, Gu L, Li W, Liu Z, Xiong Y, Idris A Tags: Cardiol Res Pract Source Type: research

Impact of Cardiac Rehabilitation on Functional Capacity and Physical Activity after Coronary Revascularization: A Scientific Review.
Conclusion: Although centre-based supervised CR programs do improve functional capacity after coronary revascularization, home-based or telerehabilitation-based CR programs are feasible, improve patient compliance in improving physical activity, and thereby increase functional capacity. Patient education improves levels of physical activity, health related quality of life, and adherence to home- and centre-based CR programs. PMID: 32274208 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - April 11, 2020 Category: Cardiology Authors: Prabhu NV, Maiya AG, Prabhu NS Tags: Cardiol Res Pract Source Type: research

Reduced Albuminuria and Potassemia Indicate Early Renal Repair Processes after Resynchronization Therapy in Cardiorenal Syndrome Type 2.
Conclusions: In patients with T2-CRS, uNGAL is a biomarker of kidney injury that correlates with the NYHA classes. A stable uNGAL value before and after CRT implantation confirms the lack of risk of contrast-induced nephropathy. Reduced albuminuria and blood potassium are biomarkers of improving T2-CRS in the early post-CRT period. PMID: 32274209 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - April 11, 2020 Category: Cardiology Authors: Gala-Błądzińska A, Romanek J, Mazur D, Stepek T, Braun M, Szafarz P, Chlebuś M, Przybylski A Tags: Cardiol Res Pract Source Type: research

Left Atrial Strain as Evaluated by Two-Dimensional Speckle Tracking Predicts Left Atrial Appendage Dysfunction in Chinese Patients with Atrial Fibrillation.
Abstract Left atrial appendage (LAA) dysfunction identified by transesophageal echocardiography (TEE) is a powerful predictor of stroke in patients with atrial fibrillation (AF). The aim of our study is to assess if there is a correlation between the left atrial (LA) functional parameter and LAA dysfunction in the AF patients. This cross-sectional study included a total of 249 Chinese AF patients who did not have cardiac valvular diseases and were undergoing cardiac ablation. TEE was performed in all the patients who were categorized into two groups according to their left atrial appendage (LAA) function. A total ...
Source: Cardiology Research and Practice - April 11, 2020 Category: Cardiology Authors: Wang Y, Li M, Zhong L, Ren S, Li H, Tang Y, Li Z, Fei H Tags: Cardiol Res Pract Source Type: research

Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and Coronary Artery Injury in Children with Kawasaki Disease.
Abstract Objective: To investigate the association between the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT ratio, AAR) and intravenous immunoglobulin (IVIG) resistance, coronary artery lesions (CAL), and coronary artery aneurysms (CAA) in children with Kawasaki disease (KD). Design: We retrospectively studied 2678 children with KD and divided them into two groups: a low-AAR group and a high-AAR group with a median AAR of 1.13 as the cut-off point. The differences in laboratory data, clinical manifestations, and coronary artery damage rates were compared between the two group...
Source: Cardiology Research and Practice - April 11, 2020 Category: Cardiology Authors: Wang J, Li J, Ren Y, Shi H, Rong X, Zhang X, Shao Y, Wu R, Chu M, Qiu H Tags: Cardiol Res Pract Source Type: research

Haemodynamic Effects of Anaemia in Patients with Acute Decompensated Heart Failure.
Abstract Anaemia is a common comorbidity in patients with heart failure (HF) and is associated with more severe symptoms and increased mortality. The aim of this study was to evaluate haemodynamic profiles of HF patients with respect to the presence of reduced left ventricular ejection fraction (LVEF) and anaemia. Methods and Results. Haemodynamic status was evaluated in 97 patients with acute decompensated HF. Impedance cardiography, echocardiography, and N-terminal probrain natriuretic peptide (NT-proBNP) results were analysed. The study group was stratified into four subgroups according to LVEF (
Source: Cardiology Research and Practice - April 11, 2020 Category: Cardiology Authors: Krzesiński P, Galas A, Gielerak G, Uziębło-Życzkowska B Tags: Cardiol Res Pract Source Type: research

Waist-to-Height Ratio (WHtR) in Predicting Coronary Artery Disease Compared to Body Mass Index and Waist Circumference in a Single Center from Saudi Arabia.
This study aims to study the efficiency of the Waist-to-Height Ratio (WHtR) for determining coronary artery disease. It compares the frequency of abnormal WHtR, as a proxy for abdominal obesity, to that of body mass index (BMI) and waist circumference (WC). It also relates the findings to other cardiometabolic risk factors in University Hospital patients. A cross-sectional study design was used, where a sample of 200 patients (142 males and 58 females) who attended the adult cardiac clinic were purposively included. BMI, WC, and WHtR were measured, where frequencies of WHtR were compared to those of BMI and WC. The finding...
Source: Cardiology Research and Practice - April 8, 2020 Category: Cardiology Authors: Alshamiri MQ, Mohd A Habbab F, Al-Qahtani SS, Alghalayini KA, Al-Qattan OM, El-Shaer F Tags: Cardiol Res Pract Source Type: research

The Role of IL-33 in Experimental Heart Transplantation.
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of proteins that are produced by a variety of cell types in multiple tissues. Under conditions of cell injury or death, IL-33 is passively released from the nucleus and acts as an "alarmin" upon binding to its specific receptor ST2, which leads to proinflammatory or anti-inflammatory effects depending on the pathological environment. To date, numerous studies have investigated the roles of IL-33 in human and murine models of diseases of the nervous system, digestive system, pulmonary system, as well as other organs and systems, including soli...
Source: Cardiology Research and Practice - April 8, 2020 Category: Cardiology Authors: Chen J, He Y, Xie Z, Wei Y, Duan L Tags: Cardiol Res Pract Source Type: research

The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload.
Abstract Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of the pathogenesis of TTS suggests that sympathetic nervous system (SNS) activation plays a central role. Specifically, stress can activate the SNS and lead to the over-release of catecholamine, which have toxic effects on myocardial tissue when present at excess...
Source: Cardiology Research and Practice - March 28, 2020 Category: Cardiology Authors: Wang X, Pei J, Hu X Tags: Cardiol Res Pract Source Type: research

Diagnostic Efficacy of Cardiac Scintigraphy with 99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation.
Conclusions: SPECT/CT-based quantitative assessment of 99mTc-Pyrophosphate accumulation in the myocardium is a highly informative noninvasive method for diagnosis of inflammatory process in the heart in patients with AF of undefined etiology. PMID: 32211203 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - March 28, 2020 Category: Cardiology Authors: Ilyushenkova J, Sazonova S, Zavadovsky K, Batalov R, Rogovskaya Y, Anfinogenova Y, Lishmanov Y Tags: Cardiol Res Pract Source Type: research

The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase.
Conclusion: MPO might provoke vascular endothelial dysfunction in hypercholesterolemic rats by reducing the NO biological activity and impairing the NO/cGMP/cGK signaling pathway. PIO might inhibit vascular MPO activity and increase NO bioavailability with the net result of reversing endothelial dysfunction. PMID: 32190383 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - March 21, 2020 Category: Cardiology Authors: Zhang D, Wang Y, Yi M, Zhang S, Wu Y Tags: Cardiol Res Pract Source Type: research

Left Ventricular End Diastolic Volume and Ejection Fraction Calculation: Correlation between Three Echocardiographic Methods.
Abstract Background: Left ventricular ejection fraction (LVEF) and end diastolic volume (EDV) are measured using Simpson's biplane (SB), 3-dimensional method (3DE), and speckle tracking (STE). Comparisons between methods in routine practice are limited. Our purpose was to compare and to determine the correlations between these three methods in clinical setting. Methods: LVEF and EDV were measured by three methods in 474 consecutive patients and compared using multiple Bland-Altman (BA) plots. The correlations (R) between methods were calculated. Results: Median (IQR) LVEF_SB, LVEF_STE, and LVEF_3DE were ...
Source: Cardiology Research and Practice - March 21, 2020 Category: Cardiology Authors: Benyounes N, Van Der Vynckt C, Tibi T, Iglesias A, Gout O, Lang S, Salomon L Tags: Cardiol Res Pract Source Type: research

The Roles of AMPK in Revascularization.
Abstract Coronary heart disease (CHD) is the most common and serious illness in the world and has been researched for many years. However, there are still no real effective ways to prevent and save patients with this disease. When patients present with myocardial infarction, the most important step is to recover ischemic prefusion, which usually is accomplished by coronary artery bypass surgery, coronary artery intervention (PCI), or coronary artery bypass grafting (CABG). These are invasive procedures, and patients with extensive lesions cannot tolerate surgery. It is, therefore, extremely urgent to search for a ...
Source: Cardiology Research and Practice - March 19, 2020 Category: Cardiology Authors: Chen MH, Fu QM Tags: Cardiol Res Pract Source Type: research

A Hypothetical Vascular Stent with Locally Enlarged Segment and the Hemodynamic Evaluation.
Abstract Among the interventional stenting methods for treating coronary bifurcation lesions, the conventional treatments still have disadvantages, which include increased intervention difficulties or inadequate supply of blood flow to side branches and may alter the physiological function of downstream organs. Thus, the optimized design of stent geometry needs to be improved based on the specific shape of branches to minimize the complications of inadequate blood flow to the downstream organs and tissues. Our research used 3D modeling and fluid dynamics simulation to design and evaluate a new stent with locally e...
Source: Cardiology Research and Practice - March 19, 2020 Category: Cardiology Authors: Niu Y, Sun A, Wang Z, Yao C, Song J Tags: Cardiol Res Pract Source Type: research

Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress.
Conclusions: The establishing of a ceRNA network can help further understand the mechanism of vein graft failure. Our data demonstrated that NEAT1 may be a core factor among the mechanical stress factors and that cyclic stress can significantly reduce expression of NEAT1, give rise to inflammation in the early stage of endothelial dysfunction, and promote EC apoptosis, which may play an essential role in vein graft failure. PMID: 32148949 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - March 11, 2020 Category: Cardiology Authors: Huang Z, Winata WA, Zhang K, Zhao Y, Li Y, Zhou N, Zhou S, Fu W, Qiao B, Li G, Shao Y, Zheng J, Dong R Tags: Cardiol Res Pract Source Type: research

Echocardiographic Predictors of All-Cause Mortality in Patients with Hypertrophic Cardiomyopathy following Pacemaker Implantation.
Abstract Objectives: To examine the association between the echocardiographic parameters measured as left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) and long-term risk of all-cause mortality in adults with hypertrophic cardiomyopathy (HCM) following pacemaker implantation. Methods: A total of 94 adult patients with HCM who underwent pacemaker implantation from November 2002 to June 2013 in our Arrhythmia Center for symptomatic bradycardia and did not receive an implantable cardiac defibrillator (ICD) or cardiac resynchronization therapy (CRT) during follow-up were retrospectivel...
Source: Cardiology Research and Practice - March 11, 2020 Category: Cardiology Authors: Zhang N, Hua W, Li X, Hu Y, Niu H, Cai C, Gu M, Chen X, Zhang S Tags: Cardiol Res Pract Source Type: research

Body Mass Index and 1-Year Unplanned Readmission in Chinese Patients with Acute Myocardial Infarction: A Retrospective Cohort Study.
Conclusion: BMI has a nonlinear relationship with 1-year unplanned readmission in patients with myocardial infarction. The 1-year unplanned readmission rate of overweight patients (BMI > 29.3 kg/m2) has increased significantly. Obesity paradox does not exist in terms of readmission of Chinese patients with myocardial infarction after PCI. PMID: 32148951 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - March 11, 2020 Category: Cardiology Authors: Sun D, Zhang Q, Li W, Wang H Tags: Cardiol Res Pract Source Type: research

Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques.
Conclusion: PVI with contemporary ablation techniques and periprocedural antithrombotic treatment induces coagulation and endothelium activation of similar magnitude with different ablation methods. PMID: 32104599 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - February 28, 2020 Category: Cardiology Authors: Hajas O, Bagoly Z, Tóth NK, Urbancsek R, Kiss A, Kovács KB, Sarkady F, Nagy A, Oláh AV, Nagy L, Clemens M, Csiba L, Csanádi Z Tags: Cardiol Res Pract Source Type: research

Risk Factors of Periprocedural Bradycardia during Primary Percutaneous Coronary Intervention in Patients with Acute ST-Elevation Myocardial Infarction.
Abstract Background: Evidence available suggests that periprocedural bradycardia negates the benefit of primary percutaneous coronary intervention (PPCI) and worsens the prognosis of patients with acute ST-elevation myocardial infarction (STEMI). Objective: To investigate the risk factors of periprocedural bradycardia during PPCI in patients with acute STEMI. Methods: We enrolled 2,536 acute STEMI patients who had PPCI from November 2007 to June 2018 in Beijing Anzhen Hospital, Capital Medical University. We divided all patients into two groups according to periprocedural bradycardia (preoperative heart ...
Source: Cardiology Research and Practice - December 13, 2019 Category: Cardiology Authors: Li Y, Lyu S Tags: Cardiol Res Pract Source Type: research

The Effect of Ivabradine on the Human Atrial Myocardial Contractility in an In Vitro Study.
Conclusions: Ivabradine did not interfere with the contractile behaviour of human atrial tissue when it was used in therapeutic dosages in vitro. However, it increased the contractility slightly, when it was used in supratherapeutic dosage. PMID: 31827920 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - December 13, 2019 Category: Cardiology Authors: Chaban R, Buschmann K, Krausgrill A, Beiras-Fernandez A, Vahl CF Tags: Cardiol Res Pract Source Type: research

Fibrinogen-to-Albumin Ratio Predicts Contrast-Induced Nephropathy in Patients after Emergency Percutaneous Coronary Intervention.
Abstract Background: The aim of the present study was to investigate the association between fibrinogen-to-albumin ratio (FAR) with contrast-induced nephropathy (CIN) in patients undergoing emergency percutaneous coronary intervention (PCI). Methods: 565 patients with emergency PCI were consecutively enrolled. The primary outcome was CIN defined as either a 25% increase in baseline serum creatinine levels or a 0.5 mg/dL (44 μmol/L) increase in absolute serum creatinine levels within 72 h after the contrast medium exposure. Logistic regression analysis was applied to analyze whether FAR...
Source: Cardiology Research and Practice - December 13, 2019 Category: Cardiology Authors: You Z, Guo T, Lin F, Lin C, Chen J, Li X, Chen Y, Lin K Tags: Cardiol Res Pract Source Type: research

Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients' Assessment.
Abstract The close connection and interaction between the cardiac and the liver functions are well-known, as cirrhotic cardiomyopathy is an important clinical entity which best describes the mutual pathogenical influence between these two organs. Due to the fact that cardiac dysfunction in patients with chronic hepatic disorders is oligosymptomatic or even asymptomatic, an early diagnosis represents a challenge for every physician. Syndecan-1-a transmembrane proteoglycan that exerts its functions mainly via its heparane sulfate chains-is a very promising biomarker, correlated not only with the degree of cardiac fi...
Source: Cardiology Research and Practice - December 10, 2019 Category: Cardiology Authors: Miftode RS, Şerban IL, Timpau AS, Miftode IL, Ion A, Buburuz AM, Costache AD, Costache II Tags: Cardiol Res Pract Source Type: research

Does Arterial Hypertension Affect Plasma Levels of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Stable Coronary Artery Disease? A Preliminary Study.
Abstract Background: Arterial hypertension (HT) is a serious and prevalent epidemiological factor in the development of coronary artery disease (CAD). Metalloproteinases (MMPs), especially MMP-2 and MMP-9, and their natural endogenous tissue inhibitors (TIMPs) are involved in the pathogenesis of HT and its complications. MMPs are also involved in the development of diabetes (DM), a risk factor for CAD. The aim of the study was to explore the influence of CAD, HT, and DM on changes in plasma levels of MMP-2 and MMP-9 and their inhibitor TIMP-4. Methods and Results: The study involved 70 patients with stable CA...
Source: Cardiology Research and Practice - November 30, 2019 Category: Cardiology Authors: Kuliczkowski W, Banaszkiewicz M, Mysiak A, Makaś G, Bil-Lula I Tags: Cardiol Res Pract Source Type: research

Left Distal Transradial Approach for Coronary Intervention: Insights from Early Clinical Experience and Future Directions.
Abstract Left distal transradial approach is a novel technique for coronary intervention. This technique is convenient for specialists to operate and welcomed for right-handed patients. The anatomical snuffbox and the first intermetacarpal are two available puncture sites on the basis of hand anatomy. In technical aspects, main differences between left distal transradial approach and conventional transradial approach are patient's special position, puncture procedure, sheath choice, and hemostasis methods. According to the preliminary data, this technique is feasible and safe and it has low rate of complications i...
Source: Cardiology Research and Practice - November 30, 2019 Category: Cardiology Authors: Feng H, Fang Z, Zhou S, Hu X Tags: Cardiol Res Pract Source Type: research

GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents.
Abstract GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1's effects on the rat coronary artery (RCA) or about the mechanisms underpinning these effects. Here, we report that GLP-1 inhibits depolarization- or thromboxane receptor agonist (U46619)-induced RCA contraction in a dosage-dependent manner. Vasorelaxation was attenuated by denuding the endothelium, L-NAME (nitric oxide synthase inhibitor), and glyburide (KATP channel blocker) but was not affected by indomethacin (cyclooxygenase inhibi...
Source: Cardiology Research and Practice - November 29, 2019 Category: Cardiology Authors: Xiong QF, Fan SH, Li XW, Niu Y, Wang J, Zhang X, Chen YF, Shi YW, Zhang LH Tags: Cardiol Res Pract Source Type: research

Appropriate Use of Transesophageal Echocardiogram for Infective Endocarditis: A Single Center Experience.
Conclusion: Transesophageal echocardiography is a valuable tool in a modern physician's arsenal for managing a variety of diseases and conditions. However, the procedure is not without associated risks and its ease of use and widespread adoption has led to frequent questionable appropriateness of use of the test. Only 56% of the TEEs performed in our analysis met appropriate use. More awareness and education is needed for the appropriate use criteria for transesophageal echocardiography as outlined by the ASE to help reduce patient exposure to procedure related complications and to decrease medical costs on unnecessary pro...
Source: Cardiology Research and Practice - November 29, 2019 Category: Cardiology Authors: Singh R, Naidu M, Bader Y, Freeman D, Zughaib M Tags: Cardiol Res Pract Source Type: research