Mechanism of thromboxane receptor-induced vasoconstriction in human saphenous vein
Publication date: Available online 25 July 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Gulsev Ozen, Khadija Aljesri, Zeynep Celik, Gulsum Turkyılmaz, Saygın Turkyılmaz, Onder Teskin, Xavier Norel, Gokce Topal (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 26, 2020 Category: Lipidology Source Type: research

Effect of acyl and alkyl analogs of platelet-activating factor on inflammatory signaling
Publication date: Available online 22 July 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Gopal Kedihithlu Marathe, Vyala Hanumanthareddy Chaithra, Liang-Yin Ke, Chu-Huang Chen (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 24, 2020 Category: Lipidology Source Type: research

Accurate identification of breast cancer margins in microenvironments of ex-vivo basal and luminal breast cancer tissues using Raman spectroscopy
Publication date: Available online 22 July 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): S. Kiran Koya, Michelle Brusatori, Sally Yurgelevic, Changhe Huang, Cameron W. Werner, Rachel E. Kast, John Shanley, Mark Sherman, Kenneth V. Honn, Krishna Rao Maddipati, Gregory W. Auner (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 24, 2020 Category: Lipidology Source Type: research

Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergic diseases
Publication date: Available online 23 July 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Jun Miyata, Koichi Fukunaga, Yusuke Kawashima, Osamu Ohara, Akihiko Kawana, Koichiro Asano, Makoto Arita (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 24, 2020 Category: Lipidology Source Type: research

Cycloarta-23-ene-3beta,25-diol a pentacyclic steroid from Euphorbia spinidens, as COX inhibitor with molecular docking, and in vivo study of its analgesic and anti-inflammatory activities in male Swiss mice and Wistar rats
Publication date: Available online 4 July 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Valiollah Hajhashemi, Mustafa Ghanadian, Abbasali Palizaban, Karim Mahnam, Hamed Eshaghi, Bahareh Gheisari, Hojjat Sadeghi-Aliabadi (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 5, 2020 Category: Lipidology Source Type: research

Distinct contributions of two choline-producing enzymatic activities to lysophosphatidic acid production in human amniotic fluid from pregnant women in the second trimester and after parturition
Publication date: Available online 22 June 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Midori Fukui, Toshihiko Tsutsumi, Aimi Yamamoto-Mikami, Katsuya Morito, NaokoTakahashi, Tamotsu Tanaka, Takeshi Iwasa, Akira Kuwahara, Minoru Irahara, Akira Tokumura (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - June 23, 2020 Category: Lipidology Source Type: research

Dual Soluble Epoxide Hydrolase Inhibitor/PPAR-γ Agonist Attenuates Renal Fibrosis
Publication date: Available online 20 June 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Anna Stavniichuk, Md. Abdul Hye Khan, Michael M. Yeboah, Marla A. Chesnik, Wojciech K. Jankiewicz, Markus Hartmann, René Blöcher, Theresa Kircher, Olexiy Savchuk, Ewgenij Proschak, John D. Imig (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - June 21, 2020 Category: Lipidology Source Type: research

Development of a highly sensitive liquid chromatography–mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man
Publication date: October 2020Source: Prostaglandins & Other Lipid Mediators, Volume 150Author(s): Lars Löfgren, Gun-Britt Forsberg, Pia Davidsson, Susanna Eketjäll, Carl Whatling (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - June 9, 2020 Category: Lipidology Source Type: research

Editorial Board
Publication date: August 2020Source: Prostaglandins & Other Lipid Mediators, Volume 149Author(s): (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - June 9, 2020 Category: Lipidology Source Type: research

The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression
Publication date: Available online 25 May 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Chunmei Geng, Guoxian Hao, Qiao Yi, Yujin Guo, Dan Chen, Wenxiu Han, Jun Zhang, Mengqi Yang, Pei Jiang (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - May 26, 2020 Category: Lipidology Source Type: research

Development of a highly sensitive liquid chromatography - mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man
Publication date: Available online 23 May 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Lars Löfgren, Gun-Britt Forsberg, Pia Davidsson, Susanna Eketjäll, Carl Whatling (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - May 24, 2020 Category: Lipidology Source Type: research

Gamma-linolenic acid alters migration, proliferation and apoptosis in human and rat glioblastoma cells
Publication date: Available online 18 May 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Juliano Andreoli Miyake, Renata Nascimento Gomes, Alison Colquhoun (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - May 19, 2020 Category: Lipidology Source Type: research

Therapeutic approaches to diabetic cardiomyopathy: Targeting the antioxidant pathway
Publication date: Available online 13 May 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Michael Arad, Maayan Waldman, Nader G. Abraham, Edith Hochhauser (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - May 14, 2020 Category: Lipidology Source Type: research

Aloe emodin shows high affinity to active site and low affinity to two other sites to result consummately reduced inhibition of lipoxygenase
Publication date: Available online 4 May 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): C.S. Sharanya, K.G. Arun, A. Sabu, M. Haridas (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - May 5, 2020 Category: Lipidology Source Type: research

A novel interaction between soluble epoxide hydrolase and the AT1 receptor in retinal microvascular damage
Publication date: Available online 30 April 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Mong-Heng Wang, Ahmed S. Ibrahim, George Hsiao, Amany Tawfik, Mohamed Al-Shabrawey (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - May 1, 2020 Category: Lipidology Source Type: research

Evaluation of the pharmacokinetics of 2-carba-cyclic phosphatidic acid by liquid chromatography-triple quadrupole mass spectrometry
Publication date: Available online 13 April 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Yoshibumi Shimizu, Keiko Fukasawa, Shinji Yamamoto, Yuki Shibaike, Ryoko Tsukahara, Masaki Ishikawa, Kensuke Iwasa, Keisuke Yoshikawa, Mari Gotoh, Kimiko Murakami-Murofushi (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - April 15, 2020 Category: Lipidology Source Type: research

Role of epoxyeicosatrienoic acids in the lung
Publication date: Available online 12 April 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Hugo F. Olivares-Rubio, J.J. Espinosa-Aguirre (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - April 13, 2020 Category: Lipidology Source Type: research

Relevance of seminal F2-dihomo-IsoPs, F2-IsoPs and F4-NeuroPs in idiopathic infertility and varicocele
Publication date: Available online 6 April 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Mariangela Longini, Elena Moretti, Cinzia Signorini, Daria Noto, Francesca Iacoponi, Giulia Collodel (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - April 7, 2020 Category: Lipidology Source Type: research

Mechanisms underlying the protective effect of leukotriene receptor antagonist montelukast against doxorubicin induced testicular injury in rats
Publication date: Available online 12 March 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Mervat Z. Mohamed, Nagwa M. Zenhom (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - March 13, 2020 Category: Lipidology Source Type: research

Sphingosine 1-phosphate signaling in ischemia and reperfusion injury
Publication date: Available online 12 March 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Zohaib Raza, Uzma Saleem, Zainab Naureen (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - March 12, 2020 Category: Lipidology Source Type: research

Lipocalin-type Prostaglandin D2 Synthase Deletion Induces Dyslipidemia and Non-alcoholic Fatty Liver Disease
Publication date: Available online 4 March 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Sunil Kumar, Ankita Srivastava, Thomas Palaia, Christopher Hall, Jenny Lee, Matthew Stevenson, Chaohui Lisa Zhao, Louis Ragolia (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - March 6, 2020 Category: Lipidology Source Type: research

Effects of antiemetic doses of dexamethasone on plasma mediators of inflammation resolution and pain after surgery in women
Publication date: Available online 19 February 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Anne Barden, Michael Phillips, Emilie Mas, Lisa M. Hill, Ian Mowat, P.S. Loh, Tomas Corcoran, Trevor A. Mori (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - February 20, 2020 Category: Lipidology Source Type: research

Editorial—Special issue of the 7th European workshop on lipid mediators
Publication date: June 2020Source: Prostaglandins & Other Lipid Mediators, Volume 148Author(s): Mireille Alhouayek, Gerard Bannenberg, Giulio G. Muccioli, Xavier Norel, Chengcan Yao, Nils Helge Schebb (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - February 20, 2020 Category: Lipidology Source Type: research

Lipoxin A4 reduces house dust mite and TNFα-induced hyperreactivity in the mouse trachea
Publication date: Available online 15 February 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Willem Abma, Malin Noreby, Craig E. Wheelock, Sven-Erik Dahlén, Mikael Adner, Jesper SäfholmAbstractLipoxin A4 (LXA4) is considered a specialised pro-resolving mediator that decreases inflammation: however, pro-inflammatory effects have been described in the airways. Here, we investigated whether LXA4 could influence airway hyperreactivity induced in mouse trachea by house dust mite extract (HDM) or TNFα. Intranasal instillation of HDM caused a serotonin (5-HT) mediated airway hyperreactivity ex...
Source: Prostaglandins and Other Lipid Mediators - February 16, 2020 Category: Lipidology Source Type: research

Synthesis and function of fatty acids and oxylipins, with a focus on Caenorhabditis elegans
Publication date: Available online 4 February 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): N.Z. Mokoena, O.M. Sebolai, J. Albertyn, C.H. PohlAbstractPolyunsaturated fatty acids (PUFAs) exhibit a diverse range of important biological functions in most biological systems. These PUFAs can be oxygenated via enzymatic or free radical-mediated reactions to form bioactive oxygenated lipid mediators termed oxylipins. Eicosanoids are broad class of oxylipins that are transient and locally synthesized signalling molecules, including prostaglandins, leukotrienes, lipoxins and thromboxanes, which mediate various ph...
Source: Prostaglandins and Other Lipid Mediators - February 6, 2020 Category: Lipidology Source Type: research

20-hydroxyeicosatetraenoic acid alters endothelial cell barrier integrity independent of oxidative stress and cell death
Publication date: Available online 4 February 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Vengai Mavangira, Jennifer Brown, Jeffery C. Gandy, Lorraine M. SordilloAbstractUnregulated inflammation during bovine mastitis is characterized by severe mammary tissue damage with systemic involvement. Vascular dysfunction underlies tissue pathology because of concurrent oxidative stress mediated by several inflammatory mediators. We recently demonstrated increased production of 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450-derived (CYP) oxylipid that correlated with oxidative stress during severe...
Source: Prostaglandins and Other Lipid Mediators - February 6, 2020 Category: Lipidology Source Type: research

CYP-Derived Eicosanoids in Inflammatory Diseases
Publication date: Available online 30 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Bahar Tunctan (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - January 31, 2020 Category: Lipidology Source Type: research

Sphingosine kinase 1 is required for myristate-induced TNFα expression in intestinal epithelial cells
Publication date: Available online 29 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Songhwa Choi, Justin M. Snider, Chris P. Cariello, Johana M. Lambert, Andrea K. Anderson, L. Ashley Cowart, Ashley J. SniderAbstractSaturated fatty acids (SFA) have been known to trigger inflammatory signaling in metabolic tissues; however, the effects of specific SFAs in the intestinal epithelium have not been well studied. Several previous studies have implicated disruption in sphingolipid metabolism by oversupply of SFAs could affect the inflammatory process. Also, our previous studies have implicated sphingosi...
Source: Prostaglandins and Other Lipid Mediators - January 29, 2020 Category: Lipidology Source Type: research

The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2
Publication date: Available online 28 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Shailendra Anoopkumar-Dukie, Tom Conere, Aileen Houston, Liam King, David Christie, Catherine McDermott, Ashley AllshireAbstractIt is widely accepted that the hypoxic nature of solid tumors contribute to their resistance to radiation therapy. There is increasing evidence that cyclooxygenase-2 (COX-2) contributes to increased resistance of tumors to radiation therapy. Several studies demonstrate that combination of COX-2 selective inhibitors with radiation therapy selectively enhances radioresponsiveness of tumor c...
Source: Prostaglandins and Other Lipid Mediators - January 28, 2020 Category: Lipidology Source Type: research

Special Issue of the 7th European Workshop on Lipid Mediators
Publication date: Available online 17 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Mireille Al Houayek, Gerard Bannenberg, Giulio G. Muccioli, Xavier Norel, Chengcan Yao, Nils Helge Schebb (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - January 19, 2020 Category: Lipidology Source Type: research

Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells
Publication date: Available online 14 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Liqiang Han, Kun Pang, Xiu ling Li, Juan J Loor, Guo yu Yang, Tengyun GaoAbstractThe accumulation of lipid droplets (LDs) in the cytoplasm plays an important role in energy balance, membrane synthesis and cell signal transduction. The aim of this study was to investigate the profile of phospholipids after SCAP-induced LD formation in bovine mammary epithelial cells (BMECs). A shRNA-SCAP vector and a SCAP/SREBP vector were used to knock down and overexpress the SCAP gene in BMECs prior to evaluating the effects on ...
Source: Prostaglandins and Other Lipid Mediators - January 15, 2020 Category: Lipidology Source Type: research

An overview of lipoxygenase inhibitors with approach of in vivo studies
Publication date: Available online 14 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Ala Orafaie, Mina Mousavian, Hossein Orafai, Hamid SadeghianAbstractLipoxygenases (LOXs) are enzymes which found in organisms that catalyze the peroxidation of polyunsaturated fatty acids (Arachidonic acid, Linoleic acid). The key role of the mentioned enzymes and their metabolites in formation of sensitivities, inflammations, many of cancers (prostate, breast, etc), obesity, diabetes and atherosclerosis had been demonstrated. This review aimed to focus on research findings introducing proved LOXs (5/12/15-LOX) in...
Source: Prostaglandins and Other Lipid Mediators - January 15, 2020 Category: Lipidology Source Type: research

Gonadal function protects against organ culture-induced vascular damage. Involvement of prostanoids
Publication date: Available online 13 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Diva M. Villalpando, Juan Gómez Rivas, Daniel Flynn, Fermín R. de Bethencourt, Mercedes FerrerAbstractAndrogen deprivation induces vascular dysfunction in which altered release and action of prostanoids has been extensively studied. On the other hand, the vascular organ-culture system has been reported as a valid model for phenotypic changes that occur in several cardiovascular pathologies. Since there are no studies analyzing the impact of androgenic loss on vascular vulnerability during induced vas...
Source: Prostaglandins and Other Lipid Mediators - January 14, 2020 Category: Lipidology Source Type: research

Prostaglandin E2 as a Therapeutic Target in Bladder Cancer: From Basic Science to Clinical Trials
Publication date: Available online 10 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Benjamin L. Woolbright, Carol C. Pilbeam, John A. TaylorAbstractBladder cancer (BCa) is a common solid tumor marked by high rates of recurrence, especially in non-muscle invasive disease. Prostaglandin E2 (PGE2) is a ubiquitously present lipid mediator responsible for numerous physiological actions. Inhibition of cyclooxygenase (COX) enzymes by the non-steroidal anti-inflammatory (NSAID) class of drugs results in reduced PGE2 levels. NSAID usage has been associated with reductions in cancers such as BCa. Clinical ...
Source: Prostaglandins and Other Lipid Mediators - January 11, 2020 Category: Lipidology Source Type: research

Seasonal expressions of prostaglandin E synthases and receptors in the prostate of the wild ground squirrel (Spermophilus dauricus)
In this study, we investigated the seasonal immunolocalizations and expressions of COX-1, COX-2 and PTGES, as well as PGE2 receptors (PTGERs) subtypes 1-4 (EP1, EP2, EP3, EP4) in the prostate of the wild ground squirrel. Histological examination observed enlarged prostatic lumens in the breeding season and significantly shrunken lumens in the nonbreeding season. COX-1, COX-2, PTGES and PTGERs were mainly localized in epithelial and stromal cells in the breeding and nonbreeding seasons. The mRNA expression levels of Cox-1, Cox-2, Ptges, Ptger2 (encoding EP2) and Ptger4 (encoding EP4) were higher in the prostate of the breed...
Source: Prostaglandins and Other Lipid Mediators - January 10, 2020 Category: Lipidology Source Type: research

Assessment of Soluble Epoxide Hydrolase Activity In Vivo: A Metabolomic Approach
Publication date: Available online 10 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Darko Stefanovski, Pei-an Betty Shih, Bruce D. Hammock, Richard M. Watanabe, Jang H. YounAbstractSoluble epoxide hydrolase (sEH) converts several FFA epoxides to corresponding diols. As many as 15 FFA epoxide-diol ratios are measured to infer sEH activity from their ratios. Using previous data, we assessed if individual epoxide-diol ratios all behave similarly to reflect changes in sEH activity, and whether analyzing these ratios together increases the power to detect changes in in-vivo sEH activity. We demonstrat...
Source: Prostaglandins and Other Lipid Mediators - January 10, 2020 Category: Lipidology Source Type: research

The Chemistry, Biology and Pharmacology of the Cyclopentenone Prostaglandins
Publication date: Available online 10 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Sumner H. BursteinAbstractThe cyclopentenone prostaglandins (CyPGs) are a small group compounds that are a subset of the eicosanoid superfamily, which are metabolites of arachidonic acid as well as other polyunsaturated fatty acids. The CyPGs are defined by a structural feature, namely, a five-membered carbocyclic ring containing an alfa-beta unsaturated keto group. The two most studied members are PGA2 and 15d-PGJ2 (15-deoxy-Δ12,14-prostaglandin J2); other less studied members are PGA1, Δ12-PGJ2, and ...
Source: Prostaglandins and Other Lipid Mediators - January 10, 2020 Category: Lipidology Source Type: research

Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metabolic syndrome
Publication date: Available online 31 December 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Laila R.B. dos Santos, Ingrid FlemingAbstractOver the last decade, cases of metabolic syndrome and type II diabetes have increased exponentially. Exercise and ω-3 polyunsaturated fatty acid (PUFA)-enriched diets are usually prescribed but no therapy is effectively able to restore the impaired glucose metabolism, hypertension, and atherogenic dyslipidemia encountered by diabetic patients. PUFAs are metabolized by different enzymes into bioactive metabolites with anti- or pro-inflammatory activity. One import...
Source: Prostaglandins and Other Lipid Mediators - January 1, 2020 Category: Lipidology Source Type: research

Cd36 gene expression in adipose and hepatic tissue mediates the lipids accumulation in liver of obese rats with sucrose-induced hepatic steatosis
Publication date: Available online 12 December 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Rodolfo Quintana Castro, Isaac Aguirre Maldonado, Ida Soto Rodríguez, Rosa A. Deschamps Lago, Peter Grube Pagola, Yolanda K. Urbina de Larrea, Victoria E. Juárez Rivera, Luis E. Ramos Manuel, Alfonso Alexander AguileraAbstractObesity is considered a global epidemic and is mainly associated with the development of diabetes, cardiovascular diseases and Non-Alcoholic Fatty Liver (NAFLD). The pathogenesis between obesity and hepatic steatosis is partially known, but could involve differentiated or tissu...
Source: Prostaglandins and Other Lipid Mediators - December 13, 2019 Category: Lipidology Source Type: research

Urinary Prostaglandin E2 is a biomarker of early adaptive hyperfiltration in solitary functioning kidney
ConclusionIncreased urinary PGE2 from elevated SNGFR and consequently increased FFSS during early stage of CKD precedes overt microalbuminuria and is a biomarker for early hyperfiltration-induced injury in individuals with SFK. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - December 13, 2019 Category: Lipidology Source Type: research

CYP-derived eicosanoids: Implications for rheumatoid arthritis
Publication date: Available online 13 December 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Malvina Hoxha, Bruno ZappacostaAbstractToday the role of cytochrome P450 metabolites in inflammatory rheumatic disease, such as rheumatoid arthritis (RA) is still poorly understood. In this review we survey the current knowledge on cytochrome P450 metabolites in rheumatoid arthritis. The balance between CYP epoxygenase- and CYP ω- hydroxylase is correlated to the regulation of NF-κB. In RA patients synovial fluid there are higher levels of IL-6, which suppresses activities of CYP enzymes, such as CYP3...
Source: Prostaglandins and Other Lipid Mediators - December 13, 2019 Category: Lipidology Source Type: research

Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model
Publication date: Available online 10 December 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Giorgio Mottola, Evan Werlin, Bian Wu, Mian Chen, Anuran Chatterjee, Melinda Schaller, Michael S. ConteAbstractInflammation ensuing from vascular injury promotes intimal hyperplasia (IH) and restenosis. Resolvin D1 (RvD1) is a lipid mediator that attenuates IH in vivo when delivered locally to the vessel wall in animal models. We tested the hypothesis that peri-procedural oral administration of RvD1 could blunt the local inflammatory response to angioplasty, and attenuate downstream IH. Carotid angioplasty was pe...
Source: Prostaglandins and Other Lipid Mediators - December 11, 2019 Category: Lipidology Source Type: research

Rubusoside-assisted solubilization of poorly soluble C6-Ceramide for a pilot pharmacokinetic study
In this study we explored the use of a natural compound rubusoside (RUB) as a solubilizer to enhance the solubility of a fluorescence-labeled C6-Ceramide (NBD C6-Ceramide) and to characterize its pharmacokinetics and tissue distribution in an animal model. RUB significantly enhanced the solubility of NBD C6-Ceramide by forming nanomicelles, and efficiently delivered NBD C6-Ceramide in rats by oral and intravenous administration. RUB loaded 1.96% of NBD C6-Ceramide in the nanomicelles and solubilized it to a concentration of 3.6 mg/mL in water. NBD C6-Ceramide in nanomicelles remained stable in aqueous solutions, all...
Source: Prostaglandins and Other Lipid Mediators - December 11, 2019 Category: Lipidology Source Type: research

Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
Publication date: April 2020Source: Prostaglandins & Other Lipid Mediators, Volume 147Author(s): Jogen Atone, Karen Wagner, Kenji Hashimoto, Bruce D. HammockAbstractCytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibitio...
Source: Prostaglandins and Other Lipid Mediators - December 6, 2019 Category: Lipidology Source Type: research

Targeting esterified oxylipins by LC–MS - Effect of sample preparation on oxylipin pattern
Publication date: February 2020Source: Prostaglandins & Other Lipid Mediators, Volume 146Author(s): Annika I. Ostermann, Elisabeth Koch, Katharina M. Rund, Laura Kutzner, Malwina Mainka, Nils Helge SchebbAbstractA major part of oxygenated metabolites of polyunsaturated fatty acids – i.e. eicosanoids and other oxylipins – in biological samples is found in the esterified form. Yet, their biological role is only poorly understood. For quantification of esterified oxylipins in biological samples current protocols mostly apply alkaline hydrolysis with or without prior lipid extraction to release oxylipins into t...
Source: Prostaglandins and Other Lipid Mediators - November 30, 2019 Category: Lipidology Source Type: research

Parasitic load determination by differential expressions of 5-lipoxygenase and PGE2 synthases in visceral leishmaniasis
In this study, we intend to explore linkage between organ specific immune response and eicosanoids. We suggest that eicosanoids (early immune modulators) and their organ specific expressions, possibly tune the outcome of mφ differently at different sites. We have observed that liver showed better containment of parasitic load than spleen, where we have found higher expression of 5-lipoxygenase (5-LO) enzyme along with IL-12 and iNOS. However, in spleen, enzymes of the PGE2 pathway i.e. PGE2 synthases (cytosolic and microsomal) along with IL-10 were predominantly higher. To further corroborate our findings, in vitro ass...
Source: Prostaglandins and Other Lipid Mediators - November 21, 2019 Category: Lipidology Source Type: research

Cytochrome P450-Derived Eicosanoids and Inflammation in Liver Diseases
Publication date: Available online 14 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Sherif M. Shoieb, Mahmoud A. El-Ghiaty, Mohammed A. Alqahtani, Ayman O.S. El-KadiAbstractHepatic inflammation is a key pathologic mediator in a wide array of acute and chronic liver diseases. Hepatitis is a crucial driver of liver tissue damage provoking the progression to severe fibrosis, cirrhosis and hepatocellular carcinoma, irrespective of the etiologic cause. Inflammatory liver diseases are collectively considered one of the most critical public health risks. Cytochrome P450 (CYP) enzymes are superfamily of...
Source: Prostaglandins and Other Lipid Mediators - November 14, 2019 Category: Lipidology Source Type: research

Role of sphingolipids in the pathogenesis of intrahepatic cholestasis
ConclusionIt is known that sphingolipids serve as modulators of liver regeneration. We assume these substances could be potential markers for detecting early onsets of intrahepatic cholestasis of pregnancy. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - November 14, 2019 Category: Lipidology Source Type: research

Parasitic load determination by differential expression of 5-Lipoxygenase and PGE2 Synthases in Visceral Leishmaniasis
In this study, we intend to explore linkage between organ specific immune response and eicosanoids. We suggest that eicosanoids (early immune modulators) and their organ specific expressions, possibly tune the outcome of mφ differently at different sites. We have observed that liver showed better containment of parasitic load than spleen, where we have found higher expression of 5-lipoxygenase (5-LO) enzyme along with IL-12 and iNOS. However, in spleen, enzymes of the PGE2 pathway (PGE2 cytosolic and PGE2 microsomal) along with IL-10 were predominantly higher. To further corroborate our findings, in vitro assays were c...
Source: Prostaglandins and Other Lipid Mediators - November 12, 2019 Category: Lipidology Source Type: research

A journey of celecoxib from pain to cancer
Publication date: Available online 11 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Pratiksha Saxena, Pramod K. Sharma, Priyank PurohitAbstractThe most enthralling and versatile class of drugs called the Non-steroidal anti-inflammatory (NSAIDs) showed its therapeutic utility in inflammation, beginning from the era of classic drug ‘Aspirin’. NSAIDs and their well-established action based on inhibiting the COX-1 and COX-2 enzyme leads to blockage of prostaglandin pathway. They further categorized into first generation (non-selective inhibitor) and second generation (selective COX-2 inh...
Source: Prostaglandins and Other Lipid Mediators - November 12, 2019 Category: Lipidology Source Type: research