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Condition: Liver Disease

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Total 328 results found since Jan 2013.

Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis via the Liver HTR2A/PPAR γ2 Pathway
The precipitous increase in occurrence of non-alcoholic steatohepatitis (NASH) is a serious threat to public health worldwide. The pathogenesis of NASH has not yet been thoroughly studied. We aimed to elucidate the interplay between serotonin (5-hydroxytryptamine, 5-HT) and NASH. The serum 5-HT levels in patients with non-alcoholic fatty liver disease (NAFLD) and a rat fed with high fat-sucrose diet (HFSD) were evaluated using liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF MS)/MS. The peripheral Tph1 inhibitor, LP533401, and a tryptophan (TRP)-free diet were administered to rats with NASH...
Source: Frontiers in Pharmacology - May 13, 2020 Category: Drugs & Pharmacology Source Type: research

Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease
Cell Death & Disease, Published online: 11 May 2020; doi:10.1038/s41419-020-2571-4Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease
Source: Cell death and disease - May 10, 2020 Category: Internal Medicine Authors: Marius Maximilian Woitok Miguel Eugenio Zoubek Dennis Doleschel Matthias Bartneck Mohamed Ramadan Mohamed Fabian Kie ßling Wiltrud Lederle Christian Trautwein Francisco Javier Cubero Source Type: research

Tumor necrosis factor-inducible gene 6 interacts with CD44, which is involved in fate-change of hepatic stellate cells.
Abstract Tumor necrosis factor-inducible gene 6 protein (TSG-6) is a cytokine secreted by mesenchymal stem cells (MSCs) and regulates MSC stemness. We previously reported that TSG-6 changes primary human hepatic stellate cells (pHSCs) into stem-like cells by activating yes-associated protein-1 (YAP-1). However, the molecular mechanism behind the reprogramming action of TSG-6 in pHSCs remains unknown. Cluster of differentiation 44 (CD44) is a transmembrane protein that has multiple functions depending on the ligand it is binding, and it is involved in various signaling pathways, including the Wnt/β-catenin pathway...
Source: BMB Reports - April 21, 2020 Category: Biochemistry Authors: Wang S, Kim J, Lee C, Jung Y Tags: BMB Rep Source Type: research

Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway.
This study aim was to investigate effects of HN on lipid accumulation in the hepatocytes and insulin signaling, and explore the underlying mechanisms. Protein expression levels were analyzed by Western blotting. Hepatic lipid accumulation was confirmed by Oil red-O staining. We found that HN-treatment ameliorated palmitate-induced lipid accumulation, expression of lipogenesis-associated genes (processed SREBP1, FAS, and SCD1), cell death, and caspase 3 activity in hepatocytes in a dose-dependent manner. Additionally, HN attenuated palmitate-induced impairment of insulin signaling. HN enhanced AMPK phosphorylation, whereas ...
Source: Biochemical and Biophysical Research communications - March 30, 2020 Category: Biochemistry Authors: Kwon C, Sun JL, Jeong JH, Jung TW Tags: Biochem Biophys Res Commun Source Type: research

Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.
Abstract Parasympathetic nervous system dysfunction is common in patients with liver disease. We have previously shown that muscarinic acetylcholine receptors (mAchRs) play an important role in the regulation of hepatic fibrosis and that the receptor agonists and antagonists affect hepatocyte proliferation. However, little is known about the impact of the different mAchR subtypes and associated signaling pathways on liver injury. Here, we treated the human liver cell line HL7702 with 10 mmol/L carbon tetrachloride (CCL4) to induce hepatocyte damage. We found that CCL4 treatment increased the protein levels of gr...
Source: Toxicology and Applied Pharmacology - March 27, 2020 Category: Toxicology Authors: Luo L, Zhang G, Mao L, Wang P, Xi C, Shi G, Leavenworth JW Tags: Toxicol Appl Pharmacol Source Type: research

Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver.
Abstract Farnesoid X receptor (FXR) is a metabolic nuclear receptor, which protects liver from many endogenous and exogenous injuries. Metallothioneins (MTs) belong to a low-molecular-weight protein family involved in metal homeostasis and the regulation of hepatic oxidative stress. In the present study, we aimed to investigate the effect of FXR on hepatic MT1 expression and the underlying mechanism. C57BL/6 mice or primary cultured mouse hepatocytes were treated with the synthetic FXR ligand GW4064 or natural ligand CDCA. RNA-Sequencing (RNA-seq) analysis was performed to identify gene expression profile in the l...
Source: Experimental Cell Research - March 3, 2020 Category: Cytology Authors: Wang B, Zhang H, Luan Z, Xu H, Wei Y, Zhao X, Xing M, Huo X, Zhang J, Su W, Guan Y, Zhang X Tags: Exp Cell Res Source Type: research

Purple sweet potato color protects against hepatocyte apoptosis through Sirt1 activation in high-fat-diet-treated mice.
Conclusion: PSPC protected against HFD-induced hepatic apoptosis by promoting Sirt1- dependent inhibition of p53-apoptotic pathway and facilitation of Akt survival pathway. This study indicates that PSPC is a candidate for nutritional intervention of NAFLD. PMID: 32110174 [PubMed - as supplied by publisher]
Source: Food and Nutrition Research - February 29, 2020 Category: Nutrition Authors: Su W, Zhang C, Chen F, Sui J, Lu J, Wang Q, Shan Q, Zheng G, Lu J, Sun C, Fan S, Wu D, Zhang Z, Zheng Y Tags: Food Nutr Res Source Type: research

Purine signaling regulating HSCs inflammatory cytokines secretion, activation, and proliferation plays a critical role in alcoholic liver disease.
Abstract Purine signaling pathway plays an important role in inflammation and tissue damage. To investigate the role of purine signaling pathway in acute alcoholic liver injury and chronic alcoholic liver fibrosis, we replicated two animal models and two cellular models. We found that body weights, liver indexes, serum biochemical parameters, serum fibrosis indexes, and pathological and immunohistochemical results had significant changes in two treatment groups compared with two control groups. In addition, gene expressions of purine receptors, inflammatory cytokines, fibrogenic cytokines, and inflammasomes increa...
Source: Molecular and Cellular Biochemistry - January 26, 2020 Category: Biochemistry Authors: Shan L, Jiang T, Ci L, Liu Z, Lv X, Li J Tags: Mol Cell Biochem Source Type: research

Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes
ConclusionsOur data reveals that exendin-4 stimulates hepatic ABCA1 expression and reduces lipid accumulation by the CaMKK/CaMKIV/PREB pathway, suggesting that ABCA1 and PREB might be the therapeutic targets in fatty liver disease.Graphical abstract
Source: Molecular Metabolism - January 7, 2020 Category: Endocrinology Source Type: research

Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor
ConclusionOur findings demonstrate that picroside II exerts protective effect on ANIT-induced cholestasis possibly through FXR activation that regulates the transporters and enzymes involved in bile acid homeostasis. Picroside II might be an effective approach for the prevention and treatment of cholestatic liver diseases.Graphical abstract
Source: Phytomedicine - December 18, 2019 Category: Drugs & Pharmacology Source Type: research

PNPLA3 I148M mediates the regulatory effect of NF-kB on inflammation in PA-treated HepG2 cells.
This study aimed to elucidate whether PNPLA3 I148M is involved in NF-kB-related inflammation regulation in NAFLD. HepG2 cells homozygous for the PNPLA3 I148M mutation were used. The human PNPLA3 promoter sequence was screened for NF-kB binding sites using the MATCH and PATCH tools. NF-kB-mediated transcriptional regulation of the PNPLA3 gene was assessed by luciferase reporter assay, EMSA and ChIP-qPCR. Wild-type (I148I) and mutant (M148M) PNPLA3 were overexpressed using stable lentivirus-mediated transfection. The pCMV vector and siRNA were transiently transfected into cells to direct NF-kB overexpression and PNPLA3 silen...
Source: J Cell Mol Med - December 2, 2019 Category: Molecular Biology Authors: Yuan S, Liu H, Yuan D, Xu J, Chen Y, Xu X, Xu F, Liang H Tags: J Cell Mol Med Source Type: research

SanWeiGanJiang San relieves liver injury via Nrf2/Bach1
Conclusions6-Gingerol is one of the blood components of SWGJS. SWGJS can regulate antioxidant enzymes, protect against liver damage in different stages, and slow the progression of liver cell damage and liver disease by increasing Nrf2 and reducing Bach1 in the nucleus, dynamically regulating Nrf2/Bach1.Graphical abstract
Source: Journal of Ethnopharmacology - December 2, 2019 Category: Drugs & Pharmacology Source Type: research

Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.
Abstract Non-alcoholic steatohepatitis (NASH) is a key step in the progression of non-alcoholic fatty liver disease (NAFLD), which causes serious health problems worldwide. The nucleotide-binding oligomerization domain, leucine-rich repeat-containing receptor-containing pyrin domain 3 (NLRP3) inflammasome and pyroptosis play crucial roles in the progression of NASH. Our team has provided clinical evidence of the effects of glucagon-like peptide-1 (GLP-1) on the improvement in liver function and histological resolution of NAFLD. Preliminary work has demonstrated that GLP-1 inhibited NLRP3 inflammasome activation in...
Source: European Journal of Pharmacology - October 4, 2019 Category: Drugs & Pharmacology Authors: Yu X, Hao M, Liu Y, Ma X, Lin W, Xu Q, Zhou H, Shao N, Kuang H Tags: Eur J Pharmacol Source Type: research

Circulating ectodysplasin A is a potential biomarker for nonalcoholic fatty liver disease
ConclusionsEDA aggravates steatosis by striking balance between lipid deposition and elimination. It was a potential biomarker of NAFLD.
Source: Clinica Chimica Acta - September 15, 2019 Category: Laboratory Medicine Source Type: research

Circulating ectodysplasin A is a potential biomarker for nonalcoholic fatty liver disease.
CONCLUSIONS: EDA aggravates steatosis by striking balance between lipid deposition and elimination. It was a potential biomarker of NAFLD. PMID: 31526774 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - September 13, 2019 Category: Chemistry Authors: Yang J, Zhou W, Zhu J, Wu Y, Xu L, Wang Y, Zhang Q, Yang Y Tags: Clin Chim Acta Source Type: research