The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections
Publication date: Available online 24 March 2020Source: Clinica Chimica ActaAuthor(s): Joris R Delanghe, Marijn M Speeckaert, Marc L De Buyzere (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 25, 2020 Category: Laboratory Medicine Source Type: research

Role of oral microbiota in atherosclerosis
Publication date: Available online 24 March 2020Source: Clinica Chimica ActaAuthor(s): Xiang-Rui Liu, Qian Xu, Jun Xiao, Yi-Ming Deng, Zhi-Han Tang, Ya-Ling Tang, Lu-Shan Liu (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 25, 2020 Category: Laboratory Medicine Source Type: research

Letter to the editor regarding: Refaat B., et al., The performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study, Clin Chim Acta 500 (2020) 69–74
Publication date: July 2020Source: Clinica Chimica Acta, Volume 506Author(s): Tarun Kumar Sharma, S.K. Vardey (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 25, 2020 Category: Laboratory Medicine Source Type: research

Identification of Clinically Relevant Variants by Whole Exome Sequencing in Chinese Patients with Sporadic Non-syndromic Type A Aortic Dissection
Publication date: Available online 21 March 2020Source: Clinica Chimica ActaAuthor(s): He Zhao, Yi Yang, Xudong Pan, Wei Li, Lizhong Sun, Jun Guo (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 22, 2020 Category: Laboratory Medicine Source Type: research

More Accurate LDL-C Calculation: Externally Validated, Guideline Endorsed
Publication date: Available online 20 March 2020Source: Clinica Chimica ActaAuthor(s): Adam J. Brownstein, Seth S. Martin (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 21, 2020 Category: Laboratory Medicine Source Type: research

The percentage of non-oxidized PTH concentration remains stable over a period of 1 year in hemodialyzed patients
Publication date: July 2020Source: Clinica Chimica Acta, Volume 506Author(s): Etienne Cavalier, Pierre Lukas, Xavier Warling, Martial Moonen, Nicole Smelten, Pierre Delanaye (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 21, 2020 Category: Laboratory Medicine Source Type: research

The performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study
Publication date: Available online 19 March 2020Source: Clinica Chimica ActaAuthor(s): Tarun Kumar Sharma, S.K. Vardey (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 20, 2020 Category: Laboratory Medicine Source Type: research

Age-specific reference intervals for anti-Müllerian hormone in Chinese boys: a population-based study
Publication date: Available online 18 March 2020Source: Clinica Chimica ActaAuthor(s): Jin Wang, Li Jiang, Xinxin Zhang, Shuo Gong, Mengyi Chen, Xijiang Hu, Hui Yao (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 19, 2020 Category: Laboratory Medicine Source Type: research

The percentage of non-oxidized PTH concentration remains stable over a period of 1 year in hemodialyzed patients
Publication date: Available online 17 March 2020Source: Clinica Chimica ActaAuthor(s): Etienne Cavalier, Pierre Lukas, Xavier Warling, Martial Moonen, Nicole Smelten, Pierre Delanaye (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 18, 2020 Category: Laboratory Medicine Source Type: research

A high performance liquid chromatography fluorescence method for the analysis of both pyridoxal-5-phosphate and thiamine pyrophosphate in whole blood
Publication date: Available online 18 March 2020Source: Clinica Chimica ActaAuthor(s): Van Long Nguyen, Mustafa Darman, Andrea Ireland, Michael Fitzpatrick (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 18, 2020 Category: Laboratory Medicine Source Type: research

COX-2 in liver fibrosis
Publication date: Available online 14 March 2020Source: Clinica Chimica ActaAuthor(s): Hu Yang, Yang Xuefeng, Wu Shandong, Xiao Jianhua (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 16, 2020 Category: Laboratory Medicine Source Type: research

Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis
Publication date: Available online 13 March 2020Source: Clinica Chimica ActaAuthor(s): Giuseppe Lippi, Mario Plebani, Brandon Michael Henry (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 15, 2020 Category: Laboratory Medicine Source Type: research

Serum D-dimer as a diagnostic index of PJI and retrospective analysis of etiology in patients with PJI
Publication date: Available online 13 March 2020Source: Clinica Chimica ActaAuthor(s): Qian Hu, Yaoyang Fu, Lingli Tang (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 15, 2020 Category: Laboratory Medicine Source Type: research

Oxidation of Parathyroid Hormone
Publication date: Available online 13 March 2020Source: Clinica Chimica ActaAuthor(s): Stan R. Ursem, Marc G. Vervloet, Renate T. de Jongh, Annemieke C. Heijboer (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 15, 2020 Category: Laboratory Medicine Source Type: research

A novel SYNE2 mutation identified by whole exome sequencing in a Korean family with Emery-Dreifuss Muscular Dystrophy
Publication date: Available online 14 March 2020Source: Clinica Chimica ActaAuthor(s): Sook Joung Lee, Sangjee Lee, Eunseok Choi, Soyoung Shin, Joonhong Park (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 15, 2020 Category: Laboratory Medicine Source Type: research

Clinical and pathological features and varied mutational spectra of pathogenic genes in 55 Chinese patients with nephronophthisis
Publication date: Available online 12 March 2020Source: Clinica Chimica ActaAuthor(s): Zhihui Yue, Hongrong Lin, Min Li, Haiyan Wang, Ting Liu, Miaoyue Hu, Huamu Chen, Huajuan Tong, Liangzhong Sun (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 13, 2020 Category: Laboratory Medicine Source Type: research

Molecular diagnosis of dystrophinopathies in Morocco and report of six novel mutations
Publication date: Available online 10 March 2020Source: Clinica Chimica ActaAuthor(s): Youssef El Kadiri, Yassir Selouani, Ilham Ratbi, Jaber Lyahyai, Abdelali Zrhidri, Maryem Sahli, Mouna Ouhenach, Imane cherkaoui Jaouad, Abdelaziz Sefiani, Aziza Sbiti (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 12, 2020 Category: Laboratory Medicine Source Type: research

Identification of novel missense mutations associated with non-syndromic syndactyly in two vietnamese trios by whole exome sequencing
Publication date: Available online 9 March 2020Source: Clinica Chimica ActaAuthor(s): Nguyen Thy Ngoc, Nguyen Thuy Duong, Do Hai Quynh, Nguyen Dang Ton, Hoang Hai Duc, Le Thi Minh Huong, Luong Thi Lan Anh, Nong Van Hai (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 10, 2020 Category: Laboratory Medicine Source Type: research

Data mining: Seasonal fluctuations and associations between thyroid stimulating hormone and lipid profiles
Publication date: Available online 9 March 2020Source: Clinica Chimica ActaAuthor(s): Danchen Wang, Songlin Yu, Yutong Zou, Honglei Li, Xinqi Cheng, Tengda Xu, Ling Qiu (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 10, 2020 Category: Laboratory Medicine Source Type: research

The association and discordance between glycated hemoglobin A1c and glycated albumin, assessed using a blend of multiple linear regression and random forest regression
Publication date: Available online 10 March 2020Source: Clinica Chimica ActaAuthor(s): Yuping Zeng, He He, Jun Zhou, Mei Zhang, Hengjian Huang, Zhenmei An (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 10, 2020 Category: Laboratory Medicine Source Type: research

Serum haptoglobin correlates positively with cholesterol and triglyceride concentrations in an obese Mongolian population
Publication date: Available online 8 March 2020Source: Clinica Chimica ActaAuthor(s): Mikiko Soejima, Lkhagvasuren Munkhtulga, Kyoji Furukawa, Sadahiko Iwamoto, Yoshiro Koda (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 9, 2020 Category: Laboratory Medicine Source Type: research

High risk screening for Gaucher disease in patients with splenomegaly and/or thrombocytopenia in China: 55 cases identified
Publication date: Available online 9 March 2020Source: Clinica Chimica ActaAuthor(s): Yonglan Huang, Xuefang Jia, Chengfang Tang, Sichi Liu, Huiying Sheng, Xiaoyuan Zhao, Chunhua Zeng, Li Liu (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 9, 2020 Category: Laboratory Medicine Source Type: research

Do Cytokines Correlate with Refractory Kawasaki Disease in Children?
Publication date: Available online 7 March 2020Source: Clinica Chimica ActaAuthor(s): Ying Wang, Su Yun Qian, Yue Yuan, Qin Wang, Lu Gao, Xi Chen, Xia Yu, Zhen Zhen (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 8, 2020 Category: Laboratory Medicine Source Type: research

Prognostic value of combined preoperative fibrinogen-albumin ratio and platelet-lymphocyte ratio score in patients with breast cancer:a prognostic nomogram study
Publication date: Available online 7 March 2020Source: Clinica Chimica ActaAuthor(s): Yufen Zheng, Chunlong Wu, Haixi Yan, Shiyong Chen (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 8, 2020 Category: Laboratory Medicine Source Type: research

FGF23 measurement in chronic kidney disease: What is it really reflecting?
Publication date: Available online 7 March 2020Source: Clinica Chimica ActaAuthor(s): Marc G Vervloet (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 8, 2020 Category: Laboratory Medicine Source Type: research

The endothelin system as target for therapeutic interventions in cardiovascular and renal disease
Publication date: Available online 6 March 2020Source: Clinica Chimica ActaAuthor(s): Eray Eroglu, Ismail Kocyigit, Bengt Lindholm (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 7, 2020 Category: Laboratory Medicine Source Type: research

Fasting glucose-to-HbA1c ratio is a good indicator of G6PD deficiency, but not thalassemia, in patients with type 2 diabetes mellitus
Publication date: Available online 7 March 2020Source: Clinica Chimica ActaAuthor(s): Ya-Sian Chang, Li-Yun Hsiao, Chien-Yu Lin, Mu-Chin Shih, Ming-Chia Hsieh, Jan-Gowth Chang (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 7, 2020 Category: Laboratory Medicine Source Type: research

Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020
Publication date: Available online 7 March 2020Source: Clinica Chimica ActaAuthor(s): Rui Liu, Huan Han, Fang Liu, Zhihua Lv, Kailang Wu, Yingle Liu, Yong Feng, Chengliang Zhu (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 7, 2020 Category: Laboratory Medicine Source Type: research

Corrigendum to “Transforming Growth Factor Beta1 being considered a novel biomarker in knee osteoarthritis” [Clin. Chim. Acta 472 (2017) 96–101]
Publication date: Available online 4 March 2020Source: Clinica Chimica ActaAuthor(s): Jianwei He, Weiwei Cao, Inayat Azeem, Qiang Zhao, Zengwu Shao (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 5, 2020 Category: Laboratory Medicine Source Type: research

Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis
Publication date: Available online 4 March 2020Source: Clinica Chimica ActaAuthor(s): Giuseppe Lippi, Mario Plebani (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 5, 2020 Category: Laboratory Medicine Source Type: research

The management of glucocorticoid deficiency: Current and future perspectives
Publication date: Available online 5 March 2020Source: Clinica Chimica ActaAuthor(s): Rosemary Dineen, Julie Martin-Grace, Christopher J Thompson, Mark Sherlock (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 5, 2020 Category: Laboratory Medicine Source Type: research

Serum omentin-1 and risk of one-year mortality in patients with ischemic stroke
Publication date: Available online 4 March 2020Source: Clinica Chimica ActaAuthor(s): Tian Xu, Yuqing Li, Yuanyuan Su, Peng Zuo, Zhiwei Gao, Kaifu Ke (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 4, 2020 Category: Laboratory Medicine Source Type: research

Systematic Review of the Roles of Interleukins in Hepatocellular Carcinoma
Publication date: Available online 4 March 2020Source: Clinica Chimica ActaAuthor(s): Hu Yang, Yang Xuefeng, Xiao Jianhua (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 4, 2020 Category: Laboratory Medicine Source Type: research

Serum miR-338-3p and miR-199b-5p are associated with the absolute neutrophil count in patients with resectable pancreatic cancer
Publication date: Available online 4 March 2020Source: Clinica Chimica ActaAuthor(s): Fleur van der Sijde, Eveline E. Vietsch, Dana A.M. Mustafa, Yunlei Li, Casper H.J. van Eijck (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 4, 2020 Category: Laboratory Medicine Source Type: research

Molecular profiling in Parkinsonian syndromes: CSF biomarkers
Publication date: Available online 4 March 2020Source: Clinica Chimica ActaAuthor(s): Federico Paolini Paoletti, Lorenzo Gaetani, Lucilla Parnetti (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 4, 2020 Category: Laboratory Medicine Source Type: research

Editorial board member, Aims and Scope, Publication Info.
Publication date: May 2020Source: Clinica Chimica Acta, Volume 504Author(s): (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - March 4, 2020 Category: Laboratory Medicine Source Type: research

Predictive value of insulin-like growth factor 1-Child-Turcotte-Pugh score for mortality in patients with decompensated cirrhosis
Publication date: Available online 28 February 2020Source: Clinica Chimica ActaAuthor(s): Yifan Yao, Donglei Yang, Yandi Huang, Minya Dong (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 29, 2020 Category: Laboratory Medicine Source Type: research

Lipoprotein(a) Particle Number Assay Without Error from Apolipoprotein(a) Size Isoforms
Publication date: Available online 28 February 2020Source: Clinica Chimica ActaAuthor(s): John H. Contois, Rae-Anne Nguyen, Andre L. Albert (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 29, 2020 Category: Laboratory Medicine Source Type: research

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in autophagy-induced hepatocellular carcinoma
Publication date: Available online 25 February 2020Source: Clinica Chimica ActaAuthor(s): Juan Zhou, Xinxin Zhang, Huifang Tang, Jia Yu, Xuyu Zu, Zhizhong Xie, Xiaoyan Yang, Juan Hu, Fang Tan, Qing Li, Xiaoyong Lei (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 26, 2020 Category: Laboratory Medicine Source Type: research

The role of fibrinogen to albumin ratio in ankylosing spondylitis: Correlation with disease activity
Publication date: Available online 26 February 2020Source: Clinica Chimica ActaAuthor(s): Meng Liu, Yukai Huang, Zhengping Huang, Zheng Zhong, Weiming Deng, Zhixiang Huang, Qidang Huang, Tianwang Li (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 26, 2020 Category: Laboratory Medicine Source Type: research

Nrf2 in early vascular ageing: calcification, senescence and therapy
Publication date: Available online 22 February 2020Source: Clinica Chimica ActaAuthor(s): Samsul Arefin, Sarah Buchanan, Sam Hobson, Julia Steinmetz, Shno Alsalhi, Paul G Shiels, Karolina Kublickiene, Peter StenvinkelAbstractUnder normal physiological conditions, free radical generation and antioxidant defences are balanced, and reactive oxygen species (ROS) usually act as secondary messengers in a plethora of biological processes. However, when this balance is impaired, oxidative stress develops due to imbalanced redox homeostasis resulting in cellular damage. Oxidative stress is now recognized as a trigger of cellular se...
Source: Clinica Chimica Acta - February 23, 2020 Category: Laboratory Medicine Source Type: research

Endogenous ApoA-I expression in macrophages: a potential target for protection against atherosclerosis
Publication date: Available online 21 February 2020Source: Clinica Chimica ActaAuthor(s): Wujun Chen, Yudong Wu, Qi Lu, Shuai Wang, Dongming XingAbstractApoA-I is a major protein component of high-density lipoprotein (HDL) that is widely known for regulating cholesterol trafficking and inflammatory and immune responses and for protecting against atherosclerosis. ApoA-I is generally considered to be synthesized in the liver (hepatocytes) and small intestine (enterocytes). However, computer analysis of ApoA-I has shown that the ApoA-I gene may be expressed in not only hepatocytes and enterocytes but also monocyte-macrophage ...
Source: Clinica Chimica Acta - February 22, 2020 Category: Laboratory Medicine Source Type: research

Five years of screening for galactosaemia in South Africa: pitfalls of using Benedict’s test and thin layer chromatography to screen for galactosaemia in a developing country
ConclusionInadequate performance of Benedict’s test and TLC was demonstrated by false positive and false negative results leading us to conclude that screening test results require interpretation with caution. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 22, 2020 Category: Laboratory Medicine Source Type: research

Bnip3 in mitophagy: novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction
Publication date: Available online 21 February 2020Source: Clinica Chimica ActaAuthor(s): Anbo Gao, Jinyong Jiang, Feng Xie, Linxi ChenAbstractThe present review is a summary of the recent literature concerning Bnip3 expression, function, and regulation, along with its implications in mitochondrial dysfunction, disorders of mitophagy homeostasis, and development of diseases of secondary mitochondrial dysfunction. As a member of the Bcl-2 family of cell death-regulating factors, Bnip3 mediates mPTP opening, mitochondrial potential, oxidative stress, calcium overload, mitochondrial respiratory collapse, and ATP shortage of m...
Source: Clinica Chimica Acta - February 22, 2020 Category: Laboratory Medicine Source Type: research

Detection of BRCA1/2 Large Genomic Rearrangement including BRCA1 Promoter-Region Deletions using Next-Generation Sequencing
ConclusionsThese results indicated that an NGS BRCA1/2 assay could detect most LGRs including BRCA1 promoter-region deletion as well as SNVs and small InDels. Therefore, it was applicable to clinical BRCA1/2 mutation tests. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 22, 2020 Category: Laboratory Medicine Source Type: research

Utility of serum amyloid A as a potential prognostic biomarker of acute primary basal ganglia hemorrhage
ConclusionsRising serum SAA concentrations, in close correlation with inflammation and hemorrhagic severity, are independently related to mortality and poor outcome after ICH, indicating that serum SAA might serve as a potential prognostic biomarker for ICH. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 20, 2020 Category: Laboratory Medicine Source Type: research

Macrocomplexes and high-sensitivity cardiac troponin assays in samples stored for over 15 years
Publication date: June 2020Source: Clinica Chimica Acta, Volume 505Author(s): Peter A. Kavsak, Lorna Clark, Nadia Caruso, Karen Bamford, Shana Lamers, Stephen Hill, Andrew Worster (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 20, 2020 Category: Laboratory Medicine Source Type: research

PD-1/PD-L1 in Cardiovascular Disease
Publication date: Available online 19 February 2020Source: Clinica Chimica ActaAuthor(s): YunFeng Sun, Liang Li, Wu YaWei, KePing YangAbstractThe PD-1/PD-L1 coinhibitory pathway has critical roles in the immune response and autoimmunity via the regulation of T cell activity. Excessive activity and high expression of this pathway suppresses the function of T cells and immunity. Recent research has indicated that tumour cells express high levels of PD-L1, which has an immunosuppressive effect and can result in treatment failure. Anti-PD-L1 or anti-PD-1 agents have well-established beneficial effects on mortality and quality ...
Source: Clinica Chimica Acta - February 19, 2020 Category: Laboratory Medicine Source Type: research

Consolidation of Vitamin A and E Methods onto a Multiplexing Liquid Chromatography Tandem Mass Spectrometry Platform Simplifies Laboratory Workflow
ConclusionsThe development of a simplified sample preparation protocol and the use of multiplexing SPLC-MS/MS have reduced sample analysis times for vitamin A and E. This method has also optimized clinical workflow through consolidation of previously independent benches. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 19, 2020 Category: Laboratory Medicine Source Type: research

Inappropriate use of laboratory tests: How availability triggers demand – examples across Europe
ConclusionThe six paradigmatic examples described in this manuscript show that availability of laboratory resources may considerably catalyze the demand, thus underscoring that inappropriate use of laboratory resources may be commonplace in routine laboratories all across Europe and most probably beyond. They also demonstrate that the application of simple strategies may assist in overcoming this issue. We believe that laboratory specialists need to refocus on the extra-analytical parts of the testing process and engage more in interdisciplinary patient-care. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 19, 2020 Category: Laboratory Medicine Source Type: research