Chemerin in immune response and gastrointestinal pathophysiology
Publication date: May 2020Source: Clinica Chimica Acta, Volume 504Author(s): Damian Jacenik, Jakub FichnaAbstractChemerin is a multifunctional protein involved among others in adipogenesis, angiogenesis and lipid as well as glucose metabolism. Chemerin is an essential factor in promotion of chemotaxis of numerous immune cell types and plays an important role in several pathophysiologic conditions. Chemerin receptors are present on monocytes/macrophages, T cells, natural killer and dendritic cells as well as neutrophils. However, the role of chemerin and chemerin receptors in immune response and gastrointestinal diseases is...
Source: Clinica Chimica Acta - February 17, 2020 Category: Laboratory Medicine Source Type: research

Expression of the organic cation/carnitine transporter family (Octn1,-2 and-3) in mdx muscle and heart: Implications for early carnitine therapy in Duchenne muscular dystrophy to improve cellular carnitine homeostasis
DiscussionDystrophin deficiency likely disrupts Octn2 expression decreasing muscle carnitine uptake thus contributing to membranotoxic long-chain acyl-CoAs with sarcolemmal and organellar membrane oxidative injury providing a treatment rationale for early L-carnitine in DMD. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 16, 2020 Category: Laboratory Medicine Source Type: research

Optimization of the thyroid panel for diagnostic purposes: Thyrotropin cut-off values for the reflex addition of free thyroxine
DiscussionSetting optimized thyrotropin cutoffs for reflex testing of free thyroxine would reduce the need for this test. Clinical laboratories need to offer not only true results, but also become the cornerstone in the optimization of resources. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 16, 2020 Category: Laboratory Medicine Source Type: research

Positive correlation of serum fibroblast growth factor 23 with peripheral arterial stiffness in kidney transplantation patients
Publication date: Available online 15 February 2020Source: Clinica Chimica ActaAuthor(s): Yao-Chang Liu, Jen-Pi Tsai, Li-Hsuan Wang, Ming-Che Lee, Bang-Gee HsuAbstractBackgroundFibroblast growth factor 23 (FGF-23) has a role in arterial stiffness (AS) apart from regulating mineral metabolism. We investigated the association between FGF-23 concentration and peripheral AS in renal transplantation (RT) recipients.MethodsThe fasting blood samples of RT recipients (n=66) were collected and analyzed.ResultsA total of 29 (43.9%) RT recipients were classified under the peripheral AS group. The RT recipients in this group had a hig...
Source: Clinica Chimica Acta - February 16, 2020 Category: Laboratory Medicine Source Type: research

Macrocomplexes and high-sensitivity cardiac troponin assays in samples stored for over 15 years
Publication date: Available online 15 February 2020Source: Clinica Chimica ActaAuthor(s): Peter A. Kavsak, Lorna Clark, Nadia Caruso, Karen Bamford, Shana Lamers, Stephen Hill, Andrew Worster (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 16, 2020 Category: Laboratory Medicine Source Type: research

FUT2 polymorphism in Latin American populations
ConclusionsThe allelic polymorphism of FUT2 suggests that the modern Latin American populations were formed via genetic admixture among Native Americans and populations whose ancestors migrated from other continents. In this study, we have observed a discrepancy between in silico and functional analyses for FUT2 for the first time. Therefore, experimental functional analysis is required for evaluation of SNPs of FUT2. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 16, 2020 Category: Laboratory Medicine Source Type: research

A novel mutation in xanthine dehydrogenase in a case with xanthinuria in Hunan province of China
Publication date: Available online 15 February 2020Source: Clinica Chimica ActaAuthor(s): Tao Xu, Xiaobing Xie, Zhen Zhang, Ningzhi Zhao, Yuanfu Deng, Ping LiAbstractXanthinuria is a rare genetic metabolic disorder, the biochemical mechanism of xanthinuria is the disturbance of purine to uric acid metabolism due to the deficiency of xanthine dehydrogenase/xanthine oxidase (XDH/XO) and aldehyde oxidase 1 (AOX1). Xanthinuria has large clinical variability and only about half of all patients have urolithiasis. In this article, we present one xanthinuria case from an unrelated family, which diagnosed by clinical, biochemical a...
Source: Clinica Chimica Acta - February 16, 2020 Category: Laboratory Medicine Source Type: research

Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction
Publication date: Available online 12 February 2020Source: Clinica Chimica ActaAuthor(s): John W Pickering, Joanna M Young, Peter M George, Christopher J Pemberton, Antony Watson, Sally J Aldous, Toby Verryt, Richard W Troughton, A Mark Richards, Fred S Apple, Martin P ThanAbstractThe early concentration kinetic profiles of cardiac troponin in patients with non-ST-elevated myocardial infarction (NSTEMI) measured by high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) assays have not been described.In intermediate-to-high-risk of NSTEMI patients we measured serial cTn concentrations on ED arrival, at 1, 2, 3, 6-12,...
Source: Clinica Chimica Acta - February 13, 2020 Category: Laboratory Medicine Source Type: research

A Novel Functional C1 Inhibitor Activity Assay in Dried Blood Spot for Diagnosis of Hereditary Angioedema
ConclusionDBS specimen collection for measurement of functional C1-INH activity in a physician’s office is straightforward and not limited by logistic considerations and therefore, appropriate for the diagnosis of HAE in high throughput diagnostic laboratories. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 13, 2020 Category: Laboratory Medicine Source Type: research

The association of coagulation indicators with in-hospital mortality and 1-year mortality of patients with sepsis at ICU admissions: a retrospective cohort study
ConclusionIncreased INR in critically ill septic patients is related to greater in-hospital mortality and 1-year mortality of the patients. A U-shaped relationship was found between APTT and 1-year mortality of patients with sepsis. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 9, 2020 Category: Laboratory Medicine Source Type: research

Serum specific IgE antibodies in immediate drug hypersensitivity
Publication date: Available online 6 February 2020Source: Clinica Chimica ActaAuthor(s): Marie-Line M. Van Der Poorten, Athina L. Van Gasse, Margo M. Hagendorens, Margaretha A. Faber, Leander De Puysseleyr, Jessy Elst, Christel M. Mertens, Vito Sabato, Didier G. EboAbstractImmediate drug hypersensitivity reactions (IDHRs) constitute a significant health problem that may be compounded by consequences of diagnostic error. In daily practice, IDHR diagnostic work up starts with drug-specific skin testing and/or quantification of specific IgE (sigE) antibodies in serum. Here we critically review the performance, i.e. potential ...
Source: Clinica Chimica Acta - February 7, 2020 Category: Laboratory Medicine Source Type: research

Adrenal insufficiency: physiology, clinical presentation and diagnostic challenges
Publication date: Available online 7 February 2020Source: Clinica Chimica ActaAuthor(s): Julie Martin-Grace, Rosemary Dineen, Mark Sherlock, Christopher J ThompsonAbstractAdrenal insufficiency (AI) is a serious condition, which can arise from pathology affecting the adrenal gland itself (primary adrenal insufficiency, PAI), hypothalamic or pituitary pathology (secondary adrenal insufficiency, SAI), or as a result of suppression of the hypothalamic-pituitary-adrenal (HPA) axis by exogenous glucocorticoid therapy (tertiary adrenal insufficiency, TAI). AI is associated with an increase in morbidity and mortality and a reducti...
Source: Clinica Chimica Acta - February 7, 2020 Category: Laboratory Medicine Source Type: research

Fifth Generation Troponin T Assay is Subject to Antibody Interference
ConclusionsThese experiments elucidate a heterophilic antibody interference to the assay, and demonstrate potential measures to discern the interference. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 7, 2020 Category: Laboratory Medicine Source Type: research

Comparison of the time required for manual (visually read) and semi-automated POCT urinalysis and pregnancy testing with associated electronic medical record (EMR) transcription errors
In this study, we compared the time, efficiency and accuracy of these tests using manual, visually read methods and a semi-automated analyzer that was not interfaced to the EMR.MethodsWe prospectively enrolled 2525 patients at five Ob/Gyn clinics. Urine samples were tested using three different dipsticks for UA (2, 7 and 10 test pads) and the Sure-Vue™ urine pregnancy test kit. The samples were analyzed on the CLINITEK Status® Connect System and results compared for time taken and errors in results’ transcription.ResultsUsing the CLINITEK Status Connect System, average test time and average total test time ...
Source: Clinica Chimica Acta - February 7, 2020 Category: Laboratory Medicine Source Type: research

How to assess renal function in patients with a neobladder
Publication date: Available online 4 February 2020Source: Clinica Chimica ActaAuthor(s): Sigurd E. Delanghe, Marijn M. Speeckaert, Joris R. Delanghe (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 6, 2020 Category: Laboratory Medicine Source Type: research

A novel genomic-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma
Publication date: Available online 4 February 2020Source: Clinica Chimica ActaAuthor(s): Fu-Biao Ni, Zhuo Lin, Xu-Hui Fan, Ke-Qing Shi, Jian-Yang Ao, Xiao-Dong Wang, Rui-Cong ChenAbstractThere is a lack of precise and clinical accessible model to predict the prognosis of hepatocellular carcinoma (HCC) in clinic practice currently. Here, an inclusive nomogram was developed by integrating genomic markers and clinicopathologic factors for predicting the outcome of patients with HCC. A total of 365 samples of HCC were obtained from the Cancer Genome Atlas (TCGA) database. The LASSO analysis was carried out to identify HCC-rela...
Source: Clinica Chimica Acta - February 6, 2020 Category: Laboratory Medicine Source Type: research

Pathogenesis and management of heparin-induced thrombocytopenia and thrombosis
Publication date: Available online 4 February 2020Source: Clinica Chimica ActaAuthor(s): Pan Zhou, Jia-Xin Yin, Hua-Lin Tao, Hong-wei ZhangAbstractHeparin-induced thrombocytopenia and thrombosis is a severe immune-mediated adverse drug effect caused by the IgG antibodies to platelet factor4/heparin complexes. Activated platelets, vascular endothelium, and monocytes generate the life-threatening thrombocytopenia and thrombosis. In this review, we will update the reader on recent findings on the pathogenesis and clinical management of heparin-induced thrombocytopenia and thrombosis. Firstly, PF4/heparin complexes make IgM me...
Source: Clinica Chimica Acta - February 6, 2020 Category: Laboratory Medicine Source Type: research

Short-term biological variation and diurnal rhythm of cardiac troponin I (Access hs-TnI) in healthy subjects
ConclusionsTroponin I demonstrates a diurnal rhythm with decreasing values throughout daytime and the peak concentrations in the morning. The circadian variability is statistically significant, but not relevant from a clinical viewpoint. The intra-individual variation (CVI) is lower than that reported in the literature and the index of individuality lower than 0.6 suggests a scarce value of reference interval (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 6, 2020 Category: Laboratory Medicine Source Type: research

Centrosome-associated CDC25B is a novel disease-causing gene for a syndrome with cataracts, dilated cardiomyopathy, and multiple endocrinopathies
We describe a unique Chinese girl who presented with intrauterine growth retardation, delayed development, bilateral cataracts, hypothyroidism, growth hormone deficiency, and juvenile dilated cardiomyopathy. She was born to consanguineous parents with a history of one fetal and one infantile death in the family. She died from cardiac failure at the age of 12.In the pursuit of a diagnosis, the family was referred to the Clinics for Rare Diseases Referral and the University of Hong Kong Undiagnosed Disease Program. Whole-exome sequencing analysis revealed a homozygous non-sense variant, NM_021873:c.313G>T (p.Glu105*), in ...
Source: Clinica Chimica Acta - February 4, 2020 Category: Laboratory Medicine Source Type: research

Comparison of estimated glomerular filtration rates in Chinese patients with chronic kidney disease among serum creatinine-, cystatin-C- and creatinine-cystatin-C-based equations: A retrospective cross-sectional study
Publication date: Available online 3 February 2020Source: Clinica Chimica ActaAuthor(s): Jian Hu, Xin Xu, Kaige Zhang, Ying Li, Jie Zheng, Wei Chen, Xiaoqin WangAbstractAccurate estimation of glomerular filtration rate (GFR) and staging of chronic kidney disease (CKD) are important. Thus far, few studies in China have systematically assessed the differences among the various estimated GFR (eGFR) equations in large cohort. A total of 6287 CKD patients and 679 healthy individuals were enrolled. To estimate the GFR values in patients, MDRD, MDRD-China (MDRD-C), CKD-EPI, cystatin-C-China (CysC-C), cystatin-C-KDIGO (CysC-K), an...
Source: Clinica Chimica Acta - February 4, 2020 Category: Laboratory Medicine Source Type: research

Endoplasmic reticulum stress and focused drug discovery in cardiovascular disease
This article reviews the relationship between ERS and cardiovascular diseases and drugs that inhibit ERS. Furthermore, we detail the role of ERS inhibitors in the treatment of cardiovascular disease. Drugs that inhibit ERS are considered as promising strategies for the treatment of cardiovascular diseases. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - February 3, 2020 Category: Laboratory Medicine Source Type: research

Potential of nano-phytochemicals in cervical cancer therapy
Publication date: Available online 1 February 2020Source: Clinica Chimica ActaAuthor(s): Neera Yadav, Shama Parveen, Monisha BanerjeeAbstractCervical cancer is common among women with a recurrence rate of 35% despite surgery, radiation, and chemotherapy. Patients receiving chemotherapy or radiotherapy routinely experience several side effects including toxicity, non-targeted damage of tissues, hair loss, neurotoxicity, multidrug resistance (MDR), nausea, anemia and neutropenia. Phytochemicals can interfere with almost every stage of carcinogenesis to prevent cancer development. Many natural compounds are known to activate/...
Source: Clinica Chimica Acta - February 3, 2020 Category: Laboratory Medicine Source Type: research

Role of SNHG16 in human cancer
Publication date: Available online 31 December 2019Source: Clinica Chimica ActaAuthor(s): Chao-Yang Gong, Rong Tang, Wei Nan, Kai-Sheng Zhou, Hai-Hong ZhangAbstractA growing body of evidence suggests that long non-coding RNAs (lncRNAs), a novel class of non-coding endogenous single-stranded RNA, play a key role in multiple physiological and pathological processes through transcriptional interference, post-transcriptional regulation, and epigenetic modification. Furthermore, many studies have shown that lncRNAs—as oncogenes or tumour suppressors—play an important role in the occurrence and development of human c...
Source: Clinica Chimica Acta - February 1, 2020 Category: Laboratory Medicine Source Type: research

Reticulocyte hemoglobin content
Publication date: Available online 31 January 2020Source: Clinica Chimica ActaAuthor(s): Chie Ogawa, Ken Tsuchiya, Kunimi MaedaAbstractIron deficiency leads to the suppression of hemoglobin (Hb) synthesis and induces metabolic disorders. In contrast, iron overload not only reduces the iron utilization efficiency but also induces oxidative stress. Iron metabolism in the body is closely regulated by hepcidin, a short peptide produced by the liver. Unfortunately, conventional iron indices may not always accurately reflect the iron status. For example, Hb concentration assessed using mature erythrocytes do not accurately refle...
Source: Clinica Chimica Acta - February 1, 2020 Category: Laboratory Medicine Source Type: research

MicroRNAs in Venous Thrombo-Embolism
Publication date: Available online 1 February 2020Source: Clinica Chimica ActaAuthor(s): Anju Angelina Hembrom, Swati Srivastava, Iti Garg, Bhuvnesh KumarAbstractBackgroundVenous Thrombo-embolism (VTE) is the major preventable cause of death and disability worldwide. It has the third highest incidence rate of hospital death after coronary artery disease (CAD) and stroke. With the establishment of Virchow’s triad stating the major factors responsible for VTE including stasis, hypercoagulability and endothelial dysfunction, the last decade reported number of studies regarding its diagnosis and prophylaxis. Till date th...
Source: Clinica Chimica Acta - February 1, 2020 Category: Laboratory Medicine Source Type: research

Annexin A1: A Double-edged Sword as Novel Cancer Biomarker
Publication date: Available online 30 January 2020Source: Clinica Chimica ActaAuthor(s): Zhuqiong Fu, Shanshan Zhang, Baiqi Wang, Weiguo Huang, Lulu Zheng, Ailan ChengAbstractThe occurrence, development, infiltration and metastasis of tumors are very complex processes involving the participation of many factors, some of which play a key role. Annexin A1 (ANXA1) is known as an anti-inflammatory protein. However, it has now been recognized to have a broader role beyond the inflammation, including roles in cell proliferation, differentiation, apoptosis, invasion, angiogenesis and metastasis. This review is intended to outline...
Source: Clinica Chimica Acta - January 31, 2020 Category: Laboratory Medicine Source Type: research

Blood levels of heme oxygenase-1 versus bilirubin in patients with coronary artery disease
Publication date: Available online 30 January 2020Source: Clinica Chimica ActaAuthor(s): Yoshimi Kishimoto, Hanako Niki, Emi Saita, Susumu Ibe, Tomohiko Umei, Kotaro Miura, Yukinori Ikegami, Reiko Ohmori, Kazuo Kondo, Yukihiko MomiyamaAbstractObjectiveHeme oxygenase-1 (HO-1) degrades heme to CO, iron, and biliverdin/bilirubin. Although serum bilirubin levels were often reported in patients with coronary artery disease (CAD), HO-1 levels in patients with CAD and the association between HO-1 and bilirubin levels have not been clarified.MethodsWe measured plasma HO-1 and serum total bilirubin levels in 262 patients undergoing...
Source: Clinica Chimica Acta - January 31, 2020 Category: Laboratory Medicine Source Type: research

Advances in prostate specific antigen biosensors-Impact of nanotechnology
Publication date: Available online 28 January 2020Source: Clinica Chimica ActaAuthor(s): M. Negahdary, N. Sattarahmady, H. HeliAbstractProstate cancer is one of the most dangerous and deadly cancers in elderly men. Early diagnosis using prostate-specific antigen (PSA) facilitates disease detection, management and treatment. Biosensors have recently been used as sensitive, selective, inexpensive and rapid diagnostic tools for PSA detection. In this review, a variety of PSA biosensors such as aptasensors, peptisensors and immunesensors are highlighted. These use aptamers, peptides and antibodies in the biorecognition element...
Source: Clinica Chimica Acta - January 29, 2020 Category: Laboratory Medicine Source Type: research

Detecting patients with PMI post-CABG based on cardiac troponin-T profiles: a latent class mixed modeling approach
ConclusionClinically relevant subgroups, including patients with PMI, can be uncovered using serially measured cTnT and a LCMM. The LCMM showed superior diagnostic accuracy of PMI. A rising cTnT profile is potentially a better criterion than a single cut-off value in diagnosing PMI post-CABG. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - January 28, 2020 Category: Laboratory Medicine Source Type: research

The 99th percentile upper reference limit for the 5th generation cardiac troponin T assay in the United States
ConclusionOur findings facilitate the interpretation of TnT Gen 5 results in US clinical practice. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - January 28, 2020 Category: Laboratory Medicine Source Type: research

IgM natural antibody T15/E06 in atherosclerosis
Publication date: Available online 25 January 2020Source: Clinica Chimica ActaAuthor(s): Jin Zou, Gang Wang, Heng Li, Xiaohua Yu, Chaoke TangAbstractAtherosclerosis is regarded as a lipid-driven chronic inflammatory disease. A variety of immune cells, including B1 cells, play an important role in the occurrence and development of atherosclerosis. T15/E06 is an IgM Nab secreted by B1 cells. The concentration of T15/E06 is significantly decreased in animal models of atherosclerosis. Accumulating evidence has shown that T15/E06 can protect against atherosclerosis by blocking macrophage lipid uptake, inhibiting vascular inflam...
Source: Clinica Chimica Acta - January 26, 2020 Category: Laboratory Medicine Source Type: research

Impact of serum omentin-1 concentrations on functional outcome among acute intracerebral hemorrhage patients
Publication date: Available online 25 January 2020Source: Clinica Chimica ActaAuthor(s): Guo-Hai Zhang, Zhe-Hao Ye, Hao-Jie Guan, Mi Guo, Xin-Xiang Zhou, Yu-Yu XuAbstractBackgroundReduced serum omentin-1 concentrations might be related to an increased risk for poor functional outcome after acute ischemic stroke. We intended to explore whether serum omentin-1 could be a promising prognostic biomarker for acute intracerebral hemorrhage.MethodsA total of 104 consecutive patients with hemorrhagic stroke underwent 90-day follow-up. The modified Rankin scale score> 2 was evaluated as worse prognosis. A multivariable logistic ...
Source: Clinica Chimica Acta - January 26, 2020 Category: Laboratory Medicine Source Type: research

Stress and neurodegeneration
Publication date: Available online 24 January 2020Source: Clinica Chimica ActaAuthor(s): Carmen Peña-Bautista, Esther Casas-Fernández, Máximo Vento, Miguel Baquero, Consuelo Cháfer-PericásAbstractNeurodegenerative diseases are a great concern because of aging worldwide population. Despite substantial effort to advance our understanding of the etiology and potential treatment of neurodegeneration, there remains a paucity of information with respect to this complex disease process. Interestingly, stress has been implicated among the potential mechanisms implicated in neurodegenerative patho...
Source: Clinica Chimica Acta - January 25, 2020 Category: Laboratory Medicine Source Type: research

Verification of reference interval for urinary alpha1-microglobulin in females
Publication date: Available online 25 January 2020Source: Clinica Chimica ActaAuthor(s): Helena Čičak, Lora Dukić, Ana-Maria Šimundić (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - January 25, 2020 Category: Laboratory Medicine Source Type: research

Plasma sestrin2 concentrations and carotid atherosclerosis
Publication date: Available online 23 January 2020Source: Clinica Chimica ActaAuthor(s): Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kazuo Kondo, Yukihiko MomiyamaAbstractBackgroundSestrin2 is a stress-inducible antioxidant protein that plays a protective role against oxidative stress. However, blood sestrin2 concentrations in subjects with carotid atherosclerosis have not been elucidated.MethodsWe investigated plasma sestrin2 concentrations in 152 subjects undergoing carotid ultrasonography. Plaque severity was evaluated as plaque score.ResultsOf the 152 subjects, plaque was found in 63 (41%). Plasma sestrin2 concentratio...
Source: Clinica Chimica Acta - January 25, 2020 Category: Laboratory Medicine Source Type: research

Comparison of the time required for manual, visually read and semi-automated POCT urinalysis and pregnancy testing with associated electronic medical record (EMR) transcription errors
In this study, we compared the time, efficiency and accuracy of these tests using manual, visually read methods and a semi-automated analyzer that was not interfaced to the EMR.MethodsWe prospectively enrolled 2525 patients at five Ob/Gyn clinics. Urine samples were tested using three different dipsticks for UA (2, 7 and 10 test pads) and the Sure-Vue™ urine pregnancy test kit. The samples were analyzed on the CLINITEK Status® Connect System and results compared for time taken and errors in results’ transcription.ResultsUsing the CLINITEK Status Connect System, average test time and average total test time ...
Source: Clinica Chimica Acta - January 25, 2020 Category: Laboratory Medicine Source Type: research

RASSF1A: A promising target for the diagnosis and treatment of cancer
Publication date: Available online 23 January 2020Source: Clinica Chimica ActaAuthor(s): Yuling Bin, Yong Ding, Weisheng Xiao, Aijun LiaoAbstractThe Ras association domain family 1 isoform A (RASSF1A), a tumor suppressor, regulates several tumor-related signaling pathways and interferes with diverse cellular processes. RASSF1A is frequently demonstrated to be inactivated by hypermethylation in numerous types of solid cancers. It is also associated with lymph node metastasis, vascular invasion, and chemo-resistance. Therefore, reactivation of RASSF1A may be a viable strategy to block tumor progress and reverse drug resistan...
Source: Clinica Chimica Acta - January 23, 2020 Category: Laboratory Medicine Source Type: research

Editorial board member, Aims and Scope, Publication Info.
Publication date: March 2020Source: Clinica Chimica Acta, Volume 502Author(s): (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - January 23, 2020 Category: Laboratory Medicine Source Type: research

Decreased mitochondrial DNA copy number in children with cerebral palsy quantified by droplet digital PCR
Publication date: Available online 21 January 2020Source: Clinica Chimica ActaAuthor(s): Bichao Lu, Fanyong Zeng, Wen Xing, Lin Liang, Jianbo Huo, Chianru Tan, Lingxiang Zhu, Zhizhong LiuAbstractBackgroundMitochondrial DNA copy number is a potential biomarker for mitochondrial dysfunction and is involved in a variety of disease states including autism, neurodegenerative diseases and traumatic brain injury, but few studies on mitochondrial DNA copy number in cerebral palsy have been reported. Therefore, this study aims to investigate the role of mitochondrial DNA copy number in children with cerebral palsy.MethodsA total of...
Source: Clinica Chimica Acta - January 22, 2020 Category: Laboratory Medicine Source Type: research

Evaluation of a panel of very long-chain lysophosphatidylcholines and acylcarnitines for screening of X-linked adrenoleukodystrophy in China
ConclusionC26:0-LPC, C24 and C26 are three most valuable biomarkers for screening of X-ALD in children group. The information of age-related variations in concentration of some biomarkers is helpful for accurate screening of X-ALD. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - January 22, 2020 Category: Laboratory Medicine Source Type: research

Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism
ConclusionThese results suggest that PS-PLA1 might be a novel target in the treatment of hyperthyroidism, especially Graves’ disease, and that its measurement might be useful as a supplementary diagnostic test for thyroid function. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - January 22, 2020 Category: Laboratory Medicine Source Type: research

Cell free DNA as a diagnostic and prognostic marker for cardiovascular diseases
Publication date: Available online 21 January 2020Source: Clinica Chimica ActaAuthor(s): Iuliia A. Polina, Daria V. Ilatovskaya, Kristine Y. DeLeon-PennellAbstractRelease of cell free DNA (cfDNA) from damaged or dead cells routinely occurs in normal physiology. Recently, cfDNA has emerged as an essential biomarker in cardiovascular disease (CVD) of potential prognostic and diagnostic significance. Within the last decade, significant research efforts have been devoted to uncovering the mechanisms mediating cfDNA release and its outcome-predicting ability. The current review focuses on the pathways for cfDNA release in myoca...
Source: Clinica Chimica Acta - January 22, 2020 Category: Laboratory Medicine Source Type: research

Long non-coding RNA TP73-AS1 in cancers
Publication date: Available online 21 January 2020Source: Clinica Chimica ActaAuthor(s): Chao-Yang Gong, Rong Tang, Kai-Xing Liu, Gao Xiang, Hai-Hong ZhangAbstractMore and more evidence indicates that long non-coding RNAs (lncRNAs), as a kind of non-coding endogenous single-stranded RNA, play an essential role as oncogenes or tumour suppressors in the occurrence and development of human cancers. The tumour protein P73 antisense RNA 1 (TP73-AS1) was initially found to be down-regulated in oligodendroglioma and may act as a non-protein-encoding RNA.Since its discovery, TP73-AS1 has been identified as a carcinogenic regulator...
Source: Clinica Chimica Acta - January 22, 2020 Category: Laboratory Medicine Source Type: research

The exchangeable apolipoproteins in lipid metabolism and obesity
Publication date: Available online 22 January 2020Source: Clinica Chimica ActaAuthor(s): Xin Su, Daoquan PengAbstractDyslipidemia, characterized by increased plasma levels of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglyceride (TG), and reduced plasma levels of high-density lipoprotein cholesterol (HDL-C), is confirmed as a hallmark of obesity and cardiovascular diseases (CVD), posing serious risks to the future health of humans. Thus, it is important to understand the molecular metabolism of dyslipidemia, which could help reduce the morbidity and mortality of obesit...
Source: Clinica Chimica Acta - January 22, 2020 Category: Laboratory Medicine Source Type: research

Biotin interferences: Have we neglected the impact on serological markers?
Publication date: Available online 21 January 2020Source: Clinica Chimica ActaAuthor(s): Jean-Louis Bayart, Julien Favresse, Anke Stoefs, Mélanie Closset, Tatiana Roy, Catherine Fillée, Hector Rodriguez-Villalobos, Benoît Kabamba-Mukadi, Damien GrusonAbstractBackgroundBiotin has been reported to be a leading cause of interference on several immunoassay platforms using the streptavidin-biotin immobilization system. While biotin interferences have now been well characterized for several assays, only few data are available on their impact on serological markers of infectious viral diseases.MethodsOverall, ...
Source: Clinica Chimica Acta - January 22, 2020 Category: Laboratory Medicine Source Type: research

Association of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Coronary Plaque Properties: An Optical Coherence Tomography-based Observational Study
Publication date: Available online 21 January 2020Source: Clinica Chimica ActaAuthor(s): Toshihiko Oshita, Ryuji Toh, Yuichiro Nagano, Koji Kuroda, Yoshinori Nagasawa, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Takuya Kubo, Takuya Iino, Manabu Nagao, Yasuhiro Irino, Tetsuya Hara, Masakazu Shinohara, Hiromasa Otake, Toshiro Shinke, Katsuyuki Nakajima, Tatsuro IshidaAbstractBackgroundCholesterol efflux from atherosclerotic lesion is a key function of high-density lipoprotein (HDL). Recently, we established a simple, high-throughput, cell-free assay to evaluate the capacity of HDL to accept...
Source: Clinica Chimica Acta - January 22, 2020 Category: Laboratory Medicine Source Type: research

Fecal microbiota transplantation in disease therapy
Publication date: Available online 20 January 2020Source: Clinica Chimica ActaAuthor(s): Hanna AntushevichAbstractFecal microbiota transplantation (FMT) is the introduction (transplantation) of gut microbiota obtained from the faeces of a healthy donor into the patient’s gastrointestinal tract. Most often, such therapy is used the treatment of gastrointestinal diseases caused by the activity of pathogenic or conditionally pathogenic microorganisms, however, recently an increasing number of studies have reported the use of fecal microbiota transplantation for the treatment of diseases such as metabolic syndrome, diabe...
Source: Clinica Chimica Acta - January 20, 2020 Category: Laboratory Medicine Source Type: research

A novel plasma based early colorectal cancer screening assay base on methylated SDC2 and SFRP2
Publication date: Available online 18 January 2020Source: Clinica Chimica ActaAuthor(s): Guodong Zhao, Yong Ma, Hui Li, Shiming Li, Yun Zhu, Xiaoyu Liu, Shangmin Xiong, Yi Liu, Jin Miao, Sujuan Fei, Minxue Zheng, Xiangwei ZhaoAbstractBackgroundMethylated SFRP2 was previously reported as a non-invasive biomarker for colorectal cancer (CRC) detection with a relatively low sensitivity for early stage CRC. The purpose of this study was to evaluate the performance of a new plasma based CRC screening assay, SpecColon test, which tested methylated SFRP2 and SDC2 simultaneously in a single qPCR reaction, in detecting CRC and advan...
Source: Clinica Chimica Acta - January 18, 2020 Category: Laboratory Medicine Source Type: research

Genetic and functional analysis of two missense mutations in CD46 predispose to postpartum atypical hemolytic uremic syndrome
This study reported the first case of a four-generation postpartum-aHUS pedigree with isolated CD46 variants and the detailed disease progression, treatment, and prognosis provided more meaningful information for the understanding the disease. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - January 14, 2020 Category: Laboratory Medicine Source Type: research

Long non-coding RNA in bladder cancer
Publication date: Available online 12 January 2020Source: Clinica Chimica ActaAuthor(s): Yuepeng Cao, Tian Tian, Weijian Li, Hanzi Xu, Chuanfei Zhan, Xuhong Wu, Chao Wang, Xiaoli Wu, W.e Wu, Shuyun Zheng, Kaipeng XieAbstractBladder cancer (BC) is the ninth most common malignant disease and ranks fourteenth in cancer mortality worldwide. Moreover, among cancers, the incidence and mortality of BC in males increased to the 6th and 9th place, respectively. The overall survival (OS) declines dramatically as the cancer progresses, especially when urothelial cells transition from noninvasive to invasive. It is well known that epi...
Source: Clinica Chimica Acta - January 13, 2020 Category: Laboratory Medicine Source Type: research