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Condition: Liver Disease
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Total 328 results found since Jan 2013.
Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3
Toxicol Appl Pharmacol. 2021 Nov 12:115795. doi: 10.1016/j.taap.2021.115795. Online ahead of print.ABSTRACTA chronic liver disease named autoimmune hepatitis (AIH) will carry elevated levels of inflammatory cytokines, but there is currently no effective treatment to cure it. Histone deacetylase 3 (HDAC3) takes an important position in regulating the expression of inflammatory genes. Nimbolide (NIB) is a limonoid extracted from the neem tree (Azadirachta indica) that has been found to be effective against many diseases, including cancer, scleroderma, and acute respiratory distress syndrome. Here, we investigated the protect...
Source: Toxicology and Applied Pharmacology - November 15, 2021 Category: Toxicology Authors: Dingchao Xia Dazhi Chen Tingchen Cai Lujian Zhu Yanhan Lin Sijie Yu Kailu Zhu Xiaodong Wang Lanman Xu Yongping Chen Source Type: research
Blocking neddylation elicits antiviral effect against hepatitis B virus replication
CONCLUSION: The manipulation of the neddylation pathway can thus provide new tools interfering with HBV persistence as well as novel therapeutic strategies against chronic hepatitis B.PMID:34716866 | DOI:10.1007/s11033-021-06886-w
Source: Mol Biol Cell - October 30, 2021 Category: Molecular Biology Authors: Karima Abounouh Mohammad Enamul Hoque Kayesh Haya Altawalah Bouchra Kitab Shuko Murakami Shintaro Ogawa Yasuhito Tanaka Hind Dehbi Pascal Pineau Michinori Kohara Soumaya Benjelloun Kyoko Tsukiyama-Kohara Sayeh Ezzikouri Source Type: research
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3
In conclusion, CAR suppressed lipid accumulation, mitochondrial dysfunction and hepatocyte apoptosis by activating PRDX3, mitigating the progression of NAFLD, and thus, CAR may represent a promising candidate for clinical treatment of steatosis.PMID:34678374 | DOI:10.1016/j.taap.2021.115758
Source: Toxicology and Applied Pharmacology - October 22, 2021 Category: Toxicology Authors: Yunfei Geng Yue Wang Ruimin Sun Xiaohui Kang Huanyu Zhao Meiyang Zhu Yu Sun Yan Hu Zhecheng Wang Xiaofeng Tian Yan Zhao Jihong Yao Source Type: research
Evaluation of the Consequence of CTNNB1 & amp; RAB1A Targeting on Hepatocellular Carcinoma Cell Line
ConclusionTargetingCTNNB1or RAB1A in HepG2 cell lines decreased the cell viability and proliferative activity. Moreover, targetingCTNNB1 was effective in decreasing cell proliferative activity compared to targetingRAB1A in HepG2 cell lines. So, targeting CTNNB1 may have a potential therapeutic effect in treatment of HCC.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1 α/ Nrf2 pathway to reduce oxidative stress and inflammatory response
In conclusion, ISL improves the ability of anti-oxidative stress, alleviates inflammatory reaction, apoptosis, and inhibits NLRP3 inflammasome to protect lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced ALF through activating the PGC-1α/Nrf2 pathway, which provides the possibility for the treatment of ALF.PMID:34555641 | DOI:10.1016/j.intimp.2021.108159
Source: International Immunopharmacology - September 23, 2021 Category: Allergy & Immunology Authors: Lu Wang Xiaohui Wang Lina Kong Shuyuan Wang Kai Huang Jingjing Wu Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Source Type: research
RNA-Seq Reveals Different Gene Expression in Liver-Specific Prohibitin 1 Knock-Out Mice
In this study, we performed RNA-sequencing (RNA-seq) analysis with liver tissues to investigate global gene expression among liver-specific Phb1−/−, Phb1+/−, and WT mice, focusing on the differentially expressed (DE) genes between Phb1+/− and WT. When 78 DE genes were analyzed for biological functions, using ingenuity pathway analysis (IPA) tool, lipid metabolism-related genes, including insulin receptor (Insr), sterol regulatory element-binding transcription factor 1 (Srebf1), Srebf2, and SREBP cleavage-activating protein (Scap) appeared to be downregulated in liver-specific Phb1+/− compared with WT. Diseases an...
Source: Frontiers in Physiology - September 3, 2021 Category: Physiology Source Type: research
Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes
In conclusion, Grp75 or Mfn2 silencing and overexpression in Huh7 cells contribute to altering MAM integrity and cholesterol storage in opposite directions, but all promote triglyceride accumulation through distinct cellular pathways. This study also highlights that besides Mfn2, Grp75 could play a central role in hepatic lipid and cholesterol metabolism in obesity and NAFLD.PMID:34419589 | DOI:10.1016/j.bbalip.2021.159030
Source: Mol Biol Cell - August 22, 2021 Category: Molecular Biology Authors: Arthur Bassot Carina Prip Buus Ana ïs Alves Olivier Berdeaux Johan Perrier V éronique Lenoir Jingwei Ji-Cao Marie-Agn ès Berger Emmanuelle Loizon Stephanie Cabaret Baptiste Panthu Jennifer Rieusset B éatrice Morio Source Type: research
Nicotinamide N-methyltransferase (NNMT) upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes
In this study, using AML12 cells, a non-transformed murine hepatocyte cell line, exposed to palmitate (a 16-C saturated fatty acid) as an experimental model, we investigated the role and mechanisms of nicotinamide N-methyltransferase (NNMT), a methyltransferase catalyzing nicotinamide methylation and degradation, in hepatic lipotoxicity. We initially identified activating transcription factor 4 (ATF4) as a major transcription factor for hepatic NNMT expression. Here, we demonstrated that palmitate upregulates NNMT expression via activating ATF4 in a mechanistic target of rapamycin complex 1 (mTORC1)-dependent mechanism in ...
Source: Am J Physiol Cell Ph... - August 11, 2021 Category: Cytology Authors: Alexandra Griffiths Jun Wang Qing Song Iredia D Iyamu Lifeng Liu Jooman Park Yuwei Jiang Rong Huang Zhenyuan Song Source Type: research
