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Cancer: Thyroid Cancer

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Total 208 results found since Jan 2013.

RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer
Conclusions: RASSF10 induces apoptosis in PTC cells by activating the p53 signalling pathway, indicating its role as a treatment target for PTC.Cell Physiol Biochem 2017;41:1229 –1239
Source: Cellular Physiology and Biochemistry - March 7, 2017 Category: Cytology Source Type: research

Small interfering RNA (siRNA) against Slug induces apoptosis and sensitizes human anaplastic thyroid carcinoma cells to doxorubicin.
CONCLUSIONS: Knockdown of Slug enhanced the antitumor activity of DOX in SW1736 cells via induction of PUMA upregulation. Our results suggest that targeting of Slug has good potential for the development of new therapeutic strategies for ATC. PMID: 28128736 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers : Section A of Disease Markers - January 19, 2017 Category: Cancer & Oncology Authors: Pan Y, Liu P, Chen D, Zhao S Tags: Cancer Biomark Source Type: research

EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer Molecular Bases of Disease
Eph receptors, the largest subfamily of transmembrane tyrosine kinase receptors, have been increasingly implicated in various physiologic and pathologic processes, and the roles of the Eph family members during tumorigenesis have recently attracted growing attentions. In the present study, we explored the function of EphB3, one member of Eph family, in papillary thyroid cancer (PTC). We found that the expression of EphB3 was significantly elevated in PTC. Either overexpression of EphB3 or activation of EphB3 by EfnB1-Fc/EfnB2-Fc stimulated in vitro migration of PTC cells. In contrast, siRNA-mediated knockdown of EphB3 or E...
Source: Journal of Biological Chemistry - January 19, 2017 Category: Chemistry Authors: Jing-Jing Li, Zhi-Jian Sun, Yan-Mei Yuan, Fen-Fen Yin, Yao-Gang Bian, Ling-Yun Long, Xue-li Zhang, Dong Xie Tags: Cell Biology Source Type: research

TRIM29 promotes progression of thyroid carcinoma via activating P13K/AKT signaling pathway.
Authors: Xu J, Li Z, Su Q, Zhao J, Ma J Abstract Thyroid cancer (TC) is a common malignancy of the endocrine system. Abnormal expression of tripartite motif-containing 29 (TRIM29) has been reported to promote tumorigenesis and predict poor prognosis in several human malignancies. The aim of this study was to assess the involvement of TRIM29 in the significance and prognosis of TC. Fifty-six tumor samples and their clinicopathological para-meters were obtained from TC patients; the expression level of TRIM29 was detected by RT-qPCR and western blotting. TRIM29 expression was knocked down by small interfering RNA (s...
Source: Oncology Reports - January 19, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Iodine-131 treatment of thyroid cancer cells leads to suppression of cell proliferation followed by induction of cell apoptosis and cell cycle arrest by regulation of B-cell translocation gene 2-mediated JNK/NF- κB pathways.
This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and BTG2 gene expression. SW579 cells were transfected with BTG2 siRNA, p53 siRNA and siNC and were then examined for the same aforementioned parameters. When treated with a JNK inhibitor of SP600125 and 131I or with a NF-κB inhibitor of BMS-345541 and 131I, non-transfected SW57...
Source: Brazilian Journal of Medical and Biological Research - January 19, 2017 Category: Research Tags: Braz J Med Biol Res Source Type: research

Effect of Slug-Mediated Down-Regulation of E-Cadherin on Invasiveness and Metastasis of Anaplastic Thyroid Cancer Cells.
CONCLUSIONS Targeting Slug signaling pathway is effective in preventing lung metastasis in ATC. PMID: 28070118 [PubMed - in process]
Source: Medical Science Monitor - January 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Thyroid transcription factor FOXE1 interacts with ETS factor ELK1 to co-regulate TERT.
CONCLUSIONS: FOXE1 interacts with ELK1 on thyroid relevant gene promoters, establishing a new regulatory pathway for its role in adult thyroid function. Co-regulation of TERT suggests a mechanism by which allelic variants in/near FOXE1 are associated with thyroid cancer risk. PMID: 27852061 [PubMed - as supplied by publisher]
Source: Oncotarget - November 18, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression.
Abstract Accumulating evidence has indicated that aberrantly expressed microRNAs (miRs) are extensively involved in cancer development and progression. MiR-639 has been reported to act as tumor promoter in various types of cancer. However, the biological function and underlying molecular mechanism of miR-639 in thyroid carcinoma (TC) have not been intensively investigated. Herein the present study aimed to investigate the functional role of miR-639 in TC. We found that miR-639 expression was upregulated in TC cells and clinical tissues. Overexpression of miR-639 promoted TC cell proliferation and cell cycle, with ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 5, 2016 Category: Drugs & Pharmacology Authors: Lei ST, Shen F, Chen JW, Feng JH, Cai WS, Shen L, Hu ZW, Xu B Tags: Biomed Pharmacother Source Type: research

Knockdown of S100A4 blocks growth and metastasis of anaplastic thyroid cancer cells in vitro and in vivo.
Abstract Anaplastic thyroid cancer (ATC) is a locally aggressive type of thyroid tumor with high rate of distant metastases. It is often incurable because it does not respond to radioiodine, radiotherapy, or chemotherapy. With conventional treatment, the median survival is about 6 months; therefore, new treatment options are needed. S100A4 is a calcium-binding protein related to the metastatic potential of carcinoma. Previous study has found S100A4 was overexpressed in human papillary thyroid carcinomas (PTC) tissues, and overexpression of S100A4 is associated with thyroid tumour invasion and metastasis. In the pr...
Source: Cancer Biomarkers : Section A of Disease Markers - September 25, 2016 Category: Cancer & Oncology Authors: Zhang K, Yu M, Hao F, Dong A, Chen D Tags: Cancer Biomark Source Type: research

Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF- β/Smad signaling pathway.
CONCLUSIONS: ANRIL may reduce p15INK4B expression through inhibiting TGF-β/Smad signaling pathway, promoting invasion and metastasis of TC cells, and the silencing of ANRIL inhibits the invasion and metastasis of TPC-1 cells. PMID: 27507052 [PubMed - as supplied by publisher]
Source: Oncotarget - August 13, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

NIR nanoparticles for imaging and siRNA delivery Medical Sciences
Anaplastic thyroid cancer (ATC), one of the most aggressive solid tumors, is characterized by rapid tumor growth and severe metastasis to other organs. Owing to the lack of effective treatment options, ATC has a mortality rate of ∼100% and median survival of less than 5 months. RNAi nanotechnology represents a...
Source: Proceedings of the National Academy of Sciences - July 11, 2016 Category: Science Authors: Liu, Y., Gunda, V., Zhu, X., Xu, X., Wu, J., Askhatova, D., Farokhzad, O. C., Parangi, S., Shi, J. Tags: Physical Sciences Source Type: research

Targeting Transforming Growth Factor-Beta1 (TGF-β1) Inhibits Tumorigenesis of Anaplastic Thyroid Carcinoma Cells Through ERK1/2-NFκkB-PUMA Signaling.
CONCLUSIONS Therapies targeting the TGF-β1 pathway may be more effective to prevent primary tumor formation. The ability of this therapy to decrease tumorigenesis may be related to ERK1/2/NF-κB/PUMA signaling. PMID: 27356491 [PubMed - in process]
Source: Medical Science Monitor - July 1, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Targeting TGF-β1 inhibits invasion of anaplastic thyroid carcinoma cell through SMAD2-dependent S100A4-MMP-2/9 signalling.
CONCLUSIONS: Therapies targeting the TGF-β1 inhibits invasion of ATC cells by impeding the SMAD2-dependent S100A4-MMP-2/9 signalling in vitro. PMID: 27347327 [PubMed]
Source: American Journal of Translational Research - June 29, 2016 Category: Research Tags: Am J Transl Res Source Type: research

Thyroid Hormone Receptor β (TRβ) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A novel signaling pathway in thyroid cancer.
Abstract Dysregulation of the thyroid hormone receptor β (TRβ) is common in human cancers. Restoration of functional TRβ delays tumor progression in models of thyroid and breast cancers implicating TRβ as a tumor suppressor. Conversely, aberrant expression of the runt-related transcription factor 2 (Runx2) is established in the progression and metastasis of thyroid, breast and other cancers. Silencing of Runx2 diminishes tumor invasive characteristics. With TRβ as a tumor suppressor and Runx2 as a tumor promoter, a compelling question is whether there is a functional relationship between these regulatory fact...
Source: Endocrinology - June 1, 2016 Category: Endocrinology Authors: Carr FE, Tai PW, Barnum MS, Gillis NE, Evans KG, Taber TH, White JH, Tomczak JA, Jaworski DM, Zaidi SK, Lian JB, Stein JL, Stein GS Tags: Endocrinology Source Type: research

Expression of adenine nucleotide translocase2 regulates 18F-FDG accumulation in thyroid cancer cells
Conclusions We showed that ANT2 expression is related with FDG uptake in the thyroid carcinoma cells by modulating ANT2 expression. Also we showed correlation between ANT2 expression and thyroid cancer stage. Our result suggests that the evaluation of ANT2 expression can be used as a possible prognostic marker for FDG PET positive tumor.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Lee, C.-H., Kim, M. J., Youn, H., Kang, K. W., Chung, J.-K. Tags: MTA I: Basic Science Posters Source Type: research