Filtered By:
Cancer: Thyroid Cancer

This page shows you your search results in order of date. This is page number 14.

Order by Relevance | Date

Total 208 results found since Jan 2013.

Differenttially Expressed Proteins In Human Mcf-7 Breast Cancer Cells Sensitive And Resistant To Paclitaxel.
Abstract Resistance of cancer cells to chemotherapeutic agents is one of the main causes of treatment failure. In order to detect proteins potentially involved in the mechanism of resistance to taxanes, we assessed differences in protein expression in MCF-7 breast cancer cells that are sensitive to paclitaxel and in the same cells with acquired resistance to paclitaxel (established in our lab). Proteins were separated using two-dimensional electrophoresis. Changes in their expression were determined and proteins with altered expression were identified using mass spectrometry. Changes in their expression were confi...
Source: Experimental Cell Research - December 31, 2014 Category: Cytology Authors: Pavlíková N, Bartoňová I, Balušíková K, Halada P, Kovář J Tags: Exp Cell Res Source Type: research

BRAF activates and physically interacts with PAK to regulate cell motility
In conclusion, we have identified a signaling pathway in thyroid cancer cells which BRAF activates and physically interacts with PAK and regulates cell motility.
Source: Endocrine-Related Cancer - October 15, 2014 Category: Endocrinology Authors: McCarty, S. K., Saji, M., Zhang, X., Knippler, C. M., Kirschner, L. S., Fernandez, S., Ringel, M. D. Tags: Research Source Type: research

Abstract 5570: Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasion by modulating signaling of EGFR
Conclusions: To our knowledge, this is the first report investigating the effect of LAMC2 on cell growth, cell cycle, migration, invasion and EGFR signaling in ATC cells, suggesting that LAMC2 may be a potential therapeutic target for treatment of ATC. Citation Format: Manoj Garg, Deepika Kanojia, Ryoko Okamoto, Vikas Madan, Wenwen Chien, Abhishek Sampath, Ling-Wen Ding, Meng Xuan, Jonathan W Said, Ngan Doan, Li-Zhen Liu, Henry Yang, Sigal Gery, Gleen D Braunstein, H.Phillip Koeffler. Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasi...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Garg, M., Kanojia, D., Okamoto, R., Madan, V., Chien, W., Sampath, A., Ding, L.-W., Xuan, M., Said, J. W., Doan, N., Liu, L.-Z., Yang, H., Gery, S., Braunstein, G. D., Koeffler, H. P. Tags: Clinical Research (Excluding Clinical Trials) Source Type: research

Abstract 2003: CPE-delta-N promotes metastasis by regulating Nedd9 and Yap1 expression
We report here that the carboxypeptidase E gene (CPE) is alternatively spliced in human tumors to yield an N-terminal truncated protein (CPE-DELTA-N) that drives metastasis. CPE-DELTA-N mRNA was elevated in human metastatic colon, breast and HCC cell lines. Suppression of CPE-DELTA-N expression in these cell lines by si-RNA significantly inhibited their growth migration and invasion. To confirm these observations in vivo, an orthotopic nude mouse model was established. The mice implanted with a tumor derived from HCC cells transfected with si- CPE-DELTA-N RNA in the liver did not show tumor growth or metastasis, compared t...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Murthy, S. R. K., Lee, T. K., Cawley, N. X., Hewitt, S. M., Loh, P. Y. Tags: Tumor Biology Source Type: research

The Roles of the Epithelial-Mesenchymal Transition Marker PRRX1 and MicroRNA 146b-5p in Papillary Thyroid Carcinoma Progression.
Abstract Thyroid carcinoma is the most common endocrine malignancy, and papillary thyroid carcinoma represents the most common thyroid cancer. Papillary thyroid carcinomas that invade locally or metastasize are associated with a poor prognosis. We found that, during epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1), papillary thyroid carcinoma cells acquired increased cancer stem cell-like features and the transcription factor paired-related homeobox protein 1 (PRX-1; alias PRRX1), a newly identified EMT inducer, was markedly up-regulated. miR-146b-5p was also transiently ...
Source: The American Journal of Pathology - June 16, 2014 Category: Pathology Authors: Hardin H, Guo Z, Shan W, Montemayor-Garcia C, Asioli S, Yu XM, Harrison AD, Chen H, Lloyd RV Tags: Am J Pathol Source Type: research

mTOR inhibition promotes TTF1-dependent redifferentiation and restores iodine uptake in thyroid carcinoma cell lines.
Conclusion: The present study has identified the TTF1-dependent molecular mechanisms through which inhibition of mTOR leads to redifferentiation of TC cells and subsequently to increased radioactive iodine uptake. PMID: 24712572 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - April 8, 2014 Category: Endocrinology Authors: Plantinga TS, Heinhuis B, Gerrits D, Netea MG, Joosten LA, Hermus AR, Oyen WJ, Schweppe RE, Haugen BR, Boerman OC, Smit JW, Netea-Maier RT Tags: J Clin Endocrinol Metab Source Type: research

TPX2 Overexpression in Medullary Thyroid Carcinoma Mediates TT Cell Proliferation.
Abstract TPX2 (targeting protein for xenopus kinesin-like protein 2), a microtubule-associated protein, plays an important role in the formation of the mitotic spindle. Abnormal expression of TPX2 in various types of malignant tumors has been reported, but less is known for medullary thyroid cancer (MTC). We investigated the expression of TPX2 in human MTC tissues and its potential use as a therapeutic target. Immunohistochemical analysis of TPX2 expression was performed for 32 cases of MTC and 8 cases of normal thyroid. TPX2 expression was found to be significantly higher in MTC compared to normal thyroid tissues...
Source: Pathology Oncology Research - February 1, 2014 Category: Pathology Authors: Yang X, Liu G, Xiao H, Yu F, Xiang X, Lu Y, Li W, Liu X, Li S, Shi Y Tags: Pathol Oncol Res Source Type: research

Effects of Silencing the RET/PTC1 Oncogene in Papillary Thyroid Carcinoma by siRNA-Squalene Nanoparticles With and Without Fusogenic Companion GALA-Cholesterol
Thyroid , Vol. 0, No. 0.
Source: Thyroid - January 10, 2014 Category: Endocrinology Tags: article Source Type: research

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells
Conclusions: Targeting tumors that overproduce Sec62 with calmodulin antagonists in combination with targeted thapsigargin analogues may offer novel personalized therapeutic options.
Source: BMC Cancer - December 5, 2013 Category: Cancer & Oncology Authors: Maximilian LinxweilerStefan SchorrNico SchäubleMartin JungJohannes LinxweilerFrank LangerHans-Joachim SchäfersAdolfo CavaliéRichard ZimmermannMarkus Greiner Source Type: research

Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasion by modulating signaling of EGFR.
Conclusions:To our knowledge, this is the first report investigating the effect of LAMC2 on cell growth, cell cycle, migration, invasion and EGFR signaling in ATC cells, suggesting that LAMC2 may be a potential therapeutic target for treatment of ATC. PMID: 24170107 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 29, 2013 Category: Endocrinology Authors: Garg M, Kanojia D, Okamoto R, Jain S, Madan V, Chien W, Sampath A, Ding LW, Xuan M, Said JW, Doan NB, Liu LZ, Yang H, Gery S, Braunstein GD, Koeffler HP Tags: J Clin Endocrinol Metab Source Type: research

The cross‐talk between estrogen receptor and peroxisome proliferator‐activated receptor gamma in thyroid cancer
CONCLUSIONSThis study provides evidence supporting a cross‐talk between ER and PPARγ. The reciprocal interaction between PPARγ and ERβ significantly inhibits the proliferation and migration of thyroid cancer cells, providing a new therapeutic strategy against thyroid cancer. Cancer 2013. © 2013 American Cancer Society.
Source: Cancer - October 2, 2013 Category: Cancer & Oncology Authors: Ryan Chu, Andrew Hasselt, Alexander C. Vlantis, Enders K. W. Ng, Shirley Y. W. Liu, Michael Dahua Fan, Siu Kwan Ng, Amy B. W. Chan, Zhimin Liu, Xin‐ying Li, George G. Chen Tags: Original Article Source Type: research

Aberrant Overexpression of Pyruvate Kinase M2 Is Associated with Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer.
CONCLUSIONS:We conclude that overexpression of PKM2 provides a selective growth advantage for PTC cells through activation of glycolysis. Aberrant PKM2 overexpression may serve as a novel biomarker and a potential treatment target for PTC. The BRAF mutation may contribute to alterations in the expression pattern of glycolytic enzymes such as PKM2. PMID: 23846818 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - July 11, 2013 Category: Endocrinology Authors: Feng C, Gao Y, Wang C, Yu X, Zhang W, Guan H, Shan Z, Teng W Tags: J Clin Endocrinol Metab Source Type: research

V600EBRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism
Highlights: ► BRAF depletion by siRNA decreases migration and invasion in thyroid cancer cells expressing oncogenic V600EBRAF. ► V600EBRAF inhibition by treatment with the PLX4720 inhibitor decreases migration and invasion in thyroid cancer cells. ► V600EBRAF induces cell invasion by a MEK/ERK-independent mechanism in thyroid cancer cells. ► V600EBRAF increases Snail expression with a concomitant decrease of its target E-cadherin.Abstract: BRAF is a main oncogene in human thyroid cancer. Here, we show that BRAF depletion by siRNA or inhibition of its activity by treatment with BRAF inhibitor PLX4720 decreases migra...
Source: Cancer Letters - March 14, 2013 Category: Cancer & Oncology Authors: Pablo Baquero, Irene Sánchez-Hernández, Eva Jiménez-Mora, Jose L. Orgaz, Benilde Jiménez, Antonio Chiloeches Tags: Research Articles Source Type: research