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Cancer: Thyroid Cancer

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Total 208 results found since Jan 2013.

Cancers, Vol. 13, Pages 185: Prognostic Value and Function of KLF5 in Papillary Thyroid Cancer
Khawla S. Al-Kuraya The Krüppel-like factor 5 (KLF5), a zinc-finger transcriptional factor, is highly expressed in several solid tumors, but its role in PTC remains unclear. We investigated the expression of KLF5 protein in a large cohort of PTC patient samples and explored its functional role and mechanism in PTC cell lines in vitro and in vivo. KLF5 overexpression was observed in 65.1% of all PTC cases and it was significantly associated with aggressive clinico-pathological parameters and poor outcome. Given the significant association between KLF5 and HIF-1α overexpression in PTC patients,...
Source: Cancers - January 7, 2021 Category: Cancer & Oncology Authors: Poyil Pratheeshkumar Abdul K. Siraj Sasidharan Padmaja Divya Sandeep Kumar Parvathareddy Sarah Siraj Roxanne Diaz Rafia Begum Saif S. Al-Sobhi Fouad Al-Dayel Khawla S. Al-Kuraya Tags: Article Source Type: research

DPP4 gene silencing inhibits proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through suppression of the MAPK pathway
ConclusionCollectively, the present study demonstrated that DPP4 gene silencing inhibits PTC cell proliferation and EMT and promotes cell apoptosis via suppression of the MAPK pathway, thus highlighting a possible regulatory pathway in PTC progression.
Source: Journal of Endocrinological Investigation - January 2, 2021 Category: Endocrinology Source Type: research

Cancers, Vol. 12, Pages 3159: Roles of Non-Coding RNAs on Anaplastic Thyroid Carcinomas
ed K. Lam Anaplastic thyroid cancer (ATC) remains as one of the most aggressive human carcinomas with poor survival rates in patients with the cancer despite therapeutic interventions. Novel targeted and personalized therapies could solve the puzzle of poor survival rates of patients with ATC. In this review, we discuss the role of non-coding RNAs in the regulation of gene expression in ATC as well as how the changes in their expression could potentially reshape the characteristics of ATCs. A broad range of miRNA, such as miR-205, miR-19a, miR-17-3p and miR-17-5p, miR-618, miR-20a, miR-155, etc., have abnormal expressi...
Source: Cancers - October 28, 2020 Category: Cancer & Oncology Authors: Plabon Kumar Das Saharia Yeasmin Asha Ichiro Abe Farhadul Islam Alfred K. Lam Tags: Review Source Type: research

Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway.
CONCLUSIONS: The expression of linc00324 is significantly increased in PTC tissues and cells. Silencing linc00324 may inhibit the proliferation of PTC cells, arrest the cell cycle in G1/G0 phase, and promote the apoptosis by inhibiting the Notch signaling pathway. PMID: 32633374 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling.
Abstract It is of great significance to explore the molecular mechanism of thyroid cancer (TC) pathogenesis for its improvement and therapy. Growth factor receptor bound protein-7 (GRB7) has been regarded as an important regulatory gene in the developments of various malignant tumors. Our study aimed to illustrate the role of GRB7 in the TC pathology mechanism. Firstly, GRB7 was found to be significantly upregulated in 49 cases of TC tissues and 5 TC cell lines by using real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting. Silencing GRB7 with siRNA dramatically inhibited proliferation an...
Source: Molecular and Cellular Biochemistry - June 22, 2020 Category: Biochemistry Authors: Tang H, Yang P, Yang X, Peng S, Hu X, Bao G Tags: Mol Cell Biochem Source Type: research

Circular RNA circ_0103552 promotes the invasion and migration of thyroid carcinoma cells by sponging miR-127.
CONCLUSIONS: The present study demonstrated that circ-0103552 acts as a regulator in the invasion and migration of TC by sponging miR-127. PMID: 32196608 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - March 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway
Conclusion: Our data suggest that apatinib can induce apoptosis and autophagy via the PI3K/Akt/mTOR signaling pathway for the treatment of PTC and that autophagy is a potential novel target for future therapy in resistant PTC.
Source: Frontiers in Oncology - March 10, 2020 Category: Cancer & Oncology Source Type: research

EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF- β signals.
EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF-β signals. Oncol Res. 2020 Mar 05;: Authors: Huang Y, Zhu Q, Lu L, Sun S, Hao F, Zhang J, Liu Z, Miao Y, Jiao X, Chen D Abstract Anaplastic thyroid carcinoma (ATC) are resistant to standard therapies and has no effective treatment. Eukaryotic translation initiation factor 5A2 (EIF5A2) has shown to be upregulated inmany malignant tumors and proposed to be a critical gene involved in tumor metastasis. In thisstudy, we aim to investigate the expression status of EIF5A2 in human ATC tissues, an...
Source: Oncology Research - March 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

GSE145077 Transcriptome analysis of CHI3L1 silencing in thyroid cancer cells
Contributor : Shih-Ping ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCHI3L1 (Chitinase-3-like protein 1), also known as YKL-40, has been associated with inflammation and cancer. Transcription profiling analysis was performed in FTC-133 thyroid cancer cells transfected with control siRNA or siRNAs against CHI3L1.
Source: GEO: Gene Expression Omnibus - February 12, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

PTPN11 Knockdown Prevents Changes in the Expression of Genes Controlling Cell Cycle, Chemotherapy Resistance, and Oncogene-Induced Senescence in Human Thyroid Cells Overexpressing BRAF V600E Oncogenic Protein
AbstractThe MAPK (RAS/BRAF/MEK/ERK) signaling pathway is a kinase cascade involved in the regulation of cell proliferation, differentiation, and survival in response to external stimuli. The V600E mutation in theBRAF gene has been detected in various tumors, resulting in a 500-fold increase in BRAF kinase activity. However, monotherapy with selective BRAF V600E inhibitors often leads to reactivation of MAPK signaling cascade and emergence of drug resistance. Therefore, new targets are being developed for the inhibition of components of the aberrantly activated cascade. It was recently discovered that resistance to BRAF V60...
Source: Biochemistry (Moscow) - December 31, 2019 Category: Biochemistry Source Type: research

GSE134694 Expression data of BCPAP cells with LRRC34 knockdown
Contributors : Daniel F Comiskey ; Albert de la ChapelleSeries Type : Expression profiling by arrayOrganism : Homo sapiensA recent genome-wide association study (GWAS) in thyroid cancer discovered 3q26 as one of five loci implicated in thyroid cancer predisposition. The tag SNP, rs6793295, is located in exon 7 of LRRC34. However, there are genetically distinct, but population-specific signals upstream of LRRC34 that demonstrate allele-specific expression. In order to reveal the regulatory gene network of LRRC34 in thyroid cells, microarray analysis was performed in the BCPAP cell line treated with siRNA against LRRC34.
Source: GEO: Gene Expression Omnibus - December 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Integrated analysis identifies DUSP5 as a novel prognostic indicator for thyroid follicular carcinoma
ConclusionDUSP5 was differentially expressed in FTC and PTC tissues. Low level of DUSP5 in FTC participates in the high frequency of metastasis, and further contributes to poor prognosis of FTC. DUSP5 could be served as a novel therapeutic target for FTC.
Source: Thoracic Cancer - December 9, 2019 Category: Cancer & Oncology Authors: Qian Zhang, Yiqian Xing, Shan Jiang, Chunmei Xu, Xiaojun Zhou, Rui Zhang, Tianyue Xie, Zhiwei Zou, Piyun Gong, Huangao Zhu, Dongmei Zhang, Huimei Ma, Lin Liao, Jianjun Dong Tags: ORIGINAL ARTICLE Source Type: research

GSE100322 Whole transcriptome sequencing of the human thyroid primary cells with knock-down of the NRG1 gene
This study reveals a novel role of NRG1 in downstream gene regulation and provides a new explanation of NRG1 ’s function in thyroid cancer.
Source: GEO: Gene Expression Omnibus - June 19, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Genistein inhibits human papillary thyroid cancer cell detachment, invasion and metastasis
In conclusion, for the first time, our study suggested that genistein has anticarcinoma effect for PTC patients in the range of 2.5 and 80 μg/ml in thyroid carcinoma cells, which was probably through cytoplasmic translocation of β-catenin. Further study will be needed to determine whether genistein could be used in clinical trial of high-risk PTC.
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chunyan Zhang, Bin Lv, Cuihua Yi, Xiujie Cui, Shaofeng Sui, Xueen Li, Mei Qi, Chunyan Hao, Bo Han, Zhiyan Liu Tags: Research Paper Source Type: research

The prognostic potential of alpha-1 type I collagen expression in papillary thyroid cancer.
Abstract The present study aimed to identify the expression of key mRNAs as prognostic factors for papillary thyroid cancer (PTC) using integrated bioinformatic analyses and in vitro assays. Using mRNA sequencing data from The Cancer Genome Atlas, we found that alpha-1 type I collagen (COL1A1), an extracellular matrix protein, was significantly overexpressed in PTC, and its expression was correlated with a lower probability of disease-free survival and clinical characteristics of PTC patients by applying Kaplan-Meier curves and logistic regression analysis. Furthermore, we performed in vitro assays, including ce...
Source: Biochemical and Biophysical Research communications - May 21, 2019 Category: Biochemistry Authors: Huang C, Yang X, Han L, Fan Z, Liu B, Zhang C, Lu T Tags: Biochem Biophys Res Commun Source Type: research