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Cancer: Thyroid Cancer

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Total 208 results found since Jan 2013.

TGFβ induces epithelial‐mesenchymal transition of thyroid cancer cells by both the BRAF/MEK/ERK and Src/FAK pathways
The epithelial‐mesenchymal transition (EMT) is a crucial process in tumour progression, by which epithelial cells acquire a mesenchymal phenotype, increasing its motility and the ability to invade distant sites. Here, we describe the molecular mechanisms by which V600EBRAF, TGFβ and the Src/FAK complex cooperatively regulate EMT induction and cell motility of anaplastic thyroid cancer cells. Analysis of EMT marker levels reveals a positive correlation between TGFβ and Snail expression, with a concomitant downregulation of E‐cadherin, accompanied by an increase of cell migration and invasion. Furthermore, we show that...
Source: Molecular Carcinogenesis - September 22, 2015 Category: Molecular Biology Authors: Pablo Baquero, Eva Jiménez‐Mora, Adrián Santos, Marina Lasa, Antonio Chiloeches Tags: Research Article Source Type: research

TGF β induces epithelial‐mesenchymal transition of thyroid cancer cells by both the BRAF/MEK/ERK and Src/FAK pathways
The epithelial‐mesenchymal transition (EMT) is a crucial process in tumour progression, by which epithelial cells acquire a mesenchymal phenotype, increasing its motility and the ability to invade distant sites. Here, we describe the molecular mechanisms by which V600EBRAF, TGFβ and the Src/FAK complex cooperatively regulate EMT induction and cell motility of anaplastic thyroid cancer cells. Analysis of EMT marker levels reveals a positive correlation between TGFβ and Snail expression, with a concomitant downregulation of E‐cadherin, accompanied by an increase of cell migration and invasion. Furthermore, we show that...
Source: Molecular Carcinogenesis - September 20, 2015 Category: Molecular Biology Authors: Pablo Baquero, Eva Jim énez‐Mora, Adrián Santos, Marina Lasa, Antonio Chiloeches Tags: Article Source Type: research

miR-584 Suppresses Invasion and Cell Migration of Thyroid Carcinoma by Regulating the Target Oncogene ROCK1
Conclusion: These results indicate that miR-584 could inhibit the expression of ROCK1, and ROCK1 knockdown would further affect the migration ability of K1 cells.Oncol Res Treat 2015;38:436-440
Source: Oncology Research and Treatment - September 7, 2015 Category: Cancer & Oncology Source Type: research

The impact of CLAUDIN-1 on follicular thyroid carcinoma aggressiveness
CLAUDIN-1 belongs to the family of transmembrane tight junction proteins tightening the paracellular cleft of epithelial cells. In human malignancies, CLAUDIN-1 is often dysregulated and located in subcellular compartments, particularly in the nucleus where it may influence cellular behaviour. Here, we studied CLAUDIN-1 in relation to the biological characteristics of follicular thyroid carcinoma (FTC). CLAUDIN-1 immuno-staining showed loss of membrane expression and increased nuclear CLAUDIN-1 localization in FTC metastases. CLAUDIN-1 function was further investigated in two different follicular thyroid carcinoma cell lin...
Source: Endocrine-Related Cancer - September 1, 2015 Category: Endocrinology Authors: Zwanziger, D., Badziong, J., Ting, S., Moeller, L. C., Schmid, K. W., Siebolts, U., Wickenhauser, C., Dralle, H., Fuehrer, D. Tags: Research Source Type: research

Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73
Conclusion Association of NO with NSAID exhibited amplified anti-tumoral effects on in vitro and in vivo MTC models by inducing p73-dependent apoptotic cell death.
Source: Thyroid Research - August 14, 2015 Category: Endocrinology Source Type: research

Abstract 1371: Systems biology analysis to identify biomarkers for lenvatinib in the preclinical cancer cell line panels
Objectives: Lenvatinib mesilate (lenvatinib) is the selective inhibitor of VEGFR1-3, and other proangiogenic and oncogenic pathway-related RTKs including fibroblast growth factor receptors (FGFR1-4), the platelet-derived growth factor receptor (PDGFR) α, KIT, and RET. Lenvatinib have been tested in several clinical trials, such as thyroid cancer and hepatocellular carcinoma in Ph3, but biomarkers to predict lenvatinib activity were not established. We performed a preclinical systems biology approach to identify biomarkers predictive of lenvatinib sensitivity in endometrial cell lines.Methods: We performed gene expression ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Dezso, Z., Ino, M., Minoshima, Y., Tohyama, O., Sugi, N. H., Agoulnik, S., Oda, Y., Funahashi, Y. Tags: Tumor Biology Source Type: research

Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
Abstract T-box genes regulate development processes, some of these genes having also a role in cell proliferation and survival. TBX15 is a T-box transcription factor that, recently, has been proposed as a marker in prostate cancer, but its function in carcinogenesis is unknown. Here the role of TBX15 in carcinogenesis was investigated using thyroid cancer cell lines. First, using western blot analysis, we show that the expression of TBX15 was altered in thyroid cancer cells lines with respect to normal thyroid cells. Transfection of thyroid cancer cells with TBX15, in the presence or absence of camptothecin as...
Source: Apoptosis - July 28, 2015 Category: Molecular Biology Source Type: research

Silencing GPX3 Expression Promotes Tumor Metastasis in Human Thyroid Cancer.
In conclusion, GPX3 is frequently methylated in human papillary thyroid cancer and the expression of GPX3 was regulated by promoter region methylation. Methylation of GPX3 is related to tumor size and lymph node metastasis. Metastasis of thyroid cancer was suppressed by GPX3 through inhibition Wnt/β-catenin signaling. PMID: 25929866 [PubMed - in process]
Source: Current Protein and Peptide Science - May 3, 2015 Category: Biochemistry Authors: Zhao H, Li J, Li X, Han C, Zhang Y, Zheng L, Guo M Tags: Curr Protein Pept Sci Source Type: research

Trefoil Factor 3 as a Novel Biomarker to Distinguish Between Adenocarcinoma and Squamous Cell Carcinoma
In conclusion, TFF3 is preferentially expressed in adenocarcinoma and may function as an additional biomarker for distinguishing adenocarcinoma from squamous cell carcinoma.
Source: Medicine - May 1, 2015 Category: Internal Medicine Tags: Article: Observational Study Source Type: research

Involvement of cysteine‐rich protein 61 in the epidermal growth factor‐induced migration of human anaplastic thyroid cancer cells
In this study, we found that EGF treatment induced cell migration, stress fiber formation, Cyr61 mRNA and protein expressions, and Cyr61 protein secretion in ATC cells. The recombinant Cyr61 protein significantly induced cell migration; however, inhibition of Cyr61 activity by a Cyr61‐specific antibody abrogated EGF‐induced cell migration. EGF treatment also affected epithelial‐to‐mesenchymal transition (EMT)‐related marker protein expression, as evidenced by an increase in vimentin and a decrease in E‐cadherin expression. Inhibition of Cyr61 expression by Cyr61 siRNA decreased cell migration and reversed the E...
Source: Molecular Carcinogenesis - March 14, 2015 Category: Molecular Biology Authors: Li‐Han Chin, Sung‐Po Hsu, Wen‐Bin Zhong, Yu‐Chih Liang Tags: Research Article Source Type: research

MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells
In conclusion, MMP2 and MMP9 participate in S1P-evoked follicular ML-1 thyroid cancer cell invasion.
Source: Molecular and Cellular Endocrinology - March 10, 2015 Category: Endocrinology Source Type: research

RAGE mediates the pro-migratory response of extracellular S100A4 in human thyroid cancer cells.
Conclusion: Our data have identified the RAGE/ -DIA-1 signaling system as a mediator for the pro-migratory response of extracellular S100A4 in human thyroid cancer. Thus, therapeutic targeting of the RAGE/DIA-1/small GTPases signaling may successfully reduce local invasion and metastasis in thyroid cancer. PMID: 25744544 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - March 7, 2015 Category: Endocrinology Tags: Thyroid Source Type: research

Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment Research Communication
This study provides the first evidence that LPA increases antioxidant gene and multidrug-resistant transporter expression. Blocking this aspect of LPA signaling provides a novel strategy for improving chemotherapy.—Venkatraman, G., Benesch, M. G. K., Tang, X., Dewald, J., McMullen, T. P. W., Brindley, D. N. Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment.
Source: FASEB Journal - March 2, 2015 Category: Biology Authors: Venkatraman, G., Benesch, M. G. K., Tang, X., Dewald, J., McMullen, T. P. W., Brindley, D. N. Tags: Research Communication Source Type: research

Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15
Conclusions This report clearly demonstrates the mechanism of resistance to FAK autophosphorylation inhibitor and the mechanism to overcome it that is important for developing FAK-targeted therapy approaches.
Source: Journal of Cancer Research and Clinical Oncology - February 5, 2015 Category: Cancer & Oncology Source Type: research

Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo.
Authors: Liu J, Dong BF, Wang PS, Ren PY, Xue S, Zhang XΝ, Han Z, Chen G Abstract Doxorubicin (DOX), a broad‑spectrum anthra-cyclin, is in wide clinical use for the treatment and prevention of thyroid cancer. However, the effectiveness of the treatment remains limited due to inherent tumor resistance to DOX. Results of a previous study demonstrated that downregulation of NIN1/RPN12 binding protein 1 homolog (NOB1) expression via adenovirus expression vector carrying NOB1 siRNA (Ad/sh-NOB1) induced cancer apoptosis and increased the radiosensitivity of papillary thyroid carcinoma (PTC) cells. However, whether kn...
Source: Oncology Reports - January 21, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research