RAGE mediates the pro-migratory response of extracellular S100A4 in human thyroid cancer cells.

Conclusion: Our data have identified the RAGE/ -DIA-1 signaling system as a mediator for the pro-migratory response of extracellular S100A4 in human thyroid cancer. Thus, therapeutic targeting of the RAGE/DIA-1/small GTPases signaling may successfully reduce local invasion and metastasis in thyroid cancer. PMID: 25744544 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research