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Cancer: Thyroid Cancer
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Total 208 results found since Jan 2013.
miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro
This study was designed to investigate the relationship between miR-4443 and TRIM14 on metastasis and energy metabolism in PTC and the underlying mechanisms. To this end, human PTC cells (SW1736 and MZ-CRC-1) were transfected with a miR-4443 mimic or miR-4443 inhibitor + siRNA-TRIM14, and then dual luciferase assay, Transwell, Seahorse, and Western blot were performed to assess the function of miR-4443 and the underlying mechanism. We found that ectopic expression of miR-4443 inhibited PTC cell migration, invasion, ATP production, and aerobic glycolysis, while inhibition of miR-4443 had the opposite effect. miR-4443 direct...
Source: Cell Biology International - May 29, 2021 Category: Cytology Authors: Xiao-Ming Zuo Hai-Wen Sun Hong Fang Yun Wu Qun Shi Yi-Fan Yu Source Type: research
Effects of RNA interference of CTHRC1 on proliferation and apoptosis of thyroid papillary cancer TCP-1 cells < em > in vitro < /em >
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Apr 20;41(4):549-554. doi: 10.12122/j.issn.1673-4254.2021.04.10.ABSTRACTOBJECTIVE: To explore the role of CTHRC1 in regulating the proliferation and apoptosis of papillary thyroid cancer cells.OBJECTIVE: Papillary thyroid cancer TPC-1 cells were transfected with a small interfering RNA (siRNA) targeting CTHRC1, with the cells transfected with a scrambled sequence as the negative control. The changes in cell proliferation and apoptosis were assessed using cell counting kit-8 (CCK-8) and flow cytometry with AV/PI double staining, respectively. The expression of c-caspase-3, c-PARP1 and pho...
Source: Journal of Southern Medical University - May 8, 2021 Category: Universities & Medical Training Authors: Z Tang X Ding S Qin C Zhang Source Type: research
