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Cancer: Thyroid Cancer

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Total 208 results found since Jan 2013.

Regulation of NADPH oxidase NOX4 by delta iodolactone (IL- δ) in thyroid cancer cells
Conclusions The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context. Graphical abstract
Source: Molecular and Cellular Endocrinology - May 27, 2018 Category: Endocrinology Source Type: research

Effects of RNAi Silencing CITED1 Gene on Biological Function of Thyroid Carcinoma Cell Line K1
Conclusions: CITED1 gene may affect the occurrence and development of thyroid papillary cancer by promoting tumor cell proliferation and migration,and inhibiting apoptosis. Key words: CITED1, K1, RNAi, apoptosis, proliferation
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Pang, H. Tags: Educational Exhibits Source Type: research

IL13R & alpha;2 siRNA inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion in papillary thyroid carcinoma cells
Source: OncoTargets and Therapy - March 8, 2018 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Long Non-coding RNA Linc-ROR Is Upregulated in Papillary Thyroid Carcinoma
AbstractLong non-coding RNAs (lncRNAs) may contribute to carcinogenesis and tumor progression by regulating transcription and gene expression. The role of lncRNAs in the regulation of thyroid cancer progression is being extensively examined. Here, we analyzed three lncRNAs that were overexpressed in papillary thyroid carcinomas, long intergenic non-protein coding RNA, regulator of reprogramming (Linc-ROR, ROR) PVT1 oncogene (PVT1), and HOX transcript antisense intergenic RNA (HOTAIR) to determine their roles in thyroid tumor development and progression. ROR expression has not been previously examined in thyroid carcinomas....
Source: Endocrine Pathology - December 26, 2017 Category: Pathology Source Type: research

The role of NRG1 in the predisposition to papillary thyroid carcinoma.
Conclusions: Our data suggest a role for transcriptional regulation of NRG1 in the predisposition to PTC. PMID: 29121253 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - November 7, 2017 Category: Endocrinology Authors: He H, Li W, Liyanarachchi S, Wang Y, Yu L, Genutis LK, Maharry S, Phay JE, Shen R, Brock P, de la Chapelle A Tags: J Clin Endocrinol Metab Source Type: research

The Impact of Cysteine-Rich Intestinal Protein 1 (CRIP1) on Thyroid Carcinoma
Conclusion: In conclusion, CRIP1 acts as an oncogene in the cell proliferation, migration, and invasion processes of thyroid carcinoma. CRIP1 may serve well as an independent prognostic marker with significant predictive power for use in thyroid carcinoma therapy.Cell Physiol Biochem 2017;43:2037 –2046
Source: Cellular Physiology and Biochemistry - October 25, 2017 Category: Cytology Source Type: research

miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma.
Authors: Qiu Z, Li H, Wang J, Sun C Abstract The present study investigated the relationship between the expression of miR-146a and miR‑146b with the occurrence and prognosis of papillary thyroid carcinoma. Experiments in vitro were also used to explore the effect of the knocked down expression of the miRNAs on growth and migration of papillary thyroid carcinoma cells. A total of 73 patients with papillary thyroid carcinoma admitted to Yidu Central Hospital of Weifang from September 2013 to September 2015 were enrolled in the study. Carcinoma samples were obtained from each patient, and adjacent tissues were use...
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Neurotrophin Receptors TrkA, p75(NTR), and Sortilin are Increased and Targetable in Thyroid Cancer.
Abstract Neurotrophin receptors are emerging targets in oncology, but their clinicopathological significance in thyroid cancer is unclear. Here, the neurotrophin tyrosine receptor kinase TrkA (also called NTRK1), the common neurotrophin receptor p75(NTR), and the pro-neurotrophin receptor sortilin were analyzed by immunohistochemistry in a cohort of thyroid cancers (n=128), and compared with adenomas and normal thyroid tissues (n=62). TrkA was detected in 20% of thyroid cancers, compared with none of the benign samples (P = 0.0007). TrkA expression was independent of histological subtypes but associated with lymph...
Source: The American Journal of Pathology - October 13, 2017 Category: Pathology Authors: Faulkner S, Jobling P, Rowe C, Rodriguez-Oliveira S, Roselli S, Thorne R, Oldmeadow C, Attia J, Jiang CC, Zhang XD, Walker MM, Hondermarck H Tags: Am J Pathol Source Type: research

Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells
Thyroid carcinoma is generally associated with good prognosis, but no effective treatments are currently available for aggressive forms not cured by standard therapy. To find novel therapeutic targets for this tumor type, we had previously performed a siRNA-based functional screening to identify genes essential for sustaining the oncogenic phenotype of thyroid tumor cells, but not required to the same extent for the viability of normal cells (non-oncogene addiction paradigm). Among those, we found the coatomer protein complex ζ1 (COPZ1) gene, which is involved in intracellular traffic, autophagy and lipid homeostasis.
Source: Cancer Letters - September 23, 2017 Category: Cancer & Oncology Authors: Chiara Anania Maria, Elena Cetti, Daniele Lecis, Katia Todoerti, Alessandro Gulino, Giuseppe Mauro, Tiziana Di Marco, Loredana Cleris, Sonia Pagliardini, Giacomo Manenti, Beatrice Belmonte, Claudio Tripodo, Antonino Neri, Angela Greco Source Type: research

A potential role for the Hippo pathway protein, YAP, in controlling proliferation, cell cycle progression, and autophagy in BCPAP and KI thyroid papillary carcinoma cells.
CONCLUSIONS: In papillary thyroid cancer YAP protein expression is positively correlated with the extent of TNM stage and positive lymph node metastasis. In thyroid cancer cell lines YAP appears to be important in stimulating cell proliferation while inhibiting autophagy. PMID: 28804541 [PubMed]
Source: American Journal of Translational Research - August 15, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Role of Adenine Nucleotide Translocase2 on the 18F-FDG uptake and differentiation in cancer
Conclusion: ANT2 expression correlated with FDG uptake in the various cancer cell lines. Higher level of ANT2 expression was observed in dedifferentiated cancer, and this indicates that ANT2 can be used as a marker of malignancy in various cancer. Research Support:
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Lee, C.-H., Youn, H., Kim, M. J., Chai, Y. J., Cho, S. W., Kang, K. W., Chung, J.-K. Tags: Radiochemistry: Imaging of Cancer Source Type: research

MiR-221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma
MiR-221 is frequently upregulated in papillary thyroid cancer (PTC) tissues and cell lines, and this study was designed to validate the association of miR-221 with PTC proliferation, apoptosis, and migration. We observed that miR-221 suppressed TIMP3 expression by binding to 3′ untranslated region of TIMP3 mRNA, and TIMP3 expression was increased with the presence of miR-221 inhibitors; TIMP3 siRNA could reverse the effects of miR-221 inhibitors on PTC cells. The results indicated that miR-221 exacerbated PTC by downregulating the expression of TIMP3. The effects of miR-221 and TIMP3 in vivo were also confirmed by human ...
Source: American Journal of Therapeutics - May 1, 2017 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research

Runt ‐related transcription factor 2 (Runx2) is responsible for galectin‐3 overexpression in human thyroid carcinoma
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - April 11, 2017 Category: Biochemistry Authors: Engin Kaptan, Serap Sancar Bas, Aylin Sancakli, Hatice Gumushan Aktas, Bertan Boran Bayrak, Refiye Yanardag, Sehnaz Bolkent Tags: Article Source Type: research

Targeting TGF- β1 suppresses survival of and invasion by anaplastic thyroid carcinoma cells.
CONCLUSIONS: Targeting TGF-β1 may be effective in inhibiting primary tumor formation, but not metastasis, by ATC cells. TGF-β1 inhibition in combination with other tumor-targeted therapies may be more effective in inhibiting ATC. PMID: 28386367 [PubMed]
Source: American Journal of Translational Research - April 9, 2017 Category: Research Tags: Am J Transl Res Source Type: research