mTOR inhibition promotes TTF1-dependent redifferentiation and restores iodine uptake in thyroid carcinoma cell lines.

Conclusion: The present study has identified the TTF1-dependent molecular mechanisms through which inhibition of mTOR leads to redifferentiation of TC cells and subsequently to increased radioactive iodine uptake.
PMID: 24712572 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - April 8, 2014 Category: Endocrinology Authors: Plantinga TS, Heinhuis B, Gerrits D, Netea MG, Joosten LA, Hermus AR, Oyen WJ, Schweppe RE, Haugen BR, Boerman OC, Smit JW, Netea-Maier RT Tags: J Clin Endocrinol Metab Source Type: research