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Cancer: Adenocarcinoma

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Total 766 results found since Jan 2013.

CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D
CONCLUSIONS: CircPRKCI is significantly highly expressed in LUAD, and the highly expressed circPRKCI is capable of facilitating LUAD cell migration, proliferation and cycle. CircPRKCI may regulate the malignant phenotype of LUAD via the miR-219a-5p/CAMK1D axis.PMID:33660800 | DOI:10.26355/eurrev_202102_25085
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: M-H Sui W-W Zhang D-M Geng D-J Sun Source Type: research

Anaplastic lymphoma kinase inhibitor NVP ‑TAE684 suppresses the proliferation of human pancreatic adenocarcinoma cells
In conclusion, the findings of the present study indicated that NVP‑TAE684 exerted its antitumor effects by inducing G2/M arrest and apoptosis via the inhibition of the ALK signaling pathway, and suggests its potential use as an antitumor agent against pancreatic adenocarcinoma.PMID:33649854 | DOI:10.3892/or.2021.7979
Source: Oncology Reports - March 2, 2021 Category: Cancer & Oncology Authors: Hong-Quan Duong Van Thai Than Huyen-Trang Nguyen Phuong-Thoa Nguyen Huyen Trang Ha Thi Thi Ngoc Ha Bui Vu Phuong Linh Dang Thi-Thanh Dinh Kyu Sic You The-Hung Dang Yeon-Sun Seong Source Type: research

GSE167590 SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer
We report 93 differentially expressed (DE) genes, with convergence on alterations to Notch-signaling pathways and ciliogenesis. These results point to SOX9 and Notch activity being in a positive feedback loop; and, SOX9 regulating cilia production in PDAC. We additionally performed ChIP-seq in PANC-1 cells to identify direct targets of SOX9 binding and integrated these results with our DE gene list. Nine of the top ten downregulated genes have evidence of direct SOX9 binding at their promoter regions.  One of these targets was the cancer stem cell marker EpCAM. Using whole-mount in situ hybridization to detect epcam ...
Source: GEO: Gene Expression Omnibus - February 27, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma 
A549 and H1395 Cells
Background and objective Cullin1 is a representative member of the Cullin family, and it plays an important role in the ubiquitination of cell cycle, transcription and signal transduction related proteins. Cullin1 is closely related to the occurrence and development of a variety of malignant tumors. The aim of this study is to investigate the effects of Cullin1 on biological function of lung adenocarcinoma A549 and H1395 Cells. Methods The expression of Cullin1 mRNA was detected by quantitative Real-time polymerase chain reaction in lung adenocarcinoma cells (A549, H358, H1395, H1650) and human normal lung epithelial cells...
Source: Chinese Journal of Lung Cancer - February 24, 2021 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 13, Pages 922: Detection of Tumor-Associated Membrane Receptors on Extracellular Vesicles from Non-Small Cell Lung Cancer Patients via Immuno-PCR
Eriksson Karlström Precision cancer medicine for non-small-cell lung cancer (NSCLC) has increased patient survival. Nevertheless, targeted agents towards tumor-associated membrane receptors only result in partial remission for a limited time, calling for approaches which allow longitudinal treatment monitoring. Rebiopsy of tumors in the lung is challenging, and metastatic lesions may have heterogeneous signaling. One way ahead is to use liquid biopsies such as circulating tumor DNA or small extracellular vesicles (sEVs) secreted by the tumor into blood or other body fluids. Herein, an immuno-PCR-based detection of the...
Source: Cancers - February 22, 2021 Category: Cancer & Oncology Authors: Christiane Stiller Kristina Viktorsson Elizabeth Paz Gomero Petra H ååg Vasiliki Arapi Vitaliy O. Kaminskyy Caroline Kamali Luigi De Petris Simon Ekman Rolf Lewensohn Amelie Eriksson Karlstr öm Tags: Article Source Type: research

Cancers, Vol. 13, Pages 827: Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and its Target APOBEC3G and Thereby Pancreatic Cancer Progression
We examined whether sulforaphane interferes with lncRNA signaling and analyzed five PDAC and two nonmalignant cell lines, patient tissues (n = 30), and online patient data (n = 350). RT-qPCR, Western blotting, MTT, colony formation, transwell and wound healing assays; gene array analysis; bioinformatics; in situ hybridization; immunohistochemistry and xenotransplantation were used. Sulforaphane regulated the expression of all of five examined lncRNAs, but basal expression, biological function and inhibition of H19 were of highest significance. H19 siRNA prevented colony formation, migration, invasion and Smad2 phosphorylat...
Source: Cancers - February 16, 2021 Category: Cancer & Oncology Authors: Yiqiao Luo Bin Yan Li Liu Libo Yin Huihui Ji Xuefeng An Jury Gladkich Zhimin Qi Carolina De La Torre Ingrid Herr Tags: Article Source Type: research

Cancers, Vol. 13, Pages 739: Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells
This study aimed at understanding the effect of metformin on histone H3 methylation, DNA methylation, and chromatin accessibility in lung cancer cells. Metformin significantly reduced H3K4me3 level at the promoters of positive cell cycle regulatory genes such as CCNB2, CDK1, CDK6, and E2F8. Eighty-eight genes involved in cell cycle showed reduced H3K4me3 levels in response to metformin, and 27% of them showed mRNA downregulation. Metformin suppressed the expression of H3K4 methyltransferases MLL1, MLL2, and WDR82. The siRNA-mediated knockdown of MLL2 significantly downregulated global H3K4me3 level and inhibited lung cance...
Source: Cancers - February 10, 2021 Category: Cancer & Oncology Authors: Dongho Kim Yujin Kim Bo Bin Lee Eun Yoon Cho Joungho Han Young Mog Shim Duk-Hwan Kim Tags: Article Source Type: research

Role of DACH1 on proliferation, invasion, and apoptosis in human lung adenocarcinoma cells.
CONCLUSION: DACH1 is downregulated in lung adenocarcinoma tissue. In vitro assessment shows that DACH1 functions as a tumor suppressor, suggesting its potential use as new target for lung cancer treatment. PMID: 33463463 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - January 18, 2021 Category: Molecular Biology Authors: Yu J, Jiang P, Zhao K, Chen Z, Zuo T, Chen B Tags: Curr Mol Med Source Type: research

Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer
Conclusion: This approach provides a new therapeutic avenue to improve the antitumor efficacy of PDAC therapies by normalizing tumor stroma using the PCBP2 siRNA nanocomplex.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yuanke Li, Zhen Zhao, Chien-Yu Lin, Yanli Liu, Kevin F. Staveley-OCarroll, Guangfu Li, Kun Cheng Tags: Research Paper Source Type: research

Deregulation of a Cis-Acting lncRNA in Non-small Cell Lung Cancer May Control HMGA1 Expression
ConclusionOur results suggest that HMGA1-lnc is a novel cis-acting lncRNA that negatively regulates HMGA1 gene expression in lung cells. Further characterization of this regulatory mechanism may advance our understanding of the maintenance of lung cancer phenotypes and uncover a novel therapeutic intervention point for tumors driven by HMGA1.
Source: Frontiers in Genetics - January 11, 2021 Category: Genetics & Stem Cells Source Type: research

Cancers, Vol. 13, Pages 208: Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican
rner Seeger Rajkumar Savai Transcription factors can serve as links between tumor microenvironment signaling and oncogenesis. Interferon regulatory factor 9 (IRF9) is recruited and expressed upon interferon stimulation and is dependent on cofactors that exert in tumor-suppressing or oncogenic functions via the JAK-STAT pathway. IRF9 is frequently overexpressed in human lung cancer and is associated with decreased patient survival; however, the underlying mechanisms remain to be elucidated. Here, we used stably transduced lung adenocarcinoma cell lines (A549 and A427) to overexpress or knockdown IRF9. Overexpression l...
Source: Cancers - January 8, 2021 Category: Cancer & Oncology Authors: David Brunn Kati Turkowski Stefan G ünther Andreas Weigert Thomas Muley Mark Kriegsmann Hauke Winter Reinhard H. Dammann Georgios T. Stathopoulos Michael Thomas Andreas Guenther Friedrich Grimminger Soni S. Pullamsetti Werner Seeger Rajkumar Savai Tags: Article Source Type: research

LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
Conclusions: Our findings reveal that MALAT1 may regulate EMT, proliferation, and migration of LECs as a ceRNA by "sponging" miR-204-5p and targeting Smad4, and serve as a promising therapeutic target in preventing PCO. PMID: 33327804 [PubMed - as supplied by publisher]
Source: Current Eye Research - December 17, 2020 Category: Opthalmology Authors: Peng C, Wang Y, Ji L, Kuang L, Yu Z, Li H, Zhang J, Zhao J Tags: Curr Eye Res Source Type: research