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Cancer: Adenocarcinoma

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Total 766 results found since Jan 2013.

Molecular insights into the microtubules depolymerizing activity of the IL-8 receptor B antagonist SB225002
CONCLUSIONS: Findings of the present study warrants further development of SB225002 as a lead compound that uniquely targets microtubules dynamics and IL-8 signaling.PMID:35647855 | DOI:10.26355/eurrev_202205_28869
Source: European Review for Medical and Pharmacological Sciences - June 1, 2022 Category: Drugs & Pharmacology Authors: A E Goda T Sakai Source Type: research

Cancers, Vol. 14, Pages 2584: Inhibition of HDAC and Signal Transduction Pathways Induces Tight Junctions and Promotes Differentiation in p63-Positive Salivary Duct Adenocarcinoma
Conclusions: p63 is not only a diagnostic marker of salivary gland neoplasia, but it also promotes the malignancy. Inhibition of HDAC and signal transduction pathways is, therefore, useful in therapy for p63-positive SDC cells.
Source: Cancers - May 24, 2022 Category: Cancer & Oncology Authors: Masaya Nakano Kizuku Ohwada Yuma Shindo Takumi Konno Takayuki Kohno Shin Kikuchi Mitsuhiro Tsujiwaki Daichi Ishii Soshi Nishida Takuya Kakuki Kazufumi Obata Ryo Miyata Makoto Kurose Atsushi Kondoh Kenichi Takano Takashi Kojima Tags: Article Source Type: research

Cancers, Vol. 14, Pages 2543: Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma
ipathi Hiroyuki Katayama Luisa Maren Solis Soto Jaime Rodriguez-Canales Carmen Behrens Ignacio Wistuba Samir Hanash Edwin J. Ostrin Activation of the NRF2 pathway through gain-of-function mutations or loss-of-function of its suppressor KEAP1 is a frequent finding in lung cancer. NRF2 activation has been reported to alter the tumor microenvironment. Here, we demonstrated that NRF2 alters tryptophan metabolism through the kynurenine pathway that is associated with a tumor-promoting, immune suppressed microenvironment. Specifically, proteomic profiles of 47 lung adenocarcinoma (LUAD) cell lines (11 KEAP1 mut...
Source: Cancers - May 21, 2022 Category: Cancer & Oncology Authors: Johannes F. Fahrmann Ichidai Tanaka Ehsan Irajizad Xiangying Mao Jennifer B. Dennison Eunice Murage Julian Casabar Jeffrey Mayo Qian Peng Muge Celiktas Jody V. Vykoukal Soyoung Park Ayumu Taguchi Oliver Delgado Satyendra C. Tripathi Hiroyuki Katayama Luis Tags: Article Source Type: research

Annotation and functional characterization of long noncoding RNAs deregulated in pancreatic adenocarcinoma
ConclusionsOur study expands the repertoire of lncRNAs deregulated in PDAC, thereby revealing novel candidate biomarkers for patient risk stratification. It also provides a roadmap for functional assays aimed to characterize novel mechanisms of action of lncRNAs in pancreatic cancer, which could be explored for therapeutic development.
Source: Cellular Oncology - May 14, 2022 Category: Cancer & Oncology Source Type: research

Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway
Exp Cell Res. 2022 Apr 26:113179. doi: 10.1016/j.yexcr.2022.113179. Online ahead of print.ABSTRACTRab22a, a member of the proto-oncogene RAS family, belongs to the Rab5 subfamily. It participates in early endosome formation and regulates vesicle trafficking. The relationship between Rab22a and tumorigenesis remains elusive. In non-small cell lung cancer specimens, immunohistochemical staining showed consistently high expression of Rab22a in lung adenocarcinoma, but not in squamous cell carcinoma. In lung adenocarcinoma cell lines, A549 and H1299, transfection with Rab22a significantly promoted cell proliferation, migration...
Source: Experimental Cell Research - April 29, 2022 Category: Cytology Authors: Jinping Wang Xue Luo Jinxi Lu Xi Wang Yuan Miao Qingchang Li Liang Wang Source Type: research

Metformin Regulates TET2 Expression to Inhibit Endometrial Carcinoma Proliferation: A New Mechanism
ConclusionsTET2 may play an important role in EC development and may be a prognostic marker. Moreover, TET2 may be involved in a novel mechanism by which metformin inhibits EC cell proliferation.
Source: Frontiers in Oncology - April 11, 2022 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 14, Pages 1848: HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms
Jonathan R. Brody Human Antigen R (HuR/ELAVL1) is known to regulate stability of mRNAs involved in pancreatic ductal adenocarcinoma (PDAC) cell survival. Although several HuR targets are established, it is likely that many remain currently unknown. Here, we identified BARD1 mRNA as a novel target of HuR. Silencing HuR caused a >70% decrease in homologous recombination repair (HRR) efficiency as measured by the double-strand break repair (pDR-GFP reporter) assay. HuR-bound mRNAs extracted from RNP-immunoprecipitation and probed on a microarray, revealed a subset of HRR genes as putative HuR targets, including...
Source: Cancers - April 6, 2022 Category: Cancer & Oncology Authors: Aditi Jain Matthew McCoy Carolyn Coats Samantha Z. Brown Sankar Addya Carl Pelz Rosalie C. Sears Charles J. Yeo Jonathan R. Brody Tags: Article Source Type: research

Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study
Oncol Lett. 2022 May;23(5):144. doi: 10.3892/ol.2022.13264. Epub 2022 Mar 11.ABSTRACTNon-small cell lung cancer (NSCLC) is one of the leading causes of cancer-associated mortality. Lung adenocarcinoma (LAC) is the most prevalent pathological subtype of NSCLC and accounts for ~40% of all lung cancer mortalities. There remains an urgent demand for the identification of novel biomarkers for the diagnosis and development of therapeutic strategies for LAC. In the present study, the profiles of the differentially-expressed circular RNAs (circRNAs) in LAC tissues compared with those in their corresponding non-cancerous tissues we...
Source: Oncology Letters - March 28, 2022 Category: Cancer & Oncology Authors: Yonggang Zhu Feng Cao Fei Liu Sihua Liu Lingjiao Meng Lina Gu Hanjun Zhao Meixiang Sang Baoen Shan Source Type: research