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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
Expression of kinesin family member C1 in pancreatic ductal adenocarcinoma affects tumor progression and stemness
This study aimed to analyze the expression and biological function of KIFC1 in PDAC. Immunohistochemically, KIFC1 was found in 37 of 81 PDAC cases (46%). A high expression of KIFC1 was significantly related to tumor size (p = 0.023) and poor overall survival (p = 0.011). Univariate and multivariate analysis indicated that KIFC1 expression was a prognostic factor in PDAC cases. As for cancer stem cell markers, KIFC1 expression tended to co-express significantly with CD44 (p < 0.01). The growth and spheroid colony formation of KIFC1 small interfering RNA (siRNA)-transfected PDAC cells were significantly lower than those o...
Source: Cancer Control - December 24, 2022 Category: Cancer & Oncology Authors: Akira Ishikawa Hiroki Fujii Takafumi Fukui Aya Kido Narutaka Katsuya Kazuhiro Sentani Kazuya Kuraoka Sho Tazuma Takeshi Sudo Masahiro Serikawa Shiro Oka Naohide Oue Source Type: research
Targeting regulation of VEGF by BPTF in non-small cell lung cancer and its potential clinical significance
ConclusionsBPTF positively regulates VEGF expression and its high expression predicts a better efficacy of bevacizumab treatment in NSCLC.
Source: European Journal of Medical Research - December 19, 2022 Category: Research Source Type: research
Activating transcription factor 4 regulates hypoxia inducible factor 1 α in chronic hypoxia in pancreatic cancer cells
Oncol Rep. 2023 Jan;49(1):14. doi: 10.3892/or.2022.8451. Epub 2022 Nov 23.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates hypoxia-inducible factors (HIFs) that mediate cellular responses to adapt to low oxygen environments. Hypoxia also causes endoplasmic reticulum (ER) stress, increasing activating transcription factor 4 (ATF4), a master regulator of the unfolded protein response (UPR) pathway that mediates cellular response to ER stress. ATF4 is overexpressed in PDAC and is assoc...
Source: Oncology Reports - November 23, 2022 Category: Cancer & Oncology Authors: Nancy T Chee Candace H Carriere Zachary Miller Scott Welford Shaun P Brothers Source Type: research
Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47
J Clin Invest. 2022 Nov 22:e153470. doi: 10.1172/JCI153470. Online ahead of print.ABSTRACTKRAS is one of the most frequently activated oncogenes in human cancers. While the role of KRAS mutation in tumorigenesis and tumor maintenance has been extensively studied, the relationship between KRAS and the tumor immune microenvironment is not fully understood. Herein, we identified a novel role of KRAS in driving tumor evasion from innate immune surveillance. In lung adenocarcinoma patient samples and Kras-driven genetic mouse models of lung cancer, mutant KRAS activated the expression of cluster of differentiation 47 (CD47), an...
Source: Clinical Lung Cancer - November 22, 2022 Category: Cancer & Oncology Authors: Huanhuan Hu Rongjie Cheng Yanbo Wang Xiaojun Wang Jianzhuang Wu Yan Kong Shoubin Zhan Zhen Zhou Hongyu Zhu Ranran Yu Gaoli Liang Qingyan Wang Xiaoju Zhu Chen-Yu Zhang Rong Yin Chao Yan Xi Chen Source Type: research
Involvement of a AS3MT/c-Fos/p53 signaling axis in arsenic-induced tumor in human lung cells
In this study, we showed that AS3MT protein expression was higher in the arsenic-exposed population compared to the unexposed population. AS3MT was also overexpressed in human lung adenocarcinoma (A549) and human bronchial epithelial (16HBE) cells exposed to arsenic (A549: 20-60 μmol/L; 16HBE: 2-6 μmol/L) for 48 h. Furthermore, we investigated the effects of AS3MT on cell proliferation and apoptosis using siRNA. The downregulation of AS3MT inhibited the proliferation and promoted the apoptosis of cells. Mechanistically, AS3MT was found to specifically bind to c-Fos, thereby inhibiting the binding of c-Fos to c-Jun. Addit...
Source: Cancer Control - November 18, 2022 Category: Cancer & Oncology Authors: Mingjun Sun Huirong Cheng Tianle Yu Jingwen Tan Ming Li Qian Chen Yun Gu Chenglan Jiang Shuting Li Yuefeng He Weihua Wen Source Type: research
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma
Matrix Biol. 2022 Nov 11:S0945-053X(22)00134-2. doi: 10.1016/j.matbio.2022.11.002. Online ahead of print.ABSTRACTSeveral collagen subtypes are involved in pancreatic ductal adenocarcinoma (PDAC) desmoplasia, which constrains therapeutic efficacy. We evaluated collagen type VIII alpha 1 chain (COL8A1), whose function in PDAC is currently unknown. We identified COL8A1 expression in 7 examined PDAC cell lines by microarray analysis, western blotting, and RT‒qPCR. Higher COL8A1 expression occurred in 2 gemcitabine-resistant PDAC cell lines; pancreas tissue (n=15) from LSL-KrasG12D/+; Pdx-1-Cre mice with advanced PDAC predisp...
Source: Matrix Biology - November 14, 2022 Category: Molecular Biology Authors: Bin Yan Li Liu Lian Zhao Ulf Hinz Yiqiao Luo Xuefeng An Jury Gladkich Carolina de la Torre Zhenhua Huang Daniel Schrapel Wolfgang Gross Franco Fortunato Michael Sch äfer Matthias M Gaida Ingrid Herr Source Type: research
