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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line
This study aimed to investigate the pathophysiological functions of ET-2 in A549 human lung adenocarcinoma cells. We analyzed the expression of ET-2 mRNA in lung adenocarcinoma tissues compared to that in non-tumor lung tissues using public online databases. The function of ET-2 in A549 cells was investigated using siRNA. ET-2 mRNA level was upregulated in lung adenocarcinoma tissues, and high ET-2 level was associated with poor overall survival in patients with lung adenocarcinoma. ET-2 silencing reduced the proliferation, migration, invasion, and enhanced apoptosis in A549 cells. Mechanistically, ET-2 silencing reduced t...
Source: Canadian Journal of Physiology and Pharmacology - June 9, 2022 Category: Drugs & Pharmacology Authors: Ratih Paramita Suprapto Yoko Suzuki Tatsuya Nagano Ken-Ichi Hirata Noriaki Emoto Source Type: research
Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/ β-catenin signaling pathway in lung adenocarcinoma
CONCLUSIONS: Our data reveal the oncogenic role of JAML in LUAD, indicating that JAML may be a predictive biomarker and novel therapeutic target for LUAD.PMID:35672776 | DOI:10.1186/s12967-022-03457-w
Source: Cancer Control - June 7, 2022 Category: Cancer & Oncology Authors: Qian Wu Rui Li Qing-Xiang Wang Meng-Yu Zhang Ting-Ting Liu Yi-Qing Qu Source Type: research
Molecular insights into the microtubules depolymerizing activity of the IL-8 receptor B antagonist SB225002
CONCLUSIONS: Findings of the present study warrants further development of SB225002 as a lead compound that uniquely targets microtubules dynamics and IL-8 signaling.PMID:35647855 | DOI:10.26355/eurrev_202205_28869
Source: Pharmacological Reviews - June 1, 2022 Category: Drugs & Pharmacology Authors: A E Goda T Sakai Source Type: research
