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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study
Oncol Lett. 2022 May;23(5):144. doi: 10.3892/ol.2022.13264. Epub 2022 Mar 11.ABSTRACTNon-small cell lung cancer (NSCLC) is one of the leading causes of cancer-associated mortality. Lung adenocarcinoma (LAC) is the most prevalent pathological subtype of NSCLC and accounts for ~40% of all lung cancer mortalities. There remains an urgent demand for the identification of novel biomarkers for the diagnosis and development of therapeutic strategies for LAC. In the present study, the profiles of the differentially-expressed circular RNAs (circRNAs) in LAC tissues compared with those in their corresponding non-cancerous tissues we...
Source: Oncology Letters - March 28, 2022 Category: Cancer & Oncology Authors: Yonggang Zhu Feng Cao Fei Liu Sihua Liu Lingjiao Meng Lina Gu Hanjun Zhao Meixiang Sang Baoen Shan Source Type: research
Knockdown of FLT4, Nup98, and Nup205 cellular genes effectively suppresses the reproduction of influenza virus strain A/WSN/1933 (H1N1) in vitro
CONCLUSION: We identified a number of genes such as FLT4, Nup98, and Nup205, the decrease in the expression of which can effectively suppress viral reproduction. The original siRNA sequences were also obtained. These results are important for the creation of therapeutic and prophylactic agents, whose action is based on the RNA interference mechanism.PMID:35339191 | DOI:10.2174/1871526522666220325121403
Source: Infectious Disorders Drug Targets - March 27, 2022 Category: Infectious Diseases Authors: Evgeny Pashkov Ekaterina Korchevaya Evgeny Faizuloev Artem Rtishchev Bogdan Cherepovich Elizaveta Bystritskaya Alexander Sidorov Alexander Poddubikov Anatoly Bykov Yuliya Dronina Oxana Svitich Vitaliy Zverev Source Type: research
Hypoxic induction of apoptosis occurs through HIF-1 α and accompanies mammalian sterile 20-like kinase 2 cleavage in human endometrial adenocarcinoma Ishikawa cells
Biochem Biophys Res Commun. 2022 Mar 4;604:104-108. doi: 10.1016/j.bbrc.2022.03.016. Online ahead of print.ABSTRACTThe incidence of endometrial cancer is increasing worldwide. One of the main causes of this cancer is a hormone imbalance; progesterone derivatives have been used for treatment. However, reports have shown that hypoxia plays important and possibly beneficial roles in endometrial function. Here, we show the effect of hypoxia on the proliferation of human endometrial adenocarcinoma Ishikawa cells. Hypoxia induced caspase-dependent apoptosis in Ishikawa cells. Overexpression and siRNA-mediated knockdown of hypoxi...
Source: Cell Research - March 18, 2022 Category: Cytology Authors: Jeonggeun Lee Namkyu Lee Hee Dong Han YoungJoo Lee Source Type: research
LncRNA RP3-326I13.1 promotes cisplatin resistance in lung adenocarcinoma by binding to HSP90B and upregulating MMP13
In conclusion, RP3-326I13.1 could promote DDP-resistance of LAD by binding to HSP90B and upregulating human matrix metalloproteinase-13 (MMP-13) and may serve as a therapeutic target, as well as a biomarker for predicting DDP-resistance in LAD.Abbreviations:DDP: Cisplatin; LAD: Lung adenocarcinoma; LncRNAs: Long non-coding RNAs; qPCR: real-time fluorescent quantitative PCR; HSP90B: Heat shock protein HSP 90-beta; RPMI: Roswell Park Memorial Institute; FBS: Fetal bovine serum; CT: computed tomography; MRI: magnetic resonance imaging; RECIST: Response evaluation criteria in solid tumors; NC: Negative control; OE: overexpress...
Source: Cancer Control - March 17, 2022 Category: Cancer & Oncology Authors: Huixin Zhou Xiaolu Huang Wenjing Shi Shihao Xu Jie Chen Kate Huang Yumin Wang Source Type: research
Lucidone inhibits autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt signaling pathway in pancreatic cancer cells
Phytother Res. 2022 Feb 28. doi: 10.1002/ptr.7385. Online ahead of print.ABSTRACTGemcitabine (GEM) drug resistance remains a difficult challenge in pancreatic ductal adenocarcinoma (PDAC) treatment. Therefore, identifying a safe and effective treatment strategy for PDAC is urgent. Lucidone is a natural compound extracted from the fruits of Lindera erythrocarpa Makino. However, the role of lucidone in PDAC inhibition remains unclear. In addition, high-mobility group box 1 (HMGB1) and receptor for advanced glycation end products (RAGE) are involved in multidrug resistance protein 1 (MDR1) regulation and GEM resistance. Thus,...
Source: Cell Research - February 28, 2022 Category: Cytology Authors: Sheng-Yi Chen Yi-Hao Hsu Sheng-Yang Wang Ying-Yin Chen Cheng-Jie Hong Gow-Chin Yen Source Type: research
Dexmedetomidine inhibits the growth and metastasis of esophageal cancer cells by down-regulation of lncRNA MALAT1
This study aims to evaluate the effect of dexmedetomidine (DEX)-on esophageal cancer (EC) via regulating long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). The effect of DEX on MALAT1 expression and EC cell viability was detected. EC cells were divided into Blank, DEX, scrambled/MALAT1 siRNA, and DEX + control/MALAT1 groups, followed by a series of experiments including quantitative reverse-transcription polymerase chain reaction (qRT-PCR), western blotting, 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT), Annexin V-FITC/PI staining, wound healing, and Transwell...
Source: Cancer Control - February 24, 2022 Category: Cancer & Oncology Authors: Wei Zhang Li Zhang Xiao-Jun Cai Dong Li Feng-Jun Cao Zhi-Gang Zuo Ying Song Xiong-Jie Yu Shan Liu Source Type: research
Transcriptomic and functional studies reveal miR-431-5p as a tumour suppressor in pancreatic ductal adenocarcinoma cells
Gene. 2022 Feb 16:146346. doi: 10.1016/j.gene.2022.146346. Online ahead of print.ABSTRACTThe lactate receptor HCAR1 (hydroxycarboxylic acid receptor 1) is highly expressed in pancreatic ductal adenocarcinoma (PDAC), where it regulates lactate transport between the cancer cells. Little is known about the underlying cause of high HCAR1 expression in PDAC, and in the present study, we investigated whether HCAR1 could be a target of miRNA regulation. By searching for predicted miRNA candidates in silico, we identified miR-431-5p as a possible regulator of HCAR1. We found miR-431-5p to repress HCAR1 expression through direct bi...
Source: Gene - February 19, 2022 Category: Genetics & Stem Cells Authors: Oyvind P Haugen Cuong Khuu Hanne M Weidemann Tor Paaske Utheim Linda Hildegard Bergersen Source Type: research
Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis
CONCLUSION: Circ_0072088 elicited oncogenic role in malignant cell progression and glycolysis of PDAC cells through circ_0072088/miR-545-3p/SLC7A11 pathway.HighlightsCirc_0072088 was upregulated in PDAC tumours and was associated with high tumour burden.Blocking circ_0072088 suppressed cell proliferation, migration, invasion, and glycolysis in PDAC cells.Circ_0072088 could directly regulate miR-545-3p, and SLC7A11 was a target of miR-545-3p.Restoring miR-545-3p mimicked the effects of circ_0072088 knockdown in PDAC cell in vitro.PMID:35166634 | DOI:10.1080/08916934.2022.2027919
Source: Autoimmunity - February 15, 2022 Category: Allergy & Immunology Authors: Hui Sun Fang Liu Hongqing Zhang Source Type: research
