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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
Thymidine phosphorylase induction by ionizing radiation antagonizes 5-fluorouracil resistance in human ductal pancreatic adenocarcinoma
Radiat Environ Biophys. 2022 Jan 27. doi: 10.1007/s00411-022-00962-w. Online ahead of print.ABSTRACTChemoresistance in pancreatic ductal adenocarcinoma (PDAC) frequently contributes to failure of systemic therapy. While the radiosensitizing properties of 5-fluorouracil (FU) are well known, it is unknown whether ionizing radiation (IR) sensitizes towards FU cytotoxicity. Here, we hypothesize that upregulation of thymidine phosphorylase (TP) by IR reverses FU chemoresistance in PDAC cells. The FU resistant variant of the human PDAC cell line AsPC-1 (FU-R) was used to determine the sensitizing effects of IR. Proliferation rat...
Source: Radiation and Environmental Biophysics - January 27, 2022 Category: Physics Authors: Lucas D Lee Ioannis Pozios Verena Liu Silke B Nachbichler Dirk B öhmer Carsten Kamphues Katharina Beyer Christiane J Bruns Martin E Kreis Hendrik Seeliger Source Type: research
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury though the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression
This study aimed to elucidate the roles and possible mechanism of MALAT1 in myocardial IR injury. IR model was established in rats by ligation of the anterior descending artery in vivo, and H9c2 and HL-1 cells were treated by hypoxia/reoxygenation (HR) to construct the model in vitro. The small interfering RNA (siRNA) for MALAT1 and miR-133a-3p mimics, inhibitor was used to transfect the cells. The expression of MALAT1, miR-133a-3p in MIRI were evaluated using real-time quantitative polymerase chain reaction (qRT-PCR)，immunohistochemistry (IHC) and western blot (WB). Relationships between MALAT1, insulin-like growth fact...
Source: European Journal of Pharmacology - December 30, 2021 Category: Drugs & Pharmacology Authors: Xin-Ming Liu Zhenzhou Zhang Jiuchang Zhong Ning Li Tao Wang Lefeng Wang Qian Zhang Source Type: research
Exosomes derived from immunogenically dying tumor cells as a versatile tool for vaccination against pancreatic cancer
Biomaterials. 2021 Dec 2;280:121306. doi: 10.1016/j.biomaterials.2021.121306. Online ahead of print.ABSTRACTDespite tremendous progress achieved in immunotherapy, many critical challenges in treating pancreatic ductal adenocarcinoma (PDAC) persist. Considering the poor vascularization of PDAC, after intramuscular administration exosomes can targeted deliver "cargos" to pancreatic tumors and bypass obstructions of the intrinsic overexpressed stroma through lymphatics. Herein, we propose a strategy to derive exosomes from immunogenically dying tumor cells and exploit their properties for several purposes, including antigen p...
Source: Biomaterials - December 24, 2021 Category: Materials Science Authors: Wenxi Zhou Xinli Chen Yu Zhou Si Shi Chen Liang Xianjun Yu Hongyi Chen Qin Guo Yiwen Zhang Peixin Liu Chao Li Yongchao Chu Yifan Luo Yu Wang Zheng Zhou Zhenhao Zhao Qinjun Chen Tao Sun Chen Jiang Source Type: research
LncRNA NFYC-AS1 promotes the development of lung adenocarcinomas through autophagy, apoptosis, and MET/c-Myc oncogenic proteins
CONCLUSIONS: In summary, the above results suggest that NFYC-AS1 may promote the proliferation of LAUD through autophagy and apoptosis.PMID:34926665 | PMC:PMC8640918 | DOI:10.21037/atm-21-4995
Source: Cancer Control - December 20, 2021 Category: Cancer & Oncology Authors: Ye Song Jike Du Pinglan Lu Qingfeng Zou Shaoting Zeng Meiyuan Liu Xiaoye Hu Wen Ma Hanhong Lin Xiaoyan Liu Feiyu Niu Source Type: research
Girdin influences pancreatic cancer progression by regulating c-MYC expression
In this study, we observed that the expression of Girdin was upregulated in pancreatic cancer cells. The siRNA-mediated gene knockdown experiments showed that reduced expression of Girdin in pancreatic cancer cells inhibited cell proliferation, migration, and invasion, while promoting cell apoptosis. Functional assays revealed that c-MYC overexpression in pancreatic cancer cells could significantly increase the cell proliferation ability and rates of cell migration and invasion, while decreasing the apoptosis rate. It has been shown that phosphorylation plays a role in the functional regulation of the c-MYC gene. Subsequen...
Source: Neoplasma - November 15, 2021 Category: Cancer & Oncology Authors: Na Shan Le-Yi Ni Yue-Sheng Zhu Yao Shen Ze-Jun Gao Zhen-Zhai Cai Source Type: research
