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LncRNA MNX1-AS1 contributes to lung adenocarcinoma progression by targeting the miR-34a/SIRT1 axis
Am J Transl Res. 2022 Jul 15;14(7):4977-4989. eCollection 2022.ABSTRACTLncRNA MNX1-AS1 is known to be involved in progression of several tumor types. However, few studies have investigated the molecular mechanism of MNX1-AS1 in lung adenocarcinoma (LAC). To explore the function of MNX1-AS1 in the pathogenesis of LAC, qRT-PCR was performed to show MNX1-AS1 expression. MNX1-AS1 expression in LAC cells was suppressed by siRNA to detect the biologic behavior. The relationships among miR-34a, MNX1-AS1 and SIRT1 were confirmed by pull-down and dual-luciferase reporter assay. Whether MNX1-AS1 was involved in LAC by targeting miR-...
Source: American Journal of Translational Research - August 12, 2022 Category: Research Authors: Gaofeng Liu Yong Zhang Xiaozhen Zhang Yan Liu Yanbin Xu Sujuan Cui Gang Li Jianjun Wang Source Type: research
