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Cancer: Adenocarcinoma
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Total 766 results found since Jan 2013.
Girdin influences pancreatic cancer progression by regulating c-MYC expression
In this study, we observed that the expression of Girdin was upregulated in pancreatic cancer cells. The siRNA-mediated gene knockdown experiments showed that reduced expression of Girdin in pancreatic cancer cells inhibited cell proliferation, migration, and invasion, while promoting cell apoptosis. Functional assays revealed that c-MYC overexpression in pancreatic cancer cells could significantly increase the cell proliferation ability and rates of cell migration and invasion, while decreasing the apoptosis rate. It has been shown that phosphorylation plays a role in the functional regulation of the c-MYC gene. Subsequen...
Source: Neoplasma - November 15, 2021 Category: Cancer & Oncology Authors: Na Shan Le-Yi Ni Yue-Sheng Zhu Yao Shen Ze-Jun Gao Zhen-Zhai Cai Source Type: research
Identification and Validation of a Proliferation-Associated Score Model Predicting Survival in Lung Adenocarcinomas
CONCLUSION: The proposed score model may function as a promising risk prediction tool for patients with lung adenocarcinoma and provide insights into the molecular regulation mechanism of lung adenocarcinoma.PMID:34721732 | PMC:PMC8554523 | DOI:10.1155/2021/3219594
Source: Disease Markers - November 1, 2021 Category: Laboratory Medicine Authors: Yunyi Bian Qihai Sui Guoshu Bi Yuansheng Zheng Mengnan Zhao Guangyu Yao Liang Xue Yi Zhang Hong Fan Source Type: research
SPTBN2, a New Biomarker of Lung Adenocarcinoma
ConclusionWe uncovered a novel gene, SPTBN2, that was significantly upregulated in LUAD tissues relative to normal tissue expression. SPTBN2 is highly expressed in LUAD, positively correlated with poor prognosis, and can promote the proliferation, migration, and invasion of LUAD cells.
Source: Frontiers in Oncology - October 20, 2021 Category: Cancer & Oncology Source Type: research
Influence of Autophagy Inhibition on Lung Adenocarcinoma Cell Migration and Invasion Ability, and Efficacy of Gefitinib
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211049000. doi: 10.1177/15330338211049000.ABSTRACTAn increasing number of studies have emphasized the role of autophagy in cancer cell metastasis and treatment of malignant tumors. Autophagy inhibitors have been widely used in combination therapies to treat advanced malignancies. Several lung adenocarcinoma cells harbor epidermal growth factor receptor (EGFR) gene mutations, and EGFR tyrosine kinase inhibitors (TKIs) are routinely used in the treatment of lung adenocarcinoma. However, a number of lung adenocarcinoma tumors do not respond or develop resistance to EGFR TKIs. ...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Ying Liu Yun Du Source Type: research
High-throughput Single-cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma
Angew Chem Int Ed Engl. 2021 Sep 10. doi: 10.1002/anie.202107223. Online ahead of print.ABSTRACTEven populations of clonal cells are heterogeneous, which requires high-throughput analysis methods with single-cell sensitivity. Here, we propose a rapid, label-free single-cell analytical method based on active capillary dielectric barrier discharge ionization mass spectrometry, which can analyze multiple metabolites in single cells at a rate of 38 cells/minute. Multiple cell types (HEK-293T, PANC-1, CFPAC-1, H6c7, HeLa and iBAs) were discriminated successfully. We found that abnormal lipid metabolism occurs in pancreatic canc...
Source: Angewandte Chemie - September 10, 2021 Category: Chemistry Authors: Qinlei Liu Wenjie Ge Tongtong Wang Jiayi Lan Sandra Mart ínez-Jarquín Christian Wolfrum Markus Stoffel Renato Zenobi Source Type: research
TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer
CONCLUSION: TrkB/BDNF signaling may be a new therapeutic target for PDAC. Therapies targeting TrkB/BDNF signaling may be a conclusive cancer therapy for refractory solid cancer.PMID:34281873 | DOI:10.21873/anticanres.15205
Source: Cell Research - July 20, 2021 Category: Cytology Authors: Yasuhiro Oyama Shinjiro Nagao Lin Na Kosuke Yanai Masayo Umebayashi Katsuya Nakamura Shuntaro Nagai Akiko Fujimura Akio Yamasaki Kazunori Nakayama Takashi Morisaki Hideya Onishi Source Type: research
P3H4 Overexpression Serves as a Prognostic Factor in Lung Adenocarcinoma
CONCLUSION: The present study systematically evaluated the functional and clinical values of P3H4 in LUAD, and explored the related biological pathways. P3H4 might promote LUAD progression through regulating tumor microenvironment-related pathways.PMID:34257701 | PMC:PMC8249155 | DOI:10.1155/2021/9971353
Source: Computational and Mathematical Methods in Medicine - July 14, 2021 Category: Statistics Authors: Xiangfeng Jin Haiqing Zhou Jianfang Song Hong Cui Yiren Luo Haiping Jiang Source Type: research
