Survival in Lung Cancer among Female Never-smokers in Rural Xuanwei 
and Fuyuan Counties in Eastern Yunnan Province, China
This study investigated the survival of lung cancer patients among female never-smokers. Methods The female never-smokers, who had lived for many years in Xuanwei and Fuyuan counties, with lung cancer newly-diagnosed between July 2006 to March 2010, were followed up through the end of 2016. Age-standardized relative survival for all cases was calculated using local life table. The Kaplan-Meier method and Log-rank test were used to analyze the relationship between the variables and the prognosis in univariate analysis. Cox regression analysis was employed in the multivariate analysis. Results Among 1,250 total subjects, 1,0...
Source: Chinese Journal of Lung Cancer - August 27, 2019 Category: Cancer & Oncology Source Type: research

Use of Ommaya Reservoirs to Deliver Pemetrexed in Leptomeningeal Metastasis from Non-small Cell Lung Cancer: A Case Report and Review of the Literature
We report a case of LM from NSCLC, who received the intrathecal chemotherapy with pemetrexed by Ommaya reservoir after prior targeted therapies. This local treatment improved the quality of life, and obtained the clearing of CSF cytology and stable lesions of LM without any notable side effects. After confirmation of LM, the patient has survived 17 months until now. Here we report the first case to demonstrate the potential effectiveness of intrathecal pemetrexed by Ommaya reservoir for the treatment of LM of NSCLC, summarize the safety and effectiveness of intrathecal chemotherapy in combination with related literatures, ...
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Immunotherapy in Epidermal Growth Factor Receptor-mutant 
Non-small Cell Lung Cancer
Targeted therapy and immunotherapy are important treatments for non-small cell lung cancer (NSCLC). At present, the clinical and basic research of epidermal growth factor receptor (EGFR) mutation NSCLC is still in the exploratory stage, needing to optimize the efficacy, combination, sequence and dosage of immunotherapy and other treatments, to clarify the relationship between EGFR mutation, immune microenvironment and the efficacy of immunotherapy. In this review, we summarized the newly updated data about immunotherapy in EGFR mutant NSCLC in term of pre-clinical study, programmed cell death protein ligand 1 (PD-L1) expre...
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Advances in the Study of the Effects of Video-assisted Thoracoscopic Segmentectomy 
on Pulmonary Function
This article focuses on the research progress of pulmonary function changes in NSCLC patients after video-assisted thoracoscopic segmentectomy. 
 DOI: 10.3779/j.issn.1009-3419.2019.08.10 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Role of Circular RNA in Diagnosis, Development and Durg Resistance of Lung Cancer
The mortality rate of lung cancer has been high all over the world. In recent years, targeted drugs have become a new and effective method for the treatment of advanced lung cancer, but the early diagnosis and long-term effective treatment are still great challenges in lung cancer. Circular RNA (circRNA) is a unique RNA molecule with ring structure, which exhibits excellent stability and expression specificity. Increasing studies found that the expression of several circRNAs in tumors were abnormal. This abnormal expression is not only related to malignancy of tumors, but also involved in regulating the progress of tumors,...
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

A Review on Comparison of Lobectomy and Segmentectomy in the Treatment of 
Early Stage Non-small Cell Lung Cancer
Lung cancer is a worldwide malignancy with high morbidity and mortality in the world. With the application of low-dose spiral computed tomography in the screening and diagnosis of lung cancer, more lung cancers are detected at an early stage and cured by surgical treatment. Anatomical lobectomy has long been the standard procedure for the treatment of early stage non-small cell lung cancer. However, whether intentional segmentectomy can be more used remains controversial. And this paper focuses on the question. 
 DOI: 10.3779/j.issn.1009-3419.2019.08.08 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Advances in Lymph Node Metastasis and Lymph Node Dissection 
in Early Non-small Cell Lung Cancer
Lung cancer is the malignant tumor with the highest morbidity and mortality in China. Non-small cell lung cancer is the main pathological type. Lymph node metastasis is the most common and primary metastatic pathway in non-small cell lung cancer. Acknowledged as the major factor determining tumor staging and prognosis. Unfortunately, it's presently hard to make an accurate preoperative judgment on the lymph node metastasis of early stage non-small cell lung cancer. Consequently, there has been a long-standing controversy on lymph node sweeping for early stage non-small cell lung cancer, especially for those clinical stage ...
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Basis of Tumor Microenvironment Relevant to Immunotherapies for Brain Metastases of NSCLC
Brain is the most frequent site for distant metastases of non-small cell lung cancer (NSCLC). Brain metastasis (BM) is also the leading cause of disabilities and death in advanced NSCLC. In recent years, the application and effectiveness of small-molecule tyrosine kinase inhibitors has formed the basis for the treatment of NSCLC brain metastases with driver gene mutations. With the development of programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) inhibitors and relevant combination therapies, immunotherapy has become an important choice for non-classic oncogene addicted NSCLC BM patients....
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation Patients
Conclusion NSCLC-NED is different from simple NSCLC or pulmonary neuroendocrine tumors. Males, ≤70 years old, severely smoking, and patients with lower tumor differentiation often have NED, and most of them are stage IV. This type of patient-driven gene positive proportion is lower than the general adenocarcinoma population, less sensitive to chemotherapy, and the overall survival is shorte r, indicating a poor prognosis.
 DOI: 10.3779/j.issn.1009-3419.2019.08.05 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Clinical Characteristics and Prognosis of Sub-centimeter Lung Adenocarcinoma
This study analyzed the clinical characteristics and prognosis of patients with sub-centimeter lung adenocarcinoma in orde r to provide the basis for the diagnosis and treatment of such patients. Methods A retrospective study was performed to analyze patients with sub-centimeter lung adenocarcinoma who underwent VATS in Peking University People’s Hospital from January 2012 to December 2016. Patients were divided into pure ground-glass nodules (pGGN) group, mixed ground-glass nodules (mGGN) group and solid nodules (SN) group according to the features of nodular imaging. The clinical characteristics of the three groups...
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Surgical Resection and Prognosis of Bronchopulmonary Carcinoid
Background and objective Bronchopulmonary carcinoid (BPC) is a rare neuroendocrine tumor, the clinical studies on treatment and prognostic factors of BPC are somewhat controversial. Our purpose was to evaluate the clinical efficacy of surgery on BPC, and to analyze the prognostic factors affecting the survival of BPC. Methods We retrospectively collected the clinical data of patients with BPC admitted to the Chinese PLA General Hospital between January 2000 and December 2017. The Kaplan-Meier method was used to calculate the survival rate of patients and to map the survival curve. Then the effects of different factors like...
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Efficacy and Safety of Crizotinib in Advanced or Recurrent 
ALK-positive Non-small Cell Lung Cancer
Conclusion Crizotinib can be used for the treatment of advanced NSCLC with ALK fusion/translocation. It is highly effective and well tolerated. 
 DOI: 10.3779/j.issn.1009-3419.2019.08.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 20, 2019 Category: Cancer & Oncology Source Type: research

Research Progress of Pulmonary Epithelioid Hemangioendothelioma
This article tries to present the etiopathogenesis, clinical manifestations, diagnosis, treatment and prognosis of P-EHE. 
 DOI: 10.3779/j.issn.1009-3419.2019.07.10 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Therapeutic Relevance of Human Microbiota and Lung Cancer
The human microbiome is closely related to human health status. Disruption of the symbiotic balance of the human microbiome is commonly found in systematic diseases such as diabetes, obesity, and chronic gastric diseases. The human microbiome confers benefits or disease susceptibility to the human body through multiple pathways, associated with approximately 20% of malignancies. The incidence and mortality of lung cancer (LC) in men in China are the highest among all malignancies, which is a serious threat to human health. Emerging evidence has suggested that the human microbiota may be closely related to lung cancer at mu...
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Role of STAT3 in Resistance of Non-small Cell Lung Cancer
The inflammatory state of tumor microenvironment play an important role in non-small cell lung cancer (NSCLC) drug resistance. As the key signal pathway connecting inflammation and tumor, activated signal transduction and transcriptional activation factor 3 (STAT3) leads togenetic abnormal expression, gene silencing, genomic instability, etc. in tumor cells, and induces therapeutic resistance. STAT3 has thepotential to be a new target for reversal of resistance. In this review, we summarize the progress of STAT3 in acquired drug resistance of NSCLC, explore the possibility of STAT3 as a new target to reverse drug resistanc...
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Diagnosis and Treatment of Pulmonary Ground-glass Nodules
Recent widespread use of high resolution computed tomography (HRCT) for the screening of lung cancer have led to an increase in the detection rate of very faint and smaller lesions known as ground-glass nodule (GGN). However, it had been proved that GGN was well associated with lung cancer in previous studies. Therefore, the classification, imaging characteristics, pathological type, follow-up, suggested managements and other clinical concerns of GGN were reviewed in this paper. 
 DOI: 10.3779/j.issn.1009-3419.2019.07.07 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Progress in Clinical Researches of PD-1/PD-L1 Checkpoint Inhibitor for 
Non-small Cell Lung Cancer
This article reviews the clinical research progress of immunological checkpoint inhibitors targeting PD-1/PD-L1 in NSCLC. 
 DOI: 10.3779/j.issn.1009-3419.2019.07.06 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Investigation on the Possibility of EGFR Mutation Testing on DNA Extracted from 
Fixation Liquid of Lung Cancer Biopsy
Conclusion Extracting the DNA from fixation liquid of lung cancer biopsy may be a kind of feasible way to detect EGFR mutation. 
 DOI: 10.3779/j.issn.1009-3419.2019.07.05 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Genetic Mutation Screening of DNA Polymerase in Human Lung Cancer
Conclusion No lung tumor specific mutations of Polb gene could be found in Chinese lung cancer patients and Polb gene mutation might not be a molecular marker for Chinese lung cancer patients. 
 DOI: 10.3779/j.issn.1009-3419.2019.07.04 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Retrospective Analysis of Risk Factors for Venous Thromboembolism 
in 283 Patients with Lung Cancer during Systemic Therapy
Conclusion LVV, serum albumin and D-dimer level may be potential and more effective predictors of VTE in lung cancer patients during systemic therapy. Basing on these factors, new predictive model can be built, a nd further study to validate its efficacy is required. DOI: 10.3779/j.issn.1009-3419.2019.07.03 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Results of Lung Cancer Screening among Urban Residents in Kunming
In this study, we participated in the National Key Public Health Program, Cancer Screening Program in Urban China and analyzed the results of lung cancer screening in 10,154 urban residents in Kunming, Yunnan Province from 2014 to 2018, and evaluated the screening effect of early diagnosis and treatment of lung cancer in urban. Methods A total of 31,824 people with high risk of lung cancer were evaluated with 40-74 year-old population in Kunming. A high-risk group underwent low-dose spiral computed tomography (CT) scan of the chest, and analyze the high risk rate and detection rate. A total of 150,535 questionnaires were c...
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

Chinese Expert Consensus on Antiangiogenic Drugs for Advanced Non-small Cell 
Lung Cancer (2019 Edition)
DOI: 10.3779/j.issn.1009-3419.2019.07.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 17, 2019 Category: Cancer & Oncology Source Type: research

A Case Report on Successful Third Challenge to the Pemetrexed-based Regimen for Advanced Non-small Cell Lung Cancer
We report one effective individual case that ado pted pemetrexed re-challenge strategy in advanced NSCLC for three times, and at the same time conduct the relevant literature review. DOI: 10.3779/j.issn.1009-3419.2019.06.11 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

A Case of Pseudoprogression During Atezolizumab Therapy 
in Lung Adenocarcinoma
Lung cancer is the most common cause of cancer-related death worldwide. There are two classes of lung cancer: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC represents approximately 85% of all lung cancer cases. Immune checkpoint inhibitors (ICIPs) are a class of inhibitors of programmed death-1 and programmed death-ligand 1. Preclinical studies have shown that ICIPs have shown good clinical efficacy and durable response in diverse cancers. Among them, atezolizumab (MPDL3280), an anti-PD-L1 monoclonal antibody, is being investigated as a potential therapy against solid tumors and hematologic ma...
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

Study Progress of Radiomics in Precision Medicine for Lung Cancer
Precision medicine, imaging first. Radiomics, a method of machine learning in artificial intelligence, provides valuable diagnostic, prognostic or predictive information through quantitative analysis on the tumor ’s region of interest to support personalized clinical decisions and improve individualized treatment, which could lay a solid foundation for achieving the precision medicine. This review provides a latest advance of the radiomic application of the precision medicine for lung cancer. DOI: 10.3779/ j.issn.1009-3419.2019.06.09 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

Predictive Value of Tumor Mutation Burden in Immunotherapy for Lung Cancer
This article reviewed the predictive value of TMB and its limitations in the field of immunotherapy for lung cancer. DOI: 10.3779/j.issn.1009-3419.2019.06.08 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

Progress on PD-1/PD-L1 Checkpoint Inhibitors in Lung Cancer
In recent years, research on immunotherapy has made great progress. Currently, immunotherapy has made significant breakthrough, especially programmed death 1/programmed death-ligand 1 (PD-1/PD-L1) checkpoint inhibitors (e.g, Nivolumab, Pembrolizumab, Atezolizumab, Durvalumab and Avelumab, etc.) have brought clinical benefits to patients with various pathological types of lung cancer, including squamous cell carcinoma, adenocarcinoma and small cell lung cancer. In this paper, the application value and current status of PD-1/PD-L1 checkpoint inhibitors in lung cancer were comprehensively analyzed by reviewing and interpretin...
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

Progress on the Study of Tumor Spread Through Air Spaces in the Clinicopathological Characteristics of Lung Adenocarcinoma and Its Influence on the Surgical Treatment and Prognosis of Lung Cancer
Tumor spread through air spaces (STAS) as a new pathological invasion mode is closely related to many clinicopathological factors. In lung adenocarcinoma, micropapillary and solid pathological subtypes are most related; STAS for early stage lung adenocarcinoma, surgical type of lobectomy seems to benefit better than sublobar resection, which may up-regulate the pathological stage of early lung cancer; Moreover, STAS is closely related to squamous cell carcinoma and other non-small cell lung cancer (NSCLC). In addition, intraoperative frozen-section pathological detection of STAS is difficult and controversial. STAS as an i...
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

New Advances in the Treatment for Small Cell Lung Cancer
Small cell lung cancer (SCLC) is a refractory cancer with high degree of malignancy, rapid disease progression, poor prognosis and easy recurrence. In the past 30 years, the traditional treatment of SCLC, mainly chemotherapy and radiotherapy, has not changed significantly, and the effective treatment method for clinical needs is extremely urgent. The rapid development of precision medicine has revealed the molecular biological characteristics of SCLC, so its diagnosis and treatment will into a new era. At present, some studies have shown that anti-angiogenic drugs, immunotherapy and so on have improved the efficacy of SCLC...
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

A Preliminary Study to Evaluate the Efficacy and Safety of A Optimized Computed Tomography-guided Pulmonary Nodule Microcoil Localization Technique
Conclusion For small pulmonary nodules requiring thoracoscopic surgery, the optimized computed tomography-guided pulmonary nodule microcoil localization technique is convenient, safe and effective, and worthy of promotion to use. 
 DOI: 10.3779/j.issn.1009-3419.2019.06.04 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

Expression and Clinical Significance of Cancer-derived Immunoglobulin G in Non-small Cell Lung Cancer by Bioinformatics and Immunohistochemistry
Conclusion High expression of cancer-IgG in NSCLC is a poor prognosis factor, which may be related to the promotion of tumor invasion and metastasis. 
 DOI: 10.3779/j.issn.1009-3419.2019.06.03 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

Performance of Deep-learning-based Artificial Intelligence on Detection of Pulmonary Nodules in Chest CT
Background and objective The detection of pulmonary nodules is a key step to achieving the early diagnosis and therapy of lung cancer. Deep learning based Artificial intelligence (AI) presents as the state of the art in the area of nodule detection, however, a validation with clinical data is necessary for further application. Therefore, the aim of this study is to evaluate the performance of AI in the detection of malignant and non-calcified nodules in chest CT. Methods Two hundred chest computed tomography (CT) data were randomly selected from a self-built nodule database from Tianjin Medical University General Hospital....
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

Advanced Pneumonic-type Lung Carcinoma: A Retrospective Study of Clinical-radiological-pathological Characteristics with Survival Analysis in A Single Chinese Hospital
Conclusion Diagnosis of pneumonic-type carcinoma is usually delayed due to clinical and radiological features mimicking pulmonary infection. TBLB combined with BAL has a quite high diagnostic yield. The most frequent histological type is invasive mucinous adenocarcinoma. The incidence of EGFR mutation or ALK rearrangement is low in pneumonic-type carcinoma. For patients without cancer driver genes, chemotherapy is recommended to improve overall survival. 
 DOI: 10.3779/j.issn.1009-3419.2019.06.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

Role of EZH2 Inhibitor Combined with Gefitinib in EGFR-TKIs Resistant Lung Cancer Cells
Conclusion The combination of EZH2 inhibitor GSK343 and gefitinib sensitize PC9/AB2 cell to gefitinib response. This study also suggests that synergistic therapy plays a role in the reversal of EGFR-tyrosine kinase inhibitor (EGFR-TKIs) resistance in lung cancer. 
 DOI: 10.3779/j.issn.1009-3419.2019.05.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Advanced Research on Non-small Cell Lung Cancer with De Novo T790M Mutation
With the development of sequencing technology, the detection rate of de novo T790M mutation is increasing. The emergence of the third generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide treatment opportunities. Secondary T790M mutation is often emphasized in clinic, but de novo T790M mutation is neglected. This review found that the incidence of de novo T790M mutation fluctuated greatly, which was mainly affected by sequencing techniques. The de novo T790M mutation is mainly low in mutation abundance, easy to combine with other gene changes, a poor predictor and prognostic factor...
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Clinical Application of Artificial Intelligence Recognition Technology 
in the Diagnosis of Stage T1 Lung Cancer
Conclusion The automatic learning of early lung cancer chest CT images by artificial intelligence can achieve high sensitivity and specificity of early lung cancer identification, and assist doctors in the diagnosis of lung cancer. 
 DOI: 10.3779/j.issn.1009-3419.2019.05.09 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Prognostic Analysis of EGFR-TKIs Combined with Gamma Knife in EGFR-mutant Lung Adenocarcinoma with Brain Metastasis
This study aimed to identify the prognostic factors of EGFR-mutant brain-metastatic lung adenocarcinoma patients who received EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in combination with gamma knife radiosurgery. Methods Retrospective analysis of EGFR-mutant lung adenocarcinoma patients with brain metastases which developed at initial diagnosis or during EGFR-TKIs treatment period were performed. Intracranial progression free survival (PFS) was statistically analyzed between different subgroups to find out the prognostic factors including gender, age, smoking history, extracranial metastasis, EGFR mutation type, size an...
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Expression of MiR-148b-3p in Lung Adenocarcinoma and Its Correlation with Prognosis
Conclusion MiR-148b-3p was significantly associated with tumor grade and tumor size in lung adenocarcinoma, and served as an independent predictor of overall survival of patients with lung adenocarcinoma. The overall survival of patients with high expression level of miR-148b-3p was significantly better than that of patients with low expression. 
 DOI: 10.3779/j.issn.1009-3419.2019.05.07 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Characteristics of Epidermal Growth Factor Receptor with Rare Mutations in Non-small Cell Lung Cancer and the Effect of EGFR Tyrosine Kinase Inhibitors on Them
Conclusion The efficiency of targeting EGFR-TKIs on different types of rare or complex mutations was heterogeneous. The PFS may be better in patients that harbored complex mutations than those with single rare mutations. Further studies with larger sa mple size are necessary. Moreover, to discover novel therapeutic targets and develop new drugs are imminentfor those patientswith no response to the existing treatments.
 DOI: 10.3779/j.issn.1009-3419.2019.05.06 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Meta-analysis of Platelet Lymphocyte Ratio as A Prognostic Factor for 
Non-small Cell Lung Cancer
Background and objective Current research shows that platelet to lymphocyte ratio (PLR) has important prognostic value in renal cell carcinoma, esophageal cancer, gastric cancer, liver cancer and colon cancer. The aim of the study is to evaluate the prognostic value of PLR in non-small cell lung cancer (NSCLC) through meta-analysis. Methods Literature search for PubMed, EMBASE, Web of Science, Medline, Cochrane Library, China National Knowledge Internet (CNKI), China Biomedical Medicine disc (CBMdisc), VIP, Wanfang Database using computer electronic system to study the association between PLR and overall survival (OS) and ...
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Study on the Difference of Gene Expression between Central and Peripheral Lung Squamous Cell Carcinoma Based on TCGA Database
Conclusion Central and peripheral lung squamous cell carcinoma showed clinical phenotype difference not only reflected in the incidence of lymph node metastasis, but also in gene expression profiles. Among them, HNF1A, CYP3A4, ALB, APOA1 at the key position of the differential gene interaction network and maybe as regulatory factors in the phenotypic difference. DOI: 10.3779/j.issn.1009-3419.2019.05.04 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Cyclic RNA Molecule circ_0007766 Promotes the Proliferation of Lung Adenocarcinoma Cells by Up-regulating the Expression of Cyclin D1/CyclinE1/CDK4
Conclusion In vitro functional studies have shown that circ_0007766 may promote the proliferation and migration of lung adenocarcinoma cells. Further molecular mechanism studies have found that circ_0007766 can up-regulate the expression of Cyclin D1/Cyclin E1/CDK4, which are the key proteins of cell cycle, and thus promote the malignant proliferation of lung adenocarcinoma. From the perspective of circRNA, this study will provide new clues for the pathogenesis, development and prognosis of lung adenocarcinoma, and provide new target for clinical treatment. 
 DOI: 10.3779/j.issn.1009-3419.2019.05.03 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Effect of Apatinib on Invasion and Migration of Lung Cancer Cells 
and Its Mechanism
Conclusion Apatinib can inhibit the invasion and migration of lung adenocarcinoma cells H1299 and H3255. By regulation of epithelial-mesenchymal transition and the expression of matrix metalloproteinase-related proteins. DOI: 10.3779/j.issn.1009-3419.2019.05.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Expert Consensus on the Diagnosis and Treatment of Bone Metastasis in Lung Cancer (2019 Version)
DOI: 10.3779/j.issn.1009-3419.2019.04.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 24, 2019 Category: Cancer & Oncology Source Type: research

Treatment-related Skin Toxicity Caused by Programmed Death-1 Inhibitor Nivolumab: 
A Case Report
Conclusion Immune-related skin toxicity associated with PD-1 inhibitor should be aware of; early detection, early treatment and the prognosis could be better. It is necessary to improve the understanding of Immune-related skin toxicity associated with PD-1 inhibitor, to diagnose and treat it early, and the prognosis could be better.
 DOI: 10.3779/j.iss n.1009-3419.2019.04.09 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2019 Category: Cancer & Oncology Source Type: research

An Overview of the Application of Artificial Neural Networks in Lung Cancer Research
This article reviewed the application of artificial neural network in the field of lung cancer. 
 DOI: 10.3779/j.issn.1009-3419.2019.04.08 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2019 Category: Cancer & Oncology Source Type: research

Clinical Research Progress of Immune Checkpoint Inhibitors in the Treatment of 
Small Cell Lung Cancer
With the in-depth study of tumor immunity, immunotherapy represented by immune checkpoint inhibitors has made a great breakthrough in solid tumors. Small cell lung cancer (SCLC) accounts for about 15%-20% of all lung cancers, with high malignancy, early metastasis and lack of effective treatment strategy. The appearance of immune checkpoint inhibitors brings new hope for SCLC. Several clinical trials have demonstrated the persistent efficacy and clinical activity of the programmed death receptor/ligand 1 (PD-1/L1) and cytotoxic T-lymphocyte antigen 4 (CTLA-4) in the treatment of SCLC. However, its efficacy and safety are n...
Source: Chinese Journal of Lung Cancer - April 20, 2019 Category: Cancer & Oncology Source Type: research

Advances of the Correlation between Driver Gene Status and Immunotherapy 
in Non-small Cell Lung Cancer
This article will revolve around the above issues. 
 DOI: 10.3779/j.issn.1009-3419.2019.04.06 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2019 Category: Cancer & Oncology Source Type: research

A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases
Conclusion Pancreatic metastasis of lung cancer is rare and the prognosis is poor. Chemotherapy can prolong survival significantly. Local radiotherapy of the pancreas may alleviate local symptoms, improve quality of life, facilitate further systemic chemotherapy for patients to prolong survival. Patients with symptoms related to pancreatic metastases can benefit from the comprehensive treatment of chemotherapy combined with local pancreatic radiotherapy. DOI: 10.3779/j.issn.1009-3419.2019.04.05 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2019 Category: Cancer & Oncology Source Type: research

Next Steps after Negative Results Obtained by EBUS-TBNA from Patients Suspected Clinically Lung Cancer with Mediastinal Lymphnode Metastasis
Conclusion Diagnostic procedures should be chosen based on the clinical character in EBUS-TBNA negative patients with suspected lung cancer. Long time follow-up is very important in patients whose diagnosis is apparently unknown. 
 DOI: 10.3779/j.issn.1009-3419.2019.04.04 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2019 Category: Cancer & Oncology Source Type: research