Cancer Screening Program in Urban Kunming of Yunnan: Evaluation of Lung Cancer Risk Assessment and Screening
This study analyzed the evaluation of lung cancer risk assessment model and screening effect in urban China of Yunnan, so as to explore the evaluation model of high-risk lung cancer population suitable for China's national conditions and develop lung cancer screening guidelines for Chinese. Methods A questionnaire survey and lung cancer risk assessment were conducted on 165,337 people in 36 street offices in 4 main urban areas of Kunming, Yunnan Province, using cluster sampling method from January 2015 to December 2019. People with high-risk of lung cancer conducted low-dose computed tomography (LDCT) screening of chest. W...
Source: Chinese Journal of Lung Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Progress of Bevacizumab in the Front-line Treatment of Advanced Non-small Cell Lung Cancer
This article is an important review of existing randomized controlled clinical research, hoping to provide a reference for clinical treatment. The addition of bevacizumab reduces the risk of disease progression in patients with advanced non-squamous NSCLC significantly. Specific combinations can also reduce the risk of death. The best combination plan needs to be confirmed by new randomized controlled studies. DOI: 10.3779/j.issn.1009-3419.2020.101.34 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Progress in Research on the Cribriform Component in Lung Adenocarcinoma
The morbidity of lung cancer ranks top in the world. At present, lung adenocarcinoma (LUAD) is the most common histologic type of lung cancer. However, the prognoses of LUAD patients with the same subtype remain heterogeneous. Histological heterogeneity is one of the main causes of diverse prognoses of patients with LUAD. Studies have shown that there are other histologic patterns that affect the clinical outcomes of LUAD patients, in addition to the five growth patterns of invasive LUAD classified by the World Health Organization (WHO) in 2015. The cribriform component (CC) is one of the research hotspots among histopatho...
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Application of Organoids in Lung Cancer Precision Medicine
This article will give an introduction to the organoid model and review the application scenarios of organoids in the context of the precise treatment of existing lung cancer. DOI: 10.3779/j.issn.1009-3419.2020.101.20 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Progress on Mechanism of MET Gene Mutation and Targeted Drugs in Non-small Cell Lung Cancer
The objective response rate of MET inhibitors is high, and the safety is good. However, resistance of MET-tyrosine kinase inhibitor (TKI) is inevitable, so it is necessary to pay attention to the study of drug resistance mechanism. In addition, the combined use of hepatocyte growth factor (HGF)/MET inhibitors and other drugs may play an important role in inhibiting and reversing drug resistance. DOI: 10.3779/j.issn.1009-3419.2020.102.32 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Analysis of the Correlation between Molecular Structural Differences of PD-1/PD-L1 Inhibitors and Adverse Events
As a new method, immunotherapy which is targeting programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) plays a more and more important role in the treatment of malignant tumors. Immunotherapy is more effective than traditional chemotherapy. However, there are also many adverse events during the application of immunocheckpoint inhibitors targeting PD-1/PD-L1, and the incidence rate of these adverse events among different drugs is different. Because the molecular structure of these drugs is an important indicator to distinguish them, this paper will analyze the correlation between molecular struc...
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Role of P21 in Resistance of Lung Cancer
This article reviews the research on P21 and lung cancer resistance, to provide new ideas for individualized treatment of lung cancer and overcoming lung cancer resistance. DOI: 10.3779/j.issn.1009-3419.2020.101.16 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Advances in Exosomes in the Pathogenesis and Diagnosis of Lung Cancer
This article reviews the value of exosome specific protein and microRNA (miRNA) in lung cancer in the diagnosis and prognosis of lung cancer. DOI: 10.3779/j.issn.1009-3419.2020.104.18 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

A Review of Epigenetic Modifications Regulate MicroRNA Expression in Lung Cancer
Lung cancer is one of the primary causes of cancer-induced death among the world. Although the network of molecular implicated in lung cancer is gradually revealed, the exact molecular mechanism of its occurrence and development has not been fully elucidated. As a class of small and endogenous single-stranded non-coding RNAs, microRNAs (miRNAs) are found in a wide range of organisms from plants, viruses to humans. miRNAs involve various functions in normal lung tissue development. They take part in a large amount of biological processes including cell growth, metabolism, proliferation and differentiation. However, aberrant...
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Pneumonectomy for Non-small Cell Lung Cancer: Predictors of Operative Mortality and Survival
Surgery is the most effective way to cure non-small cell lung cancer currently. Although sleeve lobectomy, with less reduction of respiratory function and a lower mortality rate, would not compromise oncological results in well-selected patients with central lung cancer, pneumonectomy is still necessary when complete resection could not be achieved by other surgical procedures. Cardiopulmonary complications are the most common complication after pneumonectomy. Fully understanding the related complications after pneumonectomy can help surgeons make a diagnosis timely, and further take relevant measures to reduce the adverse...
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Analysis of Influencing Factors of Preoperative Anxiety or Depression in Patients with Lung Cancer Surgery
Background and objective Preoperative anxiety/depression can bring physical and mental harm to the patients with lung cancer. There is little study on whether hospital waiting time before surgery can increase the psychological burden of patients with lung cancer. The aim of this study was to investigate the preoperative anxiety and depression of patients with lung cancer in our hospital, and to analyze the related influencing factors. Methods A total of 135 lung cancer inpatients in the Department of Thoracic Surgery of Beijing Friendship Hospital were studied. Their general information and anxiety/depression were recorded...
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Comparison of the Clinical Effect of Uniportal Video-assisted Thoracoscopic Lobectomy and Biportal Video-assisted Thoracoscopic Lobectomy in the Treatment of Lung Cancer
Background and objective In recent years, the technique of uniportal video-assisted thoracoscopic surgery has been developed. As a new surgical method, its feasibility and safety have not been generally recognized. The aim of this study is to review the technology in the treatment of lung cancer patients in stage I to part of stage IIIa. Methods The clinical data of patients accepted thoracoscopic resection of lung cancer by a same medical group from May 2018 to March 2019 in The First Affiliated Hospital of Soochow University were retrospectively analyzed. After remove of cases that did not meet the requirements, the pati...
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Correlation between Anxiety, Depression and Changes in Th17/Treg and Inflammatory Levels in Patients with Pulmonary Nodules
This study aimed to investigate the changes in anxiety, depression, the ratios of T helper cells 17 (Th17) and regulatory T cells (Tregs), and inflammation levels in patients with pulmonary nodules. Methods A total of 143 subjects from The First Affiliated Hospital of Anhui Medical University were included from April 2019 to July 2019. All of the subjects were assessed with the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory-II (BDI-II). Overall, 40 cases were healthy controls (HC) and 103 cases were patients with pulmonary nodules. The patients were divided into two groups according to the scale scores: 62 ...
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Analysis of Correlation between TTF-1 and Sensitivity to First-line Chemotherapy and Prognosis in Patients with Small Cell Lung Cancer
Conclusion TTF-1 expression is an independent predictor of first-line chemotherapy response rate and survival in patients with SCLC, and may become a biomarker to predict the efficacy and prognosis of SCLC. DOI: 10.3779/j.issn.1009-3419.2020.101.27 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 20, 2020 Category: Cancer & Oncology Source Type: research

Assessment of the Accuracy of Modified Inflation-deflation Methods for Distinguishing the Intersegmental Border
Conclusion The modified inflation-deflation method can effectively define the interseg mental and intersubsegmental borders, and guarantee the safe surgical margins of extended segmentectomy and extended subsegmentectomy to treat intersegmental and intersubsegmental small lung tumors. DOI: 10.3779/j.issn.1009-3419.2020.104.15 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 11, 2020 Category: Cancer & Oncology Source Type: research

CT-guided Percutaneous Lung Puncture for the Diagnosis of Solid Pulmonary Nodules: A Single-center Experience Summary
Conclusion Percutaneous lung puncture has a high effectiveness and safety for the diagnosis of solid pulmonary nodules. DOI: 10.3779/j.issn.1009-3419.2020.103.03 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 11, 2020 Category: Cancer & Oncology Source Type: research

Combination of Radiation Therapy and Immunotherapy for Non-small Cell Lung Cancer: Peer Exchange on Frontier Academic Topics
Lung cancer is the leading cause of cancer death worldwide as well as in China. For many years, conventional oncologic treatments such as surgery, chemotherapy, and radiotherapy (RT) have dominated the field of non-small cell lung cancer (NSCLC). The recent introduction of immunotherapy in clinical practice, led to a paradigm shift in lung cancer as in many other solid tumors. Recent pre-clinical and clinical data have shown RT may also modify antitumor immune responses through induction of immunogenic cell death and reprogramming of the tumor microenvironment. This has led many to reexamine RT as a partner therapy to immu...
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Assessment of the Accuracy of Modified Inflation-deflation Methods forDistinguishing the Intersegmental Border
Conclusion The modified inflation-deflation method can effectively define the interseg mental and intersubsegmental borders, and guarantee the safe surgical margins of extended segmentectomy and extended subsegmentectomy to treat intersegmental and intersubsegmental small lung tumors. DOI: 10.3779/j.issn.1009-3419.2020.104.15 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Auxiliary Diagnostic Value of Tumor Markers in the Cerebrospinal Fluid and Blood for Leptomeningeal Metastasis from Non-small Cell Lung Cancer
Conclusion Our study demonstrates that Serum and CSF TM can work as an auxiliary clinical diagnostic tool, which has a potential value in early diagnosis of NSCLC patients with LM. Serial measurement of TM may play an important role in the clinical management of NSCLC patients with LM, which is worthy of further promotion and clinical application. DOI: 10.3779/j.issn.1009-3419.2020.103.09 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Prospect of the Application of Interventional Therapy in Thoracic Surgery
DOI: 10.3779/j.issn.1009-3419.2020.101.09 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Study on the Application of A New Type of Anhydrous Thoracic Negative Pressure Drainage Device in Patients after Thoracic Surgery
Conclusion The new type of anhydrous thoracic negative pressure drainage device has a good effect on the rapid recovery and advancement after thoracic surgery. DOI: 10.3779/j.issn.1009-3419.2020.104.06 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Feasibility of injecting Fluorescent Agent under the Guidance of Electromagnetic Navigation Bronchoscopy in Pulmonary Nodule Resection
Conclusion Indocyanine green injection under the guidance of magnetic navigation bronchoscope is an effective way to locate pulmonary nodules, which can locate small and untouchable lesions in the lung. This meth od can help surgeons identify lesions more quickly and accurately. It is practical and worthy of promotion. DOI: 10.3779/j.issn.1009-3419.2020.103.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Predictors for the Bronchiolitis Obliterans Syndrome in Lung Transplant Patient
This article reviews the current state of knowledge on predictors for BOS. DOI: 10.3779/j.issn.1009-3419.2020.101.03 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Clinical Evaluation of Absorbable Regenerated Oxidized Cellulose in Lung Cancer Surgery
Conclusion The use of absorbable regenerated oxidized cellulose in the radical operation of tho racoscopic lung cancer has a good hemostasis effect, and is suitable for hemostasis of wounds after lymph node dissection. DOI: 10.3779/j.issn.1009-3419.2020.101.10 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

A Prospective Study of Da Vinci Surgical Robotic System with Chest Wall External Nursing Interventions
Conclusion Chest wall external nursing interventions are beneficial to the recovery of patients undergoing Vinci robotic lung cancer surgery. Especially for patients with thinner chest wall. It can reduce postoperative drainage, shorten tube retention time and accelerate discharge. Further improvement is expected to achieve better clinical results. DOI: 10.3779/j.issn.1009-3419.2020.101.07 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Minimally Invasive Therapies for Early Stage Non-small Cell Lung Cancer
Lung cancer is the most common cancer and the leading cause of cancer death in the world, among which non-small cell lung cancer (NSCLC) accounts for about 85% of the total lung cancer. With the widespread of computed tomography (CT) and other imaging screening methods, the pathological types of lung cancer have changed from central squamous cell carcinoma to the early-stage lung adenocarcinoma, which is manifested as isolated pulmonary nodules and ground glass nodules on CT. Early diagnosis and treatment of lung cancer is of crucial clinical significance, and the continuous development and improvement of minimally invasiv...
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Use of Hybrid Stent in Management of Complex Malignant Airway Stenosisand Fistulas
Conclusion Hybrid stenting proved to be useful and was well-tolerated in the management of complex malignant airway stenosis and fistula. DOI: 10.3779/j.issn.1009-3419.2020.104.05 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Diagnostic Value of Transbronchial Ultrasound-guided Needle Aspiration Biopsy in the Diagnosis of Small Cell Lung Cancer and Non-small Cell Lung Cancer
This article evaluated the accuracy and sensitivity of EBUS-TBNA in the diagnosis of SCLC and NSCLC. Methods From January 2012 to December 2018, the clinical data of 85 patients with SCLC and NSCLC who performed EBUS-TBNA in Xuan Wu Hospital CMU were retrospectively analyzed and the differences between the two groups were compared. Results 45 cases of SCLC were confirmed by immunohistochemistry and pathology. 42 cases of SCLC were diagnosed by EBUS-TBNA. The accuracy and sensitivity of diagnosis were 93.3% (42/45) and 100.0% (42/42), respectively. The positive rate of diagnosis was 48.9% (22/45) in 22 cases diagnosed by cy...
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Prognostic Risk Factors for Patients Receiving Airway Stent Placement
Conclusion For patients receiving airway stent placement, the baseline CCI and the procedure duration had prognostic significance in clinical practice. DOI: 10.3779/j.issn.1009-3419.2020.104.04 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Clinical Comparison of Airway Stent Placement in Intervention Room and Operating Room
This study aimed to make clinical comparison of airway stent placement in the intervention room and operating room.Methods Patients underwent airway stent placement between 2014 and 2018 were included in this retrospective case-control study. Clinical performance of airway stent placement in intervention room and operating room were compared. Results 82 patients were included in this study, including 39 in the intervention room and 43 in the operating room. Patients treated in the intervention room had lower Charlson comorbidity index (CCI) (P=0.018) and received less Y-shaped stents (P (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Clinical Application of Electromagnetic Navigation Bronchoscopy on the Diagnosis of Peripheral Lung Lesions
Conclusion Electromagnetic navigation bronchoscope is safe and effective in clinic. It has a high positive rate for the diagnosis of peripheral lung lesions larger than 2 cm, ENB has broad clinical application prospects. DOI: 10.3779/j.issn.1009-3419.2020.102.05 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Advances of Electromagnetic Navigation Bronchoscopyfor Peripheral Pulmonary Lesions
The incidence of peripheral pulmonary lesions (PPLs) is growing following the adoption of lung cancer screening by low-dose chest CT. The diagnosis and treatment of pulmonary nodules is one of the most difficult problems. Based on the electromagnetic positioning technology, the electromagnetic navigation bronchoscope is guided to the pulmonary nodules for biopsy or treatment, providing a new minimally invasive diagnosis and treatment method for suspicious lung lesions. This paper provides an overview of the current status and progress of electromagnetic navigation bronchoscopy in the diagnosis and treatment of peripheral p...
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Current Status and Development of Interventional Techniques for Pulmonary Diseases
This article aimed to review the current status and development of interventional diagnosis and treatment techniques for lung diseases, and introduces the characteristics of the interventional treatment of our center. DOI: 10.3779/j.issn.1009-3419.2020.102.09 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Preoperative Pulmonary Nodule Localization Methods:A Comparison of Microcoil and Sclerosing Agent
Conclusion Our study suggests that both microcoil placement and sclerosing agent injection are suitable for preoperative pulmonary nodule localization equivalently, however, compared with microcoils placement, injection of lauromacrogol, t he sclerosing agent, had lower failure rate, less complications, shorter localization time and it is worthy of promotion also by easy operation and low cost. DOI: 10.3779/j.issn.1009-3419.2020.102.07 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Therapeutic Effect of CT-guided 125I Seed Implantation on Advanced Lung Cancer and Pulmonary Metastatic Carcinoma
Conclusion The CT-guided 125I radioactive seed implantation has controllable complications and can be used as a safe and effective treatment for advanced lung cancer and lung metastases. DOI: 10.3779/j.issn.1009-3419.2020.103.04 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Safety and Effectiveness Analysis of Percutaneous Microwave Thermal Ablation Therapy Combined Brachytherapy for Lung Malignant Lesion
Conclusion Seed implantation combined with CT-guided microwave ablation for advanced lung cancer and lung metastases is safety and effective. DOI: 10.3779/j.issn.1009-3419.2020.102.06 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

CT-guided Percutaneous Lung Puncture for the Diagnosis of Solid PulmonaryNodules: A Single-center Experience Summary
Conclusion Percutaneous lung puncture has a high effectiveness and safety for the diagnosis of solid pulmonary nodules. DOI: 10.3779/j.issn.1009-3419.2020.103.03 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Chinese Expert Consensus Statement on Clinical Evaluation System of Medical Endoscopy
Nowadays, there is a rising development and popularity of medical endoscopes. The international brand dominates the endoscope market. The market size of domestic brands is also growing rapidly. The electronic technologies of hard or soft endoscopes are developing rapidly and gradually approaching to the advanced level in worldwide. However, at present, there is a lack of relevant standards for national standards and industry regulations for evaluating medical endoscopes, and also lacking of quantitative and clear understanding of the gap between domestic and foreign products. It is urgently necessary to give a comprehensiv...
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Preface of Interventional Therapy for Lung Cancer
DOI: 10.3779/j.issn.1009-3419.2020.101.08 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Pulmonary Nodules/Lung Cancer Comprehensive Management Mode: Design and Application
Conclusion Proficient screening, follow-up and healthcare can be achieved via pulmonary nodules/lung cancer comprehensive management mode, which will be extended all over west China region in future. DOI: 10.3779/j.issn.1009-3419.2020.103.06 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Malignant Melanoma of Pleura: A Case Report and Literature Review
Malignant melanoma is a kind of tumor produced by human melanocytes. It has a high degree of malignancy, early metastasis and high mortality. Most melanomas are caused by malignant skin nevus and can also be seen in the digestive tract such as rectum and anus. Primary malignant melanoma of pleura is rare, rarely seen in case reports. This paper reports the clinical data of a case of malignant melanoma with cough, expectoration and pleural effusion as the first symptoms diagnosed by thoracoscopy combined with pathology in Beijing Friendship Hospital Affiliated to Capital Medical University, and analyzes and summarizes the l...
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Intraoperative Aspiration
This article will center on operative aspiration and summarize it from anatomy, pathophysiology, manifestation, diagnosis, treatment and prevention. DOI: 10.3779/j.issn.1009-3419.2020.101.22 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Current Situation of Clinical Feature and Gene Phenotype of Young Adult Lung Cancer
This article reviewed the literature on the clinical features, gene phenotypi c characteristics and prognosis of young adult lung cancer in order to provide provide some references and clues for the study on young adult lung cancer. DOI: 10.3779/j.issn.1009-3419.2020.101.21 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Gene Fusions as Acquired Resistance Mechanisms of EGFR-TKI
Patients with sensitive epidermal growth factor receptor (EGFR) mutations often respond to tyrosine kinase inhibitors (TKIs), but acquired resistance will eventually develop. The most common mechanisms of acquired resistance include secondary EGFR mutation, MET amplification, and histologic transformation. Besides, gene fusions could also mediate the process of acquired resistance. Various gene fusions including rearranged during transfection (RET), v-raf murine sarcoma viral oncogene homolog B1 (BRAF) and anaplastic lymphoma kinase (ALK) could take place after TKIs resistance, the incidence of which is around 1%. The clin...
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Progress in Neoadjuvant Immunotherapies for Resectable Non-small Cell Lung Cancer
This article systematically reviewed the clinical trials of neoadjuvant immunotherapy for resectable NSCLC before surgery. DOI: 10.3779/j.issn.1009-3419.2020.103.07 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Advances in Diagnosis and Management of Subcentimeter Pulmonary Nodules
This article reviews and summarizes the progress in the evaluation and management of subcentimeter pulmonary nodules. DOI: 10.3779/j.issn.1009-3419.2020.102.11 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Clinical Effect of Pedicled Pericardial Fat Flap in Prevention of Bronchial Pleural Fistula in Bronchial Sleeve Lobectomy
Conclusion Wrapping bronchial anastomosis with pedicled pericardial fat flap in bronchial lobectomy for centralized NSCLC is a simple and effective approach to prevent BPF, thus safety of the operation could be significantly improved. DOI: 10.3779/j.issn.1009-3419.2020.104.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Preliminary Study on Detection of Circulating Tumor Cells in Lung Cancer by EGFR/Vimentin/Folic Acid Magnetic Sphere
Background and Objective Circulating tumor cells (CTC) play an important role in the screening and prognosis of lung cancer, but the low efficiency and specificity of CTC isolation obviously restrict its clinical application. The purpose of this study is to explore a new and efficient isolation method of CTC in patients with non-small cell lung cancer (NSCLC) in order to achieve the purpose of early diagnosis of NSCLC. Methods Three kinds of immunolipid magnetic spheres of epidermal growth factor receptor (EGFR), vimentin and folic acid (FA) were prepared by thin film method. After characterization, the sorting scheme of c...
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Surgical Treatment of Lung Cancer Combined with Interstitial Lung Disease
Conclusion Most of LC-ILD were elderly patients with multiple comorbidities and decreased p ulmonary function, leading to significantly increased surgical risk. The ILD should be fully evaluated and controlled before surgery, intraoperative trauma should be minimized, and special attention should be paid to pulmonary complications and AE-ILD after surgery. Postoperative AE-ILD has a poor p rognosis and glucocorticoids may be effective. Early diagnosis and treatment is the key to treatment of AE-ILD. DOI: 10.3779/j.issn.1009-3419.2020.104.19 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research

Analysis of Clinical Characteristics and Driver Genes in 405 Patients with Lung Cancer Complicated with Tuberculosis
Conclusion Patients with lung cancer and pulmonary tuberculosis are predominantly male with smoking history. Adenocarcinoma is the most common pathological type. The positive rate of gene mutation was not significantly different from that of simple lung cancer , but when there were cavities in the chest image, the genetic mutation rate was significantly reduced. DOI: 10.3779/j.issn.1009-3419.2020.101.25 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 20, 2020 Category: Cancer & Oncology Source Type: research