Effect of CircCCND1 on the Malignant Biological Behaviors of H446 Lung Cancer Cells by Regulating the MiR-340-5p/TGIF1 Axis
Background and objective Lung cancer is a common malignant tumor of the lung. To explore the molecular mechanism of the occurrence and development of lung cancer is a hot topic in current research. Cyclic RNA D1 (CircCCND1) is highly expressed in lung cancer and may be a potential target for the treatment of lung cancer. The aim of this study was to investigate the effect of CircCCND1 on the malignant biological behaviors of lung cancer cells by regulating the miR-340-5p/transforming growth factor β-induced factor homeobox 1 (TGIF1) axis. Methods The expression of CircCCND1, miR-340-5p, and TGIF1 mRNA in human normal lung...
Source: Chinese Journal of Lung Cancer - April 9, 2024 Category: Cancer & Oncology Source Type: research
First-line Treatment with Furmonertinib Mesylate in Lung Adenocarcinoma Patient
with EGFR Exon 20 Insertion Mutantion
With the continuous innovation of genomics, proteomics and molecular biological detection technology, the treatment of non-small cell lung cancer (NSCLC) has changed from traditional chemotherapy to immunotherapy and targeted therapy. Among them, molecular tumor markers targeting tyrosine kinase pathways play more important roles in clinical practice. For advanced NSCLC patients with positive epidermal growth factor receptor (EGFR) mutations, there are many first-line drugs on the market and they could bring significant efficacy, thus completely subverting the treatment pattern of advanced NSCLC. Common mutations of EGFR i...
Source: Chinese Journal of Lung Cancer - March 20, 2024 Category: Cancer & Oncology Source Type: research
Tumor-associated Macrophage:
Emerging Targets for Modulating the Tumor Microenvironment
This article reviews the role of anti-angiogenic drugs in modulating TAM phenotypes, highlighting their potential to reprogram M2-type TAM into an anti-tumor M1 phenotype. Additionally, the functional alterations of TAM play a significant role in anti-angiogenic therapy and immunotherapy strategies. In summary, the regulation of TAM polarization and function opens up new avenues for lung cancer treatment and may serve as a novel target for modulating the immune microenvironment of tumors.
DOI: 10.3779/j.issn.1009-3419.2024.102.13 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - March 20, 2024 Category: Cancer & Oncology Source Type: research
Role of Ferroptosis in Non-small Cell Lung Cancer and Progress
of Traditional Chinese Medicine Intervention
Non-small cell lung cancer (NSCLC) is one of the malignant tumors with high morbidity and mortality worldwide. Ferroptosis is a new type of programmed cell death caused by abnormal accumulation of iron-dependent reactive oxygen species (ROS) leading to lipid peroxidation. It involves the balance between iron metabolism, lipid metabolism, oxygen free radical reaction and lipid peroxidation. Recent studies have found that ferroptosis is closely related to the occurrence and development of NSCLC. Due to the emergence of chemotherapy resistance and radiotherapy resistance in the treatment of NSCLC, there is an urgent need to d...
Source: Chinese Journal of Lung Cancer - March 20, 2024 Category: Cancer & Oncology Source Type: research
Exploring the Role of PCDHGB4 in the Occurrence of Lung Squamous Cell Carcinoma Based on Bioinformatics Analysis
Conclusion The expression of PCDHGB4 was low in LUSC. PCDHGB4 was related to the poor prognosis of patients, and PCDHGB4 was closely relate d to the infiltration and pathway of tumor immune cells. PCDHGB4 may be a potential prognostic marker and a new target for immunotherapy in LUSC.
DOI: 10.3779/j.issn.1009-3419.2024.102.03 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - March 20, 2024 Category: Cancer & Oncology Source Type: research
Correlation Analysis between Neutrophil-to-lymphocyte Ratio
and the Risk of Malnutrition in Stage IV Primary Lung Cancer
Background and objective Malnutrition is commonly associated with poor prognosis in patients with malignant tumors. The neutrophil-to-lymphocyte ratio (NLR) is an indicator of inflammation in the body and predicts the risk of malnutrition in a variety of diseases; however, its association with malnutrition in lung cancer patients is unclear. The aim of this study is to clarify the association between NLR and nutritional status in stage IV primary lung cancer and to further determine the optimal NLR cut-off that best predicts the risk of malnutrition. Methods A retrospective analysis of 209 patients admitted to the Departme...
Source: Chinese Journal of Lung Cancer - March 20, 2024 Category: Cancer & Oncology Source Type: research
Retrospective Study of Bronchoscopic Intervention Therapy for Bronchopleural Fistula Induced by Pulmonary Surgery
Background and objective As a new technique developed in recent years, bronchoscopic intervention therapy has the advantages of minimal invasion, high safety and repeatability. The aim of this study is to investigate the clinical characteristics of bronchopleural fistula (BPF) induced by surgeries for lung malignancies or benign diseases and the effect of bronchoscopic intervention therapy for BPF, so as to provide support for prevention and treatment of BPF. Methods Data 64 patients with BPF who were treated by bronchoscopic intervention in Respiratory Disease Center of Dongzhimen Hospital, Beijing University of Chinese M...
Source: Chinese Journal of Lung Cancer - March 20, 2024 Category: Cancer & Oncology Source Type: research
Analysis of Influencing Factors of Complications for CT-guided
Percutaneous Lung Biopsy
Background and objective Computed tomography guided percutaneous lung biopsy (CT-PLB) is a widely used method for the diagnosis of lung lesions. However, it is invasive, and the most common complications are pneumothorax and pulmonary hemorrhage, which can be life-threatening in severe cases. Therefore, the aim of this study is to analyze the independent risk factors affecting the occurrence of different complications of CT-PLB, so as to reduce the incidence of complications. Methods The 605 patients with complete clinical data who underwent CT-PLB in our hospital from May 2018 to December 2019 were retrospectively analyze...
Source: Chinese Journal of Lung Cancer - March 20, 2024 Category: Cancer & Oncology Source Type: research
Impact of the Size and Depth of Pulmonary Nodules on the Surgical Approach
for Lung Resection in the Treatment of Early-stage Lung Cancer ≤2 cm
Background and objective Current studies suggest that for early-stage lung cancers with a component of ground-glass opacity measuring ≤2 cm, sublobar resection is suitable if it ensures adequate margins. However, lobectomy may be necessary for some cases to achieve this. The aim of this study was to explore the impact of size and depth on surgical techniques for wedge resection, segmentectomy, and lobectomy in early-stage lung c ancer ≤2 cm, and to determine methods for ensuring a safe resection margin during sublobar resections. Methods Clinical data from 385 patients with early-stage lung cancer ≤2 cm, who underwen...
Source: Chinese Journal of Lung Cancer - March 20, 2024 Category: Cancer & Oncology Source Type: research
Chinese Expert Consensus on Second-line Treatment for Non-small Cell Lung Cancer with Negative Driver Gene Mutations
For advanced non-small cell lung cancer (NSCLC) patients with negative driver gene mutations, chemotherapy has always been the standard treatment option, and immune checkpoint inhibitors (ICIs) provide other treatment option for these patients. At present, the first-line treatment can choose chemotherapy, anti-angiogenic drugs or immunotherapy. Although the initial treatment can achieve a certain clinical curative effect, disease progression or treatment failure is eventually unavoidable. The second-line and subsequent treatments have poor efficacy and more effective drugs are needed clinically. An expert panel of respirat...
Source: Chinese Journal of Lung Cancer - March 7, 2024 Category: Cancer & Oncology Source Type: research
A Case of Multidomain Integrated Treatment Strategy
for Complex Primary Pulmonary Sarcomatoid Carcinoma
Pulmonary sarcomatoid carcinoma (PSC) is a rare and highly malignant tumor, which includes the following five pathologic types: pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma and pulmonary blastoma. The onset of PSC is occult with non-specific clinical symptoms and signs. The clinical manifestations include irritating cough, bloody sputum, dyspnea, chest pain and so on, which are closely related to the growth and invasion site of the tumor. PSC tends to metastasize early, so most patients are already in local advanced stage or advanced stage with a median survival of 9 months at the tim...
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Intravascular Large B-cell Lymphoma Presenting with Lung Adenocarcinoma:
A Case Report and Literature Review
Intravascular large B-cell lymphoma (IVLBCL) is an aggressive extranodal large B-cell lymphoma, cocurrence in the same organ with other malignancies is very rare, especially in the lung. Here, we report a rare case of lung adenocarcinoma with IVLBCL. The patient was admitted to the hospital due to diarrhea associated with fever and cough. A computed tomography (CT) scan of the chest showed an irregular patchy high-density shadow in the upper lobe of the right lung with ground-glass opacity at the margin. After admission, the patient was given anti-infection treatment, but still had intermittent low fever (up to 37.5 oC). T...
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
High-grade Fetal Adenocarcinoma of the Lung with Scalp Metastasis: A Case Report
Fetal adenocarcinoma of the lung (FLAC) is a rare tumor. Due to its different clinicopathological features, biological behavior and clinical outcome, FLAC is classified into low-grade FLAC (L-FLAC) and high-grade FLAC (H-FLAC). Most patients with H-FLAC are middle-aged heavy smokers. Here, we describe an extremely rare case of a young male patient who denies smoking and initially presents with a mass on the top of the head and is eventually diagnosed with H-FLAC. The aim of this article is to improve the understanding and awareness of FLAC, and increase the attention to the disease, so as to prevent the underdiagnosis and ...
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Progress on Neoadjuvant Immunotherapy for Resectable Non-small Cell Lung Cancer
In recent years, there has been a consensus regarding the enhancement of prognosis in patients with advanced non-small cell lung cancer (NSCLC) through the utilization of immune checkpoint inhibitors (ICIs). Numerous clinical studies have also demonstrated the substantial value of immunotherapy for resectable NSCLC patients. Nevertheless, there remain controversies surrounding the exploration of immune combination strategies, treatment-related side effects, prognostic biomarkers, as well as other issues in the neoadjuvant therapy setting. Consequently, this article presents a comprehensive overview of the recent advancemen...
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Application Progress of Shared Decision Making Model in Patients
with Thoracic Cancer
As a new diagnosis and treatment decision-making model, shared decision making (SDM) can effectively solve the problem of patient compliance in the diagnosis and treatment of thoracic tumors, balance the status of both doctors and patients, and gradually get attention and application in the clinical practice of thoracic surgery. The application of SDM in the diagnosis and treatment of thoracic tumors is conducive to improve doctors ' diagnosis and treatment level and alleviating the pressure of responsibility, reduce patients ' psychological pressure and improve patients ' compliance and also improve medical trust and redu...
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
