Screening and Identification of the Peptides Specifically Binding to 
Human Non-small Cell Lung Cancer NCI-H1299 Cells
Conclusion We successfully obtained the peptide NSP1 that specifically binds to lung cancer NCI-H1299 cells by in vivo phage display, which provide a theoretical basis for NSCLC early diagnosis and targeted therapy. 
 DOI: 10.3779/j.issn.1009-3419.2020.103.17 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 24, 2020 Category: Cancer & Oncology Source Type: research

“Triple Trouble” in A Case of Mass Lesion
Bronchogenic carcinoma, the commonest lung tumor occurs more frequently in the elderly with typical symptoms of cough, haemoptysis, weight loss, dyspnoea or chest pain. These symptoms mimic common respiratory infections in en-demic areas like pulmonary tuberculosis. Also, metastasis at presentation itself is common, the favoured sites being liver, contra-lateral lungs, bones, brain, etc., although unusual and rare sites like heart also are known. We herein report a rare association of both carcinoma with active pulmonary tuberculosis in the same lobe associated with intracardiac metastasis. Very few cases have been publish...
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Research Progress of Targeted Therapy for HER2 Gene 
in Advanced Non-small Cell Lung Cancer
Lung cancer is the most common malignancy tumor. Non-small cell lung cancer (NSCLC) accounts for about 85% of lung cancer. Human epidermal growth factor receptor-2 (HER2) is a tyrosine kinase receptor in ERBB/HER family, which activates downstream signal transduction with other family members such as epidermal growth factor receptor (EGFR). HER2 gene mutation is closely related to the progression of many epithelial cell cancers. Tumors with high expression of HER2 show strong metastasis and invasion ability, poor sensitivity to chemotherapy, and are prone to relapse. At present, lung cancer driven gene targeted therapy has...
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development
This article reviews the current status and potential significance of ecDNA in tumor cells.
 DOI: 10.3779/j.issn.1009-3419.2020.101.48 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Research Progress of Circular RNA in Lung Cancer
Lung cancer is the most common malignant tumor with the highest morbidity and mortality worldwide, and its imposes an insupportable burden on patients due to its poor prognosis. The diagnosis and treatment of lung cancer is under great pressure. Therefore, it is urgent to explore effective therapeutic targets and molecular markers. Circular RNA (circRNA) is a kind of covalently closed non-coding RNAs, which has attracted much attention due to its conservation, stability and tissue specificity. Many studies have found that circRNA participates in the regulation of lung cancer through various mechanisms such as sponging miRN...
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Research Progress in the Treatment of Brain Metastases 
from Non-small Cell Lung Cancer
This article aims to review the research progress of current treatment methods. 
 DOI: 10.3779/j.issn.1009-3419.2020.102.39 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

A Method for Isolating Tumor Cells from Large Volume of Malignant Pleural 
Effusion and Its Efficacy Evaluation
Conclusion Our method can isolate large amount of tumor cells from a large volume of malignant pleural effusion with high purity. Using ETC-DNA as specimen improves the efficacy of gene detection, thus is worth further study. 
 DOI: 10.3779/j.issn.1009-3419.2020.103.18 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Analysis of Gene Variation in Thymoma by Microarray
Conclusion We found a variety of genes abnormally expressed in thymoma, which will provide reference for the study of pathogenesis and biomarkers of thymoma in the future. 
 DOI: 10.3779/j.issn.1009-3419.2020.102.46 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Efficacy of Stereotactic Body Radiotherapy versus Surgery for the Treatment 
of Early Non-small Cell Lung Cancer: A Meta-analysis
Conclusion The overall survival rate of surgical treatment is better than that of SBRT, but it has no obvious advantages in cancer specific survival rate. 
 DOI: 10.3779/j.issn.1009-3419.2020.101.50 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Results of EGFR Mutations Detected in Pleural Effusion and Its 
Clinical Significance in 132 Patients with Advanced Non-small Cell Lung Cancer: 
A Retrospective Study in A Single Center
Background and objective The lack of pathological quality control standard in detecting epidermal growth factor receptor (EGFR) gene mutation in malignant pleural effusion leads to confusion in the interpretation of detection results and the clinical use of EGFR-tyrosine kinase inhibitor (TKI). Therefore, it is very important to propose quality control standards and guide the detection of EGFR mutation in pleural effusion. The aim of this study is to retrospectively analyze the results of EGFR gene mutation in pleural effusion sediment section according to strict pathological quality control standards, and the therapeutic ...
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Analysis of Clinical Characteristics of 35 Cases 
of Pulmonary Sclerosing Pneumocytoma
Conclusion PSP is a clinically rare benign lung tumor, which is more common in middle-aged women. The clinical manifestations and imaging features are lack of significance. Percutaneous lung puncture pathological examination and intraoperative rapid frozen pathological sections often leads to misdiagnosis. Final diagnosis relies on postoperative pathological work-up for most cases. 
 DOI: 10.3779/j.issn.1009-3419.2020.103.19 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Clinical Value of Cerebrospinal Fluid ctDNA in Patients 
with Non-small Cell Lung Cancer Meningeal Metastasis
This study explored the feasibility of cerebrospinal fluid ctNDA for evaluating non-small cell lung cancer (NSCLC) meningeal metastasis and the potential clinical value of cerebrospinal fluid ctDNA detection in NSCLC meningeal metastasis. Methods A total of 21 patients with NSCLC meningeal metastasis were included. Tumor genomic variation was performed on the cerebrospinal fluid and peripheral blood samples of patients by second-generation gene sequencing technology. The situation was examined, and pathological evaluation of cerebrospinal fluid cytology and head magnetic resonance imaging (MRI) enhanced examination were pe...
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Analysis of Pulmonary Microbial Diversity in Patients with Advanced Lung Cancer Based on High-throughput Sequencing Technology
Conclusion The pulmonary bacterial microbiome of lung cancer of different histological types is different. This experiment enrichs the pulmonary bacterial microbiome data of lung cancer and fills the gap of pulmonary microbiome of small cell lung cancer. 
 DOI: 10.3779/j.issn.1009-3419.2020.103.16 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2020 Category: Cancer & Oncology Source Type: research

Advances in Drug Resistance Mechanisms and Prognostic Markers of Targeted Therapy in ALK-positive Non-small Cell Lung Cancer
This article will review the mechanism of ALK tyrosine kinase inhibitor (ALK-TKI) resistance and related prognostic markers to discuss the prediction for ALK-targeted therapy and the choice of subsequent treatment for drug-resistant patients. 
 DOI: 10.3779/j.issn.1009-3419.2020.101.44 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Pathological and Molecular Features of Lung Micropapillary Adenocarcinoma
This article reviews the Pathological phenomena and molecular features of micropapillary adenocarcinoma studied in recent years, aiming to deepen the understanding of micropapillary lesions and lay the foundation for formulating specific treatment strategies. 
 DOI: 10.3779/j.issn.1009-3419.2020.102.37 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Advances of Exosomes Extraction and Its Mechanism in Early Diagnosis of Lung Cancer
Lung cancer is a malignant tumor with high incidence and mortality in the world, which seriously threatens people ’s safety and health. Early diagnosis of lung cancer is the key part in the process of prevention and treatment of lung cancer. It can improve the survival of patients with lung cancer. Exosomes are closely related to the invasion and metastasis process of tumor, it plays an important role in the development of lung cancer. Biomarkers based on exosomes have become a powerful diagnostic tool of lung cancer. Exosomes are lipid bilayer vesicles with uniform size and diameter of 30 nm-200 nm secreted by cells...
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Immunotherapy Advances in Small Cell Lung Cancer
This article reviewed the clinical studies of immune checkpoint inhibitors (ICIs) in the first-line, maintenance and second or more line treatment of SCLC. Besides, predictive biomarkers were discussed to select suitable patients for immunotherapy effectively. DOI: 10.3779/j.issn.1009-3419.2020.105.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Advances in Molecular Biomarker for Pulmonary Large Cell Neuroendocrine Carcinoma
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a pathological subtype of lung neuroendocrine cancer, which accounts for 2.4%-3.1% in surgical specimens of lung cancer. It is characterized by high invasiveness and poor prognosis, and highly correlated with smoking. There are few relevant studies due to the low incidence and small sample size. Therefore, it is relatively difficult to diagnosis and treatment in clinical practice. In this review, we described molecular subtype, diagnostic and prognostic-related markers about large cell neuroendocrine carcinoma of lung based on the recent progress in genomic sequencin...
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Progress of Immunotherapy Mechanisms and Current Evidence of PD-1/PD-L1 
Checkpoint Inhibitors for Non-small Cell Lung Cancer with Brain Metastasis
Brain metastasis (BM) is a common complication in non-small cell lung cancer (NSCLC), which associates with poor prognosis. Recently, immune checkpoint inhibitors (ICIs) has revolutionized the treatment of tumors. Programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors could produce antitumor effect by activating the autoimmune system. The immunotherapy has already show to have a promising outcome for NSCLC patients with BM, while its specific curative effect and the most ideal mode of the treatment remain to be explored. Here we reviewed the tumor microenvironment (TME) in BM lesions and summarized the role...
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Research Progress of New Generation EGFR-TKIs after Third-generation
Lung cancer has the highest mortality rate in the world. The first- and second-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) greatly improve the survival time and quality of life of patients with non-small cell lung cancer (NSCLC) to some extent. However, after a period of progression-free survival, most patients develop drug resistance, in which T790M mutation is the mainly resistance mechanism. The third-generation EGFR-TKIs, represented by osimertinib, are found to have significant effect on this resistance. The effect is remarkable, but drug resistance is still inevitable. For examp...
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer
N6-methyladenosine is one of the most prevalent mRNA modification in eukaryotes. The regulation of this pervasive mark is a dynamic and reversible process. m6A RNA methylation is catalyzed by m6A writers, removed by m6A erasers and recognized by m6A readers, thereby regulating multiple RNA processes including alternative splicing, nuclear export, degradation and translation. Accumulated evidence suggests that m6A modification plays a crucial role in the pathogenic mechanism and malignant progression in non-small cell lung cancer (NSCLC), including cell survival, proliferation, migration, invasion, tumor metastasis and drug...
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Research Progress on Lung Cancer Screening
Lung cancer is the most common malignant tumor in the world. The five-year survival rate is 19.7%, which seriously threatens human health. Lung cancer screening is an effective measure to reduce lung cancer mortality. Existing studies have shown that screening with low-dose computed tomography (LDCT) can reduce lung cancer deaths by 20%. Currently, lung cancer screening is recommended internationally and nationally. Studying the development status of lung cancer screening helps us to identify the high-risk groups of lung cancer, explore reasonable screening programs, improve the cost-effectiveness of screening and reduce t...
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Mechanism and Research Progress of Microbiome in the Development of Lung Cancer
This article reviews the current researches on microbial flora and lung cancer, and provides new ideas for clinical diagnosis and treatment of lung cancer. 
 DOI: 10.3779/j.issn.1009-3419.2020.101.38 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Identification of Candidate Biomarkers for EGFR-T790M Drug-resistant 
Gene Mutation in Advanced Lung Adenocarcinoma
Conclusion Seventeen proteins associated with EGFR-T790M resistance were found, and proteins involved in the coagulation cascade pathway are expected to be biomarkers associated with predicting EGFR-T790M resistance mutations. DOI: 10.3779/j.issn.1009-3419.2020.104.20 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Incidence and Risk of PD-1/PD-L1 Inhibitor-associated Pneumonia in Advance Cancer Patients: A Meta-analysis
Conclusion Compared with chemotherapy, the risk of immune-associated pneumonia is higher in PD-1 and PD-L1 inhibitors, and its occurrence risk is high in the ICI group with NSCLC and the first-line treatment with ICI. This paper provides guidance for clinic treatment of terminal cancers and prevention of complications. 
 DOI: 10.3779/j.issn.1009-3419.2020.103.14 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Advancement of E2F1 in Common Tumors
This article reviews the latest research progress of E2F1 in current common tumors. 
 DOI: 10.3779/j.issn.1009-3419.2020.101.32 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

CAR-T Immunotherapy and Non-small Cell Lung Cancer: Bottleneck and Dawn
With the deeper understanding of the pathophysiology and pathogenesis of non-small cell lung cancer (NSCLC) which threatens human health, NSCLC treatment has entered a new era. Transition from traditional treatment based on surgery, radiotherapy and chemotherapy to individualized and precise targeted therapy and safer and more effective immunotherapy. Immune checkpoint inhibitor therapy has been approved as a first-line or second-line treatment for advanced NSCLC, and has achieved extraordinary clinical results. Meanwhile, other types of immunotherapy are rarely explored in NSCLC. Chimeric antigen receptor modified T cells...
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Correlation between Gut Microbiota and Lung Cancer
Gene-environment interactions underlie cancer susceptibility and progression. The human body is exposed to and affected by the microenvironment seiscasts of various microorganisms and their metabolites, such as the microenvironment of gut microbiota. The relative abundance of some intestinal microbes in lung cancer patients was significantly different from that in the control group. These studies suggest that gut microbiota may be associated with lung cancer through some ways. At the same time, gut microbiota is relatively manageable environmental variables compared to the external environment we are exposed to, as they ar...
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Research Advances and Obstacles of CT-based Radiomics in Diagnosis and Treatment of Lung Cancer
Radiomics, a technology based on multimodal medical image processing and analysis, is able to extract automatically and analyze massive data from computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/computed tomography (PET/CT) via high-performance computer algorithm in order to pursue early diagnosis of disease, benign and malignant tumor discrimination, dynamic evaluation of disease treatment, and individualized precision therapy. To date, many studies demonstrate that radiomics not only has great potential in early diagnosis of lung cancer and prediction of genotype, treatment efficac...
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Present and Future of Efficacy Biomarkers in Immune Checkpoint Inhibitors 
of Small Cell Lung Cancer
Inhibitions of immune checkpoints, including programmed cell death 1-programmed cell death-ligand 1 (PD-1-PD-L1) axis, cytotoxic T lymphocyte associated antigen-4, are at the forefront of immunotherapy for small cell lung cancer. However, the survival benefits emerged after three to six months since therapy initiation. A growing body of evidence suggested that the current biomarkers were not consistent and convincing. Here, we review the current biomarkers including PD-L1, tumor mutation burden, DNA damage response pathway. Furthermore, we elucidate the potential biomarkers, such as tumor-infiltrating lymphocytes, circulat...
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Immune Characteristics of Small Cell Lung Cancer
Small cell lung cancer (SCLC) is a type of malignancy with poor prognosis, and no advance in medication has been made for about 30 years except immune checkpoint inhibitor (ICI), which demonstrated efficacy in recent years. The response rate of programmed death-1 (PD-1) inhibitor alone or its combination with cytotoxic T-lymphocyte antigen-4 (CTLA-4) inhibitor as subsequent therapy was 10%-33% and the response duration was persistent. The combination of programmed death ligand-1 (PD-L1) inhibitor with chemotherapy resulted in longer survival versus chemotherapy alone. Nevertheless, comparing with immunotherapy-sensitive tu...
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

A Literature Review on the Role of TBX5 in Expression and Progression of Lung Cancer: Current Perspectives
T-box transcription factor gene (TBX) interferes with the origin and development of organs, and TBX5 is expressed highest in normal cardiac and pulmonary tissues. Lack of TBX5 may lead to thoracic malformation and abnormal diaphragmatic development, in which ectopic expression and overexpression may induce the apoptosis of cell and inhibit the development of cell. Previous studies demonstrated the potential role of TBX5 in the development and progression of esophageal adenocarcinoma, gastric cancer, colon cancer and breast cancer. We reviewed the association between the expression of TBX2 subfamily and the prognosis, and e...
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Progress of Lung Cancer Screening with Low Dose Helical Computed Tomography
Lung cancer which represents characteristics of a heavy disease burden, a large proportion of advanced lung cancer and a low five-year survival rate is a threat to human health. It is essential to implement population-based lung cancer screening to improve early detection and early treatment. The National Lung Screening Trial (NLST) demonstrated that screening with low dose helical computed tomography (LDCT) may decrease lung cancer mortality, which brings hope for the early diagnosis and treatment of lung cancer. In recent years, great progresses have been made on research of lung cancer screening with LDCT. However, whet...
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Progress in Treatment of Advanced Squamous Cell Lung Cancer
Lung cancer ranks first both in mobidity and motality in china and worldwild. Squamous cell lung carcinoma is distinguished from lung adenocarcinoma in diagnosis and treatment due to its unique clinical& pathological manifestations and gene mutation characteristics, as a result, it is also explored as a separate type in clinical researches. In addition to the clinical manifestations of elderly, central tumors, late staging at diagnosis, and multiple comorbidities, the lack of driver genes makes it nearly impossible for these patients to benefit from targeted therapy. However, the exploration of targeted therapy for lun...
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Bronchial Fistula: Rare Complication of Treatment with Anlotinib
Conclusion Although anlotinib is relatively safe, it is still necessary to pay attention t o the occurrence of BF, a rare treatment side effect that threatens the quality of life and overall survival of patients. Anlotinib, therefore, requires selective use and close observation of high-risk patients. DOI: 10.3779/j.issn.1009-3419.2020.102.40 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

A Retrospective Study of Microporous Polysaccharide Hemostatic Powder Combined with Other Repair Materials for Reducing Postoperative Pulmonary Air Leakage during Pulmonary Segmentectomy
Conclusion Compared with the use of the fibrin glue+absorbability polygly colic acid patch, the use of microporous polysaccharide hemostatic powder+fibrin glue+absorbability polyglycolic acid patch in the treatment of the inter-segment interface during segmentectomy can better reduce the incidence of postoperative air leakage and shorten the postoperative hospital stay.
 DOI: 10.3779/j.issn.1009-3419.2020.101.41 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Correlation between Pretreatment Serum Apolipoprotein Level and Prognosis of Small Cell Lung Cancer Patients
Conclusion Serum ApoA-I level and ApoB/ApoA-I level before treatment can be important prognostic factors for SCLC, which is helpful to judge the prognosis of patients. DOI: 10.3779/j.issn.1009-3419.2020.104.21 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Prognostic Analysis of NSCLC Based on the Tumor-associated Macrophages, Tumor Neo-vessels and PD-L1 Expression in Tumor Microenvironment
Conclusion The key components of TAMs and PD-L1 in tumor microenvironment are closely related to the prognosis of NSCLC patients. 
 DOI: 10.3779/j.issn.1009-3419.2020.103.15 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Chinese Expert Consensus on Standards of PD-L1 Immunohistochemistry Testing 
for Non-small Cell Lung Cancer
DOI: 10.3779/j.issn.1009-3419.2020.101.43 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: research

Progress in Survival Prognosis of Segmentectomy for 
Early-stage Non-small Cell Lung Cancer
Surgery is currently the most appropriate treatment for early-stage non-small cell lung cancer (NSCLC). Increasing unilateral or bilateral multiple primary lung cancer being found, segmentectomy has attracted wide attention for its unique advantages in the treatment for such tumors. Ground glass opacity dominant early-stage NSCLC is associated with a good prognosis and can be cured by segmentectomy, however, the treatment of solid-dominant NSCLC remains controversial owing to the invasive nature. With the in-depth study on the lymph node metastasis pathway, radiological characteristics and molecular biology of NSCLC, a lar...
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Research Progress on the Relationship between Blood Lipids and 
Lung Cancer Risk and Prognosis
This article reviews the research progress of the relationship between blood lipid levels and the risk of lung cancer, blood lipid levels and the prognosis of lung cancer patients, and the adjustment of blood lipid drugs and the prevention and treatment of lung cancer. 
 DOI: 10.3779/j.issn.1009-3419.2020.102.36 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Advances in Identification of Intersegmental Plane during Pulmonary Segmentectomy
With the popularity of computed tomography (CT) scan in recent years, early stage lung cancer has been discovered in large numbers of patients and pulmonary segmentectomy has been widely used clinically. Identification of the intersegmental plane is one of the key steps in pulmonary segmentectomy, and current methods for identifying the intersegmental plane are numerous and have their own advantages and disadvantages. We will review relevant methods to help the clinical practice. 
 DOI: 10.3779/j.issn.1009-3419.2020.101.31 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Mechanism of Ferroptosis and Its Research Progress in Lung Cancer
Ferroptosis is a recently recognized form of regulated cell death caused by an iron-dependent accumulation of lipid reactive species. However, little research on ferroptosis and lung cancer, one of the most common tumors, has been carried out. This paper tries to review the research progress of ferroptotic suppression and explain it from the different ways of ferroptosis occurrence. Furthermore, as inducing ferroptosis to treat cancer gets more attention, we introduce four kinds of ferroptosis-inducing compounds and new prospects for lung cancer therapy to provide new ideas for lung cancer treatment. DOI: 10.3779/j.issn.10...
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Highlights of PAPR Inhibitors in Small Cell Lung Cancer
Small cell lung cancer (SCLC), characterized by early metastasis, relapse, relapse and resistance and poor prognosis, still faces difficulties in treatment. Recently, Immunotherapy is a novel treatment for SCLC, researchers are also eager to achieve a breakthrough in targeted treatment of SCLC. Genomic instability of SCLC and sensitivity to cytotoxic chemotherapy, therefore, poly ADP-ribose polymerase (PARP) inhibitors targeting DNA repair related pathways have become a hotspot in the research of SCLC targeted therapy. Studies on PARP inhibitors in SCLC have been conducted in combination with other therapeutic strategies, ...
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

The Present Situation and Prospect of Day Surgery and Enhanced Recovery 
after Surgery in Thoracic Surgery
This article summarizes the current application of ERAS in the field of thoracic surgery and the development prospects of day surgery models in China. DOI: 10.3779/j.issn.1009-3419.2020.102.08 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Clinical-radiological-pathological Characteristics of 297 Cases of Surgical Pathology Confirmed Benign Pulmonary Lesions in Which Malignancy Could Not Be Excluded in Preoperative Assessment: A Retrospective Cohort Analysis in a Single Chinese Hospital
Conclusion Solid nodules accounted for most of these benign pulmonary lesions in which malignan cy could not be excluded preoperatively, and imaging characteristics suggesting malignancy were common. VATS is an important biopsy method to identify etiology and pathology for lesions. The most frequent benign pulmonary diseases that are suspected to be malignant and underwent surgical resection a re: infectious lesions, inflammatory nodules and hamartoma. DOI: 10.3779/j.issn.1009-3419.2020.104.24 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Immune-related Adverse Events Induced by ICIs in Advanced NSCLC: 
A Meta-analysis and Systematic Review
Conclusion ICIs have different toxicity profile compared with chemotherapy, and their immune-related toxicity is stronger than that of traditional chemotherapy. ICIs induced ir-AEs is organ-specific, and different ICI has specific immune-related toxicity profiles. As ICIs represent a new and distinct class of treatment for NSCLC, this article has systematically illustrated the efficacy and ir-AEs induced by ICIs, hopefully it can be useful for clinicians and patients to get a further understanding of ICIs, and facilitate early prediction, comprehensive diagnosis, and prompt management of ir-AEs by providing status referenc...
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Down-regulation of HOTAIR Reverses the Resistance of Gefitinib in HCC827 Cells by Increasing the Expression of PTEN
Background and Objective Lung cancer is the most common cancer worldwide with the highest morbidity and mortality, in which the non-small cell lung cancer accounts for 80% of all cases. The expression of (HOX transcript antisense RNA) HOTAIR were abnormal in a variety of tumor tissues and is involved in the regulation of the occurrence and development of lung cancer. The purpose of this study is to investigate the effect and mechanism of down-regulation of HOTAIR on gefitinib resistance of lung adenocarcinoma HCC827 cells by targeting PTEN. Methods The HOTAIR downstream target gene was predicted by bioinformatics database....
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Chinese Expert Consensus on Next Generation Sequencing Diagnosis 
for Non-small Cell Lung Cancer (2020 Edition)
DOI: 10.3779/j.issn.1009-3419.2020.101.45 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Treatment for Brain Metastases from EGFR Mutations NSCLC Patients: How Should We Choose in Clinical Practice?
This article refers to relevant literatures and summarizes the discussion from the perspective of pursuing the truth of disease treatment and problem solving in order to provide reference for patients'clinical practice. DOI: 10.3779/j.issn.1009-3419.2020.101.29 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 25, 2020 Category: Cancer & Oncology Source Type: research