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Total 538 results found since Jan 2013.

MicroRNA-640 Inhibition Enhances the Chemosensitivity of Human Glioblastoma Cells to Temozolomide by Targeting Bcl2 Modifying Factor
Biochem Genet. 2022 Aug 19. doi: 10.1007/s10528-022-10264-x. Online ahead of print.ABSTRACTGlioblastoma (GBM) is the most malignant and challenging type of astrocytoma and also notoriously acknowledged as the most common primary brain tumor globally. Currently, chemotherapy is the most master therapy for tumor and is essential in clinical treatment for GBM. Nevertheless, the characterization of chemotherapy resistance seriously hinders clinical chemotherapy treatment. Accordingly, there are imperious demands for the exploitation of novel chemosensitizer to promote the efficacy of chemotherapy. Our current study was conduct...
Source: Biochemical Genetics - August 19, 2022 Category: Genetics & Stem Cells Authors: Shu Jiang Chao Luo Yongli Chen Jing Chen Shuang Tao Quan Zou Chunzhi He Shanwu Dong Source Type: research

Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma
In this study, we utilize the engineering technology to generate T7 peptide-decorated exosome (T7-exo). T7 is a peptide specifically binding to the transferrin receptor. T7-exo shows excellent packaging and protection of cholesterol-modified Cy3-siYY1 while quickly releasing payloads in a cytoplasmic reductive environment. The engineered exosomes T7-siYY1-exo could deliver more effciently to GBM cells both in vitro and in vivo. Notably, in vitro experiments demonstrate that T7-siYY1-exo can enhance chemoradiotherapy sensitivity and reverse therapeutic resistance. Moreover, T7-siYY1-exo and TMZ/IR exert synergistic anti-GBM...
Source: Frontiers in Pharmacology - August 19, 2022 Category: Drugs & Pharmacology Source Type: research

COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion
CONCLUSIONS: COL1A2 plays an important role in driving GBM progression. COL1A2 inhibition attenuated GBM proliferation by promoting cell cycle arrest, indicating that COL1A2 could be a promising therapeutic target for GBM treatment.PMID:35932265 | DOI:10.3171/2022.6.JNS22319
Source: Journal of Neurosurgery - August 6, 2022 Category: Neurosurgery Authors: Yi Wang Maki Sakaguchi Hemragul Sabit Sho Tamai Toshiya Ichinose Shingo Tanaka Masashi Kinoshita Yasuo Uchida Sumio Ohtsuki Mitsutoshi Nakada Source Type: research

Inhibition of Dyrk1A Attenuates LPS-Induced Neuroinflammation via the TLR4/NF- κB P65 Signaling Pathway
This study investigated the role of Dyrk1A in regulating neuroinflammation, another critical factor that contributes to AD. In the present study, we used an immortalized murine BV2 microglia cell line induced by lipopolysaccharide (LPS) to study neuroinflammation. The expression and activity of Dyrk1A kinase were both increased by inflammation. Dyrk1A inhibition using harmine or siRNA silencing significantly reduced the production of proinflammatory factors in LPS-stimulated BV2 cells. Reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and nitric oxide (NO), as well as the expression of the inflammatory prot...
Source: Inflammation - August 2, 2022 Category: Allergy & Immunology Source Type: research

Tex264 Binding to SNX27 Regulates Itg < em > α < /em > 5 Receptor Membrane Recycling and Affects Cell Migration
Biomed Res Int. 2022 Jul 4;2022:4304419. doi: 10.1155/2022/4304419. eCollection 2022.ABSTRACTTex264 is an endoplasmic reticulum (ER) membrane protein that was recently demonstrated to act as an ER-phagy receptor under starvation conditions to mediate endoplasmic reticulum autophagy. However, how Tex264 functions in the central nervous system (CNS) and tumors is unclear. Here, we identified 89 proteins from the rat brain that may specifically interact with Tex264 and confirmed the interaction between sorting nexin 27 (SNX27) and Tex264 by coimmunoprecipitation and immunofluorescence. Our results indicated that Tex264 may pr...
Source: Biomed Res - July 15, 2022 Category: Research Authors: Xiao-Hui Xu Qian-Wen Yang Chang-Ling Yue Yun-Yi Zhu Zhao-Huan Zhang Source Type: research

Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis
This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.PMID:35820539 | DOI:10.1016/j.jconrel.2022.07.009
Source: Cancer Control - July 12, 2022 Category: Cancer & Oncology Authors: Zhenhao Zhao Yujie Zhang Chao Li Xuwen Li Yongchao Chu Qin Guo Yiwen Zhang Weiyi Xia Peixin Liu Hongyi Chen Yu Wang Chufeng Li Tao Sun Chen Jiang Source Type: research

Centromere protein J is overexpressed in human glioblastoma and promotes cell proliferation and migration
AbstractGlioblastoma is the most common and malignant type of primary brain tumor. Previous studies have shown that alterations in centrosome amplification and its components are frequently found in treatment-resistant tumors and may be associated with tumor progression. A centrosome protein essential for centrosome biogenesis is the centromere protein J (CENPJ), known to control the proliferation of neural progenitors and hepatocarcinoma cells, and also neuronal migration. However, it remains unknown the role of CENPJ in glioblastoma. Here we show that CENPJ is overexpressed in human glioblastoma cell lines in comparison ...
Source: Journal of Neurochemistry - July 7, 2022 Category: Neuroscience Authors: Gabriella P. A. de Freitas, Luiz Henrique M. Geraldo, Bruna M. Faria, Soniza Vieira Alves ‐Leon, Jorge Marcondes de Souza, Vivaldo Moura‐Neto, Bruno Pontes, Luciana F. Romão, Patrícia P. Garcez Tags: ORIGINAL ARTICLE Source Type: research