Filtered By:
Cancer: Brain Cancers
This page shows you your search results in order of date. This is page number 13.
Order by Relevance | Date
Total 538 results found since Jan 2013.
CDK-associated Cullin 1 promotes Cell Proliferation and inhibits Cell Apoptosis in Human Glioblastoma
CONCLUSION: CACUL1 can promote cell proliferation and suppress apoptosis of glioma cells and might serve as a potential oncogene for gliomas.PMID:34080964 | DOI:10.2174/1568009621666210602164225
Source: Current Cancer Drug Targets - June 3, 2021 Category: Cancer & Oncology Authors: Xiaohua Zhang Tianying Zhang Xiaojuan Han Zhongying Qiu Jianghong Cheng Xingchun Gao Xingchun Gou Source Type: research
The enzyme L-isoaspartyl (D-aspartyl) methyltransferase promotes migration and invasion in human U-87 MG and U-251 MG glioblastoma cell lines
Biomed Pharmacother. 2021 May 31;140:111766. doi: 10.1016/j.biopha.2021.111766. Online ahead of print.ABSTRACTThe protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) recognizes abnormal L-isoaspartyl and D-aspartyl residues in proteins. Among examined tissues, PIMT shows the highest level in the brain. The U-87 MG cell line is a commonly used cellular model to study the most frequent brain tumor, glioblastoma. Previously, we reported that PIMT amount increased when U-87 MG cells were detached from the extracellular matrix. Recently, we also showed that PIMT possessed pro-angiogenic properties. Together, these PIMT ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 3, 2021 Category: Drugs & Pharmacology Authors: Fatima Belkourchia Richard R Desrosiers Source Type: research
Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma
Transl Oncol. 2021 May 27;14(8):101137. doi: 10.1016/j.tranon.2021.101137. Online ahead of print.ABSTRACTThe poor prognosis of glioblastoma multiforme (GBM) is primarily due to highly invasive glioma stem-like cells (GSCs) in tumors. Upon GBM recurrence, GSCs with highly invasive and highly migratory activities must assume a less-motile state and proliferate to regenerate tumor mass. Elucidating the molecular mechanism underlying this transition from a highly invasive phenotype to a less-invasive, proliferative tumor could facilitate the identification of effective molecular targets for treating GBM. Here, we demonstrate t...
Source: Translational Oncology - May 30, 2021 Category: Cancer & Oncology Authors: Masahiro Nishikawa Akihiro Inoue Takanori Ohnishi Hajime Yano Saya Ozaki Yonehiro Kanemura Satoshi Suehiro Yoshihiro Ohtsuka Shohei Kohno Shiro Ohue Seiji Shigekawa Hideaki Watanabe Riko Kitazawa Junya Tanaka Takeharu Kunieda Source Type: research
Indoleamine 2,3-Dioxygenase 1 (IDO1) Promotes Cardiac Hypertrophy via a PI3K-AKT-mTOR-Dependent Mechanism
Cardiovasc Toxicol. 2021 May 21. doi: 10.1007/s12012-021-09657-y. Online ahead of print.ABSTRACTIndoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme for tryptophan metabolism, involved in immune cell differentiation/maturation and cancer biology. IDO1 is also expressed in cardiomyocytes, but its roles in the cardiovascular system are not fully understood. Here, we reported the functions of IDO1 during cardiac hypertrophy. Quantitative real-time PCR and Western blot experiments demonstrated the upregulation of IDO1 mRNA and protein levels in human and hypertrophic mouse hearts, as well as in angiotensin II (Ang II)-induced hyp...
Source: Cardiovascular Toxicology - May 22, 2021 Category: Cardiology Authors: Yang Liu Shuang Li Zhanqun Gao Shuangjia Li Qingyun Tan Yanmei Li Dongwei Wang Qingdong Wang Source Type: research
LINC00511 knockdown suppresses glioma cell malignant progression through miR-15a-5p/AEBP1 axis
CONCLUSION: LINC00511 knockdown inhibits glioma cell progression via miR-15a-5p/AEBP1 axis.PMID:33992709 | DOI:10.1016/j.brainresbull.2021.05.010
Source: Brain Research Bulletin - May 16, 2021 Category: Neurology Authors: Zhen Liu Bei Tao Linkun Li Pin Liu Kaiguo Xia Chuanhong Zhong Source Type: research
