Filtered By:
Cancer: Brain Cancers
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 538 results found since Jan 2013.
CDK5 Mediates Proinflammatory Effects of Microglia through Activated DRP1 Phosphorylation in Rat Model of Intracerebral Hemorrhage
CONCLUSION: CDK5 may regulate DRP1 by direct phosphorylation in microglia and further induce microglia secreting proinflammation factor.PMID:35795154 | PMC:PMC9252704 | DOI:10.1155/2022/1919064
Source: Disease Markers - July 7, 2022 Category: Laboratory Medicine Authors: Mingqing He Xiaoyan Wang Zheng Liu Qiyuan Cui Ying Chen Wenqing Geng Jinzhou Zhu Jiabing Shen Source Type: research
An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy
Biomaterials. 2022 Jun 22;287:121645. doi: 10.1016/j.biomaterials.2022.121645. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with a high mortality rate. Immunotherapy has achieved promising clinical results in multiple cancers, but shows unsatisfactory outcome in GBM patients, and poor drug delivery across the blood-brain barrier (BBB) is believed to be one of the main limitations that hinder the therapeutic efficacy of drugs. Herein, a new cationic lipid nanoparticle (LNP) that can efficiently deliver siRNA across BBB and target mouse brain is prepared fo...
Source: Biomaterials - July 2, 2022 Category: Materials Science Authors: Shuhan Liu Ji Liu Haisong Li Kuirong Mao Haorui Wang Xiandi Meng Jialiang Wang Chenxi Wu Hongmei Chen Xin Wang Xiuxiu Cong Yue Hou Ye Wang Ming Wang Yong-Guang Yang Tianmeng Sun Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
Cancers, Vol. 14, Pages 3198: Prostate Apoptosis Response-4 (Par-4): A Novel Target in Pyronaridine-Induced Apoptosis in Glioblastoma (GBM) Cells
Kalpana Joshi
Glioblastoma (GBM) is an aggressive form of brain tumor with a median survival of approximately 12 months. With no new drugs in the last few decades and limited success in clinics for known therapies, drug repurposing is an attractive choice for its treatment. Here, we examined the efficacy of pyronaridine (PYR), an anti-malarial drug in GBM cells. PYR induced anti-proliferative activity in GBM cells with IC50 ranging from 1.16 to 6.82 &micro;M. Synergistic activity was observed when PYR was combined with Doxorubicin and Ritonavir. Mechanistically, PYR triggered mitochondrial membrane depolariza...
Source: Cancers - June 29, 2022 Category: Cancer & Oncology Authors: Jeevan Ghosalkar Vinay Sonawane Tejal Pisal Swati Achrekar Radha Pujari Ashish Chugh Padma Shastry Kalpana Joshi Tags: Article Source Type: research
The combination of baicalin with knockdown of miR148a gene suppresses cell viability and proliferation and induces the apoptosis and autophagy of human glioblastoma multiforme T98G and U87MG cells
CONCLUSION: The siRNA-induced miR148a mRNA knockdown in combination with baicalin may offer a novel therapeutic strategy to more effective control the growth of human GBM cells. Thus, knockdown of this gene in combination with baicalin inhibits proliferation (cell cycle arrest in S phase in T98G but not in U87MG cells), induces apoptosis and regulates autophagy in T98G and U87MG cells, but further studies urgently needed to confirm a positive phenomenon for the treatment of GBM.PMID:35761505 | DOI:10.2174/1389201023666220627144100
Source: Current Pharmaceutical Biotechnology - June 28, 2022 Category: Biotechnology Authors: Monika Paul-Samojedny Emilia Liduk Ma łgorzata Kowalczyk Paulina Borkowska Aleksandra Zieli ńska Renata Suchanek-Raif Jan Kowalski Source Type: research
