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Cancer: Brain Cancers
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Total 538 results found since Jan 2013.
Gliomagenesis is orchestrated by the Oct3/4 regulatory network
J Neurosurg Sci. 2021 Aug 3. doi: 10.23736/S0390-5616.21.05437-0. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is a lethal brain tumor characterized by developmental hierarchical phenotypic heterogeneity, therapy resistance and recurrent growth. Neural stem cells (NSCs) from human central nervous system (CNS), and glioblastoma stem cells from patient-derived GBM (pdGSC) samples and cultured in both 2D well-plate and 3D monoclonal neurosphere culture system (pdMNCS). The pdMNCS model shows promise to establish a relevant 3D-tumor environment that maintains GBM cells in the stem cell phase within suspended neu...
Source: Journal of Neurosurgical Sciences - August 3, 2021 Category: Neurosurgery Authors: Tatyana N Ignatova Hersh J Chaitin Nickolay V Kukekov Oleg N Suslov Galina I Dulatova Khalid A Hanafy Frank D Vrionis Source Type: research
