Filtered By:
Cancer: Brain Cancers
This page shows you your search results in order of date. This is page number 14.
Order by Relevance | Date
Total 538 results found since Jan 2013.
LINC00511 knockdown suppresses glioma cell malignant progression through miR-15a-5p/AEBP1 axis
CONCLUSION: LINC00511 knockdown inhibits glioma cell progression via miR-15a-5p/AEBP1 axis.PMID:33992709 | DOI:10.1016/j.brainresbull.2021.05.010
Source: Brain Research - May 16, 2021 Category: Neurology Authors: Zhen Liu Bei Tao Linkun Li Pin Liu Kaiguo Xia Chuanhong Zhong Source Type: research
Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore
We present in vivo pharmacokinetic studies of the top analogues with evidence of brain penetration. We also report a targeted siRNA-based screen which suggests a possible role for mTOR and Akt in DNA repair inhibition by this class of drugs. Taken together, these data reveal a new class of mibefradil-based DNA repair inhibitors which can be further advanced into pre-clinical testing and eventually clinical trials, as potential GBM radiosensitizers.PMID:33953843 | PMC:PMC8092340 | DOI:10.18632/oncotarget.27933
Source: Oncotarget - May 6, 2021 Category: Cancer & Oncology Authors: Sateja Paradkar James Herrington Adam Hendricson Piyasena Hewawasam Mark Plummer Denton Hoyer Ranjini K Sundaram Yulia V Surovtseva Ranjit S Bindra Source Type: research
A Novel Role for Brain and Acute Leukemia Cytoplasmic (BAALC) in Human Breast Cancer Metastasis
This study investigates BAALC expression in human breast cancers with the aim of determining if it plays a role in the pathogenesis of the disease. BAALC protein expression was examined by immunohistochemistry in breast cancer, and matched lymph node and normal breast tissue samples. The effect of gene expression on overall survival (OS), disease-free and distant metastasis free survival (DMFS) was assessed in silico using the Kaplan-Meier Plotter (n=3,935), the TCGA invasive breast carcinoma (n=960) and GOBO (n=821) data sets. Functional effects of BAALC expression on breast cancer proliferation, migration and invasion we...
Source: Frontiers in Oncology - April 22, 2021 Category: Cancer & Oncology Source Type: research
Lentivirus vector ‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain
Mol Med Rep. 2021 Jun;23(6):422. doi: 10.3892/mmr.2021.12061. Epub 2021 Apr 13.ABSTRACTTranslation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generally do not allow for preclinical evaluation of the efficiency of novel therapies in combination with surgical resection. Therefore, the aim of the present study was to develop a larger animal model utilizing lentivirus vector‑mediated oncogenic transformation in the rabbit brain. Lentiviruses carrying constitutively active AKT and H‑Ras on...
Source: Molecular Medicine - April 13, 2021 Category: Molecular Biology Authors: Farizan Ahmad Anna Hyv ärinen Agnieszka Pirinen Venla Olsson Jaana Rummukainen Arto Immonen Johanna N ärväinen Pasi Tuunanen Timo Liimatainen Virve K ärkkäinen Jari Koistinaho Seppo Yl ä-Ηerttuala Source Type: research
