Filtered By:
Cancer: Brain Cancers
This page shows you your search results in order of date. This is page number 10.
Order by Relevance | Date
Total 538 results found since Jan 2013.
SOCS1 Mediates Berberine-Induced Amelioration of Microglial Activated States in N9 Microglia Exposed to < em > β < /em > Amyloid
Biomed Res Int. 2021 Nov 5;2021:9311855. doi: 10.1155/2021/9311855. eCollection 2021.ABSTRACTAttenuating β amyloid- (Aβ-) induced microglial activation is considered to be effective in treating Alzheimer's disease (AD). Berberine (BBR) can reduce microglial activation in Aβ-treated microglial cells; the mechanism, however, is still illusive. Silencing of cytokine signaling factor 1 (SOCS1) is the primary regulator of many cytokines involved in immune reactions, whose upregulation can reverse the activation of microglial cells. Microglia could be activated into two different statuses, classic activated state (M1 state) a...
Source: Biomed Res - November 15, 2021 Category: Research Authors: Qi Guo Chen Wang Xiaorong Xue Bin Hu He Bao Source Type: research
The balance between cell survival and death in the placenta: Do neurotrophins have a role?
Syst Biol Reprod Med. 2021 Oct 6:1-10. doi: 10.1080/19396368.2021.1980132. Online ahead of print.ABSTRACTNeurotrophins (NT) are a closely related family of growth factors, which regulate the nervous system's development, maintenance, and function. Although NTs have been well studied in neuronal cells, they are also expressed in the placenta. Despite their suggested role in regulating fetoplacental development, their precise functional significance in the placenta remains elusive. NT activate two different classes of receptors. These include the Trk, tropomyosin-related kinase family of high-affinity tropomyosin-related kin...
Source: Reproductive Biology - October 7, 2021 Category: Reproduction Medicine Authors: Prachi Pathare-Ingawale Preeti Chavan-Gautam Source Type: research
SOCS3 is Related to Cell Proliferation in Neuronal Tissue: An Integrated Analysis of Bioinformatics and Experiments
Glioma is the most common primary malignant tumor that occurs in the central nervous system. Gliomas are subdivided according to a combination of microscopic morphological, molecular, and genetic factors. Glioblastoma (GBM) is the most aggressive malignant tumor; however, efficient therapies or specific target molecules for GBM have not been developed. We accessed RNA-seq and clinical data from The Cancer Genome Atlas, the Chinese Glioma Genome Atlas, and the GSE16011 dataset, and identified differentially expressed genes (DEGs) that were common to both GBM and lower-grade glioma (LGG) in three independent cohorts. The bio...
Source: Frontiers in Genetics - September 27, 2021 Category: Genetics & Stem Cells Source Type: research
Anti-Proliferative Effects of E2F1 Suppression in Glioblastoma Cells
Glioblastoma (GBM) is an aggressive malignant brain tumor; surgery, radiation, and temozolomide still remain the main treatments. There is evidence that E2F1 is overexpressed in various types of cancer, including GBM. E2F1 is a transcription factor that controls the cell cycle progression and regulates DNA damage responses and the proliferation of pluripotent and neural stem cells. To test the potentiality of E2F1 as molecular target for GBM treatment, we suppressed theE2F1 gene (siRNA) in the U87MG cell line, aiming to inhibit cellular proliferation and modulate the radioresistance of these cells. Following E2F1 suppressi...
Source: Cytogenetic and Genome Research - September 3, 2021 Category: Genetics & Stem Cells Source Type: research
Gliomagenesis is orchestrated by the Oct3/4 regulatory network
J Neurosurg Sci. 2021 Aug 3. doi: 10.23736/S0390-5616.21.05437-0. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is a lethal brain tumor characterized by developmental hierarchical phenotypic heterogeneity, therapy resistance and recurrent growth. Neural stem cells (NSCs) from human central nervous system (CNS), and glioblastoma stem cells from patient-derived GBM (pdGSC) samples and cultured in both 2D well-plate and 3D monoclonal neurosphere culture system (pdMNCS). The pdMNCS model shows promise to establish a relevant 3D-tumor environment that maintains GBM cells in the stem cell phase within suspended neu...
Source: Journal of Neurosurgical Sciences - August 3, 2021 Category: Neurosurgery Authors: Tatyana N Ignatova Hersh J Chaitin Nickolay V Kukekov Oleg N Suslov Galina I Dulatova Khalid A Hanafy Frank D Vrionis Source Type: research
