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Cancer: Kidney Cancer

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Total 216 results found since Jan 2013.

MicroRNA-93 inhibits apoptosis and promotes proliferation, invasion and migration of renal cell carcinoma ACHN cells via the TGF- β/Smad signaling pathway by targeting RUNX3.
In conclusion, miR-93 inhibits apoptosis and promotes proliferation, invasion, and migration of RCC cells via TGF-β/Smad signaling by inhibiting RUNX3. PMID: 28804566 [PubMed]
Source: American Journal of Translational Research - August 15, 2017 Category: Research Tags: Am J Transl Res Source Type: research

MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1.
Abstract Accumulating evidence indicates that microRNAs are implicated in tumor initiation and progression through negatively regulating oncogenes or tumor suppressor genes. In the present study, we report that the expression of miR-200a was significantly lower in renal cell carcinoma (RCC) specimens and RCC cell lines. Restoration of miR-200a suppressed cell growth, arrested cell cycle progression, and promoted cell apoptosis in RCC cell lines. We next used qRT-PCR array technology to identify Sirtuin 1 (SIRT1) as one of the downregulated proteins during miR-200a overexpression in 786-O cells. Following a further...
Source: Molecular and Cellular Biochemistry - July 17, 2017 Category: Biochemistry Authors: Fu H, Song W, Chen X, Guo T, Duan B, Wang X, Tang Y, Huang L, Zhang C Tags: Mol Cell Biochem Source Type: research

HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
ConclusionsOur findings suggest crucial involvement of PHD3 in the maintenance of key cellular functions including glycolysis and protein synthesis in ccRCC.
Source: Cancer and Metabolism - July 4, 2017 Category: Cancer & Oncology Source Type: research

VHL-TGFBI signaling is involved in the synergy between 5-aza-2'-deoxycytidine and paclitaxel against human renal cell carcinoma.
CONCLUSIONS: Our study suggests that VHL-TGFBI signaling is involved in the synergy between DAC and PTX against RCC cells. In addition, the synergy between DAC and PTX is more effective in VHL inactive RCC cells. PMID: 28534376 [PubMed - in process]
Source: Journal of B.U.ON. - May 25, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Cyclic AMP responsive element-binding protein induces metastatic renal cell carcinoma by mediating the expression of matrix metallopeptidase-2/9 and proteins associated with epithelial-mesenchymal transition.
Authors: Wang X, Cui H, Lou Z, Huang S, Ren Y, Wang P, Weng G Abstract Renal cell carcinoma (RCC) is the most frequently occurring malignancy of the kidney worldwide. Anti-angiogenic targeted therapies inhibit the progression of RCC, however, limited effects on the invasion or metastasis of tumor cells have been observed. Cyclic AMP responsive element‑binding protein (CREB) is a serine/threonine kinase that has been implicated in the regulation of cell proliferation, apoptosis, cycle progression and metastasis, amongst others. Our previous research demonstrated that phosphorylated CREB (pCREB) was upregulated in ...
Source: Molecular Medicine Reports - May 12, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Overexpression of β-arrestin2 induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma.
CONCLUSIONS: The overexpression of β-arrestin2 can inhibit the growth of RCC cells in vitro, and β-arrestin2 acts as a tumor suppressor gene in RCC. The main mechanism may directly suppress the phosphorylation of IkBa and indirectly suppress NFkB activation. Thus, β-arrestin2 is expected to be an important marker of RCC prognosis and a new therapeutic target. PMID: 28485809 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 11, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Role of the Wnt/ β-catenin signaling pathway in inducing apoptosis and renal fibrosis in 5/6-nephrectomized rats.
In conclusion, inhibition of Wnt/β‑catenin signaling by β‑catenin silencing attenuated apoptosis and expression of fibrosis-associated markers in renal cells. The present study suggested that the Wnt/β‑catenin signaling pathway may serve as a potential treatment strategy for renal fibrotic disorders. PMID: 28440442 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - April 27, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Integrin signaling potentiates transforming growth factor-beta 1 (TGF- β1) dependent down-regulation of E-Cadherin expression - important implications for Epithelial to Mesenchymal Transition (EMT) in Renal Cell Carcinoma.
Integrin signaling potentiates transforming growth factor-beta 1 (TGF-β1) dependent down-regulation of E-Cadherin expression - important implications for Epithelial to Mesenchymal Transition (EMT) in Renal Cell Carcinoma. Exp Cell Res. 2017 Mar 28;: Authors: Feldkoren B, Hutchinson R, Rapaport Y, Mahajan A, Margulis V Abstract Signal transduction through the transforming growth factor-beta 1 (TGF-β1) pathway affects epithelial to mesenchymal transition (EMT), partly by modulation of E-Cadherin expression. The concurrent impact of extracellular matrix driven regulation of integrin signaling on EMT ha...
Source: Experimental Cell Research - March 28, 2017 Category: Cytology Authors: Feldkoren B, Hutchinson R, Rapaport Y, Mahajan A, Margulis V Tags: Exp Cell Res Source Type: research

ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers.
In conclusion, our results suggest that ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2, and it could be a potential biomarker for cancer prognosis and target for cancer treatment. PMID: 28178669 [PubMed - as supplied by publisher]
Source: Oncotarget - February 10, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Progression of Human Renal Cell Carcinoma via Inhibition of RhoA-ROCK Axis by PARG1.
In this study, a new RCC antigen, PTPL1 associated RhoGAP1 (PARG1), was identified by using serological identification of recombinant cDNA expression cloning with sera from RCC patients. PARG1 protein was found to be differentially expressed in RCC cells among patients. High PARG1 expression is significantly correlated with various clinicopathological factors relating to cancer cell proliferation and invasion, including G3 percentage (P = .0046), Ki-67 score (p expression is also correlated with high recurrence of N0M0 patients (P = .0084) and poor prognosis in RCC patients (P = .0345). Multivariate analysis has revealed t...
Source: Translational Oncology - January 25, 2017 Category: Cancer & Oncology Authors: Miyazaki J, Ito K, Fujita T, Matsuzaki Y, Asano T, Hayakawa M, Asano T, Kawakami Y Tags: Transl Oncol Source Type: research

Synergistic combination of YS-1 and adriamycin inhibits human renal cancer through ERK1/2 signaling pathway in  vitro and in vivo.
In this study, we found the combination between YS-1 and ADM, performed higher anticancer activity on 786-O human RCC cells in vitro and in vivo, than that reported on its anti-angiogenesis effect compared with monotherapy of ADM. Our data showed that when combined with ADM, YS-1 promoted the sensitivity of 786-O cells to ADM. The combination of YS-1 and ADM also inhibited cell proliferation, but without affecting cell apoptosis. We found that ADM monotherapy treatment notably upregulated the activity of extracellular signal-regulated kinase ERK1 and ERK2 (ERK1/2), but when combined with YS-1, the p-ERK1/2 level was redu...
Source: Oncology Reports - January 19, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells.
Abstract MicroRNA (miR) can exert various biological functions by targeting oncogenes or tumor suppressor genes in numerous human malignancies. Recent evidence has shown that miR-148a increases the drug sensitivity of various cancer cells. Herein, we show that ectopic expression of miR-148a induces apoptosis, reduces clonogenicity, and increases the sensitivity to TRAIL and cisplatin in renal cancer cells. The luciferase reporter assay showed that miR-148a negatively regulated ras-related protein 14 (Rab14) expression by binding to the miR-148a binding site in the 3' untranslated region (3'UTR) of Rab14. Rab14-spe...
Source: International Journal of Oncology - January 16, 2017 Category: Cancer & Oncology Authors: Kim EA, Kim TG, Sung EG, Song IH, Kim JY, Doh KO, Lee TJ Tags: Int J Oncol Source Type: research

GSE93290 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (A-498, 786-O, A549, TE-8, PANC-1, SW1990, PC3 and PC3M)
Contributors : Naohiko Seki ; Takayuki AraiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines ( renal cell carcinoma, lung adenocarcinoma, esophageal, pancreatic and prostate cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - January 8, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Impact of Sulfatase ‐2 on cancer progression and prognosis in patients with renal cell carcinoma
Heparan sulfate‐specific endosulfatase‐2 (SULF‐2) can modulate the signaling of heparan sulfate proteoglycan‐binding proteins. The involvement of SULF‐2 in cancer growth varies by cancer type. The roles of SULF‐2 expression in the progression and prognosis of renal cell carcinomas (RCC) have not yet been fully clarified. In the present study, the expression levels of SULF‐2 mRNA and protein in 49 clinical RCC samples were determined by RT‐PCR and immunostaining. The existence of RCC with higher SULF‐2 expression and lower SULF‐2 expression compared to the adjacent normal kidney tissues was suggested. Hi...
Source: Cancer Science - November 28, 2016 Category: Cancer & Oncology Authors: Shin Kumagai, Kei Ishibashi, Masao Kataoka, Toshiki Oguro, Yuichirou Kiko, Tomohiko Yanagida, Ken Aikawa, Yoshiyuki Kojima Tags: Original Article Source Type: research