Site-specific use of molecular markers could be a promising prognostic tool in colorectal cancer.
This article examines the clinical importance of particular recent proposals on this specific issue. Their strengths and limitations, as well as issues requiring further elucidation and practical problems hampering their clinical implementation are briefly discussed. Moreover, some suggestions intending to improve research methodology on this specific theme and to render the clinical use of this novel approach more effective and feasible, are presented. Hopefully, the assessment of certain molecular markers in a site-specific fashion could be another step towards personalized management of CRC, improving and complementing ...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Surgery for triple-negative breast cancer- does the type of anaesthesia have an influence on oxidative stress, inflammation, molecular regulators, and outcomes of disease?
Authors: Lukoseviciene V, Tikuisis R, Dulskas A, Miliauskas P, Ostapenko V Abstract Breast cancer is the most frequently diagnosed cancer in females. Triple negative breast cancer (TNBC) is a molecular subtype of breast cancer which has a high mortality rate because of aggressive proliferation, quick occurrence of metastasis, and lack of effective treatment. New data show evidence that the type of anaesthesia can affect breast cancer recurrence and long-term outcome. Because TNBC lacks targets for modern specific therapy, a perioperative period could be the field of investigations for the long-term outcomes in TNBC...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Topics related to neoadjuvant chemotherapy for resectable liver metastases from colorectal cancer.
Authors: Ke S, Zhan S, Zhu H, Yan D Abstract Metastases to the liver from colorectal cancer (CRC) are common, and only a minority of patients are candidates for upfront surgery at the initial diagnosis. Carefully selected patients can achieve long-term survival from surgery with curative intent. Unfortunately, the risk of recurrence remains substantial after liver resection. In order to reduce the risk of relapse and improve the outcomes, the role of neoadjuvant chemotherapy has been assessed for resectable colorectal liver metastases (CRLM) with an improvement in progression-free survival (PFS). In particular, thi...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of recurrence patterns of colorectal cancer in laparoscopic and open surgery groups of patients: A meta-analysis.
CONCLUSIONS: There was statistically significant difference between laparoscopic or open surgery and development of local and overall CRC recurrences. PMID: 29745069 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population.
Authors: Sun J, Zhang J Abstract PURPOSE: To identify the sentinel lymph node (SLN) in abdominal lymph node metastases of elderly patients with colorectal cancer using carbon nanoparticles (CN). METHODS: 80 colorectal cancer patients admitted to the affiliated Weihai Second Municipal Hospital of Qingdao University from November 2014 to February 2017 were selected, and divided into the control group (n=40) and the study group (n=40). The control group was treated with surgery, while the study group was administered CN tracer subcutaneously for intraoperative dye positioning; the first to four black-stained lymph...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Short-term outcomes in patients with colon cancer treated with robotic right colectomy.
CONCLUSIONS: Robotic colorectal surgery has gained a lot of supporters through the years although a debate still exists concerning the outcomes. The present study is one of the largest evaluating short-term results of RRCs performed by a single surgeon. We believe we demonstrated the safety and efficacy of RRC in the treatment of right colon nonmetastatic adenocarcinoma. PMID: 29745071 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of long-term outcomes after laparoscopic-assisted and open colectomy for splenic flexure cancer.
CONCLUSION: Laparoscopic-assisted colectomy for SFC had the same long-term outcome as open colectomy. PMID: 29745072 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Hemodynamic stability achievement by application of goal directed fluid therapy with different infusion solutions in colorectal surgery.
CONCLUSIONS: Goal directed fluid therapy with colloids, followed by crystalloids during surgery, decreased the total intraoperative fluid volumes, and provided higher values of CI intraoperatively which were also maintained postoperatively. PMID: 29745073 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.
CONCLUSION: In conclusion, these results clearly suggest that boswellic acid could be employed in the treatment of colon cancer provided further in vivo and other in depth experiments are done. PMID: 29745074 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest.
CONCLUSIONS: Taken together, we propose that geraniol and geranyl acetate may prove to be important lead molecular candidates for the treatment of colon cancer. Their anticancer activity can be attributed to the ability to trigger apoptosis, DNA damage and cell cycle arrest. PMID: 29745075 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Ten years of using adjuvant trastuzumab in breast cancer in Serbia - Single institution experience.
Authors: Cvetanovic A, Filipovic S, Zivkovic N, Popovic L, Kostic M, Djordjevic M, Karanikolic A, Krtinic D Abstract PURPOSE: The purpose of this study was to determinate disease-free interval (DFI) and overall survival (OS) in HER2-positive breast cancer patients who received adjuvant trastuzumab at the University Clinic of Nis, Serbia, and to investigate the influence of clinicopathological and biological characteristics of the tumor on prognosis. The second aim was to determinate the most frequent cause for the treatment discontinuation, recurrence rate, as well as the site of most common localization of the fir...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Association between promoter hypermethylation of the DACT2 gene and tumor stages in breast cancer.
CONCLUSION: An association was found of DACT2 promoter methylation with advanced tumor stages. This gene has been suggested as a potential biomarker, however, more investigation is required to validate this function. PMID: 29745077 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of cytological categories atypical (C3) and suspected (C4) with histopathological diagnoses of breast lesions.
Authors: Vuckovic L, Crnogorac N, Panjkovic M, Miladinovic M, Vuksanovic-Bozaric A, Filipovic A, Matic S, Jancic S Abstract PURPOSE: Fine needle aspiration cytology (FNAC) is a diagnostic method characterized by high sensitivity, specificity and predictive value. In order to obtain uniformed results of FNAC breast changes, the following categories are introduced: C1 (non-representative), C2 (benign), C3 (atypical), C4 (suspected) and C5 (malignant). The purpose of this study was to establish which pathological processes are most frequently diagnosed as C3 and C4 categories, which carry a malignant tumor risk. M...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Research on the correlation between ultrasonographic features of breast cancer and expressions of ER, CD34 and p53.
Authors: Zhao X, Li J Abstract PURPOSE: To investigate the expressions of estrogen receptor (ER), highly glycosylated type I transmembrane glycoprotein (CD34) and p53 in breast cancer tissue and analyze their correlation with color Doppler ultrasonographic features. METHODS: 86 patients who were admitted to our hospital with confirmed breast cancer diagnosis from January 2016 to December 2016 were selected. The expressions of ER, CD34 and p53 in cancer tissue and corresponding canceradjacent normal tissue were detected by immunohistochemical staining, and the color Doppler ultrasonographic features of patients ...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Multi-slice spiral CT evaluation of breast cancer chemotherapy and correlation between CT results and breast cancerspecific gene 1.
Authors: Li J, Gao W, Yu B, Wang F, Wang L Abstract PURPOSE: To investigate multi-slice spiral CT (MSCT) imaging with breast cancer chemotherapy and the correlation between MSCT and breast cancer-specific gene 1 (BCSG1). METHODS: 86 patients with breast cancer were enrolled from January 2016 to May 2017. All of them were treated with neoadjuvant chemotherapy, and underwent MSCT scan before and after treatment to evaluate the efficacy of chemotherapy. The expression of BCSG1 in tumor tissue was detected by immunohistochemistry and the correlation between CT results and BCSG1 was analyzed. RESULTS: MSCT evalu...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Distribution of EGFR SNPs -191C/A and 181946G/A in patients with lung cancer depending on smoking status in the Republic of Srpska, Bosnia and Herzegovina.
CONCLUSIONS: Patients younger than 64 years and carriers of -191CC genotype have significantly higher risk for adenocarcinoma than carriers of -191CA or -191AA genotype. Further studies on larger cohorts are necessary to evaluate -191C/A SNP as a potential biomarker. PMID: 29745081 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Correlation analysis of expressions of PTEN and p53 with the value obtained by magnetic resonance spectroscopy and apparent diffusion coefficient in the tumor and the tumor-adjacent area in magnetic resonance imaging for glioblastoma.
Authors: Li Y, Ji F, Jiang Y, Zhao T, Xu C Abstract PURPOSE: To explore the correlation of the expression levels of phosphate and tension homology deleted on chromosome ten (PTEN) and p53 of glioblastoma multiforme (GBM) with the value obtained by magnetic resonance spectroscopy (MRS) and apparent diffusion coefficient (ADC) in the tumor and the tumor-adjacent area in magnetic resonance imaging (MRI). METHODS: A total of 38 patients were operated for GBM. All the patients had received diffusion-weighted imaging (DWI) and MRS prior to surgery. ADC of water molecules and values of metabolite indexes of MRS, inclu...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

The expression and significance of tumor associated macrophages and CXCR4 in non-small cell lung cancer.
CONCLUSION: The positive rate of CD68 was 66.2% (45/68) and CXCR4 was 61.8% (42/68) in the lung cancer tissues, while the rates in normal tissues were statistically significantly lower at 27.3% (3/17) and 11.8% (2/17), respectively. The tissue expressions of CD68 and CXCR4 in NSCLC tissues were significantly correlated with a higher TNM staging and lymph node metastasis (p
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Resveratrol inhibits glioma cell growth via targeting LRIG1.
CONCLUSIONS: Resveratrol can inhibit the growth and proliferation of glioma and promote its apoptosis through upregulating the LRIG1 gene expression, which plays the effect of antiglioma growth, revealing that LRIG1 is a new biological target of resveratrol in antiglioma cell proliferation and growth. PMID: 29745084 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Significance of nuclear magnetic resonance combined with Ki-67 and VEGF detection in the diagnosis and prognosis evaluation of brain glioma.
Authors: Yuan X, Liu D, Wang Y, Li X Abstract PURPOSE: To investigate the significance of nuclear magnetic resonance (NMR) combined with Ki-67 and vascular endothelial growth factor (VEGF) detection in the diagnosis and prognosis evaluation of brain glioma. METHODS: 78 patients with brain glioma treated at the Affiliated Hospital of Jining Medical University from January 2015 to August 2017 were studied. All patients underwent the NMR diffusion tensor imaging examination. The expressions of Ki-67 and VEGF in brain glioma tissues were detected using immunohistochemistry and survival analyses were performed for p...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Adding taxane to platin-5-fluorouracil combination does not improve survival rate in patients ≥ 65 years of age with advanced gastric cancer: A retrospective-multicenter study.
CONCLUSIONS: The addition of taxanes to CF backbone leads to a significant increase in both PFS and OS in patients younger than 65 years of age but the triplet regimen with taxanes does not provide superior survival in patients older than 65 years of age. PMID: 29745086 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

High Mobility Group Box 1 (HMGB1) expression in gastric adenocarcinomas.
CONCLUSION: It was found that in the presence of HMGB1 expression, the grade of tumor differentiation decreased and the depth of invasion increased, which was associated with higher stage. These findings suggest that HMGB1 is an independent prognostic factor for GC. PMID: 29745087 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

The diagnostic, prediction of postoperative recurrence and prognostic value of HE4 in epithelial ovarian cancer.
Authors: Chen L, Yang X, Abasi X, Shapaer G, Aizimu A, Zhang S, Wan Y, Kamaer X, Tuerxun T, Abula R, Zhang Q Abstract PURPOSE: To explore the clinical value of the level of human epididymis protein 4 (HE4) in serum in the diagnosis, prediction of postoperative recurrence and prognosis of epithelial ovarian cancer (EOC). METHODS: A total of 103 EOC patients and 121 individuals with benign ovarian lesions were selected. All of them were admitted to our hospital between January 2013 and January 2014 as group A (EOC, n=103) and group B (benign ovarian lesions, n=121), respectively. Additionally, 106 serum samples c...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

HPV infection in oropharyngeal squamous cell carcinomas: correlation with tumor size.
CONCLUSIONS: HPV-depended OPSCCs - although not so common as the laryngeal ones, but still not so rare in the rural population in Greece - are characterized by a combination of specific features. Our results showed that survival was adversely effected by the stage of the disease and tumor size and indirectly by the presence of HPV - especially in young adults - while the combined surgery/radiotherapy/ chemotherapy therapy seems to prolong survival. Additionally, HPV co-existence seems to be associated with larger tumors and poor survival. PMID: 29745089 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Are ultrasonographic measurements a reliable parameter to choose non-palpable testicular masses amenable to treatment with sparing surgery?
Authors: Dell'Atti L, Fulvi P, Benedetto Galosi A Abstract PURPOSE: To analyze the dimensional characteristics between non-palpable testicular masses detected during ultrasonographic (US) study and their postoperative dimensions reported in definitive histological diagnosis, and evaluate if the sonographic measurements may be a relevant parameter to improve the identification of testicular lesions amenable to treatment with testicular-sparing surgery (TSS). METHODS: A total of 77 patients who underwent radical orchiectomy or TSS for non-palpable testicular masses suspected for malignant neoplasms were included ...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Upregulation of miR-191 promotes cell growth and invasion via targeting TIMP3 in prostate cancer.
CONCLUSION: This study demonstrated that miR-191 promoted the cell growth and invasion ability in prostate cancer through downregulating TIMP3 and might be a potential target for the biotherapy for PCa. PMID: 29745091 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Therapeutic benefits of neoadjuvant and post-operative denosumab on sacral giant cell tumor: a retrospective cohort study of 30 cases.
CONCLUSION: Neoadjuvant therapy with denosumab can significantly relieve the symptoms and neurologic deficits. PMID: 29745092 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Imatinib therapy after resection of high-risk gastrointestinal stromal tumors in Chinese patients: a median follow-up of 48 months.
Authors: Lei C, Zhao B, Wang Q, Ge L, Wang H Abstract PURPOSE: Adjuvant imatinib can be given for gastrointestinal stromal tumors (GISTs), but adequate risk stratification is necessary to select patients who will benefit from this therapy. We aimed to investigate the treatment methods and prognostic factors of high risk GISTs. METHODS: This retrospective study included 108 patients who underwent tumor resection for high-risk GISTs between January 2003 and February 2017. The patients were divided into two groups: a group of patients received postoperative imatinib adjuvant therapy (Adjuvant therapy group), and t...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Predictors of sentinel lymph node status of cutaneous melanoma in Serbian patients.
Authors: Jokic S, Markovic I, Bukumiric Z, Jokic V, Rakovic M, Tripkovic J, Stojiljkovic D, Spurnic I, Jevric M, Matic M, Dobrosavljevic D Abstract PURPOSE: Presence of metastasis in sentinel lymph node (SLN) is considered to be the most important factor in terms of patient survival. The main aim of this study was to identify predictors of positive SLN in Serbian patients with melanoma. METHODS: This retrospective study was conducted on 147 patients. Univariate chi-square and univariate logistic regression analyses were used to identify the association between prognostic factors and positive SLN. Receiver Opera...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Phase I study of gemcitabine-cisplatin versus pemetrexed cisplatin for patients with advanced or metastatic bladder cancer.
CONCLUSIONS: The gemcitabine plus cisplatin combination was more effective and well tolerated in patients with advanced or metastatic BC compared to the pemetrexed plus cisplatin regimen. PMID: 29745095 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Cytoreduction and HIPEC for peritoneal carcinomatosis of pancreatic cancer.
CONCLUSIONS: Cytoreductive surgery with HIPEC may be considered a treatment option in highly selected patients with pancreatic cancer and peritoneal carcinomatosis. PMID: 29745096 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Quality of life after cytoreductive surgery and HIPEC: A single centre prospective study.
CONCLUSIONS: The significant improvement in the physical well-being is attributed to the eradication of symptoms, whereas the relevant improvements in the emotional wellbeing subscale are explained both by the pre-operative desperation of the diagnosis or relapse of malignancy, and the post-operative hopefulness after a successful operation. PMID: 29745097 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Quality assurance protocol for superficial and deep hyperthermia systems established by the Hellenic Association of Medical Physicists (HAMP) in cooperation with the Hellenic Society of Oncologic Hyperthemia (HSOH): A study based on European Society for Hyperthermic Oncology (ESHO) quality assurance guidelines.
CONCLUSIONS: The proposed protocol, applied by medical physicists in Greece, will ensure an efficient treatment with safety and minimum adverse effects. This protocol has been approved by the Hellenic Society of Oncologic Hyperthermia and the Hellenic Association of Medical Physicists. PMID: 29745098 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Incidence and risk assessment of venous thromboembolism in cancer patients admitted to intensive care unit for postoperative care.
CONCLUSIONS: Though accompanied with the subutilizing of chemoprophylaxis, the overall incidence of VTE was relatively low in Chinese cancer patients admitted to ICU for postoperative care. In contrast, the Caprini score was high in this population. The original Caprini RAM was limited to stratify this population, but further substratification of "highest risk" category demonstrated the risk of developing VTE events was significantly higher in patients with Caprini score greater than 10. Future research with high quality evidence should be performed targeting on the accurate risk stratification and optimizing VTE...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparative performance evaluation of a new a-Si EPID that exceeds quad high-definition resolution.
CONCLUSION: The performance of three commercial EPID solutions have been quantified, evaluated, and compared using results from the PTW QC Phantom. The IVS outperformed the other panels in low and high-contrast resolution, but to fully realize the benefits of the IVS, the selection of the monitor on which to view the high-resolution images is important to prevent down sampling and visual of resolution. PMID: 29745100 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Simulations of centriole of polarized centrosome as a monopole antenna in immune and viral synapses.
Authors: Dvorak J, Melichar B, Filipova A, Grimova J, Grimova N, Rozsypalova A, Buka D, Voboril R, Zapletal R, Buchler T, Richter I, Buka D Abstract The immune synapse (IS) is a temporary interface between an antigen-presenting cell and an effector lymphocyte. Viral synapse is a molecularly organized cellular junction that is structurally similar to the IS. Primary cilium is considered as a functional homologue of the IS due to the morphological and functional similarities in architecture between both micotubule structures. It has been hypothesized that endogenous electromagnetic field in the cell is generated by a...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Serbian consensus of neoadjuvant therapy for breast cancer: NeoPULSE.
Authors: Popovic L, Tomasevic Z, Stamatovic L, Markovic I, Matovina-Brko G, Buta M, Golubovic A, Selakovic V, Trifunovic J, Mutrezani Z, Ivanovic N, Nedovic J, Ninkovic S, Filipovic S, Cvetanovic A, Djordjevic N, Karanikolic A, Ivkovic-Kapic T, Vicko F Abstract Even though surgery is the primary treatment of operable breast cancer, it has been known for decades that the administration of postoperative adjuvant or preoperative neoadjuvant therapy is extremely important. Indications for neodjuvant therapy administration have been expanded over the years, and nowadays this kind of treatment represents an inevitable op...
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Contribution disclosures.
Authors: Igić R PMID: 29745103 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Topically applied vasoconstrictor while decreasing radiation dermatitis may increase local recurrences in post-lumpectomy breast cancer patients who received radiotherapy.
Authors: Altundag K PMID: 29745104 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Primary gastric choriocarcinoma.
Authors: Ates O, Altundag K, Gullu I PMID: 29745105 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Outcome of breast cancer patients with mental disorders; we still need to learn more!
Authors: Altundag K PMID: 29745106 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

HPV mRNA expression profiling in head and neck squamous cell carcinomas.
Authors: Ragos V, Mastronikolis NS, Tsiambas E, Fotiades PP PMID: 29745107 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Why babies do not want to nurse the premalignant breast side in breast-feeding mother? A possible sign of early diagnosis of breast cancer in younger women.
Authors: Altundag K PMID: 29745108 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

The eminent gynaecologist Richard Wesley TeLinde (1894- 1989) and his contribution to diagnosis of cervical cancer.
Authors: Karamanou M, Markatos K, Laios K, Salakos N, Deligeoroglou E, Androutsos G Abstract At the beginning of the 20th century, the relation of carcinoma in situ of the cervix to the invasive cancer was poorly understood, resulting in misdiagnosis of the disease and inappropriate treatment. The work of Richard Wesley TeLinde, chairman of Gynaecology at Johns Hopkins University for almost 21 years, contributed to delineate the diagnosis of cervical carcinoma, providing suggestive evidence that carcinoma in situ often precedes invasive cervical cancer. PMID: 29745109 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - May 11, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Health-related quality of life of young women with breast cancer. Review of the literature.
CONCLUSIONS: Young women consider that their healthrelated QoL is worse compared with older women. Young women worry about their future, with particular reference to their role as mothers and especially to children-bearing. The free screening and non-exclusion of young women is particularly important for breast cancer prevention and women's well-being. PMID: 29552751 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Severe hematologic temozolomide-related toxicity and lifethreatening infections.
Authors: Stepanovic A, Nikitovic M Abstract Glioblastoma is the most frequent primary malignant brain tumor in adults. With the number of symptoms and signs, it belongs to diseases where a lot of treatment modalities are often applied. A standard treatment for patients with glioblastoma includes surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide. Each type of treatment has its own toxicity. Temozolomide is an oral alkylating cytotoxic drug and like any other alkylating agent can induce side effects. Although temozolomide is generally a well tolerated drug, with rare severe toxic ...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

The impact of multiple primary neoplasms in daily practicea systematic review of the literature.
Authors: Nemes A, Nagy V Abstract Multiple primary neoplasms (MPN) represent particular entities with growing impact in our daily practice due to their increasing incidence and implications in the treatment and outcome of oncological patients. MPN have a specific deffinition and can be classified as synchronous or metachronous depending on the time of diagnosis of the first and latter malignancies. We review in this article the possible risk factors involved in the etiology of MPN, the most frequent cancer associations, the incidence of synchronous and metachronous tumors, the stage at diagnosis, the treatment admi...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Molecular aspects in HPV-dependent laryngeal and oropharyngeal carcinoma.
Authors: Lianou AD, Ragos V, Fotiades PP, Tsiambas E, Batistatou A, Kastanioudakis I Abstract Human papillomavirus (HPV)-mediated cervical carcinogenesis represents a well analyzed model of viral implication in epithelial malignant transformation. Mechanisms of high risk (HR) HPV-related infection seem to demonstrate a similar action regarding its implication in head and neck (HN) carcinomas, predominantly in squamous cell carcinoma (SCC) histological type. The prevalence of HR HPV subtypes - mainly HPV16 - is characterized by a broad geographic heterogeneity. Furthermore, HPV-associated HNSCCs demonstrate differen...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population.
We examined patient age, sex, tumor stage and location of the tumor. Histological data were also retrieved concerning major tumor diameter, histological grade and immunohistochemical expression of cyclooxygenase (COX)-2 and epithermal growth factor receptor (EGFR). RESULTS: There was no difference between tumors of different differentiation in the expression of EGFR (p=0.146), while there was statistically significant difference in the expression of COX-2 between these groups (p=0.001). There was no difference between these patients in the expression of EGFR (p=0.136), while a statistically significant difference was f...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer.
CONCLUSIONS: High expression of miR-21 and low expression of miR-145 are closely related to the development and progression of CRC, especially with the grade of differentiation, invasion, metastasis and clinical stage. MiR-21 and miR-145 in the serum can be used as markers for early screening of CRC and indicators for prognosis prediction. PMID: 29552756 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research