Research Exceptionalism and Opportunism During the Coronavirus Pandemic.
Authors: Moris D Abstract In the era of COVID19, research has been conducted at an extraordinary pace, eliminating the time from submission to publication to unprecedented levels. This is facilitated by preprint platforms and social media which can spread, reproduce and promote new knowledge with enormous speed. However, there are many concerns regarding the risk of potential deflection from the peer review process that some journals might have adopted, in order to manage the overwhelming wave of COVID19-related submissions. Another dimension of this problem, is the inequity and the publication hurdles that many no...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Detection of critical genes associated with poor prognosis in breast cancer via integrated bioinformatics analyses.
CONCLUSION: This study revealed that the p53 signaling pathway could be an important pathway in BC progression. The three p53-related genes CCNE2, CCNB1 and RRM2 may represent candidate therapeutic gene targets for the treatment of BC. PMID: 33455094 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Overexpression of PIK3CA impacts global survival of patients with HER2 subtype breast carcinoma.
CONCLUSIONS: The PIK3CA expression showed a protective effect in relation to the OS of patients with HER2-positive breast cancer. PMID: 33455095 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

CXCL13/CXCR5 are potential biomarkers for diagnosis and prognosis for breast cancer.
CONCLUSIONS: These results suggested that CXCL13 and CXCR5 expressions could act as potential biomarkers for breast cancer diagnosis and prognosis. PMID: 33455096 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Efficacy and safety evaluation of eribulin-trastuzumab combination therapy with heavily pretreated HER2-positive metastatic breast cancer.
Authors: Sarici F, Altundag K Abstract PURPOSE: Eribulin mesylate is a non-taxane microtubule inhibitor which is a synthetic holichondrin B analog that can be used after anthracycline and taxane treatment in patients with metastatic breast cancer. We aimed to analyze the results of eribulin-trastuzumab combination in aggressively pretreated metastatic HER2-positive breast cancer patients. METHODS: In this single-center study, the records of 36 patients with HER-2-positive metastatic breast cancer who received at least one cycle of eribulin-trastuzumab in our clinic between 2015 and 2018 were analyzed retrospect...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Correlations of HACE1 expression with pathological stages, CT features and prognosis of hepatocellular carcinoma patients.
Authors: Zhang Z, Teng M, Xu Z, Wang D Abstract PURPOSE: To explore the correlations of HECT domain and ankyrin repeat-containing E3 ubiquitin protein ligase 1 (HACE1) expression with the pathological stages, computed tomography (CT) features and prognosis of patients with hepatocellular carcinoma (HCC). METHODS: The clinical data were randomly collected from 70 patients with primary HCC. The messenger RNA (mRNA) and HACE1 in the cancer and paracancer tissues were determined via real-time quantitative-polymerase chain reaction (qRT-PCR). The curve of the relationship between HACE1 expression and patients' overa...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Effect of radical resection combined with antiviral therapy in patients with hepatitis B virus-associated hepatocellular carcinoma and prognostic analysis.
Authors: Xiao C, Huang L, Xiao N, Lun J Abstract PURPOSE: To observe the clinical effect of radical resection combined with antiviral therapy in patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), and to analyze the risk factors affecting its prognosis. METHODS: The clinical data of 132 patients with HBV-associated HCC treated in our hospital from January 2015 to December 2016 were retrospectively analyzed, and the patients were randomly divided into Control group (n=66) and Anti-virus group (n=66). The changes in liver function indexes, HBV-deoxyribonucleic acid (DNA) load and alph...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Efficacy of licartin combined with transcatheter hepatic arterial chemoembolization in the treatment of middle-advanced primary liver cancer.
Authors: Jin J, Zhou T, Lou J, Yan S, Wu Y, Xie M, Wang W Abstract PURPOSE: To explore the clinical efficacy and safety of Licartin combined with transcatheter hepatic arterial chemoembolization (TACE) in the treatment of middle-advanced primary liver cancer. METHODS: The clinical data of 112 patients with middle-advanced primary liver cancer treated in our hospital from March 2015 to March 2017 were collected. Fifty-six patients underwent TACE combined with Licartin (Licartin+TACE group), while the remaining 56 patients were treated with TACE alone (TACE group). The short-term efficacy, peripheral hemogram, li...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

MiR-489 inhibits proliferation and apoptosis of glioblastoma multiforme cells via regulating TWIST1 expression.
Authors: Xiao F, Fan W, Huang X, Fang Z, Zheng X Abstract PURPOSE: To investigate the influences of micro ribonucleic acid (miR)-489 on the proliferation and apoptosis of glioblastoma multiforme (GBM) and the relationship between miR-489 and twist-related protein 1 (TWIST1) expression. METHODS: The GBM cells were isolated and cultured in vitro, and then transfected with miR-489 inhibitor, miR-489 mimics and miR-negative control (NC) or TWIST1-small interfering RNA (siRNA) and TWIST1-NC. The expression levels of miR-489 and TWIST1 gene in the cells were measured via quantitative reverse transcription-polymerase ...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

The importance of the blood levels of homocysteine, folate and vitamin B12 in patients with primary malignant brain tumors.
CONCLUSIONS: Our results pointed out that total homocysteine in blood circulation appears to be a tumor marker for monitoring primary malignant brain tumor patients before and after surgery. The association of hyperhomocysteinemia with folate deficiency, also provides strong support for viewing hyperhomocysteinemia as a predictive marker for carcinogenesis. It is hoped that future research will continue to explore the clinical relevance of homocysteine as a tumor marker and a risk factor for astrocytoma and glioblastoma. PMID: 33455102 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Therapeutic effect of thalidomide combined with temozolomide and three-dimensional conformal radiotherapy for patients with high-grade gliomas after operation.
Authors: Sui L, Li Y, Xu Z, Shen X Abstract PURPOSE: To explore the efficacy and safety of 125 I radioactive seed implantation combined with intermittent hormonal therapy (IHT) in the clinical treatment of moderate- and high-risk non-metastatic prostate cancer. METHODS: A total of 136 patients were divided into the observation group (n=68) and the control group (n=68). In the observation group, 125I radioactive seed implantation was performed, bicalutamide capsules were taken orally immediately after operation, and leuprorelin was injected from 1 week after operation. In the control group, IHT alone was adminis...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Efficacy of 125I seed implantation combined with intermittent hormonal therapy on moderate- and high-risk non-metastatic prostate cancer.
CONCLUSIONS: IRF-1/PVT1-214 may markedly boost the oxaliplatin-resistance of CRC, resulting in the late TNM stage and poor survival. These findings suggest that the IRF-1/PVT1-214 axis may be a helpful target for intervention in CRC. PMID: 33455104 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Efficacy of radical prostatectomy on prostate cancer patients and analysis of risk factors for biochemical recurrence after radical prostatectomy.
Authors: Yang X, Shi Y, Lin Y, Tian Y Abstract PURPOSE: To investigate the efficacy of radical prostatectomy on prostate cancer (PC) patients and analyze the risk factors for biochemical recurrence after radical prostatectomy. METHODS: A total of 168 PC patients aged 38-75 years admitted to and treated in our hospital from January 2017 to January 2018 underwent radical prostatectomy. Differences in the levels of prostate-specific antigen (PSA) and tumor markers in the patients before and after treatment were compared. The patients were divided into recurrence group (group 1) and non-recurrence group (group 2) a...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Hesperidin induces anticancer effects on human prostate cancer cells via ROS-mediated necrosis like cell death.
CONCLUSION: Hesperidin was shown to selectively inhibit the growth of prostate cancer cells through apoptosis triggered by ROS generation. The results support its potential to act as lead molecule in anticancer drug design. PMID: 33455106 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

EGFR mutation testing from liquid biopsy of non-small cell lung cancer at the Institute for Oncology and Radiology of Serbia.
CONCLUSIONS: EGFR mutation testing from liquid biopsy has been successfully implemented in Serbia and has proven invaluable for detecting molecular resistance mechanisms to EGFR-TKIs and as an alternative sample source for patients with scarce biopsy material or without any at all. PMID: 33455107 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Effect of thoracic hyperthermic perfusion with recombinant human endostatin plus nedaplatin in treating pleural effusion in patients with advanced non-small cell lung cancer.
CONCLUSIONS: Compared with the thoracic hyperthermic perfusion with cisplatin alone, the thoracic hyperthermic perfusion with recombinant human endostatin plus nedaplatin showed dramatically potential efficacy, decrease of the incidence rate of adverse reactions in the digestive system, improvement of quality of life of patients, and prolongation of progression of pleural effusion. PMID: 33455108 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

MicroRNA-466 regulates the proliferation, migration and invasion of the human lung cancer cells by targeting transcription factor RUNX2.
CONCLUSION: Taken all together, miR-466 suppression is associated with the growth and progression of lung cancer. The miR-466 overexpression declined the proliferation and metastasis of cancer cells and these effects were modulated through miR-466/RUNX2 molecular axis. PMID: 33455109 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

LINC00538 promotes the progression of colon cancer through inhibiting NKD2 expression.
CONCLUSIONS: This study demonstrated for the first time that LINC00538 was highly expressed in colon cancer and was associated with poor prognosis of patients. Knockdown of LINC00538 in colon cancer cell lines was able to inhibit the cell proliferation and cell cycle, while it promoted the apoptosis. It's mechanism of participating in the development of colon cancer may be through the down-regulation of NKD2 and the regulation of EZH2. PMID: 33455110 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

The role of miR-141/ Sirt1 in colon cancer.
Authors: Li Y, Gu F, Lin X Abstract PURPOSE: To explore the effects of micro ribonucleic acid-141 (miR)-141 on the proliferation and apoptosis of colon cancer cells and its association with the sirtuin 1 (Sirt1) expression. METHODS: The samples of stage I, II, III and IV colon cancer were obtained, and the miRNA expression levels was analyzed, with normal colon tissues as controls. The expression of miR-141 and miR-34 was detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and the cell proliferation and apoptosis in each group were detected via cell counting kit-8 (CCK8) assay, ...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

The role of neoadjuvant FLOT chemotherapy with and without omega 3 in locally advanced gastric carcinoma.
CONCLUSIONS: Omega 3 administrations during chemotherapy in gastric cancer increased the chemotherapy tolerability and decreased the treatment gap between cycles and hence improved gastric cancer resection. PMID: 33455112 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Prognostic potential of miR-21-3p in gastric cancer.
CONCLUSIONS: MiR-21-3p is upregulated in GC samples, which is closely related to GC progression. MiR-21-3p can be used to predict the prognosis of GC. PMID: 33455113 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

MiR-218 restrains proliferation of cervical cancer cells via targeted regulation of HMGB1/RAGE pathway.
CONCLUSIONS: MiR-218 inhibits the HMGB1/RAGE pathway to suppress the proliferation, migration and invasion of CC cells. PMID: 33455114 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Identification of key pathways and biomarkers in anaplastic thyroid cancer using an integrated analysis.
CONCLUSION: Cell cycle plays a decisive role in the high mortality rate of ATC. TOP2A, NUSAP1, PBK, KIF15, CENPF, CEP55, CDK1, CCNB2, CDCA8 and CDC20 were identified as hub genes. PMID: 33455115 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

The value of tumor infiltrating lymphocytes as prognostic factor for lymph node status and survival amongst patients with cutaneous malignant melanoma.
CONCLUSIONS: TILs density grade represents an independent prognostic factor for the OS. Therefore, we conclude that an accurate prognosis may be provided by TILs status in patients with pT3 malignant melanoma. PMID: 33455116 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Methylation of WWOX gene promotes proliferation of osteosarcoma cells.
Authors: Liu Y, Wang Q, Yu P, Miao W, Liu C, Pu Y, Zhang C Abstract PURPOSE: To explore the effects of WW domain-containing oxidoreductase (WWOX) gene methylation on proliferation and apoptosis of osteosarcoma cells. METHODS: A total of 51 patients with osteosarcoma confirmed by pathological examinations were enrolled as the observation group, while 49 cases with non-osteosarcoma diagnosed and treated in our hospital were randomly selected as the control group. Osteosarcoma cell lines MG63 and HOS were selected as observation group, while those added with methylation inhibitor were set as control group, of whic...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Effect of transurethral partial cystectomy with 2.0 μm laser in treating superficial bladder cancer.
Effect of transurethral partial cystectomy with 2.0 μm laser in treating superficial bladder cancer. J BUON. 2020 Nov-Dec;25(6):2714-2720 Authors: Tian J, Hu P, Guo H, Xu J, Ren T, Xin B, Zhou L Abstract PURPOSE: To compare and analyze the efficacy and safety of transurethral partial cystectomy with 2.0 μm laser and transurethral resection of bladder tumor (TURBT) in treating patients with superficial bladder cancer. METHODS: The clinical data of 130 patients with superficial bladder cancer were divided into two groups based on different treatments, with 65 patients in each group, and treated...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

PIWIL2 may serve as a prognostic predictor in cancers: A systematic review and meta-analysis.
Authors: Hu W, Sun X, Ye T, Feng S, Ruan Q, Xi M, Zhou X, Li M, Ye Z, Cheng X, Xie W Abstract PURPOSE: PIWIL2, one of the PIWI gene subfamily, is now thought to be closely related to poor clinical outcomes in various cancers. The aim of this research was to comprehensively estimate its predictive value in the prognosis of cancer patients. METHODS: We thoroughly searched PubMed, Web of Science and Embase databases for eligible articles published until April 4th 2019, in which the association between cancer prognosis and PIWIL2 expression level was studied. Study qualities were assessed using NOS criteria. We per...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

An evaluation of Pencil Beam vs Monte Carlo calculations for intracranial stereotactic radiosurgery.
Authors: Rembish J, Myers P, Kirby N, Saenz D, Rasmussen K, Papanikolaou N, Stathakis S Abstract PURPOSE: To compare the accuracy of two separate models when calculating dose distributions in patients undergoing stereotactic radiosurgery (SRS) treatment for brain cancer. METHODS: For this comparison, two dose calculation algorithms were evaluated on two different treatment planning systems (TPS): Elekta's Monaco Version 5.11.00 Monte Carlo Gold Standard XVMC algorithm and Brainlab's iPlan Pencil Beam algorithm. The DICOM files of 11 patients with a total of 19 targets were exported from iPlan and then imported ...
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Baseline characteristics of a nationwide cohort of pediatric patients with acute leukemias of Down syndrome.
CONCLUSION: We address this manuscript to pediatricians and neonatologists in order to emphasize the importance of diagnosing hematological disorders in children with DS, especially neonates, even if they are asymptomatic. PMID: 33455121 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 20, 2021 Category: Cancer & Oncology Tags: J BUON Source Type: research

Abbreviations In Medical Writings: Do They Also Abbreviate Our Science?
Authors: Moris D Abstract Abbreviations are commonly used in medical literature. Despite the obvious advantages of facilitation and simplification of communication, their use can be a cause of medical errors, irritation, misunderstanding and even alienation. There are strict guidelines for their use. There are scarce data about the adherence of authors and editors to these guidelines. However, the few studies that have assessed this question showed discouraging results. The poor understanding of abbreviations highlights the value of minimizing their use and defining abbreviations when they are used. PMID: 32862...
Source: Journal of B.U.ON. - December 20, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Highly prolific authors in medical science: from charisma to opportunism.
Authors: Moris D Abstract In medical science, publication record is considered to be a fundamental criterion to evaluate the cost-effectiveness and the reputation of institutions and individual scientists. In current academia, thousands of scientists demonstrate a hyperprolific academic behavior that is the resultant of multiple individual characteristics that can vary from extraordinary ability and teamwork to unjustified and unethical co-authorship. Editors, reviewers and readers should have high expectations from these authors in terms of research quality and ethos. PMID: 33277826 [PubMed - as supplied by pu...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

c-Fos/ c-Jun transcription factors in non-small cell lung carcinoma.
Authors: Manios K, Tsiambas E, Stavrakis I, Stamatelopoulos A, Kavantzas N, Agrogiannis G, C Lazaris A Abstract During lung carcinoma development, progression and metastasis, a variety of gross (chromosome) and specific (gene) genomic alterations are detected in dysplastic, neoplastic, and progressively malignant transformed epithelia as early or late genetic events. Oncogenes' overactivation combined with suppressor genes silence are crucial genetic events in malignant and pre-malignant epithelia. Especially, deregulation of crucial signalling transduction pathways that interact with strong transcription factors -...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Micro-RNAs signatures in papillary thyroid carcinoma.
Authors: Mastronikolis N, Tsiambas E, Roukas D, Fotiades P, Chrysovergis A, Papanikolaou V, Kyrodimos E, Mastronikoli S, Niotis A, Ragos V Abstract Among biomarkers that should be useful for a molecular discrimination of patients regarding treatment strategies and prognosis in solid malignancies, novel micro-RNAs (miRs) are under investigation. Quite recently, miRs are considered very promising and significant genetic markers for categorizing patients by their molecular characteristics, as well as extending their complicated genetic signatures. miRs are short, non-coding RNAs consisting of 20-25 nucleotides located...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Distinct effects of anti-diabetic medications on liver cancer risk and patient survival.
Authors: Chen PH, Zhu GZ, Li L, Chen Y, Dai HQ, Su WJ, Wu Y, Zhou J Abstract Type 2 diabetes mellitus (T2DM) is a pandemic metabolic disease worldwide. Multiple types of cancer, particularly liver cancer, are closely associated with T2DM. As a result, there is growing interest in investigating whether anti-diabetic medications could lower cancer risks in the population and even prolong patient survival among those with concurrent cancer. There are many types of anti-diabetic medications available in the clinic. The present study reviewed how different anti-diabetic drugs affect cancer risk and patient survival. On ...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Clinicopathologic features and prognosis of histologic subtypes in the right-sided colon cancer.
This study included 138 patients who underwent surgery for right-sided colon cancer. The patients were divided into three groups according to histopathological subtypes as follows: medullary carcinoma (MC, n=11), mucinous adenocarcinoma (MAC, n=29), and classic adenocarcinoma (AC, n=98). The groups were compared in terms of demographic characteristics, type of surgery, pathological outcomes and survival. RESULTS: The rate of laparoscopic surgery was significantly lower in the MC group compared with MAC and AC groups (45.4% vs 54.5% vs 35.7%, respectively, p=0.001). In MC group, T4 stage was significantly higher than in...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

The prognostic significance of Caspase-3 and survivin expression in colorectal cancer patients.
CONCLUSION: Caspase-3 expression was unrelated to the oncological outcome in colorectal cancer patients. The proposed favorable prognostic role for survivin inexpression was not confirmed. On the contrary, survivin(-) tumors were mainly of poor differentiation and advanced T stage. An inverse relationship between caspase-3 and survivin expressions was also not confirmed. Future studies focusing on specific survivin isoforms expression or inexpression may give answers on apoptotic-antiapoptotic interactions on cancer cell death. PMID: 33277831 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Effect of colorectal resection combined with intraoperative radiofrequency ablation in treating colorectal cancer with liver metastasis and analysis of its prognosis.
CONCLUSIONS: Compared with resection of CRC and liver metastasis, colorectal resection combined with RFA can significantly reduce the intraoperative blood loss and shorten the hospital stay, with a comparable long-term survival, but the tumor recurrence rate is higher than that in patients with resection. PMID: 33277832 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

LncRNA-PCAT1 controls the growth, metastasis and drug resistance of human colon cancer cells.
CONCLUSION: lncRNA-PCAT1 expression may be utilized as a vital prognostic tool in colon cancer and highlighted its regulatory effects in maintaining the colon cancer growth and proliferation. PMID: 33277833 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of the laparoscopic versus open surgery in patients aged over 75 years old with colorectal cancer. Short- and Mid-term outcomes.
Authors: Sotirova I, Gklavas A, Nastos C, Micha G, Dafnios N, Dellaportas D, Theodosopoulos T Abstract PURPOSE: The benefit of minimally invasive surgery in colorectal cancer patients has been established, however it is not clear whether these advantages apply to older patients as well. The aim of this study was to review short- and mid-term outcomes in elderly patients, over the age of 75 years, with colorectal cancer. METHODS: This was a retrospective study of selected patients over the age of 75 who underwent laparoscopic and open surgery for colorectal cancer between February 2013 and January 2018 in a tert...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Simultaneous resection of colorectal cancer and synchronous liver metastases is safe for properly selected elderly patients: A retrospective study.
CONCLUSIONS: Simultaneous resection of CRC and SCRLM was safe and feasible in elderly patients, with reasonable 3-year survival rates. Age per se should not be considered as a contraindication for simultaneous resection of CRC and SCRLM. PMID: 33277835 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Anastomotic leak after colorectal cancer surgery - risk factors in 21thcentury.
CONCLUSIONS: Risk factors described in the literature of the 20th century are no longer current. The main findings that feature postoperative recovery were associated with increased risk of AL and should be more carefully investigated in further studies which could lead towards the development of new specific post-operative protocols. PMID: 33277836 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

IRF-1 mediated long non-coding RNA PVT1-214 promotes oxaliplatin resistance of colorectal cancer via miR-128 inhibition.
CONCLUSIONS: IRF-1/PVT1-214 may markedly boost the oxaliplatin-resistance of CRC, resulting in the late TNM stage and poor survival. These findings suggest that the IRF-1/PVT1-214 axis may be a helpful target for intervention in CRC. PMID: 33277837 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

MicroRNA-1 regulates the growth and chemosensitivity of breast cancer cells by targeting MEK/ERK pathway.
CONCLUSION: miR-1 acts as a tumor suppressor and may exhibit therapeutic implications in the treatment of breast cancer. PMID: 33277838 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Ambrosin sesquiterpene lactone exerts selective and potent anticancer effects in drug-resistant human breast cancer cells (MDA-MB-231) through mitochondrial mediated apoptosis, ROS generation and targeting Akt/ β-Catenin signaling pathway.
CONCLUSIONS: Taken all together, the results of our study indicate that ambrosin sesquiterpene may be developed as a promising anticancer agent in human breast cancer provided further in-depth studies are performed. PMID: 33277839 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Efficacy of everolimus combined with endocrine therapy in HR-positive/HER-2-negativeadvanced breast cancer.
CONCLUSION: Everolimus combined with endocrine therapy has significant clinical efficacy in patients with HR-positive/HER-2-negative advanced breast cancer, and can effectively improve the survival of patients with tolerable adverse reactions. PR+, absence of visceral metastases and sensitivity to endocrine therapy are the protective prognostic factors for PFS. PMID: 33277840 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Efficacy of oncoplastic breast-conserving surgery combined with intraoperative radiotherapy on early breast cancer.
CONCLUSIONS: OBCS combined with IORT is safe and effective in the treatment of EBC, which can not only effectively ensure the surgical margin in BCS and reduce the incidence of surgical complications, but also obtain a better cosmetic effect and satisfaction with breast appearance, and improve the postoperative quality of life of patients. PMID: 33277841 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Molecular evaluation of a multiplex methylation panel for epigenetic analysis of FNAB samples from Greek patients with suspicious breast lesions.
Authors: Vavoulidis E, Petousis S, Margioula Siarkou C, Mareti E, Kougioumtsidou N, Symeonidou M, Loufopoulos PD, Daniilidis A, Chatzikyriakidou A, Lambropoulos A, Zepiridis L, Dinas K Abstract PURPOSE: Aberrant DNA methylation in promoter regions has been found in many cancers, including breast cancer (BC). A Methylation Specific PCR (MSP) was applied in breast Fine Needle Aspiration Biopsy (FNAB) material, which has been rarely used in the literature, to estimate the methylation frequencies of CND2, APC, HIN1 & CDH13 and to assess whether this multiplex methylation panel can be possibly used as an indicator-b...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Identification of invasive key genes in breast cancer by bioinformatics analysis.
CONCLUSIONS: Our studies could enhance the understanding of the molecular mechanism of breast cancer aggressiveness, and the identification of invasive key genes promoted the individualized and comprehensive treatment. PMID: 33277843 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Assessment of acute toxicities and early local recurrences in post mastectomy breast cancer patients by accelerated hypofractionated radiotherapy; a single arm clinical trial.
This study was conducted to assess the toxicity profile and dosimetry outcomes of patients receiving PMRT using IMRT or VMAT. METHODS: 67 biopsy-proven patients with carcinoma of the breast who had undergone modified radical mastectomy (MRM) were included in the study. They were treated using VMAT or IMRT to a dose of 42.56 Gy in 16 fractions. Acute and late toxicities were graded using RTOG toxicity grading scale. Toxicities and recurrences were summarized as proportions with 95% confidence intervals. Spearman's correlation was used to find association between the dose received by the organs at risk (OARs) and the gra...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Effect of postoperative sequential chemoradiotherapy and concurrent chemoradiotherapy in treating advanced endometrial cancer.
Authors: Chen L, Xiang Q Abstract PURPOSE: To evaluate the efficacy and safety of the sequential chemoradiotherapy mode of chemotherapy-radiotherapy-consolidation chemotherapy and the concurrent chemoradiotherapy after operation for advanced (stage III-IV) endometrial cancer. METHODS: A total of 116 patients with stage III-IV endometrial cancer were divided into the Sequential group (n=58) and the Concurrent group (n=58) according to the different modes of postoperative adjunctive therapy. The levels of tumor markers in the serum and the occurrence of adverse reactions were compared between the two groups, and ...
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research