Health-related quality of life of young women with breast cancer. Review of the literature.
CONCLUSIONS: Young women consider that their healthrelated QoL is worse compared with older women. Young women worry about their future, with particular reference to their role as mothers and especially to children-bearing. The free screening and non-exclusion of young women is particularly important for breast cancer prevention and women's well-being. PMID: 29552751 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Severe hematologic temozolomide-related toxicity and lifethreatening infections.
Authors: Stepanovic A, Nikitovic M Abstract Glioblastoma is the most frequent primary malignant brain tumor in adults. With the number of symptoms and signs, it belongs to diseases where a lot of treatment modalities are often applied. A standard treatment for patients with glioblastoma includes surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide. Each type of treatment has its own toxicity. Temozolomide is an oral alkylating cytotoxic drug and like any other alkylating agent can induce side effects. Although temozolomide is generally a well tolerated drug, with rare severe toxic ...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

The impact of multiple primary neoplasms in daily practicea systematic review of the literature.
Authors: Nemes A, Nagy V Abstract Multiple primary neoplasms (MPN) represent particular entities with growing impact in our daily practice due to their increasing incidence and implications in the treatment and outcome of oncological patients. MPN have a specific deffinition and can be classified as synchronous or metachronous depending on the time of diagnosis of the first and latter malignancies. We review in this article the possible risk factors involved in the etiology of MPN, the most frequent cancer associations, the incidence of synchronous and metachronous tumors, the stage at diagnosis, the treatment admi...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Molecular aspects in HPV-dependent laryngeal and oropharyngeal carcinoma.
Authors: Lianou AD, Ragos V, Fotiades PP, Tsiambas E, Batistatou A, Kastanioudakis I Abstract Human papillomavirus (HPV)-mediated cervical carcinogenesis represents a well analyzed model of viral implication in epithelial malignant transformation. Mechanisms of high risk (HR) HPV-related infection seem to demonstrate a similar action regarding its implication in head and neck (HN) carcinomas, predominantly in squamous cell carcinoma (SCC) histological type. The prevalence of HR HPV subtypes - mainly HPV16 - is characterized by a broad geographic heterogeneity. Furthermore, HPV-associated HNSCCs demonstrate differen...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population.
We examined patient age, sex, tumor stage and location of the tumor. Histological data were also retrieved concerning major tumor diameter, histological grade and immunohistochemical expression of cyclooxygenase (COX)-2 and epithermal growth factor receptor (EGFR). RESULTS: There was no difference between tumors of different differentiation in the expression of EGFR (p=0.146), while there was statistically significant difference in the expression of COX-2 between these groups (p=0.001). There was no difference between these patients in the expression of EGFR (p=0.136), while a statistically significant difference was f...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer.
CONCLUSIONS: High expression of miR-21 and low expression of miR-145 are closely related to the development and progression of CRC, especially with the grade of differentiation, invasion, metastasis and clinical stage. MiR-21 and miR-145 in the serum can be used as markers for early screening of CRC and indicators for prognosis prediction. PMID: 29552756 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Malnutrition is associated with adverse postoperative outcome in patients undergoing elective colorectal cancer resections.
CONCLUSIONS: Preoperative malnutrition status as defined by PNI is associated with greater postoperative morbidity after elective surgery for colorectal cancer. Routine nutritional assessment and ad hoc nutritional support prior to surgery could contribute to an improvement of postoperative outcome after colorectal cancer resections. PMID: 29552757 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

VEGF-C in rectal cancer tissues promotes tumor invasion and metastasis.
Authors: Miao H, Ruan S, Shen M Abstract PURPOSE: To investigate the relationship between the expression of vascular endothelial growth factor-C (VEGF-C) in rectal cancer tissues and clinicopathological factors. METHODS: The molecular expression of VEGF-C in rectal cancer tissue derived from 45 patients and normal colon tissue from 15 subjects was detected using the immunohistochemical streptavidin/biotin/peroxidase complex (SABC) three-step method. The expression of VEGF-C in rectal cancer and its relationship with clinicopathological factors were statistically analyzed via x2 test or Spearman's rank correlati...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Long non-coding RNA PVT1 functions as an oncogene in human colon cancer through miR-30d-5p/RUNX2 axis.
CONCLUSIONS: These results indicate that PVT1 could promote metastasis and proliferation of colon cancer via suppressing miR-30d-5p/RUNX2 axis, which may offer a new way for interpreting the mechanism of colon cancer development. PMID: 29552759 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Short- and long-term outcomes of laparoscopic surgery in elderly patients with rectal cancer.
CONCLUSION: Although elderly patients had greater intraoperative blood loss and a higher surgical conversion rate, laparoscopic surgery for rectal cancer provided similar short-term and long-term outcomes among middle-aged and elderly patients. PMID: 29552760 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Investigation on nutritional risk assessment and nutritional support status of surgical patients with colorectal cancer.
Authors: Wang Y, Zheng J, Gao Z, Han X, Qiu F Abstract PURPOSE: To investigate the malnutrition, the incidence of nutritional risk and the application of nutritional support for patients with colorectal cancer, so as to provide a basis for the rational clinical application of nutritional support. METHODS: A total of 264 surgical patients with colorectal cancer treated/followed up from January 2016 to March 2017 in Beijing Chaoyang Hospital were selected. The nutritional risk was assessed using the Nutritional Risk Screening 2002 (NRS2002), and the nutritional risk and application of nutritional support for pati...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Assessment of lymph node metastasis in elderly patients with colorectal cancer by sentinel lymph node identification using carbon nanoparticles.
Authors: Sun J, Zhang J Abstract PURPOSE: To evaluate the value of sentinel lymph node (SLN) identification using carbon nanoparticles in abdominal lymph node metastasis in elderly (>60 years old) patients with colorectal cancer. METHODS: Eighty patients admitted at Weihai Second Municipal Hospital affiliated to Qingdao University from November 2014 to February 2017 were selected and divided into the control group (n=40) and the observation group (n=40) using the random number method. The control group was treated with surgery, while the observation group was administered carbon nanoparticle tracer for intra...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Herbal extract of Artemisia vulgaris (mugwort) induces antitumor effects in HCT-15 human colon cancer cells via autophagy induction, cell migration suppression and loss of mitochondrial membrane potential.
CONCLUSION: These results strongly stress that the methanolic extract may prove a source for the isolation of novel anticancer lead molecules for the management of colon cancer. PMID: 29552763 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

KISS1 and KISS1R expression in gastric cancer.
CONCLUSIONS: KISS1 expression is decreased during carcinogenesis in gastric mucosa. More advanced tumors and more aggressive histological types produce lower KISS1 levels. In addition, no KISS1R is produced in malignant gastric epithelium, while KISS1R is only weakly expressed in normal gastric epithelium. PMID: 29552764 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Outcomes of laparoscopic gastrectomy for gastric cancer in elderly patients.
CONCLUSION: In summary, laparoscopic gastrectomy in elderly patients with gastric cancer can achieve similar short- and long-term outcomes as those for middle-aged patients. Age is thus not a contraindication for laparoscopic gastrectomy. PMID: 29552765 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Randomized controlled trial of endostar combined with cisplatin/ pemetrexed chemotherapy for elderly patients with advanced malignant pleural effusion of lung adenocarcinoma.
Authors: Jie Wang X, Miao K, Luo Y, Li R, Shou T, Wang P, Li X Abstract PURPOSE: To evaluate the clinical efficacy and safety of endostar combined with cisplatin/pemetrexed (CP) chemotherapy for elderly patients with advanced malignant pleural effusion (MPE) of lung adenocarcinoma. METHODS: A total of 128 lung adenocarcinoma patients with MPE were randomly divided into two groups. Patients in the treatment group were treated with pemetrexed 500 mg/m2, i.v., d 1, cisplatin intracavitary administration with a total dose of 75 mg/m2, d 2, 5 and 8, and endostar intracavitary administration 45 mg, d 1, 4 and 7. Pati...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Toxicity and efficacy of a hypofractionated (3 weekly fractions of 850c Gy) irradiation schedule for stage IIIb / IV non-small cell lung cancer elderly patients with low performance status and unfit for chemotherapy.
CONCLUSIONS: This study showed that the proposed scheme has a moderate radiation-induced lung toxicity rate and an acceptable therapeutic ratio. Taking into consideration its cost effectiveness, the proposed hypofractionated scheme is a good alternative to conventional fractionation. PMID: 29552767 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer.
Authors: Yang F Abstract PURPOSE: To investigate the expression of sirtuin type 1 (Sirt1) and adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) in non-small cell lung cancer (NSCLC), and to explore the mechanism of their functions in NSCLC. METHODS: Cancer tissues (NSCLC group) and the adjacent normal healthy tissues (control group) of 50 patients with NSCLC were selected, and H&E staining was performed to identify the histopathological differences. Reverse transcription polymerase chain reaction (RT-PCR), immunofluorescence staining and Western blot were performed to detect the expression of...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Swerchirin exerts anticancer activity on SKOV3 human ovarian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade.
CONCLUSION: In summary, we conclude that swerchirin significantly increased SKOV3 cell death due to cell cycle arrest, loss of MMP, apoptosis and inhibition of Raf/MEK/ ERK pathway. PMID: 29552769 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Study on the sensitivity of primary tumor cells of patients with cervical cancer to chemotherapeutic combinations.
Authors: Qiu F, Zhao X Abstract PURPOSE: To study the sensitivity of primary tumor cells from patients with cervical cancer to frequently used chemotherapeutic combinations. METHODS: 54 samples from cervical cancer patients were collected and used to develop cell culture in vitro. Eight frequently used chemotherapeutic combinations (taxol, taxol+cisplatin, taxol+carboplatin, topotecan+cisplatin, gemcitabine+cisplatin, docetaxel, gemcitabine, cisplatin+c yclophosphamide+doxorubicin) were prepared in different concentrations [200,100,50,25, and 12.5% plasma peak concentration (PPC)] and added to tumor cell cultur...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Anticancer activity of cucurbitacin-A in ovarian cancer cell line SKOV3 involves cell cycle arrest, apoptosis and inhibition of mTOR/PI3K/Akt signaling pathway.
CONCLUSION: The study showed that cucurbitacin-A is a potent agent against ovarian cancer cells, can be considered for further in vivo research and can also be developed as a possible lead molecule. PMID: 29552771 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

N-(p-coumaroyl) serotonin induces cell cycle arrest and apoptosis in breast cancer cells.
CONCLUSION: The treatment of breast cancer cells with CS may represent a novel therapeutic strategy and requires further investigation. PMID: 29552772 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Study of differential gene expression between invasive multifocal/ multicentric and unifocal breast cancer.
CONCLUSION: The differential expression pattern of ABCC11 and ABCB5 genes may serve as outliers, potentially associated with incidence of MMBS. PMID: 29552773 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of two public sector tertiary care hospitals' management in reducing direct medical cost burden on breast carcinoma patients in Lahore, Pakistan.
Authors: Hameed Khaliq I, Zahid Mahmood H, Akhter N, Danish Sarfraz M, Asim K, Masood Gondal K Abstract PURPOSE: Breast cancer is one of the major causes of death incurring highest morbidity and mortality amongst women of Pakistan. The purpose of this study was to assess and compare the role of two public sector tertiary care hospitals' management in reducing out of pocket (OOP) expenses on direct medical costs borne by breast carcinoma patients' household from diagnosis through treatment. Moreover, the study intended to explore the reasons of opting private diagnostic facilities by the said patients during the ser...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Observation of clinical efficacy of application of enhanced recovery after surgery in perioperative period on esophageal carcinoma patients.
Authors: Zhang Z, Zong L, Xu B, Hu R, Ma M, Wei H, Meng Y Abstract PURPOSE: To observe the clinical efficacy of the application of enhanced recovery after surgery (ERAS) in the perioperative period of esophageal carcinoma patients. METHODS: A total of 114 patients who were admitted to Affiliated Hospital of Jining Medical University for surgical treatment of esophageal carcinoma between June 2012 and June 2016 were enrolled and randomly divided into the intervention group and the regular group according to the difference of management procedures during the perioperative period. ERAS was carried out in 57 patien...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Long noncoding RNA linc-UBC1 promotes tumor invasion and metastasis by regulating EZH2 and repressing E-cadherin in esophageal squamous cell carcinoma.
CONCLUSIONS: The results indicate that linc-UBC1 is a novel oncogene in tumorigenesis and could promote the metastasis via EZH2 and E-cadherin, which may offer a possible therapeutic target in ESCC. PMID: 29552776 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Metastasis to parotid gland from non Head and Neck tumors.
CONCLUSIONS: Parotid metastases can be the first clinical manifestation of a malignant tumor from a distant site and can manifest years after curative-intent treatment of the distant primary. Histopathology and immunohistochemistry can help in the identification of the primary site. Parotidectomy with complete excision of the parotid lesion may have diagnostic and/or loco-regional control and/or curative intent, however there is still no international consensus about the therapy of parotid malignant metastasis. PMID: 29552777 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Expression of MiRNA-137 in oral squamous cell carcinoma and its clinical significance.
Authors: Sun C, Li J Abstract PURPOSE: To investigate the expression of microRNA (miRNA-137) in oral squamous cell carcinoma (OSCC) and its effects on activity, invasion and proliferation of OSCC human squamous cell carcinoma cell lines 2 (HSC-2 cell line). METHODS: 158 cases of pathologically-confirmed OSCC tissues and corresponding para-cancerous tissues were collected. The tissue mRNA was extracted and miRNA-137 expression in tissues was detected using real-time polymerase chain reaction (RT-PCR). With miRNA-137 mimics and scramble mimics transfected into OSCC HSC-2 cells, invasion and proliferation of cells...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Factors affecting the survival of patients with glioblastoma multiforme.
Authors: Nikolov V, Stojanovic M, Kostic A, Radisavljevic M, Simonovic N, Jelenkovic B, Berilazic L Abstract PURPOSE: Glioblastoma multiforme (GBM) is the most aggressive malignant tumor in the brain and no therapy can achieve full recovery/cure. The aim of this study was to identify which factors could improve the survival of operated patients, and to determine which kind of therapy was most successful. METHODS: The study was conducted at the Clinic for Neurosurgery in Nis, Clinical Centre Nis and the Oncology Institute, Clinical Center Nis. A cohort of patients who underwent surgery between January 2013 and D...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Patient-specific quality assurance for intracranial cases in robotic radiosurgery system.
CONCLUSIONS: Point dose measurement is a reliable and functional method for pre-treatment patient-specific QA in intracranial CyberKnife plans. Point dose verification should be performed to correct any possible errors prior to patient treatment. It is recommended for use in patient-specific QA process in the CyberKnife plans. PMID: 29552780 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/ β-catenin and TGF-β/EMT signaling pathways.
CONCLUSION: UNC119 was significantly up-regulated in liver cancer cells and tissues. It promoted cell growth and migration through the Wnt/β-catenin and TGF-β/EMT signaling pathways, respectively. The anti-UNC119 treatment inhibited tumor cell proliferation, growth, migration and invasion by inhibiting the Wnt/β-catenin and GF-β/ EMT signaling pathways, respectively. PMID: 29552781 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/ β/catenin and TGF/β-EMT signaling pathways.
CONCLUSION: UNC119 was significantly up-regulated in liver cancer cells and tissues. It promoted cell growth and migration through the Wnt/β-catenin and TGF-β/EMT signaling pathways, respectively. The anti-UNC119 treatment inhibited tumor cell proliferation, growth, migration and invasion by inhibiting the Wnt/β-catenin and GF-β/ EMT signaling pathways, respectively. PMID: 29552782 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Sunitinib versus sorafenib plus transarterial chemoembolization for inoperable hepatocellular carcinoma patients.
CONCLUSIONS: The SO+TACE regimen was more effective and well tolerated in patients with unresectable stage III HCC compared to the SU+TACE regimen. The SO+TACE regimen may be a better alternative to the current standard regimens. PMID: 29552783 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Potential antitumor effects of panaxatriol against DU-15 human prostate cancer cells is mediated via mitochondrial mediated apoptosis, inhibition of cell migration and sub-G1 cell cycle arrest.
CONCLUSION: Taken together, we strongly believe that panaxatriol may prove handy in the treatment and management of prostate cancer and deserves further research. PMID: 29552784 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Sugiol (127horbar;hydroxyabieta-8,11,13-trien-7-one) targets human pancreatic carcinoma cells (Mia-PaCa2) by inducing apoptosis, G2/M cell cycle arrest, ROS production and inhibition of cancer cell migration.
CONCLUSION: In conclusion our results indicate that sugiol is a potent anticancer molecule and may prove essential in pancreatic cancer therapy. PMID: 29552785 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Meta-analysis of the effect of preoperative chemotherapy on Wilms' tumor.
CONCLUSIONS: Compared with surgery alone, preoperative chemotherapy combined with surgery can increase the EFS and OS and improve the prognosis of patients. PMID: 29552786 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Anticancer effects of kaempferol in A375 human malignant melanoma cells are mediated via induction of apoptosis, cell cycle arrest, inhibition of cell migration and downregulation of m-TOR/PI3K/AKT pathway.
CONCLUSIONS: KAM exerts potent anticancer effects via induction of apoptosis, G2/M cell cycle arrest, cell migration inhibition and downregulation of m-TOR, pm-TOR, PI3K, p-PI3K and Akt protein levels. PMID: 29552787 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Anticancer action of lactucopicrin in SKMEL-5 human skin cancer cells is mediated via apoptosis induction, G2/M cell cycle arrest and downregulation of m=TOR/PI3K/AKT signalling pathway.
CONCLUSION: These results indicate that lactucopicrin shows potent anticancer action in the tested skin cancer cells and may prove a prospective lead molecule for the treatment of skin cancer. PMID: 29552788 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Expression of human telomerase reverse transcriptase (hTERT) in thyroid neoplasms.
CONCLUSION: The high expression of hTERT can be useful for making a differential diagnosis between PC and FC, and between FA and MNG when histopathological findings are equivocal. PMID: 29552789 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Haplotype analysis of XRCC1 gene polymorphisms and the risk of thyroid carcinoma.
CONCLUSIONS: XRCC1 Arg280His and Arg194Trp were associated with thyroid cancer in Pakistani population. These genetic markers may provide an insight into the disease pathogenesis and help open novel therapeutic strategies for thyroid cancer. PMID: 29552790 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Survival and nutritional factors on home parenteral nutrition (HPN): Our initial experience.
CONCLUSIONS: According to the findings of our study, HPN seems to have beneficial effect but it should be considered with caution by the physicians who should take into account the indications of each patient to receive parenteral nutrition, the underlying disease and prognosis and the access of each patient to home care services. PMID: 29552791 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Incidence and risk assessment of venous thromboembolism in cancer patients admitted to intensive care unit for postoperative care.
CONCLUSIONS: Though accompanying with the sub-utilizing of chemoprophylaxis, the overall incidence of VTE was relatively low in Chinese cancer patients admitted to ICU for postoperative care. In contrast, the Caprini score was high in this population. The original Caprini RAM was limited to stratify this population, but further substratification of "highest risk" category demonstrated the risk of developing VTE events was significantly higher in patients with Caprini score>10. Future research with high quality evidence should be performed targeting on the accurate risk stratification and optimizing VTE prophyl...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Antonio Scarpa (1752-1832) and his study on ocular cancer.
Authors: Laios K, Moschos MM Abstract Antonio Scarpa (1752-1832) is known in the history of medicine as a distinguished anatomist and surgeon. Apart from his anatomical studies that established him and especially in clinical anatomy, he focused also his interest on ophthalmology, therefore he was considered as the "father of ophthalmology in Italy". His study on ocular cancer is of particular interest, because he not only reviewed older approaches on this issue enriching them with his own clinical observations but his study served as a bridge connecting the previous tradition to the scientific study of oc...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Predictors of acute hematologic toxicity attributable to palliative radiotherapy: Analysis of patient characteristics and bone marrow dose-volume parameters.
CONCLUSIONS: Overall, HT was relatively mild. Female gender and lower baseline WBC and ANC may be predictors of HT elicited by palliative RT. PMID: 29552794 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

First application of hemi-body electron beam irradiation for Kaposi sarcoma at the lower extremities.
Authors: Platoni K, Diamantopoulos S, Dilvoi M, Delinikolas P, Kypraiou E, Efstathopoulos E, Kouloulias V Abstract Kaposi's sarcoma (KS) is a systemic neoplastic disease that can present cutaneous symptoms and is usually treated with a systematic approach due to its extent. Due to its radiosensitivity, radiotherapy is considered one of its main treatments, for palliation and local control of the skin and mucosal lesions. The aim of this paper was to report the first case of KS treated by hemi-body electron irradiation protocol in Greece. A fractionated 40 Gy hemi-body electron irradiation was prescribed to a 60-yea...
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Uncertainties in the management of pleomorphic lobular carcinoma in situ of the breast still remain.
Authors: Altundag K PMID: 29552796 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Preserved lenalidomide efficacy in a recurrent isolated subcutaneous mantle cell lymphoma relapse.
Authors: Bagacean C, Neaga A, Zdrenghea M, Tempescul A PMID: 29552797 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

CA 15-3 elevation during post-metastasectomy period may occur in breast cancer patients with oligometastatic liver metastases.
Authors: Altundag K PMID: 29552798 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Neutrophil-to-lymphocyte ratio above 2 - advocate for lymph node dissection in prostate cancer.
Authors: Coman RT, Crisan N, Kadula PA, Bocsan IS, Coman I, Andras I PMID: 29552799 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research

Chemotherapy dose adjustment in obese locally advanced or early breast cancer patients might affect survival outcome.
Authors: Altundag K PMID: 29552800 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - March 22, 2018 Category: Cancer & Oncology Tags: J BUON Source Type: research