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How desirable and undesirable features of na ïve or genetically reengineered mesenchymal stem cells are being considered in preclinical or clinical assays.
How desirable and undesirable features of naïve or genetically reengineered mesenchymal stem cells are being considered in preclinical or clinical assays. J BUON. 2017 Jul-Aug;22(4):812-830 Authors: González-Villarreal C, Guadalupe Martínez-Rodríguez H, Said-Fernández S Abstract The implantation of adult mesenchymal stem cells (MSCs) has become a promising alternative in cancer treatments. Accordingly, in this article we revised the ultimate advances in the knowledge on the MSC-homing mechanism, the cancer cell and MSCs interactions and the microvesicles and exosomes us...
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

The role of radiation therapy in the modern management of oligometastatic disease.
Authors: Li Y, Tao S, Li M, Li D Abstract Multimodal treatment approaches are indispensable for patients with advanced-stage cancer, while radiation therapy has been established as essential part of therapeutic approaches and has been introduced as a better option to face challenges, such as, local relapse or oligometastatic disease. The mere insight of the concept of oligometastases, proposed for the first time in the middle 1990s, led to the hypothesis that this condition may be cured using local ablative weapons. This hypothesis has already been demonstrated by surgical ablative techniques. Even though been cons...
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Microarray bioinformatics in cancer- a review.
Authors: Tao Z, Shi A, Li R, Wang Y, Wang X, Zhao J Abstract Bioinformatics is one of the newest fields of biological research, and should be viewed broadly as the use of mathematical, statistical, and computational methods for the processing and analysis of biological data. Over the last decade, the rapid growth of information and technology in both "genomics" and "omics" eras has been overwhelming for the laboratory scientists to process experimental results. Traditional gene-by-gene approaches in research are insufficient to meet the growth and demand of biological research in understanding t...
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Current strategies and future perspectives in fertility preservation for cancer patients.
Authors: Micu R, Petrut B, Zlatescu-Marton C, Traila A, Harsa R, Achimas-Cadariu P Abstract Nowadays, cancer is being detected at younger ages. Health care providers should consider cancer patients' desire towards fertility preservation before the initiation of possibly sterilizing treatments. The aim of the current review was to register the current state of fertility preservation procedures available for male and female cancer patients. PMID: 29155509 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

In situ preservation of parathyroid glands:advanced surgical tips for prevention of permanent hypoparathyroidism in thyroid surgery.
Authors: Dzodic R, Santrac N Abstract Hypoparathyroidism (HPT) is one of the most frequentand severe complications of thyroid surgery. It is caused by intraoperative damage, devascularization or accidental removal of the parathyroid glands (PTGs). The incidence of postoperative HPT is directly proportional to surgery extent and surgeon's experience. After 40 years of experience in thyroid surgery, the first author summarizes the already known surgical steps in thyroid surgery and adds some useful practical tips for in situ preservation of PTGs. Our surgical technique focuses on meticulous capsular dissection and pr...
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Laparoscopic hepatectomy for colorectal liver metastases located in all segments of the liver.
CONCLUSIONS: Laparoscopic hepatectomy for colorectal liver metastases located in all segments of the liver can be safely performed in selected patients, with acceptable postoperative morbidity and oncologic results. PMID: 29155511 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Efficacy and safety of cetuximab plus FOLFOX in second-line and third-line therapy in metastatic colorectal cancer.
CONCLUSION: The addition of cetuximab to FOLFOX was well-tolerated and had antitumor activity both in second- and third-line therapy in patients with mCRC. PMID: 29155512 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Laparoscopic surgery after neoadjuvant therapy in elderly patients with rectal cancer.
CONCLUSION: Although the CCI was higher in elderly patients than in the nonelderly patients, laparoscopic surgery after neoadjuvant therapy was safe and effective in elderly patients with rectal cancer. Therefore, in the absence of any contraindications, laparoscopic surgery after neoadjuvant therapy is an appropriate treatment approach for elderly patients with rectal cancer. PMID: 29155513 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

The prognostic effect of neoadjuvant chemoradiotherapy on the change of PD-L1 expression in patients with locally advanced rectal adenocarcinoma.
CONCLUSION: No prognostic effect of neoadjuvant chemoradiotherapy on the change of PD-L1 expression was demonstrated in patients with locally advanced rectal adenocarcinoma. PMID: 29155514 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Temporal characteristics of social support in colorectal cancer survivors during the first year post operation.
CONCLUSION: These findings suggest that the future intervention programs should commence soon after surgery, despite the fact that they were high before this time point. PMID: 29155515 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Association of IL-12Bpro polymorphism with tumor-infiltrating dendritic cells in colorectal cancer.
CONCLUSIONS: The IL-12Bpro polymorphism does not constitute a risk factor for CRC development. However, genotype-11 might have a complex role in the recruitment and maturation of DCs in tumor microenvironment. PMID: 29155516 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Expression of CD40/CD40L in colon cancer, and its effect on proliferation and apoptosis of SW48 colon cancer cells.
Authors: Pang X, Zhang L, Wu J, Ma C, Mu C, Zhang G, Chen W Abstract PURPOSE: To study was to study the expression of CD40/CD40L in colon cancer and investigate the effects of CD40/CD40L overexpression on the proliferation and apoptosis of SW48 colon cancer cell line. METHODS: Immunohistochemistry was used to detect the expression of CD40 protein in colon cancer tissue samples from 70 patients, and 10 adjacent normal tissue samples. A CD40L gene-containing plasmid was transfected into SW48 colon cancer cells using lipofectamine 2000. Cell proliferation was measured by MTT assay. The expression of CD40/CD40L was...
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

A meta-analysis of clinical trials over regimens with or without cetuximab for advanced gastric cancer patients.
CONCLUSION: Adding cetuximab to chemotherapy does not improve OS or DCR compared with chemotherapy alone. Cetuximab-containing combination chemotherapy can reduce the risk of neutropenia. PMID: 29155518 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Quantitative changes of gastric mucosa during carcinogenesis using stereological methods.
CONCLUSION: The results showed that H. pylori infection could cause significant quantitative changes in the cellular structure of gastric mucosa that might be influential on gastric carcinogenesis. PMID: 29155519 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

High expression level of long non-coding RNA HOTAIR is associated with poor overall survival in gastric cancer patients: evidence from meta-analysis.
CONCLUSIONS: High expression level of lncRNA HOTAIR is associated with a poor OS in GC patients. Thus, lncRNA HOTAIR might be a potentially useful independent prognostic biomarker for GC. PMID: 29155520 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Gastric adenocarcinoma with neuroendocrine differentiation: Clinicopathological features and efficacy of modified DCF chemotherapy.
CONCLUSION: NEDGC patients usually have higher LVI and PNI rates, and they present with advanced disease. In this group of patients, mDCF regimen may be an effective treatment option. However this statement needs to be verified by further prospective and multi-centered studies including a larger patient cohort. PMID: 29155521 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Impact of conversion during laparoscopic gastrectomy on outcomes of patients with gastric cancer.
CONCLUSION: Except from increased operation time, intraoperative blood loss, and length of hospital stay, conversion from laparoscopic gastrectomy to open gastrectomy had no impact on postoperative complications and long-term outcomes of patients with gastric cancer. PMID: 29155522 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

The role of Toll-like receptors in ovarian cancer.
Authors: Gata V, Florin Laurentiu I Abstract Ovarian cancer (OC) is the leading cause of death in gynecological malignancies in western countries. Chemoresistance represents a major issue and a better understanding of the interactions that take place within the tumor microenvironment is needed, such as the connection between inflammation and cancer. Toll like receptors (TLRs) are part of the basic mechanisms that are involved in the activation of the innate immune system, with extensive activation of various transcription factors, that subsequently lead to an adaptive immune response, making them key players that m...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

FAK, Src and p-Paxillin expression is decreased in liver metastasis of colorectal carcinoma patients.
Authors: Mantonakis E, Giaginis C, Pikoulis E, Felekouras E, Patsouris E, Liakakos T, Papalampros E, Theocharis S Abstract PURPOSE: The FAK/Src/Paxillin (PXN) axis has been implicated in malignant transformation, tumor growth, progression and metastasis. The present study aimed to assess FAK/Src/PXN protein expression in both primary and liver metastatic sites of colorectal adenocarcinoma (CRC). METHODS: FAK, Src and p-PXN expression was assessed immunohistochemically on 32 primary CRCs and their corresponding liver metastases, being also analyzed in relation with clinicopathological characteristics and patient...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Gene expression profiling demonstrates WNT/ β-catenin pathway genes alteration in Mexican patients with colorectal cancer and diabetes mellitus.
CONCLUSIONS: Our results suggest that WNT/β-catenin pathway is upregulated in patients with CRC and DM, demonstrating its importance and involvement in both pathologies. PMID: 29135090 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Remarkably higher efficacy and a wider safety window for nonfrontline over first-line drug combinations in the adenocarcinoma Colo 320DM cell line.
CONCLUSIONS: Human mesenchymal stem cells could be an excellent alternative to laboratory animals, when testing the safety profiles of drugs. The most promising combinations of non-frontline drugs to treat CRC are Carbo/Cispl/ Asp and Carbo/Cispl/DIM. PMID: 29135091 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

The prognostic role of Skp2 and the tumor suppressor protein p27 in colorectal cancer.
This study aimed at exploring the role of Skp2, p27 and Cks1 expression as prognostic factors for colorectal cancer (CRC) patients, and to identify a correlation between their expression and the cell proliferation marker Ki67. METHODS: We conducted a retrospective study on 130 patients with CRC treated with surgery and adjuvant treatment at the Oncology Institute Cluj-Napoca between 2006- 2010. The Skp2, p27, Cks1 and Ki67 immunoexpression was grouped from 1 to 4, according to percents of tumor cells with nuclear reactivity. Their correlation with overall survival (OS), recurrence free survival (RFS) and with the class...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Evaluation of safety of bevacizumab as second-line treatment of patients with metastatic colorectal cancer.
CONCLUSION: Use of bevacizumab caused moderate adverse effects, none of which was life-threatening. PMID: 29135093 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Towards a tailored lymphadenectomy for gastric cancer based on the correlation between the primary tumor location and the first lymphatic drain basin: Preliminary data.
CONCLUSION: Primary gastric tumors towards the lesser curvature should be treated by a modified D2 lymphadenctomy. However, for tumors towards the greater curvature, a D1(+) lymphadenectomy always including the no. 7 & 9 lymph node stations complex, might be enough. PMID: 29135094 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Does upfront therapy with cytoreductive surgery and HIPEC confer a survival benefit in patients with synchronous gastric peritoneal carcinomatosis when compared with patients with metachronous gastric peritoneal carcinomatosis?
Authors: Kopanakis N, Efstathiou E, Sarris D, Spiliotis J Abstract Gastric cancer (GC) remains the second leading cause of cancer death worldwide, accounting for 8% of the total cases and 10% of total deaths in 2008. Surgery remains the curative treatment option for GC and the main reason for treatment failure is peritoneal recurrence which, according to the literature, occurs in 40-60% of the cases, despite extensive surgery including D2 lymph node dissection. The hyperthermic intraperitoneal chemotherapy (HIPEC) technique is increasingly used in the treatment of primary and digestive peritoneal carcinomatosis (PC...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Silibinin promotes the apoptosis of gastric cancer BGC823 cells through caspase pathway.
CONCLUSION: Silibinin can inhibit the proliferation of BGC- 823 gastric cancer cells, and such an inhibitory effect is time- and concentration-dependent. Additionally, silibinin can promote the apoptosis of BGC-823 gastric cancer cells, which may be realized through mitochondrial apoptosis. PMID: 29135096 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Analysis of expression profile of miRNA in stomach adenocarcinoma.
CONCLUSION: miR-7-3 is proved to be an independent prognostic indicator for STAD and this study confirmed that tumor-specific miRNA can predict the progression and prognosis of STAD. PMID: 29135097 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma: The European experience.
CONCLUSION: The present meta-analysis demonstrates the superiority of laparoscopic over open approach for same sized tumors. Cirrhotic patients benefit from laparoscopy in terms of shorter hospital stay, complication rate and long-term oncologic outcomes. PMID: 29135098 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Tissue injury of the remnant liver following radiofrequency-assisted partial hepatectomy.
CONCLUSION: The Habib-4X liver resection technique proved to be less injurious in the remnant liver tissue after PH compared to the SCC technique. PMID: 29135099 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Safety and efficacy of liver resections in elderly patients.
CONCLUSIONS: Liver resections, even major ones, can be tolerated by elderly patients with good postoperative outcomes under the presupposition of careful patient selection. PMID: 29135100 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

NOR1 expression and its relationship with prognosis in patients with hepatocellular carcinoma.
CONCLUSION: Consequently, NOR1 is a protective protein in HCC, and the increase of its expression is favorable for the prognosis of patients. PMID: 29135101 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Changes in 18F-FDG-PET/CT tumor metabolism are not consistent with pathologic complete response in hormone-positive breast cancer.
CONCLUSION: SUVmax changes in later cycles of NAC as commonly practised in oncology clinics were not consistent with pCR (p=1.0). Complete metabolic response may not be associated with pCR in hormone-positive LABC. However, almost 80% of patients had>50% decrease in SUVmax and may still have a chance for conservative surgery and less postoperative morbidity. Therefore, 18F-FDG-PET/CT may still have a role to evaluate the tumor response with a need of larger studies and analysis for cost-effectiveness. PMID: 29135102 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Impact of Oncotype DX on chemotherapy assignment: a retrospective single-center study on female breast cancer patients.
This study was designed to determine the Recurrence Score (RS) distribution and its associated risk assessments based on traditional clinicopathologic characteristics in a single-center breast cancer (BC) deriving cohort in Greece, and to evaluate the impact of the RS results on adjuvant treatment decisions applied in this cohort. METHODS: This was a retrospective, single-center study regarding Greek female patients with early-stage breast cancer (ESBC). From 2009 to 2015, 114 cases lacking unanimity in the multidisciplinary breast meeting (MDM) fulfilled the inclusion criteria. The RS of the Oncotype DX (ODX) assay wa...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Clinicopathological and prognostic significance of cyclin D1 amplification in patients with breast cancer: a meta-analysis.
Authors: He Q, Wu J, Liu XL, Ma YH, Wu XT, Wang WY, An HX Abstract PURPOSE: Cyclin D1 plays a critical role in tumorigenesis and the regulation of the G1/S transition in the cell cycle. The relationship between cyclin D1 amplification and clinicopathological parameters in patients with breast cancer remains controversial and its impact on survival outcome is not completely clear. We conducted a meta-analysis to investigate the associations between cyclin D1 gene amplification and certain clinicopathological characteristics and the prognosis in breast cancer. METHODS: Literature search of PubMed (up to August 3,...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Impact of ABCB1 and CYP2D6 polymorphisms on tamoxifen treatment outcomes and adverse events in breast cancer patients.
CONCLUSIONS: Although no conclusive statistical association between the examined polymorphisms and the outcome or incidence of AEs in tamoxifen therapy was found, the impact of ABCB1 polymorphisms warrants further research. The importance of finding predictive pharmacogenomic biomarkers is a major challenge for individualization and pharmaco-economic rationalization of therapy. The latest international guidelines support this notion. PMID: 29135105 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Evidence for the efficacy of disulfiram and copper combination in glioblastoma multiforme - A propos of a case.
Authors: Karamanakos PM, Trafalis DT, Papachristou DJ, Panteli ES, Papavasilopoulou M, Karatzas A, Kardamakis D, Nasioulas G, Marselos M Abstract Glioblastoma multiforme (GBM) is the most common and aggressive malignancy of the central nervous system. Treatment usually involves a combination of surgical resection, chemotherapy, and radiotherapy, but ultimately this condition is incurable. Besides the dismal prognosis of GBM, financial factors have also presented challenges for advancing treatments. Taking into consideration the high cost of developing new anticancer drugs as well as the fact that GBM is a rare dise...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Benefit and outcome of using temozolomide-based chemoradiotherapy followed by temozolomide alone for glioblastoma in clinical practice.
CONCLUSION: The concomitant usage of temozolomide and radiotherapy was beneficial, and statistically significant difference among groups and subgroups was observed regarding overall survival. PMID: 29135107 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients.
Authors: Velentza L, Tolia M, Christakou C, Nikolaou M, Zerdes I, Tsoukalas N, Hajiioannou J, Tsanadis K, Rigas G, Mitsis M, Theodorou K, Pistevou-Gombaki K, Tsekeris P, Kyrgias G Abstract PURPOSE: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads to hormone secretion abnormalities and their severity in children with brain tumors. METHODS: The data were collected by relevant studies on PubMed and EMBASE. Articles up to December 2016 were included. We ...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

18F-FDG-PET/CT versus 99Tcm-MIBI-SPECT: which is better for detection of solitary pulmonary nodules ?
CONCLUSION: 99Tcm-MIBI-SPECT has comparable diagnostic value with 18F-FDG-PET/CT in differentiating benign from malignant SPNs. Considering its easy availability and low-cost, 99Tcm-MIBI-SPECT could be an alternative imaging modality in differentiating benign from malignant SPNs in areas with a backward economy. PMID: 29135109 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Pathway cross-talk network strategy reveals key pathways in non-small cell lung cancer.
CONCLUSION: We successfully revealed the disease pathway cross-talks and explored 5 key pathways in NSCLC, which may be the underlying therapeutic targets for lung cancer. PMID: 29135110 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Curative intent for unresectable advanced squamous cell esophageal cancer: Overall survival after chemoradiation.
CONCLUSIONS: With appropriate selection, patients with advanced squamous cell esophageal cancer should be considered for potentially effective treatment. PMID: 29135111 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Symptom-triggered alcohol vapor inhalation for postoperative alcohol withdrawal syndrome in patients with gastroesophageal carcinoma.
CONCLUSION: Alcohol vapor inhalation is feasible and effective to alleviate AWS timely, which is reliable for patients to get through the fasting time after surgery. PMID: 29135112 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Minichromosome maintenance (MCM) protein 4 overexpression is a potential prognostic marker for laryngeal squamous cell carcinoma.
CONCLUSIONS: We noticed a significant role for MCM4 overexpression in human LSCC tissues and their corresponding adjacent non-neoplastic tissues and found that siRNA of MCM4 can significantly decrease the proliferation of cancer cells. It is suggested that MCM4 profiling could potentially be used to predict response to treatment and prognosis in LSCC. PMID: 29135113 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Expression and role of p53 in oral lichen planus patients.
CONCLUSION: We believe that low percentage of p53-positive and well-marked keratinocytes in OLP represent the influence of mutant p53 protein, and that increasing expression of this protein could serve as a valuable diagnostic sign of early carcinogenesis. According to our results intensity of p53 coloration of keratinocytes could help assessing the malignant potential of OLP. PMID: 29135114 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Effectiveness and safety profile of ipilimumab therapy in previously treated patients with unresectable or metastatic melanoma - the Romanian Patient Access Program.
CONCLUSIONS: The use of ipilimumab in daily clinical practice demonstrated to be effective and safe, consistent with data coming from randomized clinical trials or other observational studies. PMID: 29135115 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Serum S100B levels correlate with stage, N status, mitotic rate and disease outcome in melanoma patients independent to LDH.
CONCLUSIONS: S100B serum levels reflect tumor load, correlate with response to treatment, might identify patients who are at increased risk of disease relapse, may predict prognosis independent to LDH, and could be used as early biomarkers of tumor recurrence. PMID: 29135116 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

What is the connection between serum phosphorus, cancer and heroin? A medical hypothesis based on observational studies.
Authors: Kouloulias V, Papaloucas CD, Papaloucas A Abstract Considering the results of a previous study in which 2321 regular heroin addicts who died without having stopped taking the drug since they had started - from various causes but none from cancer, may mean something. Our first thought was: Can't we hypothesize, reinforcing our previous view that heroin is a "barrier" against cancer and as the user gets in the methadone program he/she lacks the "barrier" and therefore is liable to develop cancer? We have already reported that the amount of blood phosphorus in heroin addicted is significan...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

The impact of dose matrix and voxel dimensions to dose calculation for stereotactic radiosurgery.
CONCLUSION: We considered that a good compromise between quality of dose distribution, time calculation and hard disk memory would be the use of a 64 mm(3) matrix dimension with a 2 mm(3) voxel size. PMID: 29135118 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Expression and significance of ARID1A mRNA in endometriosis- associated ovarian cancer.
Authors: Wang Q, Wang L, L Y, Ding X, Liu A Abstract PURPOSE: To investigate the expression and relevant clinical and pathological significance of AT-rich interactive domaincontaining protein 1A (ARID1A) mRNA in endometriosis-associated ovarian cancer. METHODS: The clinical and pathological data of 63 patients with ovarian clear cell carcinoma (OCCC) and of 43 patients with ovarian endometrioid adenocarcinoma (OEAC) were collected. The expression of ARID1A-encoded protein, baf250a, in ovarian cancer tissues was detected using immunohistochemistry. The ARID1A mRNA expression was detected via RNAscope hybridizati...
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma.
CONCLUSIONS: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker. PMID: 29135120 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - November 15, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research