"J BUON"[ta]; +108 new citations
108 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "J BUON"[ta] These pubmed results were generated on 2020/06/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - June 13, 2020 Category: Cancer & Oncology Tags: Report Source Type: research

Combining immune checkpoint inhibitors with denosumab: a new era in repurposing denosumab in oncology?
Authors: V Deligiorgi M, Panayiotidis MI, Trafalis DT Abstract The designation of immune checkpoint inhibitors (ICPi) as scientific breakthrough of the year 2013 marked a turning point in cancer therapeutics, unleashing the host immune system against tumors. ICPi block the cytotoxic T lymphocyte antigen 4 (CTLA-4), the programmed cell death protein (PD) 1 (PD-1), and the ligand of the latter (PD-L1) ‒the landmark immune checkpoints‒abrogating the escape of cancer cells from immunosurveillance. Despite the durable antitumor response elicited by ICPi in an expanding list of cancer types and a substantial fraction...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

GISTs of the large intestine: review of the literature.
Authors: Syllaios A, Schizas D, Davakis S, Koutras A, Vailas M, Machairas N, Mpaili E, Felekouras E Abstract Gastrointestinal stromal tumors (GISTs) of the large intestine are extremely rare entities that constitute approximately 5% of the reported GISTs and approximately 0.1% of all cancers of colon and rectum. Almost 85-95% of GISTs contain a mutation in the c-kit tyrosine kinase and positive expression of the CD117 antigen (c-KIT). About 5% of GISTs appear to be c-kit-negative and usually have a mutation on the platelet-derived growth factor receptor-a (PDGFR-a). Compared to other GISTs, GISTs of the colon demon...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Exosomal miRNAs in colorectal cancer: the carriers of useful news.
CONCLUSIONS: This review reveals the role of exosomal miRNAs in CRC management and discusses the promises and challenges associated with the introduction of this combination into clinical practice. PMID: 32277611 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Neoadjuvant chemoradiotherapy in rectal cancer and anorectal sphincter dysfunction: Review of the literature.
CONCLUSION: Current radiotherapy recommendations are oriented in exclusion of anal canal from radiation field when oncologically safe or using new sphincter-sparing techniques for neoadjuvant radiotherapy aiming to improve the patient quality of life receiving radiation therapy prior to surgery. However, more well designed studies are required to assess the pathophysiology as well as treatment options for this complex matter, which strongly affects the quality of life of rectal cancer patients. PMID: 32277612 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Circulating tumor cells in gynaecological malignancies.
Authors: Kiss I, Kolostova K, Pawlak I, Bobek V Abstract New non-invasive approaches have developed for diagnosis and treatment of malignant diseases. Cells shed from the primary tumor circulating in the bloodstream with metastasis potential are called Circulating Tumor Cells (CTCs). These cells are easily acquired from the peripheral blood of patients, while several enrichment and isolation methods are available nowadays with different benefits and positive detection rates. A brief characterization of three major categories of detection is described (nucleic acid-based, physical properties-based, antibody-based). ...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Which is the best neoadjuvant (pre-surgery) chemoradiation regimen for locally advanced rectal carcinoma? Short or long course of radiation therapy? Do we have new data?
CONCLUSION: Long-course radiotherapy with delay seems not to be different than short-course radiotherapy with delay, but prolongs substantially the treatment time. PMID: 32277614 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Cancer pain … who cares? International and national patterns of evidence-based global guidelines recommendations for physicians on the Web (2011 vs. 2018).
CONCLUSIONS: Major medical oncology and radiation oncology societies - at global level - fail to produce updated cancer pain recommendations for their physicians, with most of these providing no or inconsistent or outdated guidelines. PMID: 32277615 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Tormentic acid induces anticancer effects in cisplatin-resistant human cervical cancer cells mediated via cell cycle arrest, ROS production, and targeting mTOR/PI3K/AKT signalling pathway.
CONCLUSIONS: The outcomes of the present investigation suggest that tormentic acid-induced apoptotic effects in cisplatin-resistant HeLa cells were mediated via cell cycle arrest, ROS production and targeting of mTOR/PI3K/AKT signalling pathway. Thus, tormentic acid may be considered as a lead molecule in cancer therapeutics. PMID: 32277616 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Efficacy of bevacizumab combined with nedaplatin in the treatment of ovarian cancer and its effects on tumor markers and immunity of patients.
Authors: Zhang H, Chen C, Wang S, Li X, Fan T Abstract PURPOSE: To study the efficacy of bevacizumab combined with nedaplatin in the treatment of ovarian cancer and its effects on tumor markers and immunity of patients. METHODS: A total of 100 ovarian cancer patients treated in our hospital from January 2015 to December 2018 were enrolled and divided into experimental group (n=50) and control group (n=50) using a random number table. Patients in the control group were treated with carboplatin alone, while those in the experimental group were treated with bevacizumab combined with nedaplatin, based on the treatm...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Ovatodiolide exerts anticancer effects on human cervical cancer cells via mitotic catastrophe, apoptosis and inhibition of NF-kB pathway.
CONCLUSION: Taken together, Ovatodiolide may prove a lead molecule for the development of systemic therapy for cervical cancer. PMID: 32277618 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Bismahanine exerts anticancer effects on human cervical cancer cells by inhibition of growth, migration and invasion via suppression of NF-kB signalling pathway.
CONCLUSION: Bismahanine exhibits significant anti-proliferative effects on the cervical cancer cells and may prove essential in the development of chemotherapy for cervical cancer. PMID: 32277619 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

A cohort retrospective study of high-risk HPV recurrence in Greek women after cervical lesion treatment through detection of viral E6/E7 mRNA expression.
CONCLUSIONS: E6/E7 mRNA overexpression seems to be a promising candidate as an indicator-biomarker to determine the success of treatment. PMID: 32277620 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

3D MRI-based evaluation of the 2D brachytherapy planning in patients with advanced cervical cancer: An analysis of the delivered dose.
CONCLUSION: 2D radiography-based BRT planning can provide a good estimation for the bladder and rectum 3D D2ccm dose with a significant statistical difference for the doses in the smaller OAR volumes (D0.1ccm, D1ccm). Inability to visualize tumor tissue during 2D BRT planning provides no option in tailoring the dose distribution to the tumor volume and patient anatomy, leading to potential under/over-treatment in some patients. PMID: 32277621 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Awareness and knowledge about HPV infection and HPV vaccination among women undergoing cytology and colposcopy in Serbian cervical cancer counseling center.
CONCLUSIONS: Women undergoing cervical cancer screening in Serbia have moderate awareness of HPV infection and low awareness of HPV vaccine. However, it is promising that those who heard of HPV have high knowledge about it. PMID: 32277622 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Preoperative neoadjuvant chemotherapy combined with radical surgery in cervical cancer.
Authors: Meng X, Chu Y, Pan Y, Han L, Meng Z, Wang X Abstract PURPOSE: To investigate the efficacy of preoperative neoadjuvant chemotherapy combined with radical surgery on cervical cancer patients and its effect on the prognosis of patients and serum squamous cell carcinoma antigen (SCC-Ag) level. METHODS: 163 patients with cervical cancer composed the research group. Among them, 72 patients treated with radical resection of cervical cancer were enrolled in the control group, while the remaining 91 patients were enrolled in the study group and treated with preoperative neoadjuvant chemotherapy combined with ra...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Association of the IL-10 gene rs1800872 (-592 C > A) polymorphism with breast cancer in a Mexican population.
CONCLUSION: The IL-10 gene rs1800872 polymorphism was associated with BC susceptibility in this sample from the Mexican population. PMID: 32277624 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

The impact of structured education of breast cancer patients receiving capecitabine on mental disorders.
CONCLUSIONS: Structured education has a significant positive impact on depression, anxiety and stress symptoms of breast cancer patients receiving capecitabine. Therefore, it may be recommended for use in everyday clinical practice. PMID: 32277625 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

MicroRNA-322 regulates the growth, chemosensitivity, migration and invasion of breast cancer cells by targeting NF-kB1.
CONCLUSION: To conclude, miR-322 may exhibit therapeutic implications in breast cancer treatment and warrants further investigation. PMID: 32277626 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Prognostic significance of EGFR, MUC1 and PD-L1 expressions in cases with triple negative breast cancer.
CONCLUSION: EGFR expression was found to be one of the most important prognostic factors in addition to T and N status in cases with TNBC. PMID: 32277627 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Predictive factors of pathological response to neoadjuvant chemotherapy in patients with breast cancer.
Authors: Ryspayeva D, Lyashenko A, Dosenko I, Kostryba O, Koshyk O, Krotevych M, Smolanka I Abstract PURPOSE: To identify predictive factors connected with pathologic response in patients with breast cancer (BC) having received neoadjuvant chemotherapy (NACT). METHODS: 49 patients with BC were investigated before and after treatment in this prospective research. Different chemotherapy regimes were administered. The Miller-Payne scoring system was used to assess the tumour response. The nuclear proliferation markers Ki67 and the expression of topoisomerase IIα (Topo IIα) were evaluated. RESULTS: ...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Protective effect of rs712 polymorphism in a let-7 microRNA-binding of KRAS gene in breast cancer of a Mexican population.
CONCLUSION: Polymorphism rs712 in KRAS gene was protective factor associated with susceptibility for BC in this sample from Mexican population. PMID: 32277629 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Neutrophils-to-lymphocytes, lymphocytes to-monocytes and platelets-to-lymphocytes ratios - predictive biomarkers for response to neoadjuvant chemotherapy in breast cancer.
CONCLUSIONS: Our findings suggest that NLR can be a predictive biomarker for pCR. Further studies, on larger sample size, are necessary to establish the correlation with MPG and RCB. PMID: 32277630 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Naturally occurring glycyrrhizin triterpene exerts anticancer effects on colorectal cancer cells via induction of apoptosis and autophagy and suppression of cell migration and invasion by targeting MMP-9 and MMP-2 expression.
CONCLUSION: The results of this study reveal that glycyrrhizin can be developed as a potent anticancer agent against colorectal cancer provided further studied are performed, especially on its toxicity to humans. PMID: 32277631 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Knockdown of ZEB2-AS1 inhibits cell invasion and induces apoptosis in colorectal cancer.
CONCLUSIONS: LncRNA ZEB2-AS1 is upregulated in CRC. It accelerates CRC cells to proliferate via interacting with EZH2 and LSD1, thus promoting the progression of CRC. PMID: 32277632 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Selective efficacy and safety of first line and non front line antineoplasic agent combinations determined with individualized assays on colorectal cancer primary cultures.
CONCLUSIONS: The resistance to 5-fluorouracil/oxaliplatin of CRAC PCs and the usefulness of seven new DCs strongly suggest the convenience of performing ex vivo individualized assays to evaluate DCs, and implement new and more useful treatments, instead of submitting patients to standardized chemotherapies in a blinded manner. Approaches such as this and properly evaluated in clinical assays could increase the life expectancy of patients with cancer and improve their quality of life. PMID: 32277633 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Survival of patients with liver metastases from colorectal cancer treated with bevacizumab and FOLFOX4.
Authors: Dzunic M, Petkovic I, Cvetanovic A, Vrbic S, Pejcic I Abstract Colorectal cancer (CRC) is the third most common cancer and the second cause of cancer-related deaths worldwide. Despite early diagnosis and treatment improvement, the majority of patients will still suffer from metastatic disease (mCRC), which has a poor prognosis. Molecular diversity of CRC requires personalized targeted approach for improving patient outcomes. Antiangiogenic agents proved to be beneficial in the continuum of mCRC treatment. For efficient epidermal growth factor receptor (EGFR) directed therapy, subtle molecular selection and...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of laparoscopic complete mesocolic excision and traditional radical operation for colon cancer in the treatment of stage III colon cancer.
Authors: Yan D, Yang X, Duan Y, Zhang W, Feng L, Wang T, Du B Abstract PURPOSE: To compare the clinical efficacy and safety between laparoscopic complete mesocolic excision (CME) and traditional radical operation for colon cancer in the treatment of stage III colon cancer. METHODS: A total of 196 patients with stage III colon cancer treated in out hospital from January 2014 to February 2016 were selected and divided into two groups using a random number table. One group (CME group, n=98) received laparoscopic CME, while another group (Traditional group, n=98) underwent traditional radical operation for colon ca...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Mean platelet volume and platelet distribution width correlates with prognosis of early colon cancer.
Authors: Sakin A, Sahin S, Sakin A, Karatas F, Sengul Samanci N, Yasar N, Arici S, Demir C, Geredeli C, Dikker O, Cihan S Abstract PURPOSE: Several platelet indices have been linked to prognosis of various cancers, including metastatic colorectal cancer. The aim of this study was to investigate the prognostic effect of mean platelet volume (MPV) and platelet distribution width (PDW) in early colon cancer (CC) patients. METHODS: This retrospective study included early CC patients who were followed up and treated between 2005 and 2017. Relapse free survival (RFS) and overall survival (OS) were determined with res...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Laparoscopic and conventional left hemicolectomy in colon cancer.
This study aimed to compare the efficacy of laparoscopic and conventional left hemicolectomy for treating colon cancer and their effects on stress response and quality of life of patients. METHODS: 92 patients with colon cancer were selected. Forty three patients in the study group were treated with laparoscopic left hemicolectomy, and 49 patients in the control group were treated with conventional left hemicolectomy. The surgery, postoperative recovery, intraoperative and postoperative complications were compared between the two groups. The enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL1...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

In vitro anticancer effects of levopimaric acid in cisplatin-resistant human lung carcinoma are mediated via autophagy, ROS-mediated mitochondrial dysfunction, cell apoptosis and modulation of ERK/MAPK/JNK signalling pathway.
CONCLUSION: The current results strongly indicate that levopimaric acid may prove to be a potential anticancer drug candidate provided further in depth studies are carried out. PMID: 32277638 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of clinical efficacy between laparotomy and laparoscopic radical surgery for gastric cancer and their effects on CRP, CEA and insulin resistance.
This study aimed to compare between the clinical efficacy of laparotomy and laparoscopic radical resection of gastric cancer and their effects on C-reactive protein (CRP), carcinoembryonic antigen (CEA) and insulin resistance. METHODS: 210 patients with gastric cancer admitted to Dongying People's Hospital from September 2013 to July 2015 were included in this study. The patients were divided according to surgery type into the laparotomy group (n = 104) and the laparoscopy group (n = 106). The operative time, intraoperative bleeding, lymph node dissection, postoperative exhaust time and postoperative complications were...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Antitumor effects of flavokawain-B flavonoid in gemcitabine-resistant lung cancer cells are mediated via mitochondrial-mediated apoptosis, ROS production, cell migration and cell invasion inhibition and blocking of PI3K/AKT Signaling pathway.
CONCLUSIONS: Flavokawain-B targets gemcitabine-resistant NSCLC cells selectively without inducing any significant toxicity in normal cells and these effects are mediated via apoptosis induction, ROS production, loss of MMP, suppression of cell migration and invasion and blocking PI3K/AKT signalling pathway. PMID: 32277640 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

The effect of PD-L1 status on survival outcomes in patients with stage II-III non-small cell lung cancer treated with chemotherapy.
CONCLUSIONS: PD-L1 positivity in tumor cells was a positive prognostic factor for OS in patients with stage II and III NSCLC. PMID: 32277641 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Heptaphylline suppresses the proliferation and migration of human bladder cancer cells via induction of intrinsic apoptosis, autophagy and inhibition of β-catenin signalling pathway.
CONCLUSION: Taken together, Heptaphylline suppressed the proliferation of the bladder cancer cells and may prove beneficial in the bladder cancer treatment. PMID: 32277642 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Limonene terpenoid obstructs human bladder cancer cell (T24 cell line) growth by inducing cellular apoptosis, caspase activation, G2/M phase cell cycle arrest and stops cancer metastasis.
CONCLUSIONS: These results indicate that limonene might be used as a potent anticancer agent against human bladder cancer for which further in depth studies are needed, especially over its toxicological studies. PMID: 32277643 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Totally intracorporeal 3D laparoscopic orthotopic neobladder reconstruction following radical cystectomy for infiltrative bladder tumors: the experience of modified Studer and modified Y-shaped ileal reconstruction techniques.
CONCLUSION: Resecting a digestive segment and using it as a urinary reservoir may lead to multiple complications. Therefore, laparoscopic technical adaptations and highly skilled surgical teams are required for performing a totally intracorporeal 3D laparoscopic orthotopic ileal neobladder reconstruction. PMID: 32277644 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Assessment of ex-vivo efficacy (oncogram) of immunotherapeutic and chemotherapeutic agents in bladder cancer: A pilot study of personalized treatment.
Authors: Celik S, Sari H, Ugur Mungan M, Yorukoglu K, Celebi I, Aktas S Abstract PURPOSE: To investigate the ex-vivo efficacy of immunotherapeutics and chemotherapeutics in bladder cancer primary cell cultures, to assess the applicability of the method according to the results and to evaluate suitability of the oncogram method for personalized treatment of bladder cancer. METHODS: After receiving ethics committee approval, tumor tissue was obtained from patients with transurethral resection performed due to bladder tumor from 2015 to 2017. Primary culture was produced from the obtained fresh tissue. Each cultur...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

lncRNA SNHG1 suppresses gastric cancer cell proliferation and promotes apoptosis via Notch1 pathway.
Authors: Zhang Z, Wang H Abstract PURPOSE: To explore the influence of long non-coding ribonucleic acid (lncRNA) small nucleolar RNA host gene 1 (SNHG1) on the proliferation and apoptosis of gastric cancer cells. METHODS: SNHG1 was knocked down using small-interfering RNAs (siRNAs) in gastric cancer cell line MGC-803 and then the changes in the expression levels of SNHG1 and Notch1 in each group of cells were evaluated via quantitative reverse transcription polymerase chain reaction (qRT-PCR). RESULTS: After intervention of SNHG1 by siRNAs, compared with NC-siRNA group, SNHG1-siRNA group exhibited notably l...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Phloretin flavonoid exhibits selective antiproliferative activity in doxorubicin-resistant gastric cancer cells by inducing autophagy, inhibiting cell migration and invasion, cell cycle arrest and targeting ERK1/2 MAP pathway.
CONCLUSIONS: Phloretin may prove beneficial as a promising drug candidate for gastric cancer treatment provided further studies are carried out on it, especially toxicological studies. PMID: 32277647 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Berberine inhibits human gastric cancer cell growth via deactivation of p38/JNK pathway, induction of mitochondrial-mediated apoptosis, caspase activation and NF- κB inhibition.
CONCLUSIONS: Berberine may act as a promising drug candidate for gastric cancer as demonstrated from the current study. PMID: 32277648 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Lymph node harvesting in gastric cancer: the crucial role of t stage.
CONCLUSION: The results of the present study seem to add another value i.e. tumor's T stage in the equation of lymph node retrieval in gastric cancer resection specimens. Lymph node retrieval in gastric cancer patients appeared to be dependent to the primary tumors T stage in the given patient sample. PMID: 32277649 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of clinical efficacy between laparotomy and laparoscopic radical surgery for gastric cancer and their effects on CRP, CEA and insulin resistance.
This study aimed to compare between the clinical efficacy of laparotomy and laparoscopic radical resection of gastric cancer and their effects on C-reactive protein (CRP), carcinoembryonic antigen (CEA) and insulin resistance. METHODS: 210 patients with gastric cancer admitted to Dongying People's Hospital from September 2013 to July 2015 were included in this study. The patients were divided according to surgery type into the laparotomy group (n = 104) and the laparoscopy group (n = 106). The operative time, intraoperative bleeding, lymph node dissection, postoperative exhaust time and postoperative complications were...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Inhibition of cancer cell growth in cisplatin-resistant human oral cancer cells by withaferin-A is mediated via both apoptosis and autophagic cell death, endogenous ROS production, G2/M phase cell cycle arrest and by targeting MAPK/RAS/RAF signalling pathway.
CONCLUSIONS: These results suggest that Withaferin-A may prove a potent lead molecule in oral cancer treatment and warrants further investigations. PMID: 32277651 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Kutkoside-an iridoid glycoside, exerts anti-proliferative effects in drug-resistant human oral carcinoma cells by targeting PI3K/AKT signalling pathway, inducing apoptosis and suppressing cell migration and invasion.
CONCLUSION: Kutkoside shows potential anticancer and pro-apoptotic effects in HSC-2 oral carcinoma cells and as such may be developed as a possible anticancer agent provided further studies are performed. PMID: 32277652 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Anticancer activity of Phloretin against the human oral cancer cells is due to G0/G1 cell cycle arrest and ROS mediated cell death.
CONCLUSION: Phloretin exhibits significant growth inhibitory effects on the human oral cancer cells and may prove beneficial in oral cancer treatment. PMID: 32277653 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

MicroRNA-205 targets HER3 and suppresses the growth, chemosensitivity and metastasis of human nasopharyngeal carcinoma cells.
CONCLUSION: miR-205 may exhibit therapeutic implications in the treatment of nasopharyngeal carcinoma. PMID: 32277654 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Novel insights into laryngeal squamous cell carcinoma from association study of aberrantly expressed miRNAs, lncRNAs and clinical features in Bulgarian patients.
CONCLUSION: Our results enrich the knowledge about ncRNA involvement in LSCC tumorigenesis. Further studies are needed to evaluate the clinical utility of the differently expressed ncRNAs as potential diagnostic and prognostic biomarkers in LSCC. PMID: 32277655 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

The prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in nasopharyngeal cancer.
Authors: Gundog M, Basaran H Abstract PURPOSE: To investigate the prognostic value of pre-treatment neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and hemoglobin level in patients treated with definitive chemoradiotherapy (CRT) for nasopharyngeal carcinoma. METHODS: We retrospectively analyzed 97 patients who received definitive CRT for nasopharyngeal cancer. An NLR cut-off value of 4.42 was identified using receiver operating characteristic curve (ROC) analysis, an PLR cut-off value of 128.6 was identified using ROC analysis and a hemoglobin cut-off value of 13g/dl was identified using ROC ...
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Sentinel lymph node biopsy in clinically node negative patients with papillary thyroid carcinoma.
CONCLUSION: The proposed method of SLN biopsy using methylene blue dye is feasible, safe and accurate in the detection of LNM in the lateral neck compartment and may help in the decision to perform selective modified radical neck dissection in cN0 patients with PTC. PMID: 32277657 [PubMed - as supplied by publisher] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research