Endpoints in oncology clinical trials.
Authors: Kilickap S, Demirci U, Karadurmus N, Dogan M, Akinci B, Sendur MAN Abstract In oncology clinical trials, many different endpoints can be used as primary or secondary endpoints. Advances in cancer treatment have provided longer survival outcomes, particularly in certain types of cancer. Overall survival is accepted as the gold standard endpoint for demonstrating clinical benefit; however, it is associated with some disadvantages such as requirement of long-term follow-up, requirement of higher number of patients, and high cost. Thus, the question "what is the most appropriate endpoint in clinical trial...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Aspergillosis in immunocompromised patients with haematological malignancies.
Authors: Gletsou E, Ioannou M, Liakopoulos V, Tsiambas E, Ragos V, Stefanidis I Abstract Aspergillosis, which is saprophytic in nature, is known to cause massive destruction of paranasal sinuses in immunocompromised hosts, but in immunocompetent individuals invasive aspergillosis is rare. Diagnosis is posed from history, physical examination including anterior and posterior rhinoscopy, endoscopy of the nose and paranasal sinuses, radiological findings (CT and/or MRI), fungus cultures and histopathological examination. Non-specific presenting symptoms provide time for infection to extent from sinuses to vital surrou...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Differences in clinical features and oncologic outcomes between metastatic right and left colon cancer.
Authors: Kim K, Kim YW, Shim H, Kim BR, Kwon HY Abstract Approximately 20% to 25% of patients with colorectal cancer (CRC) have distant organ metastasis at the time of initial diagnosis. The primary tumor location has been suggested as a prognostic factor for patients with metastatic CRC. In recent years, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has been brought into focus due to their different outcomes, prognoses, and clinical responses to chemotherapy. In this article we aimed to review the underlying differences between metastatic RCC and LCC in terms of epidemiology, clinica...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Is it the right moment to include hyperthermic intraperitoneal chemotherapy as standard in ovarian cancer management? A reappraisal.
Authors: Samartzis K, Thomakos N, Liontos M, Kollia D, Malakasis A, Haidopoulos D, Bamias A, Rodolakis A, Loutradis D Abstract Ovarian cancer is a leading cause of cancer-related death in women and often is diagnosed at an advanced stage with diffuse peritoneal carcinomatosis. Since it is mainly confined to the peritoneal cavity, even after recurrence, it is an ideal target for loco-regional therapy. The standard therapeutic strategy of advanced ovarian cancer is cytoreductive surgery followed by systemic chemotherapy. Intraperitoneal chemotherapy used as adjuvant therapy has shown a survival benefit in ovarian can...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma.
Authors: Niotis A, Tsiambas E, Fotiades PP, Ragos V, Polymeneas G Abstract Aberrant cell proliferation is a major cause in the development and progression of carcinogenic process. Epithelia characterized by increased mitotic rates accumulate easily gross numerical and structural chromosomes (polysomy/aneuploidy) and specific gene (deletions, amplifications, point mutations, translocations) deregulations that lead to their progressive neoplastic and finally malignant transformation. Molecules that are critical for evaluating the proliferation status of the corresponding tissues include mainly ki-67 (cytogenetic band...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Household costs of breast cancer morbidity: An empirical assessment from Pakistan.
CONCLUSIONS: The results of this study provide rich insight into the financial burden borne by households of breast cancer patients and suggest policy implications. PMID: 30722109 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Personal and parental acceptance of human papillomavirus vaccination prior to and during the economic crisis among women in Greece.
CONCLUSION: Demographic factors affecting a woman's attitude towards vaccination prior to the economic crisis in Greece, stopped playing a significant role during the crisis, reflecting its devastating effect on most parts of the population. PMID: 30722110 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Knowledge, attitudes and behaviors of breast and cervical cancers and screenings of women working in primary health care services.
CONCLUSIONS: Although these findings indicate that health care professionals are more knowledgable in terms of breast and cervical cancer screening than non-health care workers, it is necessary to motivate healthcare professionals to increase their level of knowledge and practice on cancer screening. The most important means of achieving this is to ensure that in-service trainings, cancer screenings and the risks to be taken in case of non-screening are mentioned seriously. PMID: 30722111 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Influence of soy isoflavones in breast cancer angiogenesis: a multiplex glass ELISA approach.
CONCLUSIONS: Soluble CXCL16 and VEGF-A are two promoters of angiogenesis and metastasis in breast cancer. The stimulation of these two angiogenesis-related cytokines could represent one of the mechanisms explaining the proliferative effects of low isoflavone doses in estrogen-dependent cells. In estrogen-independent cells, soy isoflavones inhibited their secretion, demonstrating promising anti-angiogenic properties. PMID: 30722112 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Discordance of hormone receptor, human epidermal growth factor receptor-2, and Ki-67 between primary breast cancer and synchronous axillary lymph node metastasis.
CONCLUSIONS: The expression of hormone receptors tended to weaken while the proliferative status remained strong in axillary metastasis. A high Ki-67 labeling index in axillary lymph node metastasis may be a risk factor for recurrence. PMID: 30722113 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Discrepancies and misconceptions of perceived colorectal cancer screening barriers between primary health professionals and unscreened population. A comparative study in Greece.
Authors: Mastrokostas A, Gavana M, Gkrizioti M, Smyrnakis E, Cholongitas E, Benos A, Haidich AB Abstract PURPOSE: Our study aimed to compare the views of healthy eligible unscreened adults, to those of primary care providers in Greece, about colorectal cancer (CRC) screening perceived barriers. METHODS: A sample of 791 unscreened adults (50-75 years) from a recent nationwide health survey in Greece were interviewed about CRC screening barriers, and the main reason for not adhering to colonoscopy and fecal occult blood test (FOBT) was assessed. Results were compared to a concurrent survey of 161 primary care pro...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Is advanced age a hesitation for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in colorectal cancer?
Authors: Cigdem Arslan N, Bisgin T, Altay C, Yavuzsen T, Karaoglu A, Canda AE, Sarioglu S, Sokmen S Abstract PURPOSE: The purpose of this study was to assess the feasibility and safety of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with peritoneal carcinomatosis of colorectal cancer. METHODS: Patients who underwent curative complete CRS and HIPEC for peritoneal carcinomatosis of colorectal cancer with minimum follow-up of 24 months were included in the analysis. Charlson comorbidity index and ECOG performance status were used to evaluate preoperative con...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

What can preoperative blood tests tell us about colorectal cancer?
CONCLUSIONS: Preoperative complete blood count and LDH serum levels can provide valuable information about diagnosis and prognosis in colorectal cancer. PMID: 30722116 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Significance of survivin mRNA blood levels in patients with melanoma.
Authors: Samarkos M, Papaxoinis G, Athanasoula K, Benopoulou Ο, Bouros S, Anastasopoulou A, Diamantopoulos P, Gogas H, Mantzourani M Abstract PURPOSE: Survivin represents a key anti-apoptotic molecule that is highly expressed in the vast majority of tumors. The aim of the study was to examine the significance of survivin mRNA blood levels in melanoma patients. METHODS: In this prospective translational research study, survivin mRNA blood levels were measured in melanoma patients treated with adjuvant interferon or systemic treatment for advanced disease. RESULTS: Sixty-four patients with melanoma an...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

The impact of minimal invasive surgery on early complications and mortality after radical cystectomy for muscle-invasive urothelial bladder cancer.
CONCLUSIONS: The 30-day death rate after radical cystectomy for muscle-invasive urothelial bladder cancer was low. Open cystectomy was associated with more severe short-term complications as compared with the laparoscopic approach. Postoperative anemia was associated with the type of surgery, diversion type and male gender. PMID: 30722118 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Effect of increased number of neoadjuvant chemotherapy cycles on tumor resectability and pathologic response in advanced stage epithelial ovarian cancer.
CONCLUSIONS: Our data suggests that giving more than 3 cycles of NACT is unnecessary because increased number of cycles did not change the resectability and complete pathologic response, while it increased platinum resistance. Moreover OS and PFS remained similar. PMID: 30722119 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of Gemcitabine monotherapy with Gemcitabine and Cisplatin combination in metastatic pancreatic cancer: a retrospective analysis.
CONCLUSION: The cemcitabine and cisplatin combination therapy as first-line treatment of metastatic pancreatic cancer yields significantly prolonged survival over gemcitabine monotherapy. In patients with favorable performance conditions, the combination therapy should be preferred. PMID: 30722120 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

The role of biomarkers and echocardiography in the evaluation of cardiotoxicity risk in children treated for leukemia.
Authors: Raluca Maniu D, Blag C, Popa G, Bota M, Vlad C, Cainap C, Balacescu O, Pop L, Cainap SS Abstract PURPOSE: To describe the high-risk profile group, susceptible to develop anthracycline-induced cardiomyopathy in children with acute leukemia. METHODS: The study involved 35 pediatric patients diagnosed with acute lymphoblastic (ALL) or acute myeloblastic leukemia (AML), from March 2014 to December 2016. Serologic markers used for the analysis of cardiac dysfunction were troponin T, NT-proBNP and PCRhs. Also, the patients have had echocardiographic evaluation at the beginning of treatment to determine LVEF,...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Human V γ9Vδ2 T cells show potent antitumor activity against zoledronate-sensitized OSCC cell lines.
CONCLUSIONS: We found that zoledronate-treated OSCC cell lines are effectively killed by Vγ9Vδ2 T cells. Our results indicate that developing Vγ9Vδ2 T cell-based immunotherapy will be promising in treating patients with OSCC. PMID: 30722122 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Thyroid ultrasonographic charasteristics and Bethesda results after FNAB.
Authors: Triantafillou E, Papadakis G, Kanouta F, Kalaitzidou S, Drosou A, Sapera A, Tampouratzi D, Kotis M, Kyrimis T, Dracopoulou A, Veniou E, Karavasili C, Kaltzidou V, Plyta S, Tertipi A Abstract PURPOSE: Thyroid nodular disease (TND) is a frequent clinical problem and the major concern is the probability of malignancy in a solitary nodule or in one or more nodules of a multinodular goiter. For this purpose, neck ultrasound and fine needle aspiration biopsy (FNAB) under ultrasound guidance have been established as the initial investigation of choice. METHODS: A total of 1113 patients (210 male/903 female) u...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Family caregiver beliefs and barriers to effective pain management of cancer patients in home care settings.
CONCLUSIONS: This is the first time BQ II has been used in this population. The results are consistent with the international academic studies in this area, but more research is needed. BQ II was found to be a valid and reliable scale for defining caregiver attitudes and barriers to effective pain management in homecare settings. Health professional training, interventions targeted to caregivers and trained home care teams may improve the quality of cancer care in these settings. PMID: 30722124 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Hyperthermic intrathoracic chemotherapy (HITHOC) in ovarian carcinoma - a propos of a case.
Authors: Stojiljkovic D, Nikolic S, Cvetkovic A, Jokic V, Spurnic I, Jokic S, Goran M, Kocic M, Miletic N, Filipovic J, Stojiljkovic T, Lukac B Abstract A female patient aged 42, started chemotherapy for advanced ovarian carcinoma in June 2016. Considering intraoperative findings, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) were performed, followed by adjuvant chemotherapy. In March 2018, computed tomography (CT) examination showed disease progression in the form of pleural carcinomatosis with increased levels of tumor markers. In April 2018, total parietal pleurectomy, partial visc...
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Mutational status of lung cancer patients and survival outcomes for patients with limited brain metastases.
Authors: Hizal M, An Sendur M, Bilgin B, Yalcin B Abstract PMID: 30722126 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Can we rely on body mass index when predicting postoperative outcomes and survival of esophageal cancer patients?
Authors: Schizas D, Lidoriki I, Liakakos T Abstract PMID: 30722127 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - February 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

p53 mutations in oral cavity carcinoma.
Authors: Ragos V, S Mastronikolis N, Tsiambas E, Baliou E, N Mastronikolis S, Tsoukalas N, E Patsouri E, P Fotiades P Abstract Head and neck squamous cell carcinoma (HNSCC) includes a variety of SCCs derived from the anatomic regions of the oral and nasal cavity and also of the pharynx and larynx. Oral cavity SCC (OCSCC) demonstrates an increasing rate due to viral -related (High Risk Human Papilloma Virus-HR HPV) persistent infection, cigarette smoking and alcohol consumption. Gross chromosomal alterations (polysomy, aneuploidy) and specific gene aberrations such as amplifications, deletions, point mutations combi...
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Gastrointestinal stromal tumors and synchronous intra-abdominal malignancies: Review of the literature.
CONCLUSION: The synchronous occurrence of GISTs and other intra-abdominal primary tumors is more common that it has been considered and while it is not yet clear if there is a causal association for the concomitant occurrence of GIST with other malignancies a closer surveillance of GIST patients is needed due to their proved increased prevalence of a second primary tumor especially during the first year after diagnosis. PMID: 30610779 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Chromosomal instability in oral squamous cell carcinoma.
Authors: S Papanikolaou V, Kyrodimos E, Tsiambas E, Giotakis E, Psyrri A, Ragos V, Chrysovergis A Abstract Oral squamous cell carcinoma (OSCC) demonstrates an increasing rate due to high risk Human Papilloma Virus (HR-HPV) persistent infection, and also to chronic cigarette and alcohol consumption. Gross chromosomal alterations (polysomy, aneuploidy, intra-chromosome rearrangements) and specific gene aberrations such as amplifications, deletions, point mutations combined or not with epigenetic ones (promoter methylations and miRNA deregulations) are responsible for the progressive transformation of normal squamous ...
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Combination versus sequential paclitaxel plus gemcitabine as first-line chemotherapy for women with metastatic breast cancer: a prospective randomized phase II study.
CONCLUSIONS: Concomitant and sequential treatment with paclitaxel and gemcitabine had no significant difference in terms of PFS. PMID: 30610781 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Synchronous and metachronous bilateral breast cancer: A long-term experience.
CONCLUSION: The incidence rate of synchronous breast tumors has been rising thanks to growing awareness and the leading-edge imaging methods. The fact that the second tumor developed after more than 5 years among the patients with metachronous cancer gave rise to the increased rate of survival. PMID: 30610782 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

A study on the relationship between chemotherapy-induced cognitive impairment and age in patients with breast cancer.
Authors: Liu Z, Han X, Tian C, Chen J, Lei L, Liang Q, Lv X, Tang S, Ning P Abstract PURPOSE: To investigate the correlation of chemotherapy-induced cognitive impairment (CICI) with age in patients with triple-negative breast cancer (TNBC). METHODS: A total of 120 breast cancer patients with different ages and receiving chemotherapy were selected as breast cancer group, and another 120 healthy subjects were enrolled as healthy control group. Breast cancer group included 60 TNBC patients (TNBC group) and 60 patients without TNBC (non-TNBC group). Both breast cancer and healthy control group were further divided ...
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Developing a needs assessment questionnaire for women of reproductive age following breast cancer treatment: a cross-sectional pilot study in a Romanian sample.
CONCLUSIONS: The BCTNAS questionnaire provides a potential instrument to identify and assess the needs of breast cancer patients in the post-treatment period, having a positive impact on the quality of patient care. PMID: 30610784 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

TNF- α-308G/A polymorphism and the risk of colorectal cancer: A systematic review and an updated meta-analysis.
This study aimed to explore the relationship between TNF-α-308G/A polymorphism (rs1800629) and the risk of colorectal cancer (CRC) by meta-analysis. METHODS: Articles on exploring the relationship between TNF-α-308G/A polymorphism and CRC risk were searched from PubMed, Web of Science and Embase. The timeliness and authority of the included articles were evaluated. 95% confidence interval (95% CI) and odds ratio (OR) were calculated using fixed effect model or random effect model. Subgroup analysis was performed based on the ethnicity, source of control and method of genotyping. Finally, meta-analysis was c...
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Short- and long-term outcomes of laparoscopic complete mesocolic excision in elderly patients with right colon cancer.
CONCLUSION: Similar short- and long-term outcomes can be achieved among elderly and middle-aged patients with right colon cancer who underwent laparoscopic complete mesocolic excision. Age is not a limiting factor in the application of laparoscopic complete mesocolic excision. PMID: 30610786 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

MiR-421 inhibited proliferation and metastasis of colorectal cancer by targeting MTA1.
CONCLUSIONS: This research demonstrated the suppressive function of miR-421 in CRC. Therefore, the miR-421/MAT1 axis is expected to be one of the targets of CRC targeted therapy. PMID: 30610787 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

A 20-year single center experience in the surgical treatment of colorectal liver metastasis.
CONCLUSION: Surgical resection is the treatment of choice for the management of liver metastasis from colorectal cancer and can be safely performed. Follow up of patients with colorectal cancer is imperative as metachronous metastasis presents in a significant percentage of patients with negative locoregional lymph nodes of the primary tumor. The order of resection doesn't seem to alter outcome in synchronous metastasis. Recurrence is common and re-resection if feasible is the only chance of cure. PMID: 30610788 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Metastasectomy of pancreatic and periampullary adenocarcinoma to solid organ: The current evidence.
CONCLUSION: There is insufficient evidence to support a change of current practice in managing metastatic pancreatic and periampullary cancer. However, patients with ampullary cancer as the primary and any patients with first recurrence as isolated pulmonary metastases had better prognosis than patients with synchronous metastasis or metastases to the liver. This need to be explored in future studies. PMID: 30610789 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Assessing immunological surgical stress markers in patients undergoing digestive surgery for pancreatic, hepatic and gastric tumors.
CONCLUSION: This study demonstrates that plasma IL-10 concentration is positively associated with postoperative complications. PMID: 30610790 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

An open-label, single-arm phase II clinical study of induction chemotherapy and sequential Nimotuzumab combined with concurrent chemoradiotherapy in N3M0 stage nasopharyngeal carcinoma.
CONCLUSION: In N3 stage NPC, induction chemotherapy and sequential Nimotuzumab plus concurrent chemoradiotherapy yielded an excellent survival benefit, and the toxicities were tolerable. Distant metastasis was the main cause of treatment failure. PMID: 30610791 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Biological information analysis of differentially expressed genes in oral squamous cell carcinoma tissues in GEO database.
CONCLUSION: This study was helpful to further study the relationship between OSCC gene directions. PMID: 30610792 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Correlation between the expression of miR150 and FOXO4 and the local recurrence and metastasis of nasopharyngeal carcinoma after intensive radiotherapy.
Authors: Liu B, Tan Z, Jiang Y, Chen Y, Chen Y, Ling K Abstract PURPOSE: To investigate the relationship between the expression of miR150 and FOXO4 in nasopharyngeal carcinoma (NPC) and the local recurrence and metastasis after intensive radiotherapy. METHODS: 94 patients with NPC were selected in Hunan Provincial People's Hospital from May 2011 to May 2013. All patients received intensive radiotherapy. Thirty healthy controls were also included. The expression levels of miR150 and FOXO4 mRNA in blood lymphocytes were detected by RT-PCR. All patients with NPC were followed up for 36 months. Blood was drawn from...
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Arglabin is a plant sesquiterpene lactone that exerts potent anticancer effects on human oral squamous cancer cells via mitochondrial apoptosis and downregulation of the mTOR/PI3K/Akt signaling pathway to inhibit tumor growth in vivo.
CONCLUSIONS: Arglabin showed selective in vitro and in vivo anticancer activities against OSCC cells and is therefore a potential therapeutic agent for the management of OSCC. PMID: 30610794 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma.
CONCLUSIONS: Subpopulations of margin cells appeared to have stemness properties which might raise the question of re-evaluation of optimal surgical management. PMID: 30610795 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Antiproliferative and cytotoxic action of N-(p-coumaroyl) serotonin in lung cancer cells.
CONCLUSION: This is the first report on the in vitro action of CS against lung cancer, necessitating further studies towards its use as a potential anticancer agent. PMID: 30610796 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Development of novel real-time RT-qPCR methodologies for quantification of the COL11A1 mRNA general and C transcripts and evaluation in non-small cell lung cancer specimens.
Authors: Rizou T, Perlikos F, Lagiou M, Karaglani M, Nikolopoulos S, Toumpoulis I, Kroupis C Abstract PURPOSE: The purpose of this study was the development of new quantitative methodologies for the general (total) COL11A1 gene and the C transcript (RT-qPCR methods for A and E transcripts have already been developed by our group previously), the quantification of all COL11A1 transcripts and the investigation for the first time of their potential association with histopathological prognostic factors in lung cancer. METHODS: Real-time RT-qPCR methodologies with dual hybridization probes were developed on the Ligh...
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Serum sphingosine 1-phosphate in hepatocellular carcinoma patients is related to HBV infection.
CONCLUSIONS: These results suggested that serum S1P could be used as an auxiliary marker for HCC diagnosis, and used to monitor HBV infection in patients with HCC. PMID: 30610798 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

UNC119 promoted cell growth and migration by Wnt/ β-catenin signal and TGF-β/EMT signal pathway in hepatocellular carcinoma.
CONCLUSION: UNC119 is significantly up-regulated and promoted cell growth and migration in hepatic cancer cells and tissues via Wnt/β-catenin signal pathway and TGF-β/EMT signal pathway, respectively. Anti-UNC119 treatment inhibited cell proliferation, growth, migration and invasion through inhibition of Wnt/β-catenin and GF-β/EMT signal pathway, respectively. PMID: 30610799 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Expression of toll-like receptors in ovarian cancer.
Authors: Vlad C, Dina C, Kubelac P, Vlad D, Pop B, Achimas Cadariu P Abstract PURPOSE: Ovarian cancer continues to be the most lethal gynecologic malignancy, with a complex tumor microenvironment (TME). We investigated the immunohistochemical (IHC) expression of toll like receptors (TLRs) 4,5,7 and 9 together with CD68 and CD 163 as markers for tumor-associated macrophages (TAM) in relation to clinicopathological data. METHODS: Data from 102 patients with serous ovarian cancer treated between 2006 and 2011 was retrospectively reviewed. A TLR IHC score was developed and CD68, CD163 density scores were calculated...
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Influence of carboplatin on the proliferation and apoptosis of ovarian cancer cells through mTOR/p70s6k signaling pathway.
Authors: Zhou H, Zhao H, Liu H, Xu X, Dong X, Zhao E Abstract PURPOSE: To investigate the influence of carboplatin on the proliferation and apoptosis of ovarian cancer cells through mTOR/P70S6K signaling pathway. METHODS: The mRNA and protein expressions were detected via Western blotting and RT-PCR to study whether the mTOR/p70S6K signaling pathway was activated in OVCAR-3 and Caov-3 ovarian cancer cell lines. After cells were treated with different concentrations of carboplatin, the mRNA and protein expressions of mTOR, p70S6K and 4E-BP1 were detected via RT-PCR and Western blotting. OVCAR-3 cells were treate...
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Inhibition of human cervical cancer cell growth by Salviolone is mediated via autophagy induction, cell migration and cell invasion suppression, G2/M cell cycle arrest and downregulation of Nf-kB/m-TOR/PI3K/AKT pathway.
CONCLUSION: Taken all together, it is concluded that Salviolone could prove to be an important lead molecule for the treatment of cervical cancer. PMID: 30610802 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

LINC01170 promotes the progression of endometrial carcinoma by activating the AKT pathway.
CONCLUSIONS: LINC01170 promotes the progression of endometrial carcinoma through stimulating proliferation, cell cycle transition and inhibiting apoptosis of endometrial carcinoma cells via AKT pathway. PMID: 30610803 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - January 7, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research