Laparoscopic versus open gastrectomy with D2 lymph node dissection for advanced gastric cancer: a systematic review.
CONCLUSION: Although a technically demanding and time-consuming procedure, LGD2 offers the advantages of minimal invasion and can achieve the same degree of radical resections, harvested lymph nodes and short- or long-term prognosis for the treatment of locally AGC. PMID: 31424636 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

PD-1 and PD-L1 as immunotherapy targets and biomarkers in non-small cell lung cancer.
Authors: Tsoukalas N, Theocharis MKKTMTEAFPBGKS Abstract The integration of immunotherapeutic agents in the treatment of non-small cell lung cancer (NSCLC) has revolutionized the approach of the prevalent type of lung cancer. Although PD-1 and its ligands (PD-L1 and PD-L2) are stimulating molecules of the immune-checkpoint pathway, with primary function to limit inflammatory response and autoimmunity, tumor cells have found a way to exploit these molecules by obtaining the opportunity to respond with PD-L1 expression in cytokine signals and thus to evade immune surveillance. Several immunotherapeutic agents targeti...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Technical aspects, short- and long-term outcomes of laparoscopic and robotic D2-lymphadectomy in gastric cancer.
CONCLUSIONS: The superiority of laparoscopic gastrectomy towards the open technique is widely accepted, yet the proven acceptance of minimally invasive robotic techniques is still debated and not scientifically established. Technical challenges are the main point of discussion among the experts on the field, as well as the advantages of laparoscopic and robotic assisted gastrectomy over the conventional open. This review provides a comparison on technical aspects, the short and long term outcomes of open and minimally invasive gastrectomy with D2 lymphadenectomy in early and advanced gastric cancer. PMID: 31424638 [Pub...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

The function of tumor-derived exosomes.
Authors: Zhang X, Zhou CYJBXLWGZY Abstract Exosomes, especially the tumor-derived exosomes (TDEs), are extracellular vesicles released by many kinds of cells, which are involved in several biological and pathological processes. Their contents mainly include DNA, RNA and proteins. The message could be transmitted in neighboring or distant cells by secreting extracellular vesicles (EVs). Exosomes are a main intercellular communication regulator because they are involved and interact with intracellular signaling pathways. Exosomes can be detected in the tumor microenvironment, and there is growing evidence that TDEs a...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Surgical training in Greece: is there a feasible and efficient plan to overcome the Crisis?
Authors: Moris D, Felekouras GSKDITE Abstract PMID: 31424640 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Anticancer effects of curzerenone against drug-resistant human lung carcinoma cells are mediated via programmed cell death, loss of mitochondrial membrane potential, ROS, and blocking the ERK/MAPK and NF- κB signaling pathway.
CONCLUSIONS: In conclusion, the current results strongly indicate that Curzerenone may prove a potential anticancer drug candidate against drug-resistant lung cancer. PMID: 31424641 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Association between H19 polymorphisms and NSCLC risk in a Chinese Population.
CONCLUSIONS: H19 polymorphism rs2067051 and rs217727 might influence NSCLC susceptibility and the mechanism warrants further exploration. PMID: 31424642 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Clinical characteristics on low-dose high-resolution computed tomography and serum tumor markers of malignant pulmonary solid small nodules and postoperative survival analysis.
Authors: Fang R, Han H, Yang Y, Ma C, Xie B, Fu X, Lu W, Xu L, Wang D Abstract PURPOSE: To observe the clinical features of low-dose, high-resolution computed tomography (LDCT) and changes in serum tumor markers in malignant pulmonary solid small nodules (MPSSN), and to analyze the difference in survival of patients with malignant and benign PSSN 3 years after surgery. METHODS: Patients were enrolled from the thoracic surgery department of three hospitals. According to pathological diagnosis, all patients were divided into the case group (MPSSN, n=157) and the control group (BPSSN, n=75). There were no signific...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

MicroRNA-133 inhibits the growth and metastasis of the human lung cancer cells by targeting epidermal growth factor receptor.
Authors: Liu S, Chen J, Zhang T, Chen H Abstract PURPOSE: Accounting for 25% of all cancers and 20% of the cancer related-mortality, lung cancer is one of the devastating types of malignancies. The main obstacles for successful lung cancer manipulation include late diagnosis, dearth of safer chemotherapy and lack of potent therapeutic targets. Evidence indicates that microRNAs (miRs) may prove essential therapeutic targets for the management of deadly diseases, including cancer. Herein the role of miR-133 was investigated in lung cancer and the therapeutic potential of miR-133 was explored. METHODS: qRT-PCR was...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

In vitro and in vivo cytotoxic effects of chrysoeriol in human lung carcinoma are facilitated through activation of autophagy, sub-G1/G0 cell cycle arrest, cell migration and invasion inhibition and modulation of MAPK/ERK signalling pathway.
CONCLUSIONS: Chrysoeriol considerably and selectively suppresses the growth of lung cancer in vitro and in vivo and may prove beneficial in the management of this disease. PMID: 31424645 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Circulating plasminogen activator inhibitor-1 activity: a biomarker for resectable non-small cell lung cancer?
Authors: P Sotiropoulos G, Kotopouli M, Karampela I, Christodoulatos GS, Antonakos G, Marinou I, Vogiatzakis E, Lekka A, G Papavassiliou A, Dalamaga M Abstract PURPOSE: Plasminogen activator inhibitor-1 (PAI-1) participates in thrombotic, fibrinolytic, inflammatory and metabolic cascades. Since previous studies have focused on tissue and blood level concentrations, our goal was to investigate for the first time the independent relationship between plasma PAI-1 activity in resectable non small cell lung cancer (NSCLC) taking into consideration its several interfaces and study its diagnostic and prognostic potential....
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

MicroRNA-19a promotes proliferative and migratory abilities of NSCLC cells by inhibiting PTEN expression.
CONCLUSIONS: Higher expression of microRNA-19a promotes proliferative and migratory abilities of NSCLC cells by target inhibiting PTEN expression. PMID: 31424647 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Relationship between incidence of chronic obstructive pulmonary disease and lung cancer as comorbidity in primary health care in two Belgrade communities.
CONCLUSION: The number of patients with COPD registered in primary health care was similar in all investigated years. Lung cancer as comorbidity was found in a significantly smaller number of these patients. PMID: 31424648 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Sensitivity of ASPP and P-gp to neoadjuvant chemotherapy combined with gene therapy in locally advanced cervical cancer.
Authors: Xiao J, Zhou J, Liang L, Liu F, Liang H, Xu C, Meng J Abstract PURPOSE: To evaluate the sensitivity of apoptosis-stimulating protein of p53 (ASPP) and P-glycoprotein (P-gp) to the recombinant human adenovirus-p53 (rAd-p53) combined with neoadjuvant chemotherapy for locally advanced cervical cancer and their predictive value for efficacy. METHODS: 80 patients with histopathologically diagnosed locally advanced cervical cancer (stage Ib2-IIa2) and operative treatment from February 2009 to June 2013 were enrolled and randomly divided into 3 groups: radical hysterectomy group (RH group, n=30), simple intra...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways.
CONCLUSION: Taken together, these results suggest that Kaempferol exerts potent anticancer effects on ovarian cancer cells and may prove useful in the management of ovarian cancer. PMID: 31424650 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Clinical outcomes and cost-effectiveness of primary treatment of ovarian cancer in North-Western Romania.
CONCLUSIONS: Despite the higher costs, NACT did not prove to be a more effective therapeutic strategy in terms of survival of patients with stage IIIC/IV ovarian cancer. Altogether, our results state that NACT might be less cost-effective than PDS. PMID: 31424651 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Icariin inhibits the growth of human cervical cancer cells by inducing apoptosis and autophagy by targeting mTOR/PI3K/AKT signalling pathway.
CONCLUSION: Taken together Icariin may prove potent and efficacious lead molecule for the development of therapy for cervical cancer. PMID: 31424652 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Scopoletin exerts anticancer effects on human cervical cancer cell lines by triggering apoptosis, cell cycle arrest, inhibition of cell invasion and PI3K/AKT signalling pathway.
CONCLUSION: Taken together, Scopoletin may prove essential in the development of novel treatment regimes for cervical cancer. PMID: 31424653 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Therapeutic effect of bevacizumab combined with paclitaxel and carboplatin on recurrent ovarian cancer.
Authors: Cong J, Liu R, Hou J, Wang X, Jiang H, Wang J Abstract PURPOSE: To observe the clinical efficacy and safety of bevacizumab (BEV) combined with paclitaxel on recurrent ovarian cancer. METHODS: A total of 164 patients with recurrent ovarian cancer were selected and randomly divided into two groups: experimental group (n=82, BEV + paclitaxel + carboplatin) and control group (n=82, paclitaxel + carboplatin). The clinical therapeutic effects including objective response rate (ORR), complete response (CR) rate, partial response (PR) rate, stable disease (SD), progressive disease (PD), progression free surviv...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

The role of CD146 in serous ovarian carcinoma.
CONCLUSIONS: Although CD146 immunoreactivity in tumor cells did not correlate with the routinely used clinico-pathological parameters, expression of CD146 in tumor cells was an independent pronostic factor for survival in serous ovarian carcinomas. Moreover, CD146 might be regarded as a novel biomarker of tumor neovasculature. PMID: 31424655 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Low expression of TUG1 promotes cisplatin sensitivity in cervical cancer by activating the MAPK pathway.
CONCLUSIONS: TUG1 is highly expressed in CC tissues and closely related with its DDP-resistance. TUG1 knockdown could inhibit the proliferative rate but accelerate the apoptosis of CC cells through activating the MAPK pathway. PMID: 31424656 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Interaction of HCCR-1 and Bax in breast cancer.
Authors: Meng K, Yuan G, Bao H, Wang L, Ma R, Yu B, Zhao S Abstract PURPOSE: To evaluate the effect on breast cancer cell proliferation and apoptosis after silencing the HCCR-1 and to study its mechanism. METHODS: HCCR-1 siRNA was transfected into the breast cancer cell line MCF -7, and mRNA and protein level of HCCR-1 and Bax were evaluated by real-time quatitative PCR (qRT-PCR) and Western blotting, respectively. The cell proliferation and apoptosis were studied by MTT assay and flow cytometry. RESULTS: The apoptosis rate in the experimental, control and blank groups were 32.57±2.35%, 3.53±0...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Evaluation of the value of GATA3 combined with E-cadherin in the diagnosis of breast cancer.
Authors: Luo M, Huang Y, Huang J, Huang S, Wei L, Zhang Y, Zhang Z Abstract PURPOSE: To analyze the clinical value of GATA-3 combined with E-cadherin in the diagnosis of breast cancer. METHODS: 120 patients with breast cancer treated in Affiliated Tumor Hospital of Guangxi Medical University for the first time (experimental group) from May 2014 to December 2016 and 80 healthy females (control group) were retrospectively analyzed. The expression levels of GATA3 and E-cadherin in the experimental group and the control group were detected by enzyme-linked immunosorbent assay (ELISA). Binary logistic regression ana...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Interlaboratory concordance in HER2 testing: Results of a Serbian ring-study.
CONCLUSIONS: Our study highlights the difficulty encountered during HER2 testing using immunohistochemistry and CISH. This also emphasizes the need for rigorous quality control procedures for specimen preparation and analysis. PMID: 31424659 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

MicroRNA-204 inhibits the proliferation and metastasis of breast cancer cells by targeting PI3K/AKT pathway.
CONCLUSION: We conclude that miR-204 regulates the proliferation and metastasis of the breast cancer cells and as such may prove to be an important therapeutic target. PMID: 31424660 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

The functional role of the EZH2 gene in controlling breast cancer stem cells.
CONCLUSIONS: We conclude that the normal expression of EZH2 in cancer tissue controls cancer stem cell expansion, because it is highly elevated in EZH2-silencing cancer tissue. PMID: 31424661 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

The influence of reproductive factors on breast cancer risk in women with pathogenic mutations.
CONCLUSIONS: Breastfeeding represents a protective mechanism only in patients without genetic breast cancer predisposing mutations. Environmental and reproductive factors can impact the risk and the age of onset of breast cancer in patients carrying pathogenic mutations, but the mechanisms of action are not fully understood. PMID: 31424662 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

MicroRNA-155regulates the proliferation and metastasis of human breast cancers by targeting MAPK7.
CONCLUSION: Taken together, miR-155 may prove essential in the management of breast cancer. PMID: 31424663 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

The efficacy and reliability of sequential adjuvant anthracycline-based chemotherapy and weekly paclitaxel regimen in human epidermal growth factor receptor 2 negative breast cancer: A retrospective analysis of a multicentre study.
CONCLUSIONS: This multicentric retrospective study confirmed that sequential adjuvant therapy with anthracycline-based chemotherapy and paclitaxel for HER2 negative breast cancer is an effective and reliable regimen. PMID: 31424664 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Therapeutic effects of endoscopic mucosal resection on the recovery and prognosis of early gastric cancer.
Authors: Li T, Xiang PLB Abstract PURPOSE: To study the clinical effect of endoscopic mucosal resection (EMR) in the treatment of early gastric cancer (EGC), and to evaluate the recovery and prognosis, so as to provide references for clinical selection of treatment methods. METHODS: 120 patients with EGC were selected and randomly divided into the EMR group and the radical surgery group. Before surgery and 3 days after surgery, the levels of traumatic response-related indexes in serum [adrenocorticotropic hormone (ACTH), cortisol (Cor), gastrin (GAS) and motilin (MTL)] were assessed. Before surgery, 3 months an...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Clinicopathological features of Epstein-Barr virus-associated gastric carcinoma: A systematic review and meta-analysis.
CONCLUSIONS: In this meta-analysis, EBV infection rate was significantly higher in males and in diffuse cancer type. However, there was no marked association with lymph node metastasis, age and pathologic tumor stage. Thus, EBV-positive gastric cancer has distinct clinicopathological features. PMID: 31424666 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

In vitro and in vivo human gastric cancer inhibition by Trifolirhizin is facilitated via autophagy, mitochondrial mediated programmed cell death, G2/M phase cell cycle arrest and inhibition of m-TOR/PI3K/AKT signalling pathway.
CONCLUSIONS: In conclusion, it can be safely stated that Trifolirhizin has the potential to be developed as a potent anticancer agent against gastric carcinoma provided further in depth evaluation of this compound is performed. PMID: 31424667 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Association of low Syndecan-1 expression with adverse histopathological parameters in gastric carcinomas.
CONCLUSION: Low levels of tumor and stromal syndecan- 1 expression were associated with adverse histopathological parameters in gastric carcinoma. This suggests that syndecan-1 expression may be helpful for assessing the aggressiveness of gastric carcinomas. PMID: 31424668 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Effects of neoadjuvant chemotherapy combined with enteral nutrition on perioperative immunity, inflammation and intestinal flora in gastric cancer patients.
Authors: Zong L, Li H, Li S Abstract PURPOSE: To investigate the effects of neoadjuvant chemotherapy combined with enteral nutrition on perioperative immunity, inflammation and intestinal flora in gastric cancer patients. METHODS: A total of 96 gastric cancer patients scheduled to undergo operation were selected and randomly divided into the observation group (n=48) and the control group (n=48). The patients in the control group were treated with neoadjuvant chemotherapy before operation, while those in the observation group received enteral nutrition before operation based on the treatment in the control group...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Serum miR-1301-3p, miR-335-5p, miR-28-5p, and their target B7-H3 may serve as novel biomarkers for colorectal cancer.
CONCLUSION: Our results indicated that serum miR-1301-3p, miR-28-5p, miR-335-5p, and B7-H3 expressions were correlated with pathological stages of CRC and metastasis and may therefore serve as novel biomarkers for CRC diagnosis and treatment. PMID: 31424670 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

MiR-335-5p Inhibits Cell Proliferation, Migration and Invasion in Colorectal Cancer through Downregulating LDHB.
CONCLUSIONS: To sum up, the present study demonstrated that miR-335-5p regulates cell proliferation, migration as well as invasion of CRC cells through down-regulating LDHB, and demonstrated that miR-335-5p/LDHB axis may be an underlying therapeutic strategy in CRC. PMID: 31424671 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Significant association between MDM2 T309G polymorphism and colorectal cancer.
CONCLUSIONS: The SNP309 polymorphism of the MDM2 gene is associated with increased CRC risk in the Turkish population. PMID: 31424672 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

A flavone, Wogonin from Scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and G2/M cell cycle arrest via modulating the PI3K/AKT and STAT3 signalling pathways.
CONCLUSION: These results suggest that wogonin exerts potent anticancer effects on colorectal cancer cells and may prove essential in the management of colorectal cancer. PMID: 31424673 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Comparison of treatment response, survival and safety between drug-eluting bead transarterial chemoembolization with CalliSpheres ® microspheres versus conventional transarterial chemoembolization in treating hepatocellular carcinoma.
CONCLUSIONS: The short-term CR and ORR of DEB-TACE treatment with CSM are better, while OS, DFS and safety were equivalent compared to cTACE in treating HCC patients. PMID: 31424674 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Programmed cell death-1 in patients with primary liver cancer and its effect on prognosis.
Authors: Yang M, Dou WW, Sun GH, Zhang YL, Su Y, Xie RZ Abstract PURPOSE: To detect the expression of programmed cell death-1 (PD-1) in peripheral blood T lymphocytes of patients with primary liver cancer and its effect on their prognosis. METHODS: The medical records of 42 patients with primary liver cancer, 36 patients with chronic hepatitis B (CHB) and 38 healthy volunteers composed the liver cancer group, benign lesion group and control group, respectively. Fluorescence quantitative RT-PCR (qRT-PCR) was used for detecting the expression level of PD-1 mRNA in peripheral blood T lymphocytes of subjects in the...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Oridonin inhibits the proliferation, migration and invasion of human osteosarcoma cells via suppression of matrix metalloproteinase expression and STAT3 signalling pathway.
CONCLUSION: It is concluded that Oridonin exhibits significant antiproliferative effects on the osteosarcoma cells and may prove essential in the development of systemic therapy for osteosarcoma. PMID: 31424676 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Clinical evaluation of neoadjuvant chemotherapy for osteosarcoma.
Authors: Zhu W, Zhu L, Bao Y, Zhong X, Chen Y, Wu Q Abstract PURPOSE: To evaluate the clinical efficacy of neoadjuvant chemotherapy for treating osteosarcoma. METHODS: 102 osteosarcoma patients in our hospital were randomly assigned into the neoadjuvant chemotherapy group and the surgery group. Patients in the chemotherapy group received neoadjuvant chemotherapy after pathological diagnosis. Surgery was performed 3 weeks after chemotherapy, followed by 4-6 cycles of postoperative chemotherapy. Osteosarcoma patients in the surgery group were operated once diagnosed and received no chemotherapy. Limb salvage or a...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

The effect of the overexpression of miR-490 on the biological function of prostate cancer cell PC-3.
Authors: Hu Y, Hong Z, Cheng C, Xu J Abstract PURPOSE: To investigate the effect and molecular mechanism of miR-490 in prostate cancer. METHODS: qRT-PCR was used to detect the expression of miR-490 in human prostate cancer PC-3 cell line (the control group B) and normal human prostate cells (the control group A), the overexpression vector (the positive group) and human prostate cancer PC-3 cells transfected by negative control (the negative group) were built, and the results of the transfection were detected by qRT-PCR. RESULTS: The relative expression levels of miR-490 in the cells in the control group A, ...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

How reliable and useful are angiogenesis blood mediators for prostate cancer diagnosis?
Authors: Balacescu O, Crisan N, Balacescu L, Visan S, Tudoran O, Fetica B, Bungardean C, Marian C, Petrut B Abstract PURPOSE: To evaluate if a blood panel of genes involved in the modulation of the immune system, angiogenesis and tumor development could be used for prostate cancer detection. METHODS: Gene expression profiling of blood samples was assessed with the human angiogenesis RT² Profiler™ pcr array. The study group was divided into training and a testing/validation set. In total, 36 blood samples from 6 heatlhy men, 19 patients with prostate cancer (PCa) and 11 patients with benign prostate p...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Antitumor activity of Cedrelone in temozolomide-resistant human glioma cells is accompanied by mitochondrial mediated apoptosis, inhibition of angiogenesis, cell cycle disruption and modulation of ERK/MAPK signalling pathway.
CONCLUSIONS: These results indicate that Cedrelone could inhibit the growth of temozolomide-resistant malignant glioma in vitro and may be used for the development of chemotherapy against this disease. PMID: 31424680 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Research on correlations of MiR-203 expression with onset and prognosis of bladder cancer.
Authors: Huang Z, Liu G Abstract PURPOSE: To investigate the correlations of the expression of micro ribonucleic acid (miR)-203 with the onset and prognosis of bladder cancer. METHODS: Human bladder cancer T24 cell line with miR-203 overexpression were constructed. Effects of miR-203 expression on cell proliferation and apoptosis were detected via methyl thiazolyl tetrazolium (MTT) assay and flow cytometry, respectively. Fifty-eight patients with bladder cancer treated in our hospital were selected, and para-carcinoma tissues were used as controls. The expression of miR-203 in bladder cancer tissues was detecte...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

In vitro and in vivo growth inhibition of human leukemia cells by Nodakenetin are mediated via mitochondrial apoptosis, cell cycle arrest and inhibition of cell migration and invasion.
CONCLUSIONS: These results indicate Nodakenetin significantly inhibits the growth of leukemia cells in vitro and in vivo and may be a valuable molecule in the management of leukemia, and as such needs further in depth investigations. PMID: 31424682 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Correlations of Moesin expression with the pathological stage, nerve infiltration, tumor location and pain severity in patients with pancreatic cancer.
Authors: Liang L, Dong M, Cong K, Chen Y, Ma Z Abstract PURPOSE: The study aimed to investigate the correlations of the expression of membrane-organizing extension spike protein (moesin) with the pathological stage, nerve infiltration, tumor location and pain severity in patients with pancreatic cancer (PC) and analyze its possible mechanism. METHODS: A total of 43 patients with pancreatic cancer receiving surgical resection in our hospital were enrolled, with the adjacent tissues as controls. Then, quantitative polymerase chain reaction (qPCR) and Western blotting were carried out to measure the expression lev...
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Trend in esophageal cancer mortality in Serbia, 1991-2015 (a population-based study): an age-period-cohort analysis and a joinpoint regression analysis.
CONCLUSIONS: The trend of esophageal cancer mortality should be elucidated in future analytical epidemiological studies in Serbia. PMID: 31424684 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research

Clinical features and prognostic factors for surgical treatment of esophageal squamous cell carcinoma in elderly patients.
CONCLUSION: The pathological type and pathological stage were the important independent risk factors of prognosis. PMID: 31424685 [PubMed - in process] (Source: Journal of B.U.ON.)
Source: Journal of B.U.ON. - August 20, 2019 Category: Cancer & Oncology Tags: J BUON Source Type: research