Filtered By:
Cancer: Kidney Cancer
This page shows you your search results in order of date. This is page number 2.
Order by Relevance | Date
Total 216 results found since Jan 2013.
PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-18FFluoroglutamine
ConclusionsWe report one of the first direct orthotopic mouse models of ccRCC lung lesions. Using PET/MR imaging, lung tumors were easily discerned from normal tissue. Higher uptake of [18F]FGln was observed in a ccRCC cell line and lung lesions compared to HEK293 cells and normal lung tissue, respectively. [18F]FGln cell uptake was modulated by exogenous glutamine, V-9302, siRNA knockdown of ASCT2, and CB-839. Interestingly, in a pilot therapeutic study with CB-839, we observed no difference in treated tumors relative to untreated controls. This was in contrast with cellular studies, where CB-839 increased glutamine uptake.
Source: Molecular Imaging and Biology - June 22, 2022 Category: Molecular Biology Source Type: research
GSE148795 Study of transcriptional effects of FOXS1 silencing and TGF-beta treatment in SNU-449 hepatocellular carcinoma cell line
Conclusions: FOXS1 is a novel TGFβ target and a key mediator of EMT. Its induction in cancer is associated with a poor prognosis. Thus, determining the exp ression of FOXS1 in advanced tumors in which the pro-metastatic arm of TGFβ is activated could help to identify patients who may benefit from targeted therapies using TGFβ inhibitors.
Source: GEO: Gene Expression Omnibus - June 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Epigenetically-regulated miR-30a/c-5p directly target TWF1 and hamper ccRCC cell aggressiveness
Transl Res. 2022 Jun 10:S1931-5244(22)00141-4. doi: 10.1016/j.trsl.2022.06.009. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) is highly prone to metastasize and displays an extremely low 5-year survival rate. Not only miRNAs (miRs) are key gene expression regulators but can also be epigenetically modified. Abnormal miR expression has been linked with epithelial-mesenchymal transition (EMT)-driven ccRCC progression. MiR-30a/c-5p were found downregulated in ccRCC and associated with aggressiveness. Herein, we sought to unravel miR-30a/c-5p mechanistic role in ccRCC. RNA sequencing and genome-wide meth...
Source: Translational Research : the journal of laboratory and clinical medicine - June 13, 2022 Category: Laboratory Medicine Authors: Gon çalo Outeiro-Pinho Daniela Barros-Silva Filipa Moreira-Silva Jo ão Lobo Isa Carneiro Ant ónio Morais Eduarda P Martins C éline S Gonçalves Bruno M Costa Margareta P Correia Rui Henrique Carmen Jer ónimo Source Type: research
miR-4461 inhibits the progression of Gallbladder carcinoma via regulating EGFR/AKT signaling
In conclusion, miR-4461 suppresses GBC cells self-renewal, tumorigenicity, proliferation, and metastasis by inactivating EGFR/AKT signaling, and may therefore prove to be a potential therapeutic target for GBC patients.PMID:35196196 | DOI:10.1080/15384101.2022.2042775
Source: Cancer Control - February 23, 2022 Category: Cancer & Oncology Authors: Xingzhou Yan Pinghua Yang Hu Liu Yongyang Zhao Zhixiong Wu Baohua Zhang Source Type: research
Calcitriol ameliorates renal injury with high-salt diet-induced hypertension by upregulating GLIS2 expression and AMPK/mTOR-regulated autophagy
Gene. 2022 Jan 31:146239. doi: 10.1016/j.gene.2022.146239. Online ahead of print.ABSTRACTThe goal of the present study was to investigate the protective effect of calcitriol on high-salt diet-induced hypertension. The hypertension rat model was established by a long-term high-salt diet (8% NaCl). Rats were treated with calcitriol, losartan, or their combination. Histological staining was used to confirm renal pathology. Global transcriptome analysis of renal tissues was performed, and the mechanism of the therapeutic effect of calcitriol was analysed by functional annotation and pathway analysis of the differentially expre...
Source: Gene - February 3, 2022 Category: Genetics & Stem Cells Authors: Ruifeng Ding Yufeng Jiang Yi Yang Yong Shi Yang Ji Timing Zhen Zhiliang Fu Xunxia Bao Jia Tan Shuyong Zhang Jiahui Li Kaichen Xing Xinli Zhou Sibo Zhu Source Type: research
CD248+ Cancer-Associated Fibroblasts: A Novel Prognostic and Therapeutic Target for Renal Cell Carcinoma
ConclusionCD248+ CAFs participate in the regulation of RCC progression and immunosuppressive TME, which may represent a novel prognostic and therapeutic target for RCC.
Source: Frontiers in Oncology - December 14, 2021 Category: Cancer & Oncology Source Type: research
hZIP1 Inhibits Progression of Clear Cell Renal Cell Carcinoma by Suppressing NF-kB/HIF-1 α Pathway
ConclusionOur work has vital implications that hZIP1 suppresses ccRCC progression by inhibiting NF-kB/HIF-1α pathway.
Source: Frontiers in Oncology - December 2, 2021 Category: Cancer & Oncology Source Type: research
Clinicopathological and Preclinical Patient-Derived Model Studies Define High Expression of NRN1 as a Diagnostic and Therapeutic Target for Clear Cell Renal Cell Carcinoma
ConclusionNRN1 can be a potential diagnostic and therapeutic target in RCC as analyzed by preclinical patient-derived cancer models and clinicopathological studies.
Source: Frontiers in Oncology - November 3, 2021 Category: Cancer & Oncology Source Type: research
Comprehensive Multi-Omics Identification of Interferon- γ Response Characteristics Reveals That RBCK1 Regulates the Immunosuppressive Microenvironment of Renal Cell Carcinoma
In conclusion, this study identified IFN-γ response clusters, which might be used to improve the prognostic accuracy of immune contexture in the ccRCC microenvironment. Immune-cold RBCK1high patients have pro-tumorigenic immune infiltration and significantly worse outcomes than RBCK1low patients based on results from multi-omics to real-world data. Our discovery of novel independent prognostic indicators for RCC highlights the association between tumor alterations and immune phenotype.
Source: Frontiers in Immunology - November 2, 2021 Category: Allergy & Immunology Source Type: research
Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma
In this study, we performed a comprehensive transcriptome-based computational analysis on hundreds of HNSCC patients from TCGA and GEO databases, and found that DCLK1 expression positively correlates with NOTCH signaling pathway activation. Since NOTCH signaling has a recognized role in HNSCC tumorigenesis, we next performed a series of in vitro experiments in a collection of HNSCC cell lines to investigate the role of DCLK1 in NOTCH pathway regulation. Our analyses revealed that DCLK1 inhibition, using either a pharmacological inhibitor or siRNA, resulted in substantially decreased proliferation, invasion, migration, and ...
Source: Frontiers in Oncology - July 16, 2021 Category: Cancer & Oncology Source Type: research
