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Total 216 results found since Jan 2013.

Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma
In this study, we found that SUV420H2 is overexpressed in renal cancers and that high SUV420H2 expression is associated with a poor prognosis, as evidenced by RCC RNA-seq results derived from the TCGA. SUV420H2 knockdown using siRNA led to growth suppression and cell apoptosis in the A498 cell line. Furthermore, we identified DHRS2 as a direct target of SUV420H2 in the apoptosis process through a ChIP assay with a histone 4 lysine 20 (H4K20) trimethylation antibody. Rescue experiments showed that cotreatment with siSUV420H2 and siDHRS2 attenuated cell growth suppression induced by SUV420H2 knockdown only. Additionally, tre...
Source: Cell Research - April 29, 2023 Category: Cytology Authors: Tae Young Ryu Jinkwon Lee Yunsang Kang Mi-Young Son Dae-Soo Kim Youn Su Lee Mi-Young Kim Hyun-Soo Cho Source Type: research

Molecules, Vol. 27, Pages 8457: CD70-Targeted Micelles Enhance HIF2 & alpha; siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells
Molecules, Vol. 27, Pages 8457: CD70-Targeted Micelles Enhance HIF2α siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells Molecules doi: 10.3390/molecules27238457 Authors: Noah Trac Hyun Seok Oh Leila Izzy Jones Randy Caliliw Shinji Ohtake Brian Shuch Eun Ji Chung The majority of clear cell renal cell carcinomas (ccRCCs) are characterized by mutations in the Von Hippel–Lindau (VHL) tumor suppressor gene, which leads to the stabilization and accumulation of the HIF2α transcription factor that upregulates key oncogenic pat...
Source: Molecules - December 2, 2022 Category: Chemistry Authors: Noah Trac Hyun Seok Oh Leila Izzy Jones Randy Caliliw Shinji Ohtake Brian Shuch Eun Ji Chung Tags: Article Source Type: research

RUNX2 Mediates Renal Cell Carcinoma Invasion through Calpain2
In this study, RUNX2-negative A498 cells and strongly positive ACHN cells were selected as the study subjects. An invasion chamber assay was used to detect the invasive ability of the cells. The expression of each protein was detected by Western blotting or immunofluorescence assays. The invasive ability of A498 cells was enhanced after the expression of RUNX2 protein was upregulated, whereas ACHN cells decreased after the expression of RUNX2 protein was silenced. The expression of calcium-activated neutral protease 2 (Calpain2) and fibronectin (FN) proteins was upregulated in A498 cells overexpressing RUNX2 protein, where...
Source: Biological and Pharmaceutical Bulletin - November 3, 2022 Category: Drugs & Pharmacology Authors: Xiaoyu Zhang Zongtao Ren Bin Liu Shufei Wei Source Type: research

HIF2 inactivation and tumor suppression with a tumor-directed RNA-silencing drug in mice and humans
CONCLUSIONS: To our knowledge, this is the first example of functional inactivation of an oncoprotein and tumor suppression with a systemic, tumor-directed, RNA-silencing drug. These studies provide a proof-of-principle of HIF2α inhibition by RNA-targeting drugs in ccRCC and establish a paradigm for tumor-directed RNA-based therapeutics in cancer.PMID:36190432 | DOI:10.1158/1078-0432.CCR-22-0963
Source: Clinical Cancer Research - October 3, 2022 Category: Cancer & Oncology Authors: Yuanqing Ma Allison Joyce Olivia Brandenburg Faeze Saatchi Christina Stevens Vanina Toffessi Tcheuyap Alana Christie Quyen Do Oluwatomilade Fatunde Alyssa Macchiaroli So C Wong Layton Woolford Qurratulain Yousuf Jeffrey Miyata Deyssy Carrillo Oreoluwa Ona Source Type: research

ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma
ConclusionsACSL3 regulates the accumulation of lipid droplets in ccRCC and is essential for tumor growth. In addition, ACSL3 also modulates ferroptosis sensitivity in a manner dependent on the composition of exogenous fatty acids. Both functions of ACSL3 could be exploited for ccRCC therapy.
Source: Cancer and Metabolism - October 3, 2022 Category: Cancer & Oncology Source Type: research

Cellular and soluble immune checkpoint signaling forms PD-L1 and PD-1 in renal tumor tissue and in blood
AbstractImmune checkpoint blockade therapy is a treatment option of various metastatic cancer diseases including renal cell carcinoma (RCC). Approved antibody drugs target the co-inhibitory signaling of Programmed  Cell Death Ligand-1 (PD-L1) and its receptor Programmed Cell Death-1 (PD-1). The combined evaluation of PD-L1 and PD-1 at the mRNA and protein levels in tumor tissue with differentiation of tumor and immune cells as well as of soluble forms (sPD-L1) and (sPD-1) in blood is of basic interest in ass essing biomarker surrogates. Here, we demonstrate that PD-L1 determined as fraction of stained tumor cells (TPS-sco...
Source: Cancer Immunology, Immunotherapy - September 10, 2022 Category: Cancer & Oncology Source Type: research

Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation
In this report, the expression of the enzyme responsible for L2HG degradation, L-2HG dehydrogenase (L2HGDH), is knocked down, using lentiviral shRNA, as well as siRNA, in primary cultures of normal Renal Proximal Tubule (RPT) cells. The knockdown (KD) results in increased L-2HG levels, decreased demethylation of 5mC in genomic DNA, and increased methylation of H3 Histones. Consequences include reduced tubulogenesis by RPT cells in matrigel, and reduced expression of molecular markers of differentiation, including membrane transporters as well as HNF1α and HNF1β, which regulate their transcription. These results are consi...
Source: Frontiers in Endocrinology - September 5, 2022 Category: Endocrinology Source Type: research

CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1
Exp Cell Res. 2022 Jul 7:113279. doi: 10.1016/j.yexcr.2022.113279. Online ahead of print.ABSTRACTCholesterol homeostasis plays an important role in the maintenance of normal body functions. CYP27A1 is a key enzyme known to regulate cholesterol homeostasis, which catalyzes the conversion of cholesterol to 27-HC and has been implicated in the occurrence and metastasis of various cancer types. The present study aimed to explore the regulatory role of CYP27A1 in the development of clear cell renal cell carcinoma (ccRCC). In particular, the effect of CYP27A1 on the proliferation and migration of ccRCC cells was investigated. Th...
Source: Experimental Cell Research - July 10, 2022 Category: Cytology Authors: Zhijuan Liang Wei Jiao Liping Wang Yuanbin Chen Dan Li Zhao Zhang Zhilei Zhang Ye Liang Haitao Niu Source Type: research